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Items: 48


Biology and significance of alpha-fetoprotein in hepatocellular carcinoma.

Galle PR, Foerster F, Kudo M, Chan SL, Llovet JM, Qin S, Schelman WR, Chintharlapalli S, Abada PB, Sherman M, Zhu AX.

Liver Int. 2019 Aug 22. doi: 10.1111/liv.14223. [Epub ahead of print] Review.


Inhibition of Sphingosine Phosphate Receptor 1 Signaling Enhances the Efficacy of VEGF Receptor Inhibition.

Fischl AS, Wang X, Falcon BL, Almonte-Baldonado R, Bodenmiller D, Evans G, Stewart J, Wilson T, Hipskind P, Manro J, Uhlik MT, Chintharlapalli S, Gerald D, Alsop DC, Benjamin LE, Bhatt RS.

Mol Cancer Ther. 2019 Apr;18(4):856-867. doi: 10.1158/1535-7163.MCT-18-0548. Epub 2019 Feb 20.


GDF15 and Growth Control.

Emmerson PJ, Duffin KL, Chintharlapalli S, Wu X.

Front Physiol. 2018 Nov 27;9:1712. doi: 10.3389/fphys.2018.01712. eCollection 2018. Review.


Efficacy and safety of ramucirumab-containing chemotherapy in patients with pretreated metastatic gastric neuroendocrine carcinoma.

Mishima S, Kawazoe A, Matsumoto H, Kuboki Y, Bando H, Kojima T, Doi T, Ohtsu A, Yoshino T, Nonte EM, Chintharlapalli S, Nasir A, Kuwata T, Shitara K.

ESMO Open. 2018 Nov 1;3(7):e000443. doi: 10.1136/esmoopen-2018-000443. eCollection 2018.


An Endothelial Cell/Mesenchymal Stem Cell Coculture Cord Formation Assay to Model Vascular Biology In Vitro.

Swearingen M, Falcon B, Chintharlapalli S, Uhlik M.

Methods Mol Biol. 2018;1683:371-382. doi: 10.1007/978-1-4939-7357-6_21.


Angiopoietin-2 Blockade Promotes Survival of Corneal Transplants.

Zhang L, Li G, Sessa R, Kang GJ, Shi M, Ge S, Gong AJ, Wen Y, Chintharlapalli S, Chen L.

Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):79-86. doi: 10.1167/iovs.16-20485.


Antagonist antibodies to vascular endothelial growth factor receptor 2 (VEGFR-2) as anti-angiogenic agents.

Falcon BL, Chintharlapalli S, Uhlik MT, Pytowski B.

Pharmacol Ther. 2016 Aug;164:204-25. doi: 10.1016/j.pharmthera.2016.06.001. Epub 2016 Jun 8. Review.


Stromal-Based Signatures for the Classification of Gastric Cancer.

Uhlik MT, Liu J, Falcon BL, Iyer S, Stewart J, Celikkaya H, O'Mahony M, Sevinsky C, Lowes C, Douglass L, Jeffries C, Bodenmiller D, Chintharlapalli S, Fischl A, Gerald D, Xue Q, Lee JY, Santamaria-Pang A, Al-Kofahi Y, Sui Y, Desai K, Doman T, Aggarwal A, Carter JH, Pytowski B, Jaminet SC, Ginty F, Nasir A, Nagy JA, Dvorak HF, Benjamin LE.

Cancer Res. 2016 May 1;76(9):2573-86. doi: 10.1158/0008-5472.CAN-16-0022.


A bi-functional antibody-receptor domain fusion protein simultaneously targeting IGF-IR and VEGF for degradation.

Shen Y, Zeng L, Novosyadlyy R, Forest A, Zhu A, Korytko A, Zhang H, Eastman SW, Topper M, Hindi S, Covino N, Persaud K, Kang Y, Burtrum D, Surguladze D, Prewett M, Chintharlapalli S, Wroblewski VJ, Shen J, Balderes P, Zhu Z, Snavely M, Ludwig DL.

MAbs. 2015;7(5):931-45. doi: 10.1080/19420862.2015.1055442.


An in vitro cord formation assay identifies unique vascular phenotypes associated with angiogenic growth factors.

Falcon BL, Swearingen M, Gough WH, Lee L, Foreman R, Uhlik M, Hanson JC, Lee JA, McClure DB, Chintharlapalli S.

PLoS One. 2014 Sep 11;9(9):e106901. doi: 10.1371/journal.pone.0106901. eCollection 2014.


Development and characterization of a high-throughput in vitro cord formation model insensitive to VEGF inhibition.

Falcon BL, O'Clair B, McClure D, Evans GF, Stewart J, Swearingen ML, Chen Y, Allard K, Lee LN, Neote K, McEwen DP, Uhlik MT, Chintharlapalli S.

J Hematol Oncol. 2013 Apr 27;6:31. doi: 10.1186/1756-8722-6-31.


Angiopoietin-2: an attractive target for improved antiangiogenic tumor therapy.

Gerald D, Chintharlapalli S, Augustin HG, Benjamin LE.

Cancer Res. 2013 Mar 15;73(6):1649-57. doi: 10.1158/0008-5472.CAN-12-4697. Epub 2013 Mar 6. Review.


Induction of the transcriptional repressor ZBTB4 in prostate cancer cells by drug-induced targeting of microRNA-17-92/106b-25 clusters.

Kim K, Chadalapaka G, Pathi SS, Jin UH, Lee JS, Park YY, Cho SG, Chintharlapalli S, Safe S.

Mol Cancer Ther. 2012 Sep;11(9):1852-62. doi: 10.1158/1535-7163.MCT-12-0181. Epub 2012 Jun 29.


Tasisulam sodium, an antitumor agent that inhibits mitotic progression and induces vascular normalization.

Meier T, Uhlik M, Chintharlapalli S, Dowless M, Van Horn R, Stewart J, Blosser W, Cook J, Young D, Ye X, Evans G, Credille K, Ballard D, Huber L, Capen A, Chedid M, Ilaria R Jr, Smith MC, Stancato L.

Mol Cancer Ther. 2011 Nov;10(11):2168-78. doi: 10.1158/1535-7163.MCT-11-0323. Epub 2011 Sep 8.


Inhibition of pituitary tumor-transforming gene-1 in thyroid cancer cells by drugs that decrease specificity proteins.

Chintharlapalli S, Papineni S, Lee SO, Lei P, Jin UH, Sherman SI, Santarpia L, Safe S.

Mol Carcinog. 2011 Sep;50(9):655-67. doi: 10.1002/mc.20738. Epub 2011 Jan 25.


Apoptotic Effect of Tolfenamic Acid in KB Human Oral Cancer Cells: Possible Involvement of the p38 MAPK Pathway.

Kim JH, Jung JY, Shim JH, Kim J, Choi KH, Shin JA, Choi ES, Lee SO, Chintharlapalli S, Kwon KH, Leem DH, Cho NP, Cho SD.

J Clin Biochem Nutr. 2010 Jul;47(1):74-80. doi: 10.3164/jcbn.10-02. Epub 2010 Jun 17.


Inactivation of the orphan nuclear receptor TR3/Nur77 inhibits pancreatic cancer cell and tumor growth.

Lee SO, Abdelrahim M, Yoon K, Chintharlapalli S, Papineni S, Kim K, Wang H, Safe S.

Cancer Res. 2010 Sep 1;70(17):6824-36. doi: 10.1158/0008-5472.CAN-10-1992. Epub 2010 Jul 21.


Activation of nerve growth factor-induced B alpha by methylene-substituted diindolylmethanes in bladder cancer cells induces apoptosis and inhibits tumor growth.

Cho SD, Lee SO, Chintharlapalli S, Abdelrahim M, Khan S, Yoon K, Kamat AM, Safe S.

Mol Pharmacol. 2010 Mar;77(3):396-404. doi: 10.1124/mol.109.061143. Epub 2009 Dec 18.


The p38 MAPK pathway is critical for 5,5'-dibromodiindolylmethane-induced apoptosis to prevent oral squamous carcinoma cells.

Choi KH, Kim HK, Kim JH, Choi ES, Shin JA, Lee SO, Chintharlapalli S, Safe S, Abdelrahim M, Kong G, Choi HS, Jung JY, Cho HT, Cho NP, Cho SD.

Eur J Cancer Prev. 2010 Mar;19(2):153-9. doi: 10.1097/CEJ.0b013e328333d088.


Peroxisome proliferator-activated receptor gamma-dependent activity of indole ring-substituted 1,1-bis(3'-indolyl)-1-(p-biphenyl)methanes in cancer cells.

Guo J, Chintharlapalli S, Lee SO, Cho SD, Lei P, Papineni S, Safe S.

Cancer Chemother Pharmacol. 2010 May;66(1):141-50. doi: 10.1007/s00280-009-1144-0. Epub 2009 Oct 13.


p21 expression is induced by activation of nuclear nerve growth factor-induced Balpha (Nur77) in pancreatic cancer cells.

Lee SO, Chintharlapalli S, Liu S, Papineni S, Cho SD, Yoon K, Safe S.

Mol Cancer Res. 2009 Jul;7(7):1169-78. doi: 10.1158/1541-7786.MCR-08-0473. Epub 2009 Jul 7.


Oncogenic microRNA-27a is a target for anticancer agent methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate in colon cancer cells.

Chintharlapalli S, Papineni S, Abdelrahim M, Abudayyeh A, Jutooru I, Chadalapaka G, Wu F, Mertens-Talcott S, Vanderlaag K, Cho SD, Smith R 3rd, Safe S.

Int J Cancer. 2009 Oct 15;125(8):1965-74. doi: 10.1002/ijc.24530.


Tolfenamic acid inhibits esophageal cancer through repression of specificity proteins and c-Met.

Papineni S, Chintharlapalli S, Abdelrahim M, Lee SO, Burghardt R, Abudayyeh A, Baker C, Herrera L, Safe S.

Carcinogenesis. 2009 Jul;30(7):1193-201. doi: 10.1093/carcin/bgp092. Epub 2009 Apr 30.


Induction of apoptosis and nonsteroidal anti-inflammatory drug-activated gene 1 in pancreatic cancer cells by a glycyrrhetinic acid derivative.

Jutooru I, Chadalapaka G, Chintharlapalli S, Papineni S, Safe S.

Mol Carcinog. 2009 Aug;48(8):692-702. doi: 10.1002/mc.20518.


1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth.

Inamoto T, Papineni S, Chintharlapalli S, Cho SD, Safe S, Kamat AM.

Mol Cancer Ther. 2008 Dec;7(12):3825-33. doi: 10.1158/1535-7163.MCT-08-0730.


5,5'-Dibromo-bis(3'-indolyl)methane induces Kruppel-like factor 4 and p21 in colon cancer cells.

Cho SD, Chintharlapalli S, Abdelrahim M, Papineni S, Liu S, Guo J, Lei P, Abudayyeh A, Safe S.

Mol Cancer Ther. 2008 Jul;7(7):2109-20. doi: 10.1158/1535-7163.MCT-07-2311.


Curcumin decreases specificity protein expression in bladder cancer cells.

Chadalapaka G, Jutooru I, Chintharlapalli S, Papineni S, Smith R 3rd, Li X, Safe S.

Cancer Res. 2008 Jul 1;68(13):5345-54. doi: 10.1158/0008-5472.CAN-07-6805.


Cancer chemotherapy with indole-3-carbinol, bis(3'-indolyl)methane and synthetic analogs.

Safe S, Papineni S, Chintharlapalli S.

Cancer Lett. 2008 Oct 8;269(2):326-38. doi: 10.1016/j.canlet.2008.04.021. Epub 2008 May 22. Review.


1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through activation of c-jun N-terminal kinase.

Lei P, Abdelrahim M, Cho SD, Liu S, Chintharlapalli S, Safe S.

Carcinogenesis. 2008 Jun;29(6):1139-47. doi: 10.1093/carcin/bgn103. Epub 2008 May 5.


1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes induce apoptosis and inhibit renal cell carcinoma growth.

York M, Abdelrahim M, Chintharlapalli S, Lucero SD, Safe S.

Clin Cancer Res. 2007 Nov 15;13(22 Pt 1):6743-52.


1,1-bis(3'-indolyl)-1-(p-methoxyphenyl)methane activates Nur77-independent proapoptotic responses in colon cancer cells.

Cho SD, Lei P, Abdelrahim M, Yoon K, Liu S, Guo J, Papineni S, Chintharlapalli S, Safe S.

Mol Carcinog. 2008 Apr;47(4):252-63.


2-cyano-lup-1-en-3-oxo-20-oic acid, a cyano derivative of betulinic acid, activates peroxisome proliferator-activated receptor gamma in colon and pancreatic cancer cells.

Chintharlapalli S, Papineni S, Liu S, Jutooru I, Chadalapaka G, Cho SD, Murthy RS, You Y, Safe S.

Carcinogenesis. 2007 Nov;28(11):2337-46. Epub 2007 Aug 27.


Anthocyanin fraction from potato extracts is cytotoxic to prostate cancer cells through activation of caspase-dependent and caspase-independent pathways.

Reddivari L, Vanamala J, Chintharlapalli S, Safe SH, Miller JC Jr.

Carcinogenesis. 2007 Oct;28(10):2227-35. Epub 2007 May 23.


Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors.

Chintharlapalli S, Papineni S, Ramaiah SK, Safe S.

Cancer Res. 2007 Mar 15;67(6):2816-23.


Nur77 agonists induce proapoptotic genes and responses in colon cancer cells through nuclear receptor-dependent and nuclear receptor-independent pathways.

Cho SD, Yoon K, Chintharlapalli S, Abdelrahim M, Lei P, Hamilton S, Khan S, Ramaiah SK, Safe S.

Cancer Res. 2007 Jan 15;67(2):674-83.


Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways.

Chintharlapalli S, Burghardt R, Papineni S, Ramaiah S, Yoon K, Safe S.

J Biol Chem. 2005 Jul 1;280(26):24903-14. Epub 2005 May 3.


2-Cyano-3,12-dioxoolean-1,9-dien-28-oic acid and related compounds inhibit growth of colon cancer cells through peroxisome proliferator-activated receptor gamma-dependent and -independent pathways.

Chintharlapalli S, Papineni S, Konopleva M, Andreef M, Samudio I, Safe S.

Mol Pharmacol. 2005 Jul;68(1):119-28. Epub 2005 Mar 29.


BMRP is a Bcl-2 binding protein that induces apoptosis.

Chintharlapalli SR, Jasti M, Malladi S, Parsa KV, Ballestero RP, González-García M.

J Cell Biochem. 2005 Feb 15;94(3):611-26.


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