Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 104

1.

A novel form of Deleted in breast cancer 1 (DBC1) lacking the N-terminal domain does not bind SIRT1 and is dynamically regulated in vivo.

Santos L, Colman L, Contreras P, Chini CC, Carlomagno A, Leyva A, Bresque M, Marmisolle I, Quijano C, Durán R, Irigoín F, Prieto-Echagüe V, Vendelbo MH, Sotelo-Silveira JR, Chini EN, Badano JL, Calliari AJ, Escande C.

Sci Rep. 2019 Oct 7;9(1):14381. doi: 10.1038/s41598-019-50789-7.

2.

The Multi-faceted Ecto-enzyme CD38: Roles in Immunomodulation, Cancer, Aging, and Metabolic Diseases.

Hogan KA, Chini CCS, Chini EN.

Front Immunol. 2019 May 31;10:1187. doi: 10.3389/fimmu.2019.01187. eCollection 2019. Review.

3.

Targeting CD38 Enhances the Antileukemic Activity of Ibrutinib in Chronic Lymphocytic Leukemia.

Manna A, Aulakh S, Jani P, Ahmed S, Akhtar S, Coignet M, Heckman M, Meghji Z, Bhatia K, Sharma A, Sher T, Alegria V, Malavasi F, Chini EN, Chanan-Khan A, Ailawadhi S, Paulus A.

Clin Cancer Res. 2019 Jul 1;25(13):3974-3985. doi: 10.1158/1078-0432.CCR-18-3412. Epub 2019 Apr 2.

PMID:
30940652
4.

Targeting senescent cells alleviates obesity-induced metabolic dysfunction.

Palmer AK, Xu M, Zhu Y, Pirtskhalava T, Weivoda MM, Hachfeld CM, Prata LG, van Dijk TH, Verkade E, Casaclang-Verzosa G, Johnson KO, Cubro H, Doornebal EJ, Ogrodnik M, Jurk D, Jensen MD, Chini EN, Miller JD, Matveyenko A, Stout MB, Schafer MJ, White TA, Hickson LJ, Demaria M, Garovic V, Grande J, Arriaga EA, Kuipers F, von Zglinicki T, LeBrasseur NK, Campisi J, Tchkonia T, Kirkland JL.

Aging Cell. 2019 Jun;18(3):e12950. doi: 10.1111/acel.12950. Epub 2019 Mar 25.

5.

Measuring CD38 Hydrolase and Cyclase Activities: 1,N6-Ethenonicotinamide Adenine Dinucleotide (ε-NAD) and Nicotinamide Guanine Dinucleotide (NGD) Fluorescence-based Methods.

de Oliveira GC, Kanamori KS, Auxiliadora-Martins M, Chini CCS, Chini EN.

Bio Protoc. 2018 Jul 20;8(14). pii: e2938. doi: 10.21769/BioProtoc.2938.

7.

A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline.

Tarragó MG, Chini CCS, Kanamori KS, Warner GM, Caride A, de Oliveira GC, Rud M, Samani A, Hein KZ, Huang R, Jurk D, Cho DS, Boslett JJ, Miller JD, Zweier JL, Passos JF, Doles JD, Becherer DJ, Chini EN.

Cell Metab. 2018 May 1;27(5):1081-1095.e10. doi: 10.1016/j.cmet.2018.03.016.

8.

The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of Aging.

Chini EN, Chini CCS, Espindola Netto JM, de Oliveira GC, van Schooten W.

Trends Pharmacol Sci. 2018 Apr;39(4):424-436. doi: 10.1016/j.tips.2018.02.001. Epub 2018 Feb 23. Review.

9.

Rho GTPase effectors and NAD metabolism in cancer immune suppression.

Chaker M, Minden A, Chen S, Weiss RH, Chini EN, Mahipal A, Azmi AS.

Expert Opin Ther Targets. 2018 Jan;22(1):9-17. doi: 10.1080/14728222.2018.1413091. Epub 2017 Dec 10. Review.

10.

Preclinical efficacy of the novel competitive NAMPT inhibitor STF-118804 in pancreatic cancer.

Espindola-Netto JM, Chini CCS, Tarragó M, Wang E, Dutta S, Pal K, Mukhopadhyay D, Sola-Penna M, Chini EN.

Oncotarget. 2017 Jun 29;8(49):85054-85067. doi: 10.18632/oncotarget.18841. eCollection 2017 Oct 17.

11.

The Nuclear Receptor LXR Limits Bacterial Infection of Host Macrophages through a Mechanism that Impacts Cellular NAD Metabolism.

Matalonga J, Glaria E, Bresque M, Escande C, Carbó JM, Kiefer K, Vicente R, León TE, Beceiro S, Pascual-García M, Serret J, Sanjurjo L, Morón-Ros S, Riera A, Paytubi S, Juarez A, Sotillo F, Lindbom L, Caelles C, Sarrias MR, Sancho J, Castrillo A, Chini EN, Valledor AF.

Cell Rep. 2017 Jan 31;18(5):1241-1255. doi: 10.1016/j.celrep.2017.01.007.

12.

NAD and the aging process: Role in life, death and everything in between.

Chini CCS, Tarragó MG, Chini EN.

Mol Cell Endocrinol. 2017 Nov 5;455:62-74. doi: 10.1016/j.mce.2016.11.003. Epub 2016 Nov 5. Review.

13.

A High Dose of Isoniazid Disturbs Endobiotic Homeostasis in Mouse Liver.

Li F, Wang P, Liu K, Tarrago MG, Lu J, Chini EN, Ma X.

Drug Metab Dispos. 2016 Nov;44(11):1742-1751. Epub 2016 Aug 16.

14.

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism.

Camacho-Pereira J, Tarragó MG, Chini CCS, Nin V, Escande C, Warner GM, Puranik AS, Schoon RA, Reid JM, Galina A, Chini EN.

Cell Metab. 2016 Jun 14;23(6):1127-1139. doi: 10.1016/j.cmet.2016.05.006.

15.

Correction: SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington's Disease Mice.

Tulino R, Benjamin AC, Jolinon N, Smith DL, Chini EN, Carnemolla A, Bates GP.

PLoS One. 2016 Feb 26;11(2):e0150682. doi: 10.1371/journal.pone.0150682. eCollection 2016.

16.

SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington's Disease Mice.

Tulino R, Benjamin AC, Jolinon N, Smith DL, Chini EN, Carnemolla A, Bates GP.

PLoS One. 2016 Jan 27;11(1):e0145425. doi: 10.1371/journal.pone.0145425. eCollection 2016. Erratum in: PLoS One. 2016;11(2):e0150682.

17.

SIRT1-Activating Compounds (STAC) Negatively Regulate Pancreatic Cancer Cell Growth and Viability Through a SIRT1 Lysosomal-Dependent Pathway.

Chini CC, Espindola-Netto JM, Mondal G, Guerrico AM, Nin V, Escande C, Sola-Penna M, Zhang JS, Billadeau DD, Chini EN.

Clin Cancer Res. 2016 May 15;22(10):2496-507. doi: 10.1158/1078-0432.CCR-15-1760. Epub 2015 Dec 11.

18.

Food Restriction Ameliorates the Development of Polycystic Kidney Disease.

Warner G, Hein KZ, Nin V, Edwards M, Chini CC, Hopp K, Harris PC, Torres VE, Chini EN.

J Am Soc Nephrol. 2016 May;27(5):1437-47. doi: 10.1681/ASN.2015020132. Epub 2015 Nov 4.

19.

Phenotypic Characterization of Mice Carrying Homozygous Deletion of KLF11, a Gene in Which Mutations Cause Human Neonatal and MODY VII Diabetes.

Mathison A, Escande C, Calvo E, Seo S, White T, Salmonson A, Faubion WA Jr, Buttar N, Iovanna J, Lomberk G, Chini EN, Urrutia R.

Endocrinology. 2015 Oct;156(10):3581-95. doi: 10.1210/en.2015-1145. Epub 2015 Aug 6.

20.

Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity.

Palmer AK, Tchkonia T, LeBrasseur NK, Chini EN, Xu M, Kirkland JL.

Diabetes. 2015 Jul;64(7):2289-98. doi: 10.2337/db14-1820. Review.

21.

Cardiomyopathy and Worsened Ischemic Heart Failure in SM22-α Cre-Mediated Neuropilin-1 Null Mice: Dysregulation of PGC1α and Mitochondrial Homeostasis.

Wang Y, Cao Y, Yamada S, Thirunavukkarasu M, Nin V, Joshi M, Rishi MT, Bhattacharya S, Camacho-Pereira J, Sharma AK, Shameer K, Kocher JP, Sanchez JA, Wang E, Hoeppner LH, Dutta SK, Leof EB, Shah V, Claffey KP, Chini EN, Simons M, Terzic A, Maulik N, Mukhopadhyay D.

Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1401-12. doi: 10.1161/ATVBAHA.115.305566. Epub 2015 Apr 16.

22.

DBC1 is a suppressor of B cell activation by negatively regulating alternative NF-κB transcriptional activity.

Kong S, Thiruppathi M, Qiu Q, Lin Z, Dong H, Chini EN, Prabhakar BS, Fang D.

J Immunol. 2014 Dec 1;193(11):5515-24. doi: 10.4049/jimmunol.1401798. Epub 2014 Oct 31.

23.

Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer.

Roy D, Mondal S, Wang C, He X, Khurana A, Giri S, Hoffmann R, Jung DB, Kim SH, Chini EN, Periera JC, Folmes CD, Mariani A, Dowdy SC, Bakkum-Gamez JN, Riska SM, Oberg AL, Karoly ED, Bell LN, Chien J, Shridhar V.

Cancer Metab. 2014 Aug 18;2:13. doi: 10.1186/2049-3002-2-13. eCollection 2014. Erratum in: Cancer Metab. 2014;2:24.

24.

Deleted in breast cancer 1 limits adipose tissue fat accumulation and plays a key role in the development of metabolic syndrome phenotype.

Escande C, Nin V, Pirtskhalava T, Chini CC, Tchkonia T, Kirkland JL, Chini EN.

Diabetes. 2015 Jan;64(1):12-22. doi: 10.2337/db14-0192. Epub 2014 Jul 22.

25.

Growth hormone signaling in muscle and adipose tissue of obese human subjects: associations with measures of body composition and interaction with resveratrol treatment.

Clasen BF, Poulsen MM, Escande C, Pedersen SB, Møller N, Chini EN, Jessen N, Jørgensen JO.

J Clin Endocrinol Metab. 2014 Dec;99(12):E2565-73. doi: 10.1210/jc.2014-2215.

PMID:
25050904
26.

Deleted in Breast Cancer 1 regulates cellular senescence during obesity.

Escande C, Nin V, Pirtskhalava T, Chini CC, Thereza Barbosa M, Mathison A, Urrutia R, Tchkonia T, Kirkland JL, Chini EN.

Aging Cell. 2014 Oct;13(5):951-3. doi: 10.1111/acel.12235. Epub 2014 Jul 3.

27.

Deleted in breast cancer 1 (DBC1) protein regulates hepatic gluconeogenesis.

Nin V, Chini CC, Escande C, Capellini V, Chini EN.

J Biol Chem. 2014 Feb 28;289(9):5518-27. doi: 10.1074/jbc.M113.512913. Epub 2014 Jan 10.

28.

Erratum to: Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer.

Roy D, Mondal S, Wang C, He X, Khurana A, Giri S, Hoffmann R, Jung DB, Kim SH, Chini EN, Periera JC, Folmes CD, Mariani A, Dowdy SC, Bakkum-Gamez JN, Riska SM, Oberg AL, Karoly ED, Bell LN, Chien J, Shridhar V.

Cancer Metab. 2014 Nov 4;2:24. doi: 10.1186/2049-3002-2-24. eCollection 2014.

29.

Resveratrol delays Wallerian degeneration in a NAD(+) and DBC1 dependent manner.

Calliari A, Bobba N, Escande C, Chini EN.

Exp Neurol. 2014 Jan;251:91-100. doi: 10.1016/j.expneurol.2013.11.013. Epub 2013 Nov 16.

PMID:
24252177
30.

Targeting of NAD metabolism in pancreatic cancer cells: potential novel therapy for pancreatic tumors.

Chini CC, Guerrico AM, Nin V, Camacho-Pereira J, Escande C, Barbosa MT, Chini EN.

Clin Cancer Res. 2014 Jan 1;20(1):120-30. doi: 10.1158/1078-0432.CCR-13-0150. Epub 2013 Sep 11.

31.

Deleted in breast cancer-1 (DBC-1) in the interface between metabolism, aging and cancer.

Chini EN, Chini CC, Nin V, Escande C.

Biosci Rep. 2013 Aug 23;33(4). pii: e00058. doi: 10.1042/BSR20130062. Review.

32.

Krüppel-like factor 11 regulates the expression of metabolic genes via an evolutionarily conserved protein interaction domain functionally disrupted in maturity onset diabetes of the young.

Lomberk G, Grzenda A, Mathison A, Escande C, Zhang JS, Calvo E, Miller LJ, Iovanna J, Chini EN, Fernandez-Zapico ME, Urrutia R.

J Biol Chem. 2013 Jun 14;288(24):17745-58. doi: 10.1074/jbc.M112.434670. Epub 2013 Apr 15.

33.

DBC1 (Deleted in Breast Cancer 1) modulates the stability and function of the nuclear receptor Rev-erbα.

Chini CC, Escande C, Nin V, Chini EN.

Biochem J. 2013 May 1;451(3):453-61. doi: 10.1042/BJ20121085.

34.

Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome.

Escande C, Nin V, Price NL, Capellini V, Gomes AP, Barbosa MT, O'Neil L, White TA, Sinclair DA, Chini EN.

Diabetes. 2013 Apr;62(4):1084-93. doi: 10.2337/db12-1139. Epub 2012 Nov 19.

35.

Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase.

Nin V, Escande C, Chini CC, Giri S, Camacho-Pereira J, Matalonga J, Lou Z, Chini EN.

J Biol Chem. 2012 Jul 6;287(28):23489-501. doi: 10.1074/jbc.M112.365874. Epub 2012 May 2.

36.

Altered behavioral and metabolic circadian rhythms in mice with disrupted NAD+ oscillation.

Sahar S, Nin V, Barbosa MT, Chini EN, Sassone-Corsi P.

Aging (Albany NY). 2011 Aug;3(8):794-802.

37.

HDAC3 is negatively regulated by the nuclear protein DBC1.

Chini CC, Escande C, Nin V, Chini EN.

J Biol Chem. 2010 Dec 24;285(52):40830-7. doi: 10.1074/jbc.M110.153270. Epub 2010 Oct 28.

38.

Dietary restriction: standing up for sirtuins.

Baur JA, Chen D, Chini EN, Chua K, Cohen HY, de Cabo R, Deng C, Dimmeler S, Gius D, Guarente LP, Helfand SL, Imai S, Itoh H, Kadowaki T, Koya D, Leeuwenburgh C, McBurney M, Nabeshima Y, Neri C, Oberdoerffer P, Pestell RG, Rogina B, Sadoshima J, Sartorelli V, Serrano M, Sinclair DA, Steegborn C, Tatar M, Tissenbaum HA, Tong Q, Tsubota K, Vaquero A, Verdin E.

Science. 2010 Aug 27;329(5995):1012-3; author reply 1013-4. doi: 10.1126/science.329.5995.1012. No abstract available.

39.

CD38 expression, function, and gene resequencing in a human lymphoblastoid cell line-based model system.

Hartman WR, Pelleymounter LL, Moon I, Kalari K, Liu M, Wu TY, Escande C, Nin V, Chini EN, Weinshilboum RM.

Leuk Lymphoma. 2010 Jul;51(7):1315-25. doi: 10.3109/10428194.2010.483299.

40.

Spontaneous activity, economy of activity, and resistance to diet-induced obesity in rats bred for high intrinsic aerobic capacity.

Novak CM, Escande C, Burghardt PR, Zhang M, Barbosa MT, Chini EN, Britton SL, Koch LG, Akil H, Levine JA.

Horm Behav. 2010 Aug;58(3):355-67. doi: 10.1016/j.yhbeh.2010.03.013. Epub 2010 Mar 27.

41.

Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice.

Escande C, Chini CC, Nin V, Dykhouse KM, Novak CM, Levine J, van Deursen J, Gores GJ, Chen J, Lou Z, Chini EN.

J Clin Invest. 2010 Feb;120(2):545-58. doi: 10.1172/JCI39319. Epub 2010 Jan 11.

42.

Endurance capacity, not body size, determines physical activity levels: role of skeletal muscle PEPCK.

Novak CM, Escande C, Gerber SM, Chini EN, Zhang M, Britton SL, Koch LG, Levine JA.

PLoS One. 2009 Jun 12;4(6):e5869. doi: 10.1371/journal.pone.0005869.

44.

Calcium regulation and signaling in apicomplexan parasites.

Nagamune K, Moreno SN, Chini EN, Sibley LD.

Subcell Biochem. 2008;47:70-81. Review.

PMID:
18512342
45.

Abscisic acid controls calcium-dependent egress and development in Toxoplasma gondii.

Nagamune K, Hicks LM, Fux B, Brossier F, Chini EN, Sibley LD.

Nature. 2008 Jan 10;451(7175):207-10. doi: 10.1038/nature06478.

46.

The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity.

Barbosa MT, Soares SM, Novak CM, Sinclair D, Levine JA, Aksoy P, Chini EN.

FASEB J. 2007 Nov;21(13):3629-39. Epub 2007 Jun 21.

PMID:
17585054
47.

Reduction in soluble guanylyl cyclase-specific activity following prolonged treatment of porcine pulmonary artery with nitric oxide.

Perkins WJ, Taniguchi M, Warner DO, Chini EN, Jones KA.

Am J Physiol Lung Cell Mol Physiol. 2007 Jul;293(1):L84-95. Epub 2007 Mar 23.

48.

Integrin ligands mobilize Ca2+ from ryanodine receptor-gated stores and lysosome-related acidic organelles in pulmonary arterial smooth muscle cells.

Umesh A, Thompson MA, Chini EN, Yip KP, Sham JS.

J Biol Chem. 2006 Nov 10;281(45):34312-23. Epub 2006 Sep 9.

49.

Regulation of SIRT 1 mediated NAD dependent deacetylation: a novel role for the multifunctional enzyme CD38.

Aksoy P, Escande C, White TA, Thompson M, Soares S, Benech JC, Chini EN.

Biochem Biophys Res Commun. 2006 Oct 13;349(1):353-9. Epub 2006 Aug 22.

PMID:
16935261
50.

Differential effects of volatile anesthetics on M3 muscarinic receptor coupling to the Galphaq heterotrimeric G protein.

Nakayama T, Penheiter AR, Penheiter SG, Chini EN, Thompson M, Warner DO, Jones KA.

Anesthesiology. 2006 Aug;105(2):313-24.

PMID:
16871065

Supplemental Content

Loading ...
Support Center