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Items: 1 to 50 of 97


Irisin counteracts high glucose and fatty acid induced cytotoxicity by preserving AMPK-insulin receptor signaling axis in C2C12 myoblast.

Yano N, Zhang L, Wei D, Dubielecka PM, Wei L, Zhuang S, Zhu P, Qin G, Liu PY, Chin YE, Zhao TC.

Am J Physiol Endocrinol Metab. 2020 Mar 17. doi: 10.1152/ajpendo.00219.2019. [Epub ahead of print]


Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression.

Xu Q, Long Q, Zhu D, Fu D, Zhang B, Han L, Qian M, Guo J, Xu J, Cao L, Chin YE, Coppé JP, Lam EW, Campisi J, Sun Y.

Aging Cell. 2019 Dec;18(6):e13027. doi: 10.1111/acel.13027. Epub 2019 Sep 7.


CREBZF as a Key Regulator of STAT3 Pathway in the Control of Liver Regeneration in Mice.

Hu Z, Han Y, Liu Y, Zhao Z, Ma F, Cui A, Zhang F, Liu Z, Xue Y, Bai J, Wu H, Bian H, Chin YE, Yu Y, Meng Z, Wang H, Liu Y, Fan J, Gao X, Chen Y, Li Y.

Hepatology. 2019 Aug 30. doi: 10.1002/hep.30919. [Epub ahead of print]


SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism.

Wang T, Cao Y, Zheng Q, Tu J, Zhou W, He J, Zhong J, Chen Y, Wang J, Cai R, Zuo Y, Wei B, Fan Q, Yang J, Wu Y, Yi J, Li D, Liu M, Wang C, Zhou A, Li Y, Wu X, Yang W, Chin YE, Chen G, Cheng J.

Mol Cell. 2019 Aug 22;75(4):823-834.e5. doi: 10.1016/j.molcel.2019.06.008. Epub 2019 Jul 10.


p38-Regulated/activated protein kinase plays a pivotal role in protecting heart against ischemia-reperfusion injury and preserving cardiac performance.

Zhao YT, Du J, Yano N, Wang H, Wang J, Dubielecka PM, Zhang LX, Qin G, Zhuang S, Liu PY, Chin YE, Zhao TC.

Am J Physiol Cell Physiol. 2019 Sep 1;317(3):C525-C533. doi: 10.1152/ajpcell.00122.2019. Epub 2019 Jul 10.


Absence of GdX/UBL4A Protects against Inflammatory Diseases by Regulating NF-кB Signaling in Macrophages and Dendritic Cells.

Liu C, Zhou Y, Li M, Wang Y, Yang L, Yang S, Feng Y, Wang Y, Wang Y, Ren F, Li J, Dong Z, Chin YE, Fu X, Wu L, Chang Z.

Theranostics. 2019 Feb 14;9(5):1369-1384. doi: 10.7150/thno.32451. eCollection 2019.


Human Embryonic Stem Cell-Derived Cardiovascular Progenitors Repair Infarcted Hearts Through Modulation of Macrophages via Activation of Signal Transducer and Activator of Transcription 6.

Wang J, Liu M, Wu Q, Li Q, Gao L, Jiang Y, Deng B, Huang W, Bi W, Chen Z, Chin YE, Paul C, Wang Y, Yang HT.

Antioxid Redox Signal. 2019 Aug 10;31(5):369-386. doi: 10.1089/ars.2018.7688. Epub 2019 Apr 16.


STAT4 activation by leukemia inhibitory factor confers a therapeutic effect on intestinal inflammation.

Zhang YS, Xin DE, Wang Z, Song X, Sun Y, Zou QC, Yue J, Zhang C, Zhang JM, Liu Z, Zhang X, Zhao TC, Su B, Chin YE.

EMBO J. 2019 Mar 15;38(6). pii: e99595. doi: 10.15252/embj.201899595. Epub 2019 Feb 15.


Missed appointments (DNAs) among the burns patient population.

Chin YR, Maraka J, Allison K.

Burns. 2019 Mar;45(2):502-503. doi: 10.1016/j.burns.2018.06.003. Epub 2018 Dec 7. No abstract available.


Identification of a cellularly active SIRT6 allosteric activator.

Huang Z, Zhao J, Deng W, Chen Y, Shang J, Song K, Zhang L, Wang C, Lu S, Yang X, He B, Min J, Hu H, Tan M, Xu J, Zhang Q, Zhong J, Sun X, Mao Z, Lin H, Xiao M, Chin YE, Jiang H, Xu Y, Chen G, Zhang J.

Nat Chem Biol. 2018 Dec;14(12):1118-1126. doi: 10.1038/s41589-018-0150-0. Epub 2018 Oct 29.


Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance.

Chen F, Long Q, Fu D, Zhu D, Ji Y, Han L, Zhang B, Xu Q, Liu B, Li Y, Wu S, Yang C, Qian M, Xu J, Liu S, Cao L, Chin YE, Lam EW, Coppé JP, Sun Y.

Nat Commun. 2018 Oct 17;9(1):4315. doi: 10.1038/s41467-018-06860-4.


Transgenic overexpression of active HDAC4 in the heart attenuates cardiac function and exacerbates remodeling in infarcted myocardium.

Zhang LX, Du J, Zhao YT, Wang J, Zhang S, Dubielecka PM, Wei L, Zhuang S, Qin G, Chin YE, Zhao TC.

J Appl Physiol (1985). 2018 Dec 1;125(6):1968-1978. doi: 10.1152/japplphysiol.00006.2018. Epub 2018 Oct 4.


Correction to: CCN2 inhibits lung cancer metastasis through promoting DAPK-dependent anoikis and inducing EGFR degradation.

Chang CC, Yang MH, Lin BR, Chen ST, Pan SH, Hsiao M, Lai TC, Lin SK, Jeng YM, Chu CY, Chen RH, Yang PC, Chin YE, Kuo ML.

Cell Death Differ. 2019 Jan;26(1):196. doi: 10.1038/s41418-018-0140-5.


Irisin promotes cardiac progenitor cell-induced myocardial repair and functional improvement in infarcted heart.

Zhao YT, Wang J, Yano N, Zhang LX, Wang H, Zhang S, Qin G, Dubielecka PM, Zhuang S, Liu PY, Chin YE, Zhao TC.

J Cell Physiol. 2019 Feb;234(2):1671-1681. doi: 10.1002/jcp.27037. Epub 2018 Sep 1.


Myocyte-specific overexpressing HDAC4 promotes myocardial ischemia/reperfusion injury.

Zhang L, Wang H, Zhao Y, Wang J, Dubielecka PM, Zhuang S, Qin G, Chin YE, Kao RL, Zhao TC.

Mol Med. 2018 Jul 17;24(1):37. doi: 10.1186/s10020-018-0037-2.


The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1.

Zhang B, Fu D, Xu Q, Cong X, Wu C, Zhong X, Ma Y, Lv Z, Chen F, Han L, Qian M, Chin YE, Lam EW, Chiao P, Sun Y.

Nat Commun. 2018 Apr 30;9(1):1723. doi: 10.1038/s41467-018-04010-4.


Acetylation within the N- and C-Terminal Domains of Src Regulates Distinct Roles of STAT3-Mediated Tumorigenesis.

Huang C, Zhang Z, Chen L, Lee HW, Ayrapetov MK, Zhao TC, Hao Y, Gao J, Yang C, Mehta GU, Zhuang Z, Zhang X, Hu G, Chin YE.

Cancer Res. 2018 Jun 1;78(11):2825-2838. doi: 10.1158/0008-5472.CAN-17-2314. Epub 2018 Mar 12.


Phosphorylation of glutaminase by PKCε is essential for its enzymatic activity and critically contributes to tumorigenesis.

Han T, Zhan W, Gan M, Liu F, Yu B, Chin YE, Wang JB.

Cell Res. 2018 Jun;28(6):655-669. doi: 10.1038/s41422-018-0021-y. Epub 2018 Mar 7.


Role of influenza A virus NP acetylation on viral growth and replication.

Giese S, Ciminski K, Bolte H, Moreira ÉA, Lakdawala S, Hu Z, David Q, Kolesnikova L, Götz V, Zhao Y, Dengjel J, Chin YE, Xu K, Schwemmle M.

Nat Commun. 2017 Nov 2;8(1):1259. doi: 10.1038/s41467-017-01112-3.


JMJD5 cleaves monomethylated histone H3 N-tail under DNA damaging stress.

Shen J, Xiang X, Chen L, Wang H, Wu L, Sun Y, Ma L, Gu X, Liu H, Wang L, Yu YN, Shao J, Huang C, Chin YE.

EMBO Rep. 2017 Dec;18(12):2131-2143. doi: 10.15252/embr.201743892. Epub 2017 Oct 5.


Glutamic Pyruvate Transaminase GPT2 Promotes Tumorigenesis of Breast Cancer Cells by Activating Sonic Hedgehog Signaling.

Cao Y, Lin SH, Wang Y, Chin YE, Kang L, Mi J.

Theranostics. 2017 Jul 22;7(12):3021-3033. doi: 10.7150/thno.18992. eCollection 2017.


Inactivation of STAT3 Signaling Impairs Hair Cell Differentiation in the Developing Mouse Cochlea.

Chen Q, Quan Y, Wang N, Xie C, Ji Z, He H, Chai R, Li H, Yin S, Chin YE, Wei X, Gao WQ.

Stem Cell Reports. 2017 Jul 11;9(1):231-246. doi: 10.1016/j.stemcr.2017.05.031. Epub 2017 Jun 29.


Re: Bacteriological study in perianal abscess is not useful and not cost-effective.

Bisset CN, Dick L, Chin YR, Summers L, Renwick A.

ANZ J Surg. 2017 May;87(5):420-421. doi: 10.1111/ans.13878. No abstract available.


Geminin facilitates FoxO3 deacetylation to promote breast cancer cell metastasis.

Zhang L, Cai M, Gong Z, Zhang B, Li Y, Guan L, Hou X, Li Q, Liu G, Xue Z, Yang MH, Ye J, Chin YE, You H.

J Clin Invest. 2017 Jun 1;127(6):2159-2175. doi: 10.1172/JCI90077. Epub 2017 Apr 24.


Irisin plays a pivotal role to protect the heart against ischemia and reperfusion injury.

Wang H, Zhao YT, Zhang S, Dubielecka PM, Du J, Yano N, Chin YE, Zhuang S, Qin G, Zhao TC.

J Cell Physiol. 2017 Dec;232(12):3775-3785. doi: 10.1002/jcp.25857. Epub 2017 May 3.


Opposing Roles of Acetylation and Phosphorylation in LIFR-Dependent Self-Renewal Growth Signaling in Mouse Embryonic Stem Cells.

Wang XJ, Qiao Y, Xiao MM, Wang L, Chen J, Lv W, Xu L, Li Y, Wang Y, Tan MD, Huang C, Li J, Zhao TC, Hou Z, Jing N, Chin YE.

Cell Rep. 2017 Jan 24;18(4):933-946. doi: 10.1016/j.celrep.2016.12.081.


Sodium Butyrate Protects -Against High Fat Diet-Induced Cardiac Dysfunction and Metabolic Disorders in Type II Diabetic Mice.

Zhang L, Du J, Yano N, Wang H, Zhao YT, Dubielecka PM, Zhuang S, Chin YE, Qin G, Zhao TC.

J Cell Biochem. 2017 Aug;118(8):2395-2408. doi: 10.1002/jcb.25902. Epub 2017 Apr 25.


Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation.

Ma L, Huang C, Wang XJ, Xin DE, Wang LS, Zou QC, Zhang YS, Tan MD, Wang YM, Zhao TC, Chatterjee D, Altura RA, Wang C, Xu YS, Yang JH, Fan YS, Han BH, Si J, Zhang X, Cheng J, Chang Z, Chin YE.

Mol Cell. 2017 Jan 19;65(2):296-309. doi: 10.1016/j.molcel.2016.12.002. Epub 2017 Jan 5.


PCAF acts as a gastric cancer suppressor through a novel PCAF-p16-CDK4 axis.

Fei HJ, Zu LD, Wu J, Jiang XS, Wang JL, Chin YE, Fu GH.

Am J Cancer Res. 2016 Dec 1;6(12):2772-2786. eCollection 2016.


STAT3 Undergoes Acetylation-dependent Mitochondrial Translocation to Regulate Pyruvate Metabolism.

Xu YS, Liang JJ, Wang Y, Zhao XJ, Xu L, Xu YY, Zou QC, Zhang JM, Tu CE, Cui YG, Sun WH, Huang C, Yang JH, Chin YE.

Sci Rep. 2016 Dec 22;6:39517. doi: 10.1038/srep39517.


The LIM protein AJUBA promotes colorectal cancer cell survival through suppression of JAK1/STAT1/IFIT2 network.

Jia H, Song L, Cong Q, Wang J, Xu H, Chu Y, Li Q, Zhang Y, Zou X, Zhang C, Chin YE, Zhang X, Li Z, Zhu K, Wang B, Peng H, Hou Z.

Oncogene. 2017 May 11;36(19):2655-2666. doi: 10.1038/onc.2016.418. Epub 2016 Nov 28.


SENP1 regulates IFN-γ-STAT1 signaling through STAT3-SOCS3 negative feedback loop.

Yu T, Zuo Y, Cai R, Huang X, Wu S, Zhang C, Chin YE, Li D, Zhang Z, Xia N, Wang Q, Shen H, Yao X, Zhang ZY, Xue S, Shen L, Cheng J.

J Mol Cell Biol. 2017 Apr 1;9(2):144-153. doi: 10.1093/jmcb/mjw042.


SUMOylation and SENP3 regulate STAT3 activation in head and neck cancer.

Zhou Z, Wang M, Li J, Xiao M, Chin YE, Cheng J, Yeh ET, Yang J, Yi J.

Oncogene. 2016 Nov 10;35(45):5826-5838. doi: 10.1038/onc.2016.124. Epub 2016 May 16.


Type I interferons exert anti-tumor effect via reversing immunosuppression mediated by mesenchymal stromal cells.

Shou P, Chen Q, Jiang J, Xu C, Zhang J, Zheng C, Jiang M, Velletri T, Cao W, Huang Y, Yang Q, Han X, Zhang L, Wei L, Rabson AB, Chin YE, Wang Y, Shi Y.

Oncogene. 2016 Nov 17;35(46):5953-5962. doi: 10.1038/onc.2016.128. Epub 2016 Apr 25.


SUMOylated ORC2 Recruits a Histone Demethylase to Regulate Centromeric Histone Modification and Genomic Stability.

Huang C, Cheng J, Bawa-Khalfe T, Yao X, Chin YE, Yeh ETH.

Cell Rep. 2016 Apr 5;15(1):147-157. doi: 10.1016/j.celrep.2016.02.091. Epub 2016 Mar 24.


Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice.

Gong Q, Hu Z, Zhang F, Cui A, Chen X, Jiang H, Gao J, Chen X, Han Y, Liang Q, Ye D, Shi L, Chin YE, Wang Y, Xiao H, Guo F, Liu Y, Zang M, Xu A, Li Y.

Hepatology. 2016 Aug;64(2):425-38. doi: 10.1002/hep.28523. Epub 2016 Apr 15.


The STAT3 HIES mutation is a gain-of-function mutation that activates genes via AGG-element carrying promoters.

Xu L, Ji JJ, Le W, Xu YS, Dou D, Pan J, Jiao Y, Zhong T, Wu D, Wang Y, Wen C, Xie GQ, Yao F, Zhao H, Fan YS, Chin YE.

Nucleic Acids Res. 2015 Oct 15;43(18):8898-912. doi: 10.1093/nar/gkv911. Epub 2015 Sep 17.


The NF-κB p65/miR-23a-27a-24 cluster is a target for leukemia treatment.

Zhang YC, Ye H, Zeng Z, Chin YE, Huang YN, Fu GH.

Oncotarget. 2015 Oct 20;6(32):33554-67. doi: 10.18632/oncotarget.5591.


mTOR and post-translational modifications rely on mitochondrion as the arsenal for cellular metabolism regulation.

Zhuge CJ, Chen SJ, Chin YE.

Sci China Life Sci. 2015 Aug;58(8):810-2. doi: 10.1007/s11427-015-4909-1. Epub 2015 Jul 23. No abstract available.


Leukemia inhibitory factor attenuates renal fibrosis through Stat3-miR-29c.

Yu Y, Wang Y, Niu Y, Fu L, Chin YE, Yu C.

Am J Physiol Renal Physiol. 2015 Oct 1;309(7):F595-603. doi: 10.1152/ajprenal.00634.2014. Epub 2015 Jul 8.


NF-κB-induced microRNA-31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis.

Yan S, Xu Z, Lou F, Zhang L, Ke F, Bai J, Liu Z, Liu J, Wang H, Zhu H, Sun Y, Cai W, Gao Y, Su B, Li Q, Yang X, Yu J, Lai Y, Yu XZ, Zheng Y, Shen N, Chin YE, Wang H.

Nat Commun. 2015 Jul 3;6:7652. doi: 10.1038/ncomms8652.


PCAF-primed EZH2 acetylation regulates its stability and promotes lung adenocarcinoma progression.

Wan J, Zhan J, Li S, Ma J, Xu W, Liu C, Xue X, Xie Y, Fang W, Chin YE, Zhang H.

Nucleic Acids Res. 2015 Apr 20;43(7):3591-604. doi: 10.1093/nar/gkv238. Epub 2015 Mar 23.


EGF Receptor Inhibition Alleviates Hyperuricemic Nephropathy.

Liu N, Wang L, Yang T, Xiong C, Xu L, Shi Y, Bao W, Chin YE, Cheng SB, Yan H, Qiu A, Zhuang S.

J Am Soc Nephrol. 2015 Nov;26(11):2716-29. doi: 10.1681/ASN.2014080793. Epub 2015 Mar 18.


Lung Tumor Suppressor GPRC5A Binds EGFR and Restrains Its Effector Signaling.

Zhong S, Yin H, Liao Y, Yao F, Li Q, Zhang J, Jiao H, Zhao Y, Xu D, Liu S, Song H, Gao Y, Liu J, Ma L, Pang Z, Yang R, Ding C, Sun B, Lin X, Ye X, Guo W, Han B, Zhou BP, Chin YE, Deng J.

Cancer Res. 2015 May 1;75(9):1801-14. doi: 10.1158/0008-5472.CAN-14-2005. Epub 2015 Mar 5.


Gprc5a-deficiency confers susceptibility to endotoxin-induced acute lung injury via NF-κB pathway.

Liao Y, Song H, Xu D, Jiao H, Yao F, Liu J, Wu Y, Zhong S, Yin H, Liu S, Wang X, Guo W, Sun B, Han B, Chin YE, Deng J.

Cell Cycle. 2015;14(9):1403-12. doi: 10.1080/15384101.2015.1006006.


AF9 promotes hESC neural differentiation through recruiting TET2 to neurodevelopmental gene loci for methylcytosine hydroxylation.

Qiao Y, Wang X, Wang R, Li Y, Yu F, Yang X, Song L, Xu G, Chin YE, Jing N.

Cell Discov. 2015 Jul 28;1:15017. doi: 10.1038/celldisc.2015.17. eCollection 2015.


EGFR phosphorylates and inhibits lung tumor suppressor GPRC5A in lung cancer.

Lin X, Zhong S, Ye X, Liao Y, Yao F, Yang X, Sun B, Zhang J, Li Q, Gao Y, Wang Y, Liu J, Han B, Chin YE, Zhou BP, Deng J.

Mol Cancer. 2014 Oct 14;13:233. doi: 10.1186/1476-4598-13-233.


Whole-exome and targeted gene sequencing of gallbladder carcinoma identifies recurrent mutations in the ErbB pathway.

Li M, Zhang Z, Li X, Ye J, Wu X, Tan Z, Liu C, Shen B, Wang XA, Wu W, Zhou D, Zhang D, Wang T, Liu B, Qu K, Ding Q, Weng H, Ding Q, Mu J, Shu Y, Bao R, Cao Y, Chen P, Liu T, Jiang L, Hu Y, Dong P, Gu J, Lu W, Shi W, Lu J, Gong W, Tang Z, Zhang Y, Wang X, Chin YE, Weng X, Zhang H, Tang W, Zheng Y, He L, Wang H, Liu Y, Liu Y.

Nat Genet. 2014 Aug;46(8):872-6. doi: 10.1038/ng.3030. Epub 2014 Jul 6.


A microRNA 221- and 222-mediated feedback loop maintains constitutive activation of NFκB and STAT3 in colorectal cancer cells.

Liu S, Sun X, Wang M, Hou Y, Zhan Y, Jiang Y, Liu Z, Cao X, Chen P, Liu Z, Chen X, Tao Y, Xu C, Mao J, Cheng C, Li C, Hu Y, Wang L, Chin YE, Shi Y, Siebenlist U, Zhang X.

Gastroenterology. 2014 Oct;147(4):847-859.e11. doi: 10.1053/j.gastro.2014.06.006. Epub 2014 Jun 12.


Snail recruits Ring1B to mediate transcriptional repression and cell migration in pancreatic cancer cells.

Chen J, Xu H, Zou X, Wang J, Zhu Y, Chen H, Shen B, Deng X, Zhou A, Chin YE, Rauscher FJ 3rd, Peng C, Hou Z.

Cancer Res. 2014 Aug 15;74(16):4353-63. doi: 10.1158/0008-5472.CAN-14-0181. Epub 2014 Jun 5.

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