Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 295

1.

Preclinical efficacy in therapeutic area guidelines from the U.S. Food and Drug Administration and the European Medicines Agency: a cross-sectional study.

Langhof H, Chin WWL, Wieschowski S, Federico C, Kimmelman J, Strech D.

Br J Pharmacol. 2018 Nov;175(22):4229-4238. doi: 10.1111/bph.14485. Epub 2018 Oct 1.

2.

Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery.

Coussens NP, Sittampalam GS, Guha R, Brimacombe K, Grossman A, Chung TDY, Weidner JR, Riss T, Trask OJ, Auld D, Dahlin JL, Devanaryan V, Foley TL, McGee J, Kahl SD, Kales SC, Arkin M, Baell J, Bejcek B, Gal-Edd N, Glicksman M, Haas JV, Iversen PW, Hoeppner M, Lathrop S, Sayers E, Liu H, Trawick B, McVey J, Lemmon VP, Li Z, McManus O, Minor L, Napper A, Wildey MJ, Pacifici R, Chin WW, Xia M, Xu X, Lal-Nag M, Hall MD, Michael S, Inglese J, Simeonov A, Austin CP.

Clin Transl Sci. 2018 Sep;11(5):461-470. doi: 10.1111/cts.12570. Epub 2018 Jul 24. Review.

3.

Preclinical efficacy studies in investigator brochures: Do they enable risk-benefit assessment?

Wieschowski S, Chin WWL, Federico C, Sievers S, Kimmelman J, Strech D.

PLoS Biol. 2018 Apr 5;16(4):e2004879. doi: 10.1371/journal.pbio.2004879. eCollection 2018 Apr.

4.

What evidence do we need for biomarker qualification?

Leptak C, Menetski JP, Wagner JA, Aubrecht J, Brady L, Brumfield M, Chin WW, Hoffmann S, Kelloff G, Lavezzari G, Ranganathan R, Sauer JM, Sistare FD, Zabka T, Wholley D.

Sci Transl Med. 2017 Nov 22;9(417). pii: eaal4599. doi: 10.1126/scitranslmed.aal4599. Review.

PMID:
29167393
5.

Moving toward a paradigm shift in the regulatory requirements for pediatric medicines.

Chin WW, Joos A.

Eur J Pediatr. 2016 Dec;175(12):1881-1891. Epub 2016 Sep 19. Review.

PMID:
27646479
6.

Ethics Reporting in Biospecimen and Genetic Research: Current Practice and Suggestions for Changes.

Chin WW, Wieschowski S, Prokein J, Illig T, Strech D.

PLoS Biol. 2016 Aug 2;14(8):e1002521. doi: 10.1371/journal.pbio.1002521. eCollection 2016 Aug.

7.

Changing of the Guard.

Wierman ME, Chin WW, Clemmons DR, Gagel RF, Larsen JL.

Endocr Rev. 2016 Feb;2016(1):1-2. doi: 10.1210/EDRV-ER.2015-1072.2016.1.test. No abstract available.

PMID:
27454359
8.

A Delicate Balance--Pharmaceutical Innovation and Access.

Chin WW.

N Engl J Med. 2015 Nov 5;373(19):1799-801. doi: 10.1056/NEJMp1513227. No abstract available.

PMID:
26535511
9.

Changing of the Guard.

Wierman ME, Chin WW, Clemmons DR, Gagel RF, Larsen JL.

Endocr Rev. 2015 Aug;36(4):345-6. doi: 10.1210/EDRV-ER.2015-1072. No abstract available.

PMID:
26240982
10.

Aberrant cerebellar development of transgenic mice expressing dominant-negative thyroid hormone receptor in cerebellar Purkinje cells.

Yu L, Iwasaki T, Xu M, Lesmana R, Xiong Y, Shimokawa N, Chin WW, Koibuchi N.

Endocrinology. 2015 Apr;156(4):1565-76. doi: 10.1210/en.2014-1079. Epub 2015 Jan 20.

PMID:
25603044
11.

A brief literature and patent review of nanosuspensions to a final drug product.

Chin WW, Parmentier J, Widzinski M, Tan EH, Gokhale R.

J Pharm Sci. 2014 Oct;103(10):2980-99. doi: 10.1002/jps.24098. Epub 2014 Aug 6. Review.

PMID:
25099918
12.

Distinct breast cancer subtypes in women with early-onset disease across races.

Singh M, Ding Y, Zhang LY, Song D, Gong Y, Adams S, Ross DS, Wang JH, Grover S, Doval DC, Shao C, He ZL, Chang V, Chin WW, Deng FM, Singh B, Zhang D, Xu RL, Lee P.

Am J Cancer Res. 2014 Jul 16;4(4):337-52. eCollection 2014.

13.

A divided INN crowd.

Chin WW.

Nat Biotechnol. 2014 Feb;32(2):130. doi: 10.1038/nbt.2820. No abstract available.

PMID:
24509752
14.

Effect of binders on the release rates of direct molded verapamil tablets using twin-screw extruder in melt granulation.

Tan DC, Chin WW, Tan EH, Hong S, Gu W, Gokhale R.

Int J Pharm. 2014 Mar 10;463(1):89-97. doi: 10.1016/j.ijpharm.2013.12.053. Epub 2014 Jan 7.

PMID:
24406670
15.

How to revive breakthrough innovation in the pharmaceutical industry.

Munos BH, Chin WW.

Sci Transl Med. 2011 Jun 29;3(89):89cm16. doi: 10.1126/scitranslmed.3002273.

PMID:
21715677
16.

A Nonsecosteroidal Vitamin D Receptor Modulator Ameliorates Experimental Autoimmune Encephalomyelitis without Causing Hypercalcemia.

Na S, Ma Y, Zhao J, Schmidt C, Zeng QQ, Chandrasekhar S, Chin WW, Nagpal S.

Autoimmune Dis. 2011 Jan 26;2011:132958. doi: 10.4061/2011/132958.

17.

Chlorin e6-polyvinylpyrrolidone mediated photodynamic therapy--A potential bladder sparing option for high risk non-muscle invasive bladder cancer.

Lee LS, Thong PS, Olivo M, Chin WW, Ramaswamy B, Kho KW, Lim PL, Lau WK.

Photodiagnosis Photodyn Ther. 2010 Dec;7(4):213-20. doi: 10.1016/j.pdpdt.2010.08.005. Epub 2010 Sep 29.

PMID:
21112542
18.

Diet, physical activity, and cardiovascular disease risk factors among older Chinese Americans living in New York City.

Wong SS, Beth Dixon L, Gilbride JA, Chin WW, Kwan TW.

J Community Health. 2011 Jun;36(3):446-55. doi: 10.1007/s10900-010-9326-6.

PMID:
21080043
19.

Effect of polyvinylpyrrolidone on the interaction of chlorin e6 with plasma proteins and its subcellular localization.

Chin WW, Praveen T, Heng PW, Olivo M.

Eur J Pharm Biopharm. 2010 Oct;76(2):245-52. doi: 10.1016/j.ejpb.2010.06.005. Epub 2010 Jun 15.

PMID:
20558287
20.

A call for sharing: adapting pharmaceutical research to new realities.

Munos BH, Chin WW.

Sci Transl Med. 2009 Dec 2;1(9):9cm8. doi: 10.1126/scitranslmed.3000155.

PMID:
20368187
21.

Clinical application of fluorescence endoscopic imaging using hypericin for the diagnosis of human oral cavity lesions.

Thong PS, Olivo M, Chin WW, Bhuvaneswari R, Mancer K, Soo KC.

Br J Cancer. 2009 Nov 3;101(9):1580-4. doi: 10.1038/sj.bjc.6605357. Epub 2009 Oct 6.

22.

Membrane transport enhancement of chlorin e6-polyvinylpyrrolidone and its photodynamic efficacy on the chick chorioallantoic model.

Chin WW, Heng PW, Lim PL, Lau WK, Olivo M.

J Biophotonics. 2008 Oct;1(5):395-407. doi: 10.1002/jbio.200810005.

PMID:
19343663
23.

In-vivo optical detection of cancer using chlorin e6--polyvinylpyrrolidone induced fluorescence imaging and spectroscopy.

Chin WW, Thong PS, Bhuvaneswari R, Soo KC, Heng PW, Olivo M.

BMC Med Imaging. 2009 Jan 8;9:1. doi: 10.1186/1471-2342-9-1.

24.

Immune response against angiosarcoma following lower fluence rate clinical photodynamic therapy.

Thong PS, Olivo M, Kho KW, Bhuvaneswari R, Chin WW, Ong KW, Soo KC.

J Environ Pathol Toxicol Oncol. 2008;27(1):35-42.

PMID:
18551894
25.

Molecular profiling of angiogenesis in hypericin mediated photodynamic therapy.

Bhuvaneswari R, Gan YY, Lucky SS, Chin WW, Ali SM, Soo KC, Olivo M.

Mol Cancer. 2008 Jun 13;7:56. doi: 10.1186/1476-4598-7-56.

26.
27.

Improved formulation of photosensitizer chlorin e6 polyvinylpyrrolidone for fluorescence diagnostic imaging and photodynamic therapy of human cancer.

Chin WW, Heng PW, Thong PS, Bhuvaneswari R, Hirt W, Kuenzel S, Soo KC, Olivo M.

Eur J Pharm Biopharm. 2008 Aug;69(3):1083-93. doi: 10.1016/j.ejpb.2008.02.013. Epub 2008 Mar 10.

PMID:
18396019
29.

Fluorescence detection of bladder cancer using urine cytology.

Fu CY, Ng BK, Razul SG, Chin WW, Tan PH, Lau WK, Olivo M.

Int J Oncol. 2007 Sep;31(3):525-30.

PMID:
17671678
30.
31.

The potential application of chlorin e6-polyvinylpyrrolidone formulation in photodynamic therapy.

Chin WW, Heng PW, Bhuvaneswari R, Lau WK, Olivo M.

Photochem Photobiol Sci. 2006 Nov;5(11):1031-7. Epub 2006 Sep 21.

PMID:
17077899
32.

Fluorescence imaging and phototoxicity effects of new formulation of chlorin e6-polyvinylpyrrolidone.

Chin WW, Lau WK, Heng PW, Bhuvaneswari R, Olivo M.

J Photochem Photobiol B. 2006 Aug 1;84(2):103-10. Epub 2006 Mar 20.

PMID:
16542848
33.

Identification and characterization of noncalcemic, tissue-selective, nonsecosteroidal vitamin D receptor modulators.

Ma Y, Khalifa B, Yee YK, Lu J, Memezawa A, Savkur RS, Yamamoto Y, Chintalacharuvu SR, Yamaoka K, Stayrook KR, Bramlett KS, Zeng QQ, Chandrasekhar S, Yu XP, Linebarger JH, Iturria SJ, Burris TP, Kato S, Chin WW, Nagpal S.

J Clin Invest. 2006 Apr;116(4):892-904. Epub 2006 Mar 9.

34.

Chlorin e6-polyvinylpyrrolidone as a fluorescent marker for fluorescence diagnosis of human bladder cancer implanted on the chick chorioallantoic membrane model.

Chin WW, Lau WK, Bhuvaneswari R, Heng PW, Olivo M.

Cancer Lett. 2007 Jan 8;245(1-2):127-33. Epub 2006 Mar 3.

PMID:
16516376
35.

The interaction of TRbeta1-N terminus with steroid receptor coactivator-1 (SRC-1) serves a full transcriptional activation function of SRC-1.

Iwasaki T, Takeshita A, Miyazaki W, Chin WW, Koibuchi N.

Endocrinology. 2006 Mar;147(3):1452-7. Epub 2005 Dec 15.

PMID:
16357047
36.

Human splicing factor SPF45 (RBM17) confers broad multidrug resistance to anticancer drugs when overexpressed--a phenotype partially reversed by selective estrogen receptor modulators.

Perry WL 3rd, Shepard RL, Sampath J, Yaden B, Chin WW, Iversen PW, Jin S, Lesoon A, O'Brien KA, Peek VL, Rolfe M, Shyjan A, Tighe M, Williamson M, Krishnan V, Moore RE, Dantzig AH.

Cancer Res. 2005 Aug 1;65(15):6593-600.

37.

Enhanced photodynamic activity of hypericin by penetration enhancer N-methyl pyrrolidone formulations in the chick chorioallantoic membrane model.

Saw CL, Heng PW, Chin WW, Soo KC, Olivo M.

Cancer Lett. 2006 Jul 8;238(1):104-10. Epub 2005 Jul 28.

PMID:
16054752
38.

Transport of hypericin across chick chorioallantoic membrane and photodynamic therapy vasculature assessment.

Saw CL, Olivo M, Chin WW, Soo KC, Heng PW.

Biol Pharm Bull. 2005 Jun;28(6):1054-60.

39.

Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein.

Gray SG, Iglesias AH, Lizcano F, Villanueva R, Camelo S, Jingu H, Teh BT, Koibuchi N, Chin WW, Kokkotou E, Dangond F.

J Biol Chem. 2005 Aug 5;280(31):28507-18. Epub 2005 May 31.

40.

Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator.

Iwasaki T, Koibuchi N, Chin WW.

Endocrinology. 2005 Sep;146(9):3892-9. Epub 2005 May 26.

PMID:
15919756
41.

Photodynamic diagnosis of a human nasopharyngeal carcinoma xenograft model using the novel Chlorin e6 photosensitizer Fotolon.

Ramaswamy B, Manivasager V, Chin WW, Soo KC, Olivo M.

Int J Oncol. 2005 Jun;26(6):1501-6.

PMID:
15870862
42.

Retinoid-related receptor (ROR) alpha mRNA expression is altered in the brain of male mice lacking all ligand-binding thyroid hormone receptor (TR) isoforms.

Vasudevan N, Kia HK, Hadjimarkou M, Koibuchi N, Chin WW, Forrest D, Vennstrom B, Pfaff D.

Endocrine. 2005 Feb;26(1):25-32.

PMID:
15805582
44.

Ligand modulates VDR-Ser/Thr protein phosphatase interaction and p70S6 kinase phosphorylation in a cell-context-dependent manner.

Bettoun DJ, Lu J, Khalifa B, Yee Y, Chin WW, Nagpal S.

J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):195-8.

PMID:
15225771
45.

Current perspectives on the role of thyroid hormone in growth and development of cerebellum.

Koibuchi N, Jingu H, Iwasaki T, Chin WW.

Cerebellum. 2003;2(4):279-89. Review.

PMID:
14964687
46.

Retinoid X receptor is a nonsilent major contributor to vitamin D receptor-mediated transcriptional activation.

Bettoun DJ, Burris TP, Houck KA, Buck DW 2nd, Stayrook KR, Khalifa B, Lu J, Chin WW, Nagpal S.

Mol Endocrinol. 2003 Nov;17(11):2320-8. Epub 2003 Jul 31.

PMID:
12893883
47.

Molecular and clinical evidence for the unique nature of individual selective estrogen receptor modulators.

Draper MW, Chin WW.

Clin Obstet Gynecol. 2003 Jun;46(2):265-97. Review. No abstract available.

PMID:
12808380
49.
50.

A chemical switch regulates fibrate specificity for peroxisome proliferator-activated receptor alpha (PPARalpha ) versus liver X receptor.

Thomas J, Bramlett KS, Montrose C, Foxworthy P, Eacho PI, McCann D, Cao G, Kiefer A, McCowan J, Yu KL, Grese T, Chin WW, Burris TP, Michael LF.

J Biol Chem. 2003 Jan 24;278(4):2403-10. Epub 2002 Nov 18.

Supplemental Content

Support Center