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Items: 43


Preclinical Efficacy and Safety Comparison of CD3 Bispecific and ADC Modalities Targeting BCMA for the Treatment of Multiple Myeloma.

Panowski SH, Kuo TC, Zhang Y, Chen A, Geng T, Aschenbrenner L, Kamperschroer C, Pascua E, Chen W, Delaria K, Farias S, Bateman M, Dushin RG, Chin SM, Van Blarcom TJ, Yeung YA, Lindquist KC, Chunyk AG, Kuang B, Han B, Mirsky M, Pardo I, Buetow B, Martin TG, Wolf JL, Shelton D, Rajpal A, Strop P, Chaparro-Riggers J, Sasu BJ.

Mol Cancer Ther. 2019 Nov;18(11):2008-2020. doi: 10.1158/1535-7163.MCT-19-0007. Epub 2019 Aug 21.


Impact of charge switching stimuli on supramolecular perylene monoimide assemblies.

Dannenhoffer A, Sai H, Huang D, Nagasing B, Harutyunyan B, Fairfield DJ, Aytun T, Chin SM, Bedzyk MJ, Olvera de la Cruz M, Stupp SI.

Chem Sci. 2019 May 14;10(22):5779-5786. doi: 10.1039/c8sc05595e. eCollection 2019 Jun 14.


Microscopic Colitis is Characterized by Intestinal Dysbiosis.

Morgan DM, Cao Y, Miller K, McGoldrick J, Bellavance D, Chin SM, Halvorsen S, Maxner B, Richter JM, Sassi S, Burke KE, Yarze JC, Ludvigsson JF, Staller K, Chung DC, Khalili H.

Clin Gastroenterol Hepatol. 2019 Jun 26. pii: S1542-3565(19)30726-8. doi: 10.1016/j.cgh.2019.06.035. [Epub ahead of print] No abstract available.


Early Prophylactic Hypothermia for Patients With Severe Traumatic Injury: Premature to Close the Case.

Chin SM, Wion D.

Front Neurol. 2019 Apr 9;10:344. doi: 10.3389/fneur.2019.00344. eCollection 2019. No abstract available.


Preclinical Evaluation of Allogeneic CAR T Cells Targeting BCMA for the Treatment of Multiple Myeloma.

Sommer C, Boldajipour B, Kuo TC, Bentley T, Sutton J, Chen A, Geng T, Dong H, Galetto R, Valton J, Pertel T, Juillerat A, Gariboldi A, Pascua E, Brown C, Chin SM, Sai T, Ni Y, Duchateau P, Smith J, Rajpal A, Van Blarcom T, Chaparro-Riggers J, Sasu BJ.

Mol Ther. 2019 Jun 5;27(6):1126-1138. doi: 10.1016/j.ymthe.2019.04.001. Epub 2019 Apr 8.


Atheroma Niche-Responsive Nanocarriers for Immunotherapeutic Delivery.

Peters EB, Tsihlis ND, Karver MR, Chin SM, Musetti B, Ledford BT, Bahnson EM, Stupp SI, Kibbe MR.

Adv Healthc Mater. 2019 Feb;8(3):e1801545. doi: 10.1002/adhm.201801545. Epub 2019 Jan 8.


Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab.

Chin SM, Kimberlin CR, Roe-Zurz Z, Zhang P, Xu A, Liao-Chan S, Sen D, Nager AR, Oakdale NS, Brown C, Wang F, Yang Y, Lindquist K, Yeung YA, Salek-Ardakani S, Chaparro-Riggers J.

Nat Commun. 2018 Nov 8;9(1):4679. doi: 10.1038/s41467-018-07136-7.


Supramolecular Nanostructure Activates TrkB Receptor Signaling of Neuronal Cells by Mimicking Brain-Derived Neurotrophic Factor.

Edelbrock AN, Àlvarez Z, Simkin D, Fyrner T, Chin SM, Sato K, Kiskinis E, Stupp SI.

Nano Lett. 2018 Oct 10;18(10):6237-6247. doi: 10.1021/acs.nanolett.8b02317. Epub 2018 Sep 13.


Covalent-supramolecular hybrid polymers as muscle-inspired anisotropic actuators.

Chin SM, Synatschke CV, Liu S, Nap RJ, Sather NA, Wang Q, Álvarez Z, Edelbrock AN, Fyrner T, Palmer LC, Szleifer I, Olvera de la Cruz M, Stupp SI.

Nat Commun. 2018 Jun 19;9(1):2395. doi: 10.1038/s41467-018-04800-w.


Efficient RNA drug delivery using red blood cell extracellular vesicles.

Usman WM, Pham TC, Kwok YY, Vu LT, Ma V, Peng B, Chan YS, Wei L, Chin SM, Azad A, He AB, Leung AYH, Yang M, Shyh-Chang N, Cho WC, Shi J, Le MTN.

Nat Commun. 2018 Jun 15;9(1):2359. doi: 10.1038/s41467-018-04791-8.


Cost of Medical Care of Patients with Advanced Serious Illness in Singapore (COMPASS): prospective cohort study protocol.

Teo I, Singh R, Malhotra C, Ozdemir S, Dent RA, Kumarakulasinghe NB, Yeo WL, Cheung YB, Malhotra R, Kanesvaran R, Yee ACP, Chan N, Wu HY, Chin SM, Allyn HYM, Yang GM, Neo PSH, Nadkarni NV, Harding R, Finkelstein EA.

BMC Cancer. 2018 Apr 23;18(1):459. doi: 10.1186/s12885-018-4356-z.


A Kriging based spatiotemporal approach for traffic volume data imputation.

Yang H, Yang J, Han LD, Liu X, Pu L, Chin SM, Hwang HL.

PLoS One. 2018 Apr 17;13(4):e0195957. doi: 10.1371/journal.pone.0195957. eCollection 2018.


Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice.

Pereira ER, Kedrin D, Seano G, Gautier O, Meijer EFJ, Jones D, Chin SM, Kitahara S, Bouta EM, Chang J, Beech E, Jeong HS, Carroll MC, Taghian AG, Padera TP.

Science. 2018 Mar 23;359(6382):1403-1407. doi: 10.1126/science.aal3622. Epub 2018 Mar 22.


Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2.

Incio J, Ligibel JA, McManus DT, Suboj P, Jung K, Kawaguchi K, Pinter M, Babykutty S, Chin SM, Vardam TD, Huang Y, Rahbari NN, Roberge S, Wang D, Gomes-Santos IL, Puchner SB, Schlett CL, Hoffmman U, Ancukiewicz M, Tolaney SM, Krop IE, Duda DG, Boucher Y, Fukumura D, Jain RK.

Sci Transl Med. 2018 Mar 14;10(432). pii: eaag0945. doi: 10.1126/scitranslmed.aag0945.


Methicillin-resistant Staphylococcus aureus causes sustained collecting lymphatic vessel dysfunction.

Jones D, Meijer EFJ, Blatter C, Liao S, Pereira ER, Bouta EM, Jung K, Chin SM, Huang P, Munn LL, Vakoc BJ, Otto M, Padera TP.

Sci Transl Med. 2018 Jan 17;10(424). pii: eaam7964. doi: 10.1126/scitranslmed.aam7964.


A novel CXCR4 antagonist IgG1 antibody (PF-06747143) for the treatment of hematologic malignancies.

Liu SH, Gu Y, Pascual B, Yan Z, Hallin M, Zhang C, Fan C, Wang W, Lam J, Spilker ME, Yafawi R, Blasi E, Simmons B, Huser N, Ho WH, Lindquist K, Tran TT, Kudaravalli J, Ma JT, Jimenez G, Barman I, Brown C, Chin SM, Costa MJ, Shelton D, Smeal T, Fantin VR, Pernasetti F.

Blood Adv. 2017 Jun 21;1(15):1088-1100. doi: 10.1182/bloodadvances.2016003921. eCollection 2017 Jun 27.


Clinical Predictors and Natural History of Disease Extension in Patients with Ulcerative Proctitis.

Walsh E, Chah YW, Chin SM, Lochhead P, Yajnik V, Denmark V, Garber JJ, Khalili H.

Inflamm Bowel Dis. 2017 Nov;23(11):2035-2041. doi: 10.1097/MIB.0000000000001214.


Obesity, but Not Physical Activity, Is Associated With Higher Prevalence of Asymptomatic Diverticulosis.

Mashayekhi R, Bellavance DR, Chin SM, Maxner B, Staller K, Xavier RJ, Chung DC, Khalili H.

Clin Gastroenterol Hepatol. 2018 Apr;16(4):586-587. doi: 10.1016/j.cgh.2017.09.005. Epub 2017 Sep 9. No abstract available.


ASPirin Intervention for the REDuction of colorectal cancer risk (ASPIRED): a study protocol for a randomized controlled trial.

Drew DA, Chin SM, Gilpin KK, Parziale M, Pond E, Schuck MM, Stewart K, Flagg M, Rawlings CA, Backman V, Carolan PJ, Chung DC, Colizzo FP 3rd, Freedman M, Gala M, Garber JJ, Huttenhower C, Kedrin D, Khalili H, Kwon DS, Markowitz SD, Milne GL, Nishioka NS, Richter JM, Roy HK, Staller K, Wang M, Chan AT.

Trials. 2017 Feb 1;18(1):50. doi: 10.1186/s13063-016-1744-z.


Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection in Patients With Inflammatory Bowel Disease: A Single-Center Experience.

Chin SM, Sauk J, Mahabamunuge J, Kaplan JL, Hohmann EL, Khalili H.

Clin Gastroenterol Hepatol. 2017 Apr;15(4):597-599. doi: 10.1016/j.cgh.2016.11.028. Epub 2016 Dec 3. No abstract available.


Flow-induced HDAC1 phosphorylation and nuclear export in angiogenic sprouting.

Bazou D, Ng MR, Song JW, Chin SM, Maimon N, Munn LL.

Sci Rep. 2016 Sep 27;6:34046. doi: 10.1038/srep34046.


Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy.

Incio J, Liu H, Suboj P, Chin SM, Chen IX, Pinter M, Ng MR, Nia HT, Grahovac J, Kao S, Babykutty S, Huang Y, Jung K, Rahbari NN, Han X, Chauhan VP, Martin JD, Kahn J, Huang P, Desphande V, Michaelson J, Michelakos TP, Ferrone CR, Soares R, Boucher Y, Fukumura D, Jain RK.

Cancer Discov. 2016 Aug;6(8):852-69. doi: 10.1158/2159-8290.CD-15-1177. Epub 2016 May 31.


TIRF microscopy analysis of human Cof1, Cof2, and ADF effects on actin filament severing and turnover.

Chin SM, Jansen S, Goode BL.

J Mol Biol. 2016 Apr 24;428(8):1604-16. doi: 10.1016/j.jmb.2016.03.006. Epub 2016 Mar 17.


PlGF/VEGFR-1 Signaling Promotes Macrophage Polarization and Accelerated Tumor Progression in Obesity.

Incio J, Tam J, Rahbari NN, Suboj P, McManus DT, Chin SM, Vardam TD, Batista A, Babykutty S, Jung K, Khachatryan A, Hato T, Ligibel JA, Krop IE, Puchner SB, Schlett CL, Hoffmman U, Ancukiewicz M, Shibuya M, Carmeliet P, Soares R, Duda DG, Jain RK, Fukumura D.

Clin Cancer Res. 2016 Jun 15;22(12):2993-3004. doi: 10.1158/1078-0432.CCR-15-1839. Epub 2016 Feb 9.


Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages.

Incio J, Suboj P, Chin SM, Vardam-Kaur T, Liu H, Hato T, Babykutty S, Chen I, Deshpande V, Jain RK, Fukumura D.

PLoS One. 2015 Dec 7;10(12):e0141392. doi: 10.1371/journal.pone.0141392. eCollection 2015.


Single-molecule imaging of a three-component ordered actin disassembly mechanism.

Jansen S, Collins A, Chin SM, Ydenberg CA, Gelles J, Goode BL.

Nat Commun. 2015 May 21;6:7202. doi: 10.1038/ncomms8202.


The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity.

Abdiche YN, Yeung YA, Chaparro-Riggers J, Barman I, Strop P, Chin SM, Pham A, Bolton G, McDonough D, Lindquist K, Pons J, Rajpal A.

MAbs. 2015;7(2):331-43. doi: 10.1080/19420862.2015.1008353.


Location matters: site of conjugation modulates stability and pharmacokinetics of antibody drug conjugates.

Strop P, Liu SH, Dorywalska M, Delaria K, Dushin RG, Tran TT, Ho WH, Farias S, Casas MG, Abdiche Y, Zhou D, Chandrasekaran R, Samain C, Loo C, Rossi A, Rickert M, Krimm S, Wong T, Chin SM, Yu J, Dilley J, Chaparro-Riggers J, Filzen GF, O'Donnell CJ, Wang F, Myers JS, Pons J, Shelton DL, Rajpal A.

Chem Biol. 2013 Feb 21;20(2):161-7. doi: 10.1016/j.chembiol.2013.01.010.


Anti-IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function.

Lee LF, Logronio K, Tu GH, Zhai W, Ni I, Mei L, Dilley J, Yu J, Rajpal A, Brown C, Appah C, Chin SM, Han B, Affolter T, Lin JC.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12674-9. doi: 10.1073/pnas.1203795109. Epub 2012 Jun 25. Erratum in: Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16393.


Generating bispecific human IgG1 and IgG2 antibodies from any antibody pair.

Strop P, Ho WH, Boustany LM, Abdiche YN, Lindquist KC, Farias SE, Rickert M, Appah CT, Pascua E, Radcliffe T, Sutton J, Chaparro-Riggers J, Chen W, Casas MG, Chin SM, Wong OK, Liu SH, Vergara G, Shelton D, Rajpal A, Pons J.

J Mol Biol. 2012 Jul 13;420(3):204-19. doi: 10.1016/j.jmb.2012.04.020. Epub 2012 Apr 25.


Silver triflate catalyzed tandem heterocyclization/alkynylation of 1-((2-tosylamino)aryl)but-2-yne-1,4-diols to 2-alkynyl indoles.

Mothe SR, Kothandaraman P, Lauw SJ, Chin SM, Chan PW.

Chemistry. 2012 May 14;18(20):6133-7. doi: 10.1002/chem.201200578. Epub 2012 Apr 18.


Proprotein convertase substilisin/kexin type 9 antagonism reduces low-density lipoprotein cholesterol in statin-treated hypercholesterolemic nonhuman primates.

Liang H, Chaparro-Riggers J, Strop P, Geng T, Sutton JE, Tsai D, Bai L, Abdiche Y, Dilley J, Yu J, Wu S, Chin SM, Lee NA, Rossi A, Lin JC, Rajpal A, Pons J, Shelton DL.

J Pharmacol Exp Ther. 2012 Feb;340(2):228-36. doi: 10.1124/jpet.111.187419. Epub 2011 Oct 21.


Clinical pathway for colorectal procedures.

Chin SM.

Hosp Case Manag. 2002 Dec;10(12):183-5. No abstract available.


Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2.

Kavanaugh WM, Pot DA, Chin SM, Deuter-Reinhard M, Jefferson AB, Norris FA, Masiarz FR, Cousens LS, Majerus PW, Williams LT.

Curr Biol. 1996 Apr 1;6(4):438-45.


Molecular diagnosis of Duchenne muscular dystrophy in Singapore.

Low PS, Lai PS, Lee WL, Chin SM, Ong HT, Tay JS.

Ann Acad Med Singapore. 1996 Jan;25(1):84-9. Review.


Three chemically distinct types of oxidants formed by iron-mediated Fenton reactions in the presence of DNA.

Luo Y, Han Z, Chin SM, Linn S.

Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12438-42.


Expression and characterization of recombinant hepatitis A virus 3C proteinase.

Malcolm BA, Chin SM, Jewell DA, Stratton-Thomas JR, Thudium KB, Ralston R, Rosenberg S.

Biochemistry. 1992 Apr 7;31(13):3358-63.


Characterization of group specific antibodies in primates: studies with SIV envelope in macaques.

Haigwood NL, Misher L, Chin SM, Blair M, Planelles V, Scandella CJ, Steimer KS, Gardner MB, Yilma T, Hirsch VM, et al.

J Med Primatol. 1992 Feb-May;21(2-3):82-90.


Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro.

Imlay JA, Chin SM, Linn S.

Science. 1988 Apr 29;240(4852):640-2.


Nursing care study: aortic valve replacement.

Chin SM.

Nurs Times. 1976 Apr 1;72(13):489-91. No abstract available.


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