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Items: 1 to 50 of 129

1.

Anesthetic considerations for scoliosis surgery in a patient with recessive severe/lethal form of osteogenesis imperfecta.

Chin JWE, Stuart GM.

Paediatr Anaesth. 2018 Aug 16. doi: 10.1111/pan.13461. [Epub ahead of print]

PMID:
30117226
2.

Mitotic phosphorylation regulates Hsp72 spindle localization by uncoupling ATP binding from substrate release.

Mukherjee M, Sabir S, O'Regan L, Sampson J, Richards MW, Huguenin-Dezot N, Ault JR, Chin JW, Zhuravleva A, Fry AM, Bayliss R.

Sci Signal. 2018 Aug 14;11(543). pii: eaao2464. doi: 10.1126/scisignal.aao2464.

PMID:
30108182
3.

Pyrophosphorylation via selective phosphoprotein derivatization.

Marmelstein AM, Morgan JAM, Penkert M, Rogerson DT, Chin JW, Krause E, Fiedler D.

Chem Sci. 2018 Jun 12;9(27):5929-5936. doi: 10.1039/c8sc01233d. eCollection 2018 Jul 21.

4.

Genetically Encoded Protein Phosphorylation in Mammalian Cells.

Beránek V, Reinkemeier CD, Zhang MS, Liang AD, Kym G, Chin JW.

Cell Chem Biol. 2018 May 31. pii: S2451-9456(18)30184-3. doi: 10.1016/j.chembiol.2018.05.013. [Epub ahead of print]

5.

Mutually orthogonal pyrrolysyl-tRNA synthetase/tRNA pairs.

Willis JCW, Chin JW.

Nat Chem. 2018 Aug;10(8):831-837. doi: 10.1038/s41557-018-0052-5. Epub 2018 May 28.

PMID:
29807989
6.

Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21.

Dickson C, Fletcher AJ, Vaysburd M, Yang JC, Mallery DL, Zeng J, Johnson CM, McLaughlin SH, Skehel M, Maslen S, Cruickshank J, Huguenin-Dezot N, Chin JW, Neuhaus D, James LC.

Elife. 2018 Apr 18;7. pii: e32660. doi: 10.7554/eLife.32660.

7.

Mitotic spindle association of TACC3 requires Aurora-A-dependent stabilization of a cryptic α-helix.

Burgess SG, Mukherjee M, Sabir S, Joseph N, Gutiérrez-Caballero C, Richards MW, Huguenin-Dezot N, Chin JW, Kennedy EJ, Pfuhl M, Royle SJ, Gergely F, Bayliss R.

EMBO J. 2018 Apr 13;37(8). pii: e97902. doi: 10.15252/embj.201797902. Epub 2018 Mar 6.

8.

Detecting RNA base methylations in single cells by in situ hybridization.

Ranasinghe RT, Challand MR, Ganzinger KA, Lewis BW, Softley C, Schmied WH, Horrocks MH, Shivji N, Chin JW, Spencer J, Klenerman D.

Nat Commun. 2018 Feb 13;9(1):655. doi: 10.1038/s41467-017-02714-7.

9.

Rapid and Efficient Generation of Stable Antibody-Drug Conjugates via an Encoded Cyclopropene and an Inverse-Electron-Demand Diels-Alder Reaction.

Oller-Salvia B, Kym G, Chin JW.

Angew Chem Int Ed Engl. 2018 Mar 5;57(11):2831-2834. doi: 10.1002/anie.201712370. Epub 2018 Feb 14.

10.

Toward an orthogonal central dogma.

Liu CC, Jewett MC, Chin JW, Voigt CA.

Nat Chem Biol. 2018 Jan 16;14(2):103-106. doi: 10.1038/nchembio.2554. No abstract available.

PMID:
29337969
11.

Labeling and identifying cell-specific proteomes in the mouse brain.

Krogager TP, Ernst RJ, Elliott TS, Calo L, Beránek V, Ciabatti E, Spillantini MG, Tripodi M, Hastings MH, Chin JW.

Nat Biotechnol. 2018 Feb;36(2):156-159. doi: 10.1038/nbt.4056. Epub 2017 Dec 18.

12.

Encoding optical control in LCK kinase to quantitatively investigate its activity in live cells.

Liaunardy-Jopeace A, Murton BL, Mahesh M, Chin JW, James JR.

Nat Struct Mol Biol. 2017 Dec;24(12):1155-1163. doi: 10.1038/nsmb.3492. Epub 2017 Oct 30.

13.

Expanding and reprogramming the genetic code.

Chin JW.

Nature. 2017 Oct 4;550(7674):53-60. doi: 10.1038/nature24031. Review.

PMID:
28980641
14.

Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(ii) catalyst.

Kwan TT, Boutureira O, Frye EC, Walsh SJ, Gupta MK, Wallace S, Wu Y, Zhang F, Sore HF, Galloway WRJD, Chin JW, Welch M, Bernardes GJL, Spring DR.

Chem Sci. 2017 May 1;8(5):3871-3878. doi: 10.1039/c6sc05313k. Epub 2017 Mar 14.

15.

Correction: Computationally guided discovery of a reactive, hydrophilic trans-5-oxocene dienophile for bioorthogonal labeling.

Lambert WD, Scinto SL, Dmitrenko O, Boyd SJ, Magboo R, Mehl RA, Chin JW, Fox JM, Wallace S.

Org Biomol Chem. 2017 Sep 13;15(35):7476. doi: 10.1039/c7ob90144e.

PMID:
28848969
16.

Computationally guided discovery of a reactive, hydrophilic trans-5-oxocene dienophile for bioorthogonal labeling.

Lambert WD, Scinto SL, Dmitrenko O, Boyd SJ, Magboo R, Mehl RA, Chin JW, Fox JM, Wallace S.

Org Biomol Chem. 2017 Aug 9;15(31):6640-6644. doi: 10.1039/c7ob01707c.

17.

Intein Zymogens: Conditional Assembly and Splicing of Split Inteins via Targeted Proteolysis.

Gramespacher JA, Stevens AJ, Nguyen DP, Chin JW, Muir TW.

J Am Chem Soc. 2017 Jun 21;139(24):8074-8077. doi: 10.1021/jacs.7b02618. Epub 2017 Jun 7.

18.

Biosynthesis and genetic encoding of phosphothreonine through parallel selection and deep sequencing.

Zhang MS, Brunner SF, Huguenin-Dezot N, Liang AD, Schmied WH, Rogerson DT, Chin JW.

Nat Methods. 2017 Jul;14(7):729-736. doi: 10.1038/nmeth.4302. Epub 2017 May 29.

19.

Randomised, double-blind, parallel group, placebo-controlled study to evaluate the analgesic efficacy and safety of VVZ-149 injections for postoperative pain following laparoscopic colorectal surgery.

Nedeljkovic SS, Correll DJ, Bao X, Zamor N, Zeballos JL, Zhang Y, Young MJ, Ledley J, Sorace J, Eng K, Hamsher CP, Maniam R, Chin JW, Tsui B, Cho S, Lee DH.

BMJ Open. 2017 Feb 17;7(2):e011035. doi: 10.1136/bmjopen-2016-011035.

20.

Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET.

Perdios L, Lowe AR, Saladino G, Bunney TD, Thiyagarajan N, Alexandrov Y, Dunsby C, French PM, Chin JW, Gervasio FL, Tate EW, Katan M.

Sci Rep. 2017 Jan 3;7:39841. doi: 10.1038/srep39841.

21.

Defining synonymous codon compression schemes by genome recoding.

Wang K, Fredens J, Brunner SF, Kim SH, Chia T, Chin JW.

Nature. 2016 Nov 3;539(7627):59-64. doi: 10.1038/nature20124. Epub 2016 Oct 24.

22.

Genetic code expansion in the mouse brain.

Ernst RJ, Krogager TP, Maywood ES, Zanchi R, Beránek V, Elliott TS, Barry NP, Hastings MH, Chin JW.

Nat Chem Biol. 2016 Oct;12(10):776-778. doi: 10.1038/nchembio.2160. Epub 2016 Aug 29.

23.

Ribosome Subunit Stapling for Orthogonal Translation in E.coli.

Fried SD, Schmied WH, Uttamapinant C, Chin JW.

Angew Chem Weinheim Bergstr Ger. 2015 Oct 19;127(43):12982-12985. Epub 2015 Aug 26.

24.

Tagging and Enriching Proteins Enables Cell-Specific Proteomics.

Elliott TS, Bianco A, Townsley FM, Fried SD, Chin JW.

Cell Chem Biol. 2016 Jul 21;23(7):805-815. doi: 10.1016/j.chembiol.2016.05.018.

25.

Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity.

Huguenin-Dezot N, De Cesare V, Peltier J, Knebel A, Kristaryianto YA, Rogerson DT, Kulathu Y, Trost M, Chin JW.

Cell Rep. 2016 Jul 26;16(4):1180-1193. doi: 10.1016/j.celrep.2016.06.064. Epub 2016 Jul 14.

26.

Genetically encoded optical activation of DNA recombination in human cells.

Luo J, Arbely E, Zhang J, Chou C, Uprety R, Chin JW, Deiters A.

Chem Commun (Camb). 2016 Jun 30;52(55):8529-32. doi: 10.1039/c6cc03934k.

27.

Photoactivation of Mutant Isocitrate Dehydrogenase 2 Reveals Rapid Cancer-Associated Metabolic and Epigenetic Changes.

Walker OS, Elsässer SJ, Mahesh M, Bachman M, Balasubramanian S, Chin JW.

J Am Chem Soc. 2016 Jan 27;138(3):718-21. doi: 10.1021/jacs.5b07627. Epub 2016 Jan 12.

28.

Genetic code expansion in stable cell lines enables encoded chromatin modification.

Elsässer SJ, Ernst RJ, Walker OS, Chin JW.

Nat Methods. 2016 Feb;13(2):158-64. doi: 10.1038/nmeth.3701. Epub 2016 Jan 4.

29.

Structural and Mechanistic Insights into the Regulation of the Fundamental Rho Regulator RhoGDIα by Lysine Acetylation.

Kuhlmann N, Wroblowski S, Knyphausen P, de Boor S, Brenig J, Zienert AY, Meyer-Teschendorf K, Praefcke GJ, Nolte H, Krüger M, Schacherl M, Baumann U, James LC, Chin JW, Lammers M.

J Biol Chem. 2016 Mar 11;291(11):5484-99. doi: 10.1074/jbc.M115.707091. Epub 2015 Dec 30.

30.

EGF-dependent re-routing of vesicular recycling switches spontaneous phosphorylation suppression to EGFR signaling.

Baumdick M, Brüggemann Y, Schmick M, Xouri G, Sabet O, Davis L, Chin JW, Bastiaens PI.

Elife. 2015 Nov 26;4. pii: e12223. doi: 10.7554/eLife.12223.

31.

Ribosome Subunit Stapling for Orthogonal Translation in E. coli.

Fried SD, Schmied WH, Uttamapinant C, Chin JW.

Angew Chem Int Ed Engl. 2015 Oct 19;54(43):12791-4. doi: 10.1002/anie.201506311. Epub 2015 Aug 26.

32.

Conformationally Strained trans-Cyclooctene with Improved Stability and Excellent Reactivity in Tetrazine Ligation.

Darko A, Wallace S, Dmitrenko O, Machovina MM, Mehl RA, Chin JW, Fox JM.

Chem Sci. 2014 Oct 1;5(10):3770-3776.

33.

Selective, rapid and optically switchable regulation of protein function in live mammalian cells.

Tsai YH, Essig S, James JR, Lang K, Chin JW.

Nat Chem. 2015 Jul;7(7):554-561. doi: 10.1038/nchem.2253. Epub 2015 May 18.

34.

Efficient genetic encoding of phosphoserine and its nonhydrolyzable analog.

Rogerson DT, Sachdeva A, Wang K, Haq T, Kazlauskaite A, Hancock SM, Huguenin-Dezot N, Muqit MM, Fry AM, Bayliss R, Chin JW.

Nat Chem Biol. 2015 Jul;11(7):496-503. doi: 10.1038/nchembio.1823. Epub 2015 Jun 1.

35.

Ubiquitination of the Dishevelled DIX domain blocks its head-to-tail polymerization.

Madrzak J, Fiedler M, Johnson CM, Ewan R, Knebel A, Bienz M, Chin JW.

Nat Commun. 2015 Apr 24;6:6718. doi: 10.1038/ncomms7718.

36.

Site-Specific Glycoconjugation of Protein via Bioorthogonal Tetrazine Cycloaddition with a Genetically Encoded trans-Cyclooctene or Bicyclononyne.

Machida T, Lang K, Xue L, Chin JW, Winssinger N.

Bioconjug Chem. 2015 May 20;26(5):802-6. doi: 10.1021/acs.bioconjchem.5b00101. Epub 2015 Apr 24.

37.

Genetic code expansion enables live-cell and super-resolution imaging of site-specifically labeled cellular proteins.

Uttamapinant C, Howe JD, Lang K, Beránek V, Davis L, Mahesh M, Barry NP, Chin JW.

J Am Chem Soc. 2015 Apr 15;137(14):4602-5. doi: 10.1021/ja512838z. Epub 2015 Apr 1.

39.

Genetic encoding of unnatural amino acids for labeling proteins.

Lang K, Davis L, Chin JW.

Methods Mol Biol. 2015;1266:217-28. doi: 10.1007/978-1-4939-2272-7_15.

PMID:
25560078
40.

Ubiquitin C-terminal hydrolases cleave isopeptide- and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers.

Bett JS, Ritorto MS, Ewan R, Jaffray EG, Virdee S, Chin JW, Knebel A, Kurz T, Trost M, Tatham MH, Hay RT.

Biochem J. 2015 Mar 15;466(3):489-98. doi: 10.1042/BJ20141349.

41.

Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly.

Price AJ, Jacques DA, McEwan WA, Fletcher AJ, Essig S, Chin JW, Halambage UD, Aiken C, James LC.

PLoS Pathog. 2014 Oct 30;10(10):e1004459. doi: 10.1371/journal.ppat.1004459. eCollection 2014 Oct.

42.

Efficient multisite unnatural amino acid incorporation in mammalian cells via optimized pyrrolysyl tRNA synthetase/tRNA expression and engineered eRF1.

Schmied WH, Elsässer SJ, Uttamapinant C, Chin JW.

J Am Chem Soc. 2014 Nov 5;136(44):15577-83. doi: 10.1021/ja5069728. Epub 2014 Oct 28.

43.

Genetically encoded optochemical probes for simultaneous fluorescence reporting and light activation of protein function with two-photon excitation.

Luo J, Uprety R, Naro Y, Chou C, Nguyen DP, Chin JW, Deiters A.

J Am Chem Soc. 2014 Nov 5;136(44):15551-8. doi: 10.1021/ja5055862. Epub 2014 Oct 23.

44.

Genetic code expansion and bioorthogonal labelling enables cell specific proteomics in an animal.

Elliott TS, Bianco A, Chin JW.

Curr Opin Chem Biol. 2014 Aug;21:154-60. doi: 10.1016/j.cbpa.2014.07.001. Epub 2014 Aug 20. Review.

PMID:
25159020
45.

Concerted, rapid, quantitative, and site-specific dual labeling of proteins.

Sachdeva A, Wang K, Elliott T, Chin JW.

J Am Chem Soc. 2014 Jun 4;136(22):7785-8. doi: 10.1021/ja4129789. Epub 2014 May 23.

46.

Optimized orthogonal translation of unnatural amino acids enables spontaneous protein double-labelling and FRET.

Wang K, Sachdeva A, Cox DJ, Wilf NM, Lang K, Wallace S, Mehl RA, Chin JW.

Nat Chem. 2014 May;6(5):393-403. doi: 10.1038/nchem.1919. Epub 2014 Apr 20. Erratum in: Nat Chem. 2014 Feb;7(2):178. Wilf, Nabil W [corrected to Wilf, Nabil M].

47.

Proteome labeling and protein identification in specific tissues and at specific developmental stages in an animal.

Elliott TS, Townsley FM, Bianco A, Ernst RJ, Sachdeva A, Elsässer SJ, Davis L, Lang K, Pisa R, Greiss S, Lilley KS, Chin JW.

Nat Biotechnol. 2014 May;32(5):465-72. doi: 10.1038/nbt.2860. Epub 2014 Apr 13.

48.

Cellular incorporation of unnatural amino acids and bioorthogonal labeling of proteins.

Lang K, Chin JW.

Chem Rev. 2014 May 14;114(9):4764-806. doi: 10.1021/cr400355w. Epub 2014 Mar 21. Review. No abstract available.

PMID:
24655057
49.

Expanding and reprogramming the genetic code of cells and animals.

Chin JW.

Annu Rev Biochem. 2014;83:379-408. doi: 10.1146/annurev-biochem-060713-035737. Epub 2014 Feb 10. Review.

PMID:
24555827
50.

Genetic encoding of photocaged cysteine allows photoactivation of TEV protease in live mammalian cells.

Nguyen DP, Mahesh M, Elsässer SJ, Hancock SM, Uttamapinant C, Chin JW.

J Am Chem Soc. 2014 Feb 12;136(6):2240-3. doi: 10.1021/ja412191m. Epub 2014 Jan 30.

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