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Discovery of BR102375, a new class of non-TZD PPARγ full agonist for the treatment of type 2 diabetes.

Choung W, Yang D, Kim H, Choi H, Lee BR, Park M, Jang SM, Lim JS, Kim WS, Kim KH, Chin J, Jung K, Lee G, Hong E, Jang TH, Joo J, Hwang H, Myung J, Kim SH.

Bioorg Med Chem Lett. 2019 Jun 19. pii: S0960-894X(19)30407-X. doi: 10.1016/j.bmcl.2019.06.027. [Epub ahead of print]


Early Seizure Activity Accelerates Depletion of Hippocampal Neural Stem Cells and Impairs Spatial Discrimination in an Alzheimer's Disease Model.

Fu CH, Iascone DM, Petrof I, Hazra A, Zhang X, Pyfer MS, Tosi U, Corbett BF, Cai J, Lee J, Park J, Iacovitti L, Scharfman HE, Enikolopov G, Chin J.

Cell Rep. 2019 Jun 25;27(13):3741-3751.e4. doi: 10.1016/j.celrep.2019.05.101.


Advanced dementia: an integrated homecare programme.

Hum A, Tay RY, Wong YKY, Ali NB, Leong IYO, Wu HY, Chin JJ, Lee AOK, Koh MYH.

BMJ Support Palliat Care. 2019 Jun 25. pii: bmjspcare-2019-001798. doi: 10.1136/bmjspcare-2019-001798. [Epub ahead of print]


Maintaining peri-implant health: an evaluation of understanding among dental hygienists and therapists in Wales.

Chin JS, Rees J, Locke M, Addy LD.

Br Dent J. 2019 Jun;226(11):867-870. doi: 10.1038/s41415-019-0365-9.


Efficient Phage Display with Multiple Distinct Non-Canonical Amino Acids Using Orthogonal Ribosome-Mediated Genetic Code Expansion.

Oller-Salvia B, Chin JW.

Angew Chem Int Ed Engl. 2019 Jun 3. doi: 10.1002/anie.201902658. [Epub ahead of print]


Behavioral Approaches to Studying Innate Stress in Zebrafish.

Chin JSR, Albert LT, Loomis CL, Keene AC, Duboué ER.

J Vis Exp. 2019 May 1;(147). doi: 10.3791/59092.


Total synthesis of Escherichia coli with a recoded genome.

Fredens J, Wang K, de la Torre D, Funke LFH, Robertson WE, Christova Y, Chia T, Schmied WH, Dunkelmann DL, Beránek V, Uttamapinant C, Llamazares AG, Elliott TS, Chin JW.

Nature. 2019 May;569(7757):514-518. doi: 10.1038/s41586-019-1192-5. Epub 2019 May 15.


Teaching of implant dentistry in dental hygiene and therapy schools in the UK and Ireland.

Chin JS, Addy LD, Rees J, Locke M.

Br Dent J. 2019 May;226(9):692-696. doi: 10.1038/s41415-019-0259-x.


Biomimicking Fiber Scaffold as an Effective In Vitro and In Vivo MicroRNA Screening Platform for Directing Tissue Regeneration.

Zhang N, Milbreta U, Chin JS, Pinese C, Lin J, Shirahama H, Jiang W, Liu H, Mi R, Hoke A, Wu W, Chew SY.

Adv Sci (Weinh). 2019 Feb 27;6(9):1800808. doi: 10.1002/advs.201800808. eCollection 2019 May 3.


Manipulation of Gene Function in Mexican Cavefish.

Stahl BA, Jaggard JB, Chin JSR, Kowalko JE, Keene AC, Duboué ER.

J Vis Exp. 2019 Apr 22;(146). doi: 10.3791/59093.


Tuberculous meningitis: A neglected tropical disease?

Chin JH.

Neurol Clin Pract. 2019 Apr;9(2):152-154. doi: 10.1212/CPJ.0000000000000606.


A Novel Orally Active Inverse Agonist of Estrogen-related Receptor Gamma (ERRγ), DN200434, A Booster of NIS in Anaplastic Thyroid Cancer.

Singh TD, Song J, Kim J, Chin J, Ji HD, Lee JE, Lee SB, Yoon H, Yu JH, Kim SK, Yoon GS, Hwang H, Lee HW, Oh JM, Lee SW, Lee J, Choi HS, Na SY, Choi WI, Park YJ, Song YS, Kim YA, Lee IK, Cho SJ, Jeon YH.

Clin Cancer Res. 2019 Apr 22. doi: 10.1158/1078-0432.CCR-18-3007. [Epub ahead of print]


One-step synthesis and XPS investigations of chiral NHC-Au(0)/Au(i) nanoparticles.

Young AJ, Sauer M, Rubio GMDM, Sato A, Foelske A, Serpell CJ, Chin JM, Reithofer MR.

Nanoscale. 2019 Apr 25;11(17):8327-8333. doi: 10.1039/c9nr00905a.


Scaffold-mediated non-viral delivery platform for CRISPR/Cas9-based genome editing.

Chin JS, Chooi WH, Wang H, Ong W, Leong KW, Chew SY.

Acta Biomater. 2019 May;90:60-70. doi: 10.1016/j.actbio.2019.04.020. Epub 2019 Apr 9.


Identification and Characterization of LARGE EMBRYO, a New Gene Controlling Embryo Size in Rice (Oryza sativa L.).

Lee G, Piao R, Lee Y, Kim B, Seo J, Lee D, Jang S, Jin Z, Lee C, Chin JH, Koh HJ.

Rice (N Y). 2019 Apr 11;12(1):22. doi: 10.1186/s12284-019-0277-y.


Drug therapies and delivery mechanisms to treat perturbed skin wound healing.

Chin JS, Madden L, Chew SY, Becker DL.

Adv Drug Deliv Rev. 2019 Apr 6. pii: S0169-409X(19)30042-0. doi: 10.1016/j.addr.2019.03.006. [Epub ahead of print]


Clinical Effects of Frontal Behavioral Impairment: Cortical Thickness and Cognitive Decline in Individuals with Subjective Cognitive Decline and Amnestic Mild Cognitive Impairment.

Kim SJ, Jung NY, Kim YJ, Park SB, Kim K, Kim Y, Jang H, Kim SE, Cho SH, Kim JP, Jung YH, Woo SY, Kim SW, Lockhart SN, Kim EJ, Kim HJ, Lee JM, Chin J, Na DL, Seo SW.

J Alzheimers Dis. 2019;69(1):213-225. doi: 10.3233/JAD-190007.


Xpert MTB/RIF Ultra for Detection of Mycobacterium tuberculosis in Cerebrospinal Fluid.

Chin JH, Musubire AK, Morgan N, Pellinen J, Grossman S, Bhatt JM, Wadda V, Ssengooba W.

J Clin Microbiol. 2019 May 24;57(6). pii: e00249-19. doi: 10.1128/JCM.00249-19. Print 2019 Jun. No abstract available.


Osteopathic Physical Exam Findings in Chronic Hepatitis C: A Case Study.

Chin J, Francis M, Lavalliere JM, Lomiguen CM.

Cureus. 2019 Jan 22;11(1):e3939. doi: 10.7759/cureus.3939.


Gut Microbiota, a Potential New Target for Chinese Herbal Medicines in Treating Diabetes Mellitus.

Zhang B, Yue R, Chen Y, Yang M, Huang X, Shui J, Peng Y, Chin J.

Evid Based Complement Alternat Med. 2019 Feb 18;2019:2634898. doi: 10.1155/2019/2634898. eCollection 2019. Review.


Re-standardization of the Korean-Instrumental Activities of Daily Living (K-IADL): Clinical Usefulness for Various Neurodegenerative Diseases.

Chin J, Park J, Yang SJ, Yeom J, Ahn Y, Baek MJ, Ryu HJ, Lee BH, Han NE, Ryu KH, Kang Y.

Dement Neurocogn Disord. 2018 Mar;17(1):11-22. doi: 10.12779/dnd.2018.17.1.11. Epub 2018 Mar 31.


Novel allelic variant of Lpa1 gene associated with a significant reduction in seed phytic acid content in rice (Oryza sativa L.).

Kishor DS, Lee C, Lee D, Venkatesh J, Seo J, Chin JH, Jin Z, Hong SK, Ham JK, Koh HJ.

PLoS One. 2019 Mar 14;14(3):e0209636. doi: 10.1371/journal.pone.0209636. eCollection 2019.


Perioperative rupture risk of unruptured intracranial aneurysms in cardiovascular surgery.

Nam JS, Jeon SB, Jo JY, Joung KW, Chin JH, Lee EH, Chung CH, Choi IC.

Brain. 2019 May 1;142(5):1408-1415. doi: 10.1093/brain/awz058.


Limited Use of Outpatient Stress Testing in Young Patients With Atypical Chest Pain.

Chin JC, Seidensticker DF, Lin AH, Williams E 4th.

Fed Pract. 2018 Nov;35(Suppl 6):S30-S34.


Exploring the role of teams and technology in patients' medication decision making.

Mercer K, Guirguis L, Burns C, Chin J, Dogba MJ, Dolovich L, Guénette L, Jenkins L, Légaré F, McKinnon A, McMurray J, Waked K, Grindrod KA.

J Am Pharm Assoc (2003). 2019 Mar - Apr;59(2S):S35-S43.e1. doi: 10.1016/j.japh.2018.12.010. Epub 2019 Feb 5.


Saccharoquinoline, a Cytotoxic Alkaloidal Meroterpenoid from Marine-Derived Bacterium Saccharomonospora sp.

Le TC, Lee EJ, Lee J, Hong A, Yim CY, Yang I, Choi H, Chin J, Cho SJ, Ko J, Hwang H, Nam SJ, Fenical W.

Mar Drugs. 2019 Feb 2;17(2). pii: E98. doi: 10.3390/md17020098.


Video or verbal? A randomised trial of the informed consent process prior to endoscopy.

Schauer C, Floyd T, Chin J, Vandal A, Lampen-Smith A.

N Z Med J. 2019 Feb 1;132(1489):57-68.


Direct ink writing of catalytically active UiO-66 polymer composites.

Young AJ, Guillet-Nicolas R, Marshall ES, Kleitz F, Goodhand AJ, Glanville LBL, Reithofer MR, Chin JM.

Chem Commun (Camb). 2019 Feb 14;55(15):2190-2193. doi: 10.1039/c8cc10018g.


Stereolithographic 3D printing of extrinsically self-healing composites.

Sanders P, Young AJ, Qin Y, Fancey KS, Reithofer MR, Guillet-Nicolas R, Kleitz F, Pamme N, Chin JM.

Sci Rep. 2019 Jan 23;9(1):388. doi: 10.1038/s41598-018-36828-9.


Integrated Genomic and Metabolomic Approach to the Discovery of Potential Anti-Quorum Sensing Natural Products from Microbes Associated with Marine Samples from Singapore.

Ong JFM, Goh HC, Lim SC, Pang LM, Chin JSF, Tan KS, Liang ZX, Yang L, Glukhov E, Gerwick WH, Tan LT.

Mar Drugs. 2019 Jan 21;17(1). pii: E72. doi: 10.3390/md17010072.


Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-γ Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer.

Kim J, Song J, Ji HD, Yoo EK, Lee JE, Lee SB, Oh JM, Lee S, Hwang JS, Yoon H, Kim DS, Lee SJ, Jeong M, Lee S, Kim KH, Choi HS, Lee SW, Park KG, Lee IK, Kim SH, Hwang H, Jeon YH, Chin J, Cho SJ.

J Med Chem. 2019 Feb 28;62(4):1837-1858. doi: 10.1021/acs.jmedchem.8b01296. Epub 2019 Feb 4.


Effects of mavoglurant on visual attention and pupil reactivity while viewing photographs of faces in Fragile X Syndrome.

Hessl D, Harvey D, Sansone S, Crestodina C, Chin J, Joshi R, Hagerman RJ, Berry-Kravis E.

PLoS One. 2019 Jan 17;14(1):e0209984. doi: 10.1371/journal.pone.0209984. eCollection 2019.


Genetic Dissection of Grain Nutritional Traits and Leaf Blight Resistance in Rice.

Descalsota-Empleo GI, Noraziyah AAS, Navea IP, Chung C, Dwiyanti MS, Labios RJD, Ikmal AM, Juanillas VM, Inabangan-Asilo MA, Amparado A, Reinke R, Cruz CMV, Chin JH, Swamy BPM.

Genes (Basel). 2019 Jan 8;10(1). pii: E30. doi: 10.3390/genes10010030.


White Matter Network Disruption and Cognitive Dysfunction in Neuromyelitis Optica Spectrum Disorder.

Cho EB, Han CE, Seo SW, Chin J, Shin JH, Cho HJ, Seok JM, Kim ST, Kim BJ, Na DL, Lee KH, Seong JK, Min JH.

Front Neurol. 2018 Dec 17;9:1104. doi: 10.3389/fneur.2018.01104. eCollection 2018.


Scaffold-Mediated Sustained, Non-viral Delivery of miR-219/miR-338 Promotes CNS Remyelination.

Milbreta U, Lin J, Pinese C, Ong W, Chin JS, Shirahama H, Mi R, Williams A, Bechler ME, Wang J, Ffrench-Constant C, Hoke A, Chew SY.

Mol Ther. 2019 Feb 6;27(2):411-423. doi: 10.1016/j.ymthe.2018.11.016. Epub 2018 Dec 1.


Infant oral mutilation (IOM) related to traditional practices among inner city pre-school children in Sudan.

Elgamri AI, Ahmed AT, Haj-Siddig OE, Chin JR.

Afr Health Sci. 2018 Jun;18(2):359-368. doi: 10.4314/ahs.v18i2.21.


Identification of BR101549 as a lead candidate of non-TZD PPARγ agonist for the treatment of type 2 diabetes: Proof-of-concept evaluation and SAR.

Choung W, Jung HJ, Yang D, Nam EH, Choi H, Lee BR, Park M, Jang SM, Lim JS, Kim WS, Kim KH, Chin J, Jung K, Lee G, Hong E, Jang TH, Myung J, Kim SH.

Bioorg Med Chem Lett. 2019 Feb 15;29(4):631-637. doi: 10.1016/j.bmcl.2018.12.043. Epub 2018 Dec 19.


Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid.

Huguenin-Dezot N, Alonzo DA, Heberlig GW, Mahesh M, Nguyen DP, Dornan MH, Boddy CN, Schmeing TM, Chin JW.

Nature. 2019 Jan;565(7737):112-117. doi: 10.1038/s41586-018-0781-z. Epub 2018 Dec 12.


Transforming phosphorus use on the island of Ireland: A model for a sustainable system.

Macintosh KA, Chin J, Jacobs B, Cordell D, McDowell RW, Butler P, Haygarth PM, Williams P, Quinn JP, O'Flaherty V, McGrath JW.

Sci Total Environ. 2019 Mar 15;656:852-861. doi: 10.1016/j.scitotenv.2018.11.389. Epub 2018 Nov 29.


Novel mutations in CLN6 cause late-infantile neuronal ceroid lipofuscinosis without visual impairment in two unrelated patients.

Chin JJ, Behnam B, Davids M, Sharma P, Zein WM, Wang C, Chepa-Lotrea X, Gallantine WB, Toro C, Adams DR, Tifft CJ, Gahl WA, Malicdan MCV.

Mol Genet Metab. 2019 Feb;126(2):188-195. doi: 10.1016/j.ymgme.2018.12.001. Epub 2018 Dec 3.


Controlling orthogonal ribosome subunit interactions enables evolution of new function.

Schmied WH, Tnimov Z, Uttamapinant C, Rae CD, Fried SD, Chin JW.

Nature. 2018 Dec;564(7736):444-448. doi: 10.1038/s41586-018-0773-z. Epub 2018 Dec 5.


Scalalactams A⁻D, Scalarane Sesterterpenes with a γ-Lactam Moiety from a Korean Spongia Sp. Marine Sponge.

Yang I, Lee J, Lee J, Hahn D, Chin J, Won DH, Ko J, Choi H, Hong A, Nam SJ, Kang H.

Molecules. 2018 Dec 3;23(12). pii: E3187. doi: 10.3390/molecules23123187.


Translational switching of Cry1 protein expression confers reversible control of circadian behavior in arrhythmic Cry-deficient mice.

Maywood ES, Elliott TS, Patton AP, Krogager TP, Chesham JE, Ernst RJ, Beránek V, Brancaccio M, Chin JW, Hastings MH.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12388-E12397. doi: 10.1073/pnas.1811438115. Epub 2018 Nov 28.


Justice and global care chains: Lessons from Singapore.

Jecker NS, Chin JJ.

Dev World Bioeth. 2018 Nov 26. doi: 10.1111/dewb.12213. [Epub ahead of print]


Seongsanamides A-D: Antiallergic Bicyclic Peptides from Bacillus safensis KCTC 12796BP.

Kim GJ, Li X, Kim SH, Yang I, Hahn D, Chin J, Nam SJ, Nam JW, Nam DH, Oh DC, Chang HW, Choi H.

Org Lett. 2018 Dec 7;20(23):7539-7543. doi: 10.1021/acs.orglett.8b03293. Epub 2018 Nov 20.


Exploring new treatment for spinalized rats by synergising robotic rehabilitation system and regenerative medicine.

Anopas D, Junquan L, Milbreta U, Lin VPH, Chin JS, Wee SK, Er TP, Chew SY, Ang WT.

Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:4205-4208. doi: 10.1109/EMBC.2018.8513316.


Characterization of clinical human prostate cancer lesions using 3.0-T sodium MRI registered to Gleason-graded whole-mount histopathology.

Broeke NC, Peterson J, Lee J, Martin PR, Farag A, Gomez JA, Moussa M, Gaed M, Chin J, Pautler SE, Ward A, Bauman G, Bartha R, Scholl TJ.

J Magn Reson Imaging. 2019 May;49(5):1409-1419. doi: 10.1002/jmri.26336. Epub 2018 Nov 14.


Transcription Factor Eb Is Required for Macropinocytosis-Mediated Growth Recovery of Nutrient-Deprived Kras-Mutant Cells.

Jeong S, Byun JK, Cho SJ, Chin J, Lee IK, Choi YK, Park KG.

Nutrients. 2018 Nov 2;10(11). pii: E1638. doi: 10.3390/nu10111638.


Droplet Breakup Dynamics in Bi-Layer Bifurcating Microchannel.

Ren Y, Koh KS, Yew M, Chin JK, Chan Y, Yan Y.

Micromachines (Basel). 2018 Jan 31;9(2). pii: E57. doi: 10.3390/mi9020057.

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