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Items: 13


A defect in KCa3.1 channel activity limits the ability of CD8+ T cells from cancer patients to infiltrate an adenosine-rich microenvironment.

Chimote AA, Balajthy A, Arnold MJ, Newton HS, Hajdu P, Qualtieri J, Wise-Draper T, Conforti L.

Sci Signal. 2018 Apr 24;11(527). pii: eaaq1616. doi: 10.1126/scisignal.aaq1616.


Kv1.3 Channels Mark Functionally Competent CD8+ Tumor-Infiltrating Lymphocytes in Head and Neck Cancer.

Chimote AA, Hajdu P, Sfyris AM, Gleich BN, Wise-Draper T, Casper KA, Conforti L.

Cancer Res. 2017 Jan 1;77(1):53-61. doi: 10.1158/0008-5472.CAN-16-2372. Epub 2016 Nov 4.


Nanovesicle-targeted Kv1.3 knockdown in memory T cells suppresses CD40L expression and memory phenotype.

Chimote AA, Hajdu P, Kottyan LC, Harley JB, Yun Y, Conforti L.

J Autoimmun. 2016 May;69:86-93. doi: 10.1016/j.jaut.2016.03.004. Epub 2016 Mar 16.


The C-terminus SH3-binding domain of Kv1.3 is required for the actin-mediated immobilization of the channel via cortactin.

Hajdu P, Martin GV, Chimote AA, Szilagyi O, Takimoto K, Conforti L.

Mol Biol Cell. 2015 May 1;26(9):1640-51. doi: 10.1091/mbc.E14-07-1195. Epub 2015 Mar 4.


Selective inhibition of KCa3.1 channels mediates adenosine regulation of the motility of human T cells.

Chimote AA, Hajdu P, Kucher V, Boiko N, Kuras Z, Szilagyi O, Yun YH, Conforti L.

J Immunol. 2013 Dec 15;191(12):6273-80. doi: 10.4049/jimmunol.1300702. Epub 2013 Nov 13.


Functionalized liposomes loaded with siRNAs targeting ion channels in effector memory T cells as a potential therapy for autoimmunity.

Hajdu P, Chimote AA, Thompson TH, Koo Y, Yun Y, Conforti L.

Biomaterials. 2013 Dec;34(38):10249-57. doi: 10.1016/j.biomaterials.2013.09.019. Epub 2013 Sep 27.


KCa3.1 and TRPM7 channels at the uropod regulate migration of activated human T cells.

Kuras Z, Yun YH, Chimote AA, Neumeier L, Conforti L.

PLoS One. 2012;7(8):e43859. doi: 10.1371/journal.pone.0043859. Epub 2012 Aug 27.


Modulation of Kv1.3 channels by protein kinase A I in T lymphocytes is mediated by the disc large 1-tyrosine kinase Lck complex.

Kuras Z, Kucher V, Gordon SM, Neumeier L, Chimote AA, Filipovich AH, Conforti L.

Am J Physiol Cell Physiol. 2012 May 15;302(10):C1504-12. doi: 10.1152/ajpcell.00263.2011. Epub 2012 Feb 29.


Disruption of kv1.3 channel forward vesicular trafficking by hypoxia in human T lymphocytes.

Chimote AA, Kuras Z, Conforti L.

J Biol Chem. 2012 Jan 13;287(3):2055-67. doi: 10.1074/jbc.M111.274209. Epub 2011 Nov 30.


Ion transport in a human lens epithelial cell line exposed to hyposmotic and apoptotic stress.

Chimote AA, Adragna NC, Lauf PK.

J Cell Physiol. 2010 Apr;223(1):110-22. doi: 10.1002/jcp.22015.


Lithium fluxes indicate presence of Na-Cl cotransport (NCC) in human lens epithelial cells.

Lauf PK, Chimote AA, Adragna NC.

Cell Physiol Biochem. 2008;21(5-6):335-46. doi: 10.1159/000129627. Epub 2008 Apr 24.


Apparent intermediate K conductance channel hyposmotic activation in human lens epithelial cells.

Lauf PK, Misri S, Chimote AA, Adragna NC.

Am J Physiol Cell Physiol. 2008 Mar;294(3):C820-32. doi: 10.1152/ajpcell.00375.2007. Epub 2008 Jan 9.


KCC isoforms in a human lens epithelial cell line (B3) and lens tissue extracts.

Misri S, Chimote AA, Adragna NC, Warwar R, Brown TL, Lauf PK.

Exp Eye Res. 2006 Nov;83(5):1287-94. Epub 2006 Sep 1.


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