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The Neutrophil Life Cycle.

Hidalgo A, Chilvers ER, Summers C, Koenderman L.

Trends Immunol. 2019 Jul;40(7):584-597. doi: 10.1016/ Epub 2019 May 29. Review.


Neutrophil GM-CSF receptor dynamics in acute lung injury.

De Alessandris S, Ferguson GJ, Dodd AJ, Juss JK, Devaprasad A, Piper S, Wyatt O, Killick H, Corkill DJ, Cohen ES, Pandit A, Radstake TRDJ, Simmonds R, Condliffe AM, Sleeman MA, Cowburn AS, Finch DK, Chilvers ER.

J Leukoc Biol. 2019 Jun;105(6):1183-1194. doi: 10.1002/JLB.3MA0918-347R. Epub 2019 Apr 3.


Real-time deformability cytometry reveals sequential contraction and expansion during neutrophil priming.

Bashant KR, Vassallo A, Herold C, Berner R, Menschner L, Subburayalu J, Kaplan MJ, Summers C, Guck J, Chilvers ER, Toepfner N.

J Leukoc Biol. 2019 Jun;105(6):1143-1153. doi: 10.1002/JLB.MA0718-295RR. Epub 2019 Mar 5.


Use of autologous 99mTechnetium-labelled neutrophils to quantify lung neutrophil clearance in COPD.

Tregay N, Begg M, Cahn A, Farahi N, Povey K, Madhavan S, Simmonds R, Gillett D, Solanki C, Wong A, Maison J, Lennon M, Bradley G, Jarvis E, de Groot M, Wilson F, Babar J, Peters AM, Hessel EM, Chilvers ER.

Thorax. 2019 Jul;74(7):659-666. doi: 10.1136/thoraxjnl-2018-212509. Epub 2019 Jan 23.



Farahi N, Loutsios C, Tregay N, Wright AKA, Berair R, Lok LSC, Gillett D, Cullum I, Simmonds RP, Summers C, Wong A, Solanki CK, Buscombe J, Pang PH, Thavakumar A, Peters AM, Brightling CE, Condliffe AM, Chilvers ER.

J Allergy Clin Immunol. 2019 Mar;143(3):1265-1266. doi: 10.1016/j.jaci.2018.11.026. Epub 2019 Jan 11. No abstract available.


C5a anaphylatoxin and its role in critical illness-induced organ dysfunction.

Wood AJT, Vassallo A, Summers C, Chilvers ER, Conway-Morris A.

Eur J Clin Invest. 2018 Dec;48(12):e13028. doi: 10.1111/eci.13028. Epub 2018 Oct 15. Review.


Cardiac sarcoidosis - an expert review for the chest physician.

Ho JSY, Chilvers ER, Thillai M.

Expert Rev Respir Med. 2019 Jun;13(6):507-520. doi: 10.1080/17476348.2018.1511431. Epub 2018 Sep 3.


In vivo imaging reveals increased eosinophil uptake in the lungs of obese asthmatic patients.

Farahi N, Loutsios C, Tregay N, Wright AKA, Berair R, Lok LSC, Gillett D, Cullum I, Simmonds RP, Summers C, Wong A, Solanki CK, Buscombe J, Pang PH, Thavakumar A, Peters AM, Brightling CE, Condliffe AM, Chilvers ER.

J Allergy Clin Immunol. 2018 Nov;142(5):1659-1662.e8. doi: 10.1016/j.jaci.2018.07.011. Epub 2018 Jul 30. No abstract available.


Randomised controlled trial of GM-CSF in critically ill patients with impaired neutrophil phagocytosis.

Pinder EM, Rostron AJ, Hellyer TP, Ruchaud-Sparagano MH, Scott J, Macfarlane JG, Wiscombe S, Widdrington JD, Roy AI, Linnett VC, Baudouin SV, Wright SE, Chadwick T, Fouweather T, Juss JK, Chilvers ER, Bowett SA, Parker J, McAuley DF, Conway Morris A, Simpson AJ.

Thorax. 2018 Oct;73(10):918-925. doi: 10.1136/thoraxjnl-2017-211323. Epub 2018 Jul 31.


Radiolabelled leucocytes in human pulmonary disease.

Farahi N, Loutsios C, Tregay N, Summers C, Lok LSC, Ruparelia P, Solanki CK, Gillett D, Chilvers ER, Peters AM.

Br Med Bull. 2018 Sep 1;127(1):69-82. doi: 10.1093/bmb/ldy022. Review.


Metabolic Profiling of Human Eosinophils.

Porter L, Toepfner N, Bashant KR, Guck J, Ashcroft M, Farahi N, Chilvers ER.

Front Immunol. 2018 Jun 21;9:1404. doi: 10.3389/fimmu.2018.01404. eCollection 2018.


Priming and de-priming of neutrophil responses in vitro and in vivo.

Vogt KL, Summers C, Chilvers ER, Condliffe AM.

Eur J Clin Invest. 2018 Nov;48 Suppl 2:e12967. doi: 10.1111/eci.12967. Epub 2018 Jul 5. Review.


In vivo imaging of hepatic neutrophil migration in severe alcoholic hepatitis with 111In-radiolabelled leucocytes.

Potts JR, Farahi N, Howard MR, Taylor MR, Heard S, Shankar AN, Alexander GJ, Chilvers ER, Verma S, Peters AM.

Biosci Rep. 2018 Jul 31;38(4). pii: BSR20180466. doi: 10.1042/BSR20180466. Print 2018 Aug 31.


The Efficacy and Mechanism Evaluation of Treating Idiopathic Pulmonary fibrosis with the Addition of Co-trimoxazole (EME-TIPAC): study protocol for a randomised controlled trial.

Hammond M, Clark AB, Cahn AP, Chilvers ER, Fraser WD, Livermore DM, Maher TM, Parfrey H, Swart AM, Stirling S, Thickett D, Whyte M, Wilson A.

Trials. 2018 Feb 5;19(1):89. doi: 10.1186/s13063-018-2453-6.


Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury.

Proudfoot A, Bayliffe A, O'Kane CM, Wright T, Serone A, Bareille PJ, Brown V, Hamid UI, Chen Y, Wilson R, Cordy J, Morley P, de Wildt R, Elborn S, Hind M, Chilvers ER, Griffiths M, Summers C, McAuley DF.

Thorax. 2018 Aug;73(8):723-730. doi: 10.1136/thoraxjnl-2017-210305. Epub 2018 Jan 29.


Detection of human disease conditions by single-cell morpho-rheological phenotyping of blood.

Toepfner N, Herold C, Otto O, Rosendahl P, Jacobi A, Kräter M, Stächele J, Menschner L, Herbig M, Ciuffreda L, Ranford-Cartwright L, Grzybek M, Coskun Ü, Reithuber E, Garriss G, Mellroth P, Henriques-Normark B, Tregay N, Suttorp M, Bornhäuser M, Chilvers ER, Berner R, Guck J.

Elife. 2018 Jan 13;7. pii: e29213. doi: 10.7554/eLife.29213.


Cardiovascular adaptation to hypoxia and the role of peripheral resistance.

Cowburn AS, Macias D, Summers C, Chilvers ER, Johnson RS.

Elife. 2017 Oct 19;6. pii: e28755. doi: 10.7554/eLife.28755.


Human Cytomegalovirus Delays Neutrophil Apoptosis and Stimulates the Release of a Prosurvival Secretome.

Pocock JM, Storisteanu DML, Reeves MB, Juss JK, Wills MR, Cowburn AS, Chilvers ER.

Front Immunol. 2017 Sep 25;8:1185. doi: 10.3389/fimmu.2017.01185. eCollection 2017.


Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses.

Sadiku P, Willson JA, Dickinson RS, Murphy F, Harris AJ, Lewis A, Sammut D, Mirchandani AS, Ryan E, Watts ER, Thompson AAR, Marriott HM, Dockrell DH, Taylor CT, Schneider M, Maxwell PH, Chilvers ER, Mazzone M, Moral V, Pugh CW, Ratcliffe PJ, Schofield CJ, Ghesquiere B, Carmeliet P, Whyte MK, Walmsley SR.

J Clin Invest. 2017 Sep 1;127(9):3407-3420. doi: 10.1172/JCI90848. Epub 2017 Aug 14.


Effects of tocilizumab on neutrophil function and kinetics.

Lok LSC, Farahi N, Juss JK, Loutsios C, Solanki CK, Peters AM, Donaldson F, Porter-Brown B, Chilvers ER.

Eur J Clin Invest. 2017 Oct;47(10):736-745. doi: 10.1111/eci.12799. Epub 2017 Aug 31.


NBEAL2 is required for neutrophil and NK cell function and pathogen defense.

Sowerby JM, Thomas DC, Clare S, Espéli M, Guerrero JA, Hoenderdos K, Harcourt K, Marsden M, Abdul-Karim J, Clement M, Antrobus R, Umrania Y, Barton PR, Flint SM, Juss JK, Condliffe AM, Lyons PA, Humphreys IR, Chilvers ER, Ouwehand WH, Dougan G, Smith KG.

J Clin Invest. 2017 Sep 1;127(9):3521-3526. doi: 10.1172/JCI91684. Epub 2017 Aug 7.


Bone morphogenetic protein 9 (BMP9) and BMP10 enhance tumor necrosis factor-α-induced monocyte recruitment to the vascular endothelium mainly via activin receptor-like kinase 2.

Mitrofan CG, Appleby SL, Nash GB, Mallat Z, Chilvers ER, Upton PD, Morrell NW.

J Biol Chem. 2017 Aug 18;292(33):13714-13726. doi: 10.1074/jbc.M117.778506. Epub 2017 Jun 23.


Mechanical deformation induces depolarization of neutrophils.

Ekpenyong AE, Toepfner N, Fiddler C, Herbig M, Li W, Cojoc G, Summers C, Guck J, Chilvers ER.

Sci Adv. 2017 Jun 14;3(6):e1602536. doi: 10.1126/sciadv.1602536. eCollection 2017 Jun.


Exposure of patients to ionising radiation during lung cancer diagnostic work-up.

Rintoul RC, Atherton R, Tweed K, Yates S, Chilvers ER.

Thorax. 2017 Sep;72(9):853-855. doi: 10.1136/thoraxjnl-2016-209641. Epub 2017 Apr 25.


Hypoxia determines survival outcomes of bacterial infection through HIF-1alpha dependent re-programming of leukocyte metabolism.

Thompson AA, Dickinson RS, Murphy F, Thomson JP, Marriott HM, Tavares A, Willson J, Williams L, Lewis A, Mirchandani A, Dos Santos Coelho P, Doherty C, Ryan E, Watts E, Morton NM, Forbes S, Stimson RH, Hameed AG, Arnold N, Preston JA, Lawrie A, Finisguerra V, Mazzone M, Sadiku P, Goveia J, Taverna F, Carmeliet P, Foster SJ, Chilvers ER, Cowburn AS, Dockrell DH, Johnson RS, Meehan RR, Whyte MK, Walmsley SR.

Sci Immunol. 2017 Feb 10;2(8). pii: eaal2861. doi: 10.1126/sciimmunol.aal2861.


Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity.

Thomas DC, Clare S, Sowerby JM, Pardo M, Juss JK, Goulding DA, van der Weyden L, Storisteanu D, Prakash A, Espéli M, Flint S, Lee JC, Hoenderdos K, Kane L, Harcourt K, Mukhopadhyay S, Umrania Y, Antrobus R, Nathan JA, Adams DJ, Bateman A, Choudhary JS, Lyons PA, Condliffe AM, Chilvers ER, Dougan G, Smith KG.

J Exp Med. 2017 Apr 3;214(4):1111-1128. doi: 10.1084/jem.20161382. Epub 2017 Mar 28.


Neutrophil-mediated IL-6 receptor trans-signaling and the risk of chronic obstructive pulmonary disease and asthma.

Farahi N, Paige E, Balla J, Prudence E, Ferreira RC, Southwood M, Appleby SL, Bakke P, Gulsvik A, Litonjua AA, Sparrow D, Silverman EK, Cho MH, Danesh J, Paul DS, Freitag DF, Chilvers ER.

Hum Mol Genet. 2017 Apr 15;26(8):1584-1596. doi: 10.1093/hmg/ddx053.


Identification of LukPQ, a novel, equid-adapted leukocidin of Staphylococcus aureus.

Koop G, Vrieling M, Storisteanu DM, Lok LS, Monie T, van Wigcheren G, Raisen C, Ba X, Gleadall N, Hadjirin N, Timmerman AJ, Wagenaar JA, Klunder HM, Fitzgerald JR, Zadoks R, Paterson GK, Torres C, Waller AS, Loeffler A, Loncaric I, Hoet AE, Bergström K, De Martino L, Pomba C, de Lencastre H, Ben Slama K, Gharsa H, Richardson EJ, Chilvers ER, de Haas C, van Kessel K, van Strijp JA, Harrison EM, Holmes MA.

Sci Rep. 2017 Jan 20;7:40660. doi: 10.1038/srep40660.


Quantification of Lung PET Images: Challenges and Opportunities.

Chen DL, Cheriyan J, Chilvers ER, Choudhury G, Coello C, Connell M, Fisk M, Groves AM, Gunn RN, Holman BF, Hutton BF, Lee S, MacNee W, Mohan D, Parr D, Subramanian D, Tal-Singer R, Thielemans K, van Beek EJ, Vass L, Wellen JW, Wilkinson I, Wilson FJ.

J Nucl Med. 2017 Feb;58(2):201-207. doi: 10.2967/jnumed.116.184796. Epub 2017 Jan 12. Review.


Hypoxia causes IL-8 secretion, Charcot Leyden crystal formation, and suppression of corticosteroid-induced apoptosis in human eosinophils.

Porter LM, Cowburn AS, Farahi N, Deighton J, Farrow SN, Fiddler CA, Juss JK, Condliffe AM, Chilvers ER.

Clin Exp Allergy. 2017 Jun;47(6):770-784. doi: 10.1111/cea.12877. Epub 2017 Feb 3.


Evasion of Neutrophil Extracellular Traps by Respiratory Pathogens.

Storisteanu DM, Pocock JM, Cowburn AS, Juss JK, Nadesalingam A, Nizet V, Chilvers ER.

Am J Respir Cell Mol Biol. 2017 Apr;56(4):423-431. doi: 10.1165/rcmb.2016-0193PS. Review.


Hypoxic regulation of neutrophil function and consequences for Staphylococcus aureus infection.

Lodge KM, Thompson AA, Chilvers ER, Condliffe AM.

Microbes Infect. 2017 Mar;19(3):166-176. doi: 10.1016/j.micinf.2016.10.005. Epub 2016 Oct 24. Review.


Bone Morphogenetic Protein 9 Enhances Lipopolysaccharide-Induced Leukocyte Recruitment to the Vascular Endothelium.

Appleby SL, Mitrofan CG, Crosby A, Hoenderdos K, Lodge K, Upton PD, Yates CM, Nash GB, Chilvers ER, Morrell NW.

J Immunol. 2016 Oct 15;197(8):3302-3314. doi: 10.4049/jimmunol.1601219. Epub 2016 Sep 19.


Circulating granulocyte lifespan in compensated alcohol-related cirrhosis: a pilot study.

Potts JR, Farahi N, Heard S, Chilvers ER, Verma S, Peters AM.

Physiol Rep. 2016 Sep;4(17). pii: e12836. doi: 10.14814/phy2.12836.


Hypoxia upregulates neutrophil degranulation and potential for tissue injury.

Hoenderdos K, Lodge KM, Hirst RA, Chen C, Palazzo SG, Emerenciana A, Summers C, Angyal A, Porter L, Juss JK, O'Callaghan C, Chilvers ER, Condliffe AM.

Thorax. 2016 Nov;71(11):1030-1038. doi: 10.1136/thoraxjnl-2015-207604. Epub 2016 Aug 31.


Incidence and recognition of acute respiratory distress syndrome in a UK intensive care unit.

Summers C, Singh NR, Worpole L, Simmonds R, Babar J, Condliffe AM, Gunning KE, Johnston AJ, Chilvers ER.

Thorax. 2016 Nov;71(11):1050-1051. doi: 10.1136/thoraxjnl-2016-208402. Epub 2016 Aug 22.


Severe Colitis Associated with Pirfenidone Use in Idiopathic Pulmonary Fibrosis.

Fiddler CA, Simler N, Parfrey H, Miremadi A, Chilvers ER.

Ann Am Thorac Soc. 2016 Aug;13(8):1430-2. doi: 10.1513/AnnalsATS.201602-118LE. No abstract available.


C13orf31 (FAMIN) is a central regulator of immunometabolic function.

Cader MZ, Boroviak K, Zhang Q, Assadi G, Kempster SL, Sewell GW, Saveljeva S, Ashcroft JW, Clare S, Mukhopadhyay S, Brown KP, Tschurtschenthaler M, Raine T, Doe B, Chilvers ER, Griffin JL, Kaneider NC, Floto RA, D'Amato M, Bradley A, Wakelam MJ, Dougan G, Kaser A.

Nat Immunol. 2016 Sep;17(9):1046-56. doi: 10.1038/ni.3532. Epub 2016 Aug 1.


The Aminopeptidase CD13 Induces Homotypic Aggregation in Neutrophils and Impairs Collagen Invasion.

Fiddler CA, Parfrey H, Cowburn AS, Luo D, Nash GB, Murphy G, Chilvers ER.

PLoS One. 2016 Jul 28;11(7):e0160108. doi: 10.1371/journal.pone.0160108. eCollection 2016.


HIF2α-arginase axis is essential for the development of pulmonary hypertension.

Cowburn AS, Crosby A, Macias D, Branco C, Colaço RD, Southwood M, Toshner M, Crotty Alexander LE, Morrell NW, Chilvers ER, Johnson RS.

Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8801-6. doi: 10.1073/pnas.1602978113. Epub 2016 Jul 18.


Acute Respiratory Distress Syndrome Neutrophils Have a Distinct Phenotype and Are Resistant to Phosphoinositide 3-Kinase Inhibition.

Juss JK, House D, Amour A, Begg M, Herre J, Storisteanu DM, Hoenderdos K, Bradley G, Lennon M, Summers C, Hessel EM, Condliffe A, Chilvers ER.

Am J Respir Crit Care Med. 2016 Oct 15;194(8):961-973.


Genome-wide transcription profiling in neutrophils in acute respiratory distress syndrome.

Juss J, Herre J, Begg M, Bradley G, Lennon M, Amour A, House D, Hessel EM, Summers C, Condliffe AM, Chilvers ER.

Lancet. 2015 Feb 26;385 Suppl 1:S55. doi: 10.1016/S0140-6736(15)60370-1.


TARM1 Is a Novel Leukocyte Receptor Complex-Encoded ITAM Receptor That Costimulates Proinflammatory Cytokine Secretion by Macrophages and Neutrophils.

Radjabova V, Mastroeni P, Skjødt K, Zaccone P, de Bono B, Goodall JC, Chilvers ER, Juss JK, Jones DC, Trowsdale J, Barrow AD.

J Immunol. 2015 Oct 1;195(7):3149-59. doi: 10.4049/jimmunol.1401847. Epub 2015 Aug 26.


Mechanotransduction in neutrophil activation and deactivation.

Ekpenyong AE, Toepfner N, Chilvers ER, Guck J.

Biochim Biophys Acta. 2015 Nov;1853(11 Pt B):3105-16. doi: 10.1016/j.bbamcr.2015.07.015. Epub 2015 Jul 23.


Clinical application of autologous technetium-99m-labelled eosinophils to detect focal eosinophilic inflammation in the lung.

Loutsios C, Farahi N, Simmonds R, Cullum I, Gillett D, Solanki C, Solanki K, Buscombe J, Condliffe AM, Peters AM, Chilvers ER.

Thorax. 2015 Nov;70(11):1085-6. doi: 10.1136/thoraxjnl-2015-207156. Epub 2015 Jun 24.


Alveolar Macrophages Isolated Directly From Human Cytomegalovirus (HCMV)-Seropositive Individuals Are Sites of HCMV Reactivation In Vivo.

Poole E, Juss JK, Krishna B, Herre J, Chilvers ER, Sinclair J.

J Infect Dis. 2015 Jun 15;211(12):1936-42. doi: 10.1093/infdis/jiu837. Epub 2014 Dec 30.


Measurement of eosinophil kinetics in healthy volunteers.

Farahi N, Loutsios C, Simmonds RP, Porter L, Gillett D, Heard S, Peters AM, Condliffe AM, Chilvers ER.

Methods Mol Biol. 2014;1178:165-76. doi: 10.1007/978-1-4939-1016-8_15.


Future treatment in patients with chronic obstructive pulmonary disease: to reverse or not to reverse steroid resistance-that is the question.

Koenderman L, Chilvers ER.

J Allergy Clin Immunol. 2014 Aug;134(2):323-4. doi: 10.1016/j.jaci.2014.04.030. Epub 2014 Jun 13. No abstract available.


Mathematical modeling supports the presence of neutrophil depriming in vivo.

Summers C, Chilvers ER, Peters AM.

Physiol Rep. 2014 Mar 20;2(3):e00241. doi: 10.1002/phy2.241. Print 2014.


Pulmonary retention of primed neutrophils: a novel protective host response, which is impaired in the acute respiratory distress syndrome.

Summers C, Singh NR, White JF, Mackenzie IM, Johnston A, Solanki C, Balan KK, Peters AM, Chilvers ER.

Thorax. 2014 Jul;69(7):623-9. doi: 10.1136/thoraxjnl-2013-204742. Epub 2014 Apr 4.

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