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Items: 1 to 50 of 125

1.

Improving natural product research translation: From source to clinical trial.

Sorkin BC, Kuszak AJ, Bloss G, Fukagawa NK, Hoffman FA, Jafari M, Barrett B, Brown PN, Bushman FD, Casper SJ, Chilton FH, Coffey CS, Ferruzzi MG, Hopp DC, Kiely M, Lakens D, MacMillan JB, Meltzer DO, Pahor M, Paul J, Pritchett-Corning K, Quinney SK, Rehermann B, Setchell KDR, Sipes NS, Stephens JM, Taylor DL, Tiriac H, Walters MA, Xi D, Zappalá G, Pauli GF.

FASEB J. 2020 Jan;34(1):41-65. doi: 10.1096/fj.201902143R. Epub 2019 Dec 10.

PMID:
31914647
2.

Evolution of Hominin Polyunsaturated Fatty Acid Metabolism: From Africa to the New World.

Harris DN, Ruczinski I, Yanek LR, Becker LC, Becker DM, Guio H, Cui T, Chilton FH, Mathias RA, O'Connor TD.

Genome Biol Evol. 2019 May 1;11(5):1417-1430. doi: 10.1093/gbe/evz071.

3.

Allele-specific methylation in the FADS genomic region in DNA from human saliva, CD4+ cells, and total leukocytes.

Rahbar E, Waits CMK, Kirby EH Jr, Miller LR, Ainsworth HC, Cui T, Sergeant S, Howard TD, Langefeld CD, Chilton FH.

Clin Epigenetics. 2018 Apr 6;10:46. doi: 10.1186/s13148-018-0480-5. eCollection 2018.

4.

Tissue-specific impact of FADS cluster variants on FADS1 and FADS2 gene expression.

Reynolds LM, Howard TD, Ruczinski I, Kanchan K, Seeds MC, Mathias RA, Chilton FH.

PLoS One. 2018 Mar 28;13(3):e0194610. doi: 10.1371/journal.pone.0194610. eCollection 2018.

5.

Substrate specificity and membrane topologies of the iron-containing ω3 and ω6 desaturases from Mortierella alpina.

Wang M, Chen H, Ailati A, Chen W, Chilton FH, Todd Lowther W, Chen YQ.

Appl Microbiol Biotechnol. 2018 Jan;102(1):211-223. doi: 10.1007/s00253-017-8585-x. Epub 2017 Oct 30.

6.

Precision Nutrition and Omega-3 Polyunsaturated Fatty Acids: A Case for Personalized Supplementation Approaches for the Prevention and Management of Human Diseases.

Chilton FH, Dutta R, Reynolds LM, Sergeant S, Mathias RA, Seeds MC.

Nutrients. 2017 Oct 25;9(11). pii: E1165. doi: 10.3390/nu9111165. Review.

7.

Uncovering the DNA methylation landscape in key regulatory regions within the FADS cluster.

Rahbar E, Ainsworth HC, Howard TD, Hawkins GA, Ruczinski I, Mathias R, Seeds MC, Sergeant S, Hixson JE, Herrington DM, Langefeld CD, Chilton FH.

PLoS One. 2017 Sep 28;12(9):e0180903. doi: 10.1371/journal.pone.0180903. eCollection 2017.

8.

Impact of Genetic and Epigenetic Variations Within the FADS Cluster on the Composition and Metabolism of Polyunsaturated Fatty Acids in Prostate Cancer.

Cui T, Hester AG, Seeds MC, Rahbar E, Howard TD, Sergeant S, Chilton FH.

Prostate. 2016 Sep;76(13):1182-91. doi: 10.1002/pros.23205. Epub 2016 May 16.

9.

Gamma-linolenic acid, Dihommo-gamma linolenic, Eicosanoids and Inflammatory Processes.

Sergeant S, Rahbar E, Chilton FH.

Eur J Pharmacol. 2016 Aug 15;785:77-86. doi: 10.1016/j.ejphar.2016.04.020. Epub 2016 Apr 12. Review.

10.

Alterations in levels and ratios of n-3 and n-6 polyunsaturated fatty acids in the temporal cortex and liver of vervet monkeys from birth to early adulthood.

Miller LR, Jorgensen MJ, Kaplan JR, Seeds MC, Rahbar E, Morgan TM, Welborn A, Chilton SM, Gillis J, Hester A, Rukstalis M, Sergeant S, Chilton FH.

Physiol Behav. 2016 Mar 15;156:71-8. doi: 10.1016/j.physbeh.2015.12.009. Epub 2015 Dec 17.

11.

Impact of methods used to express levels of circulating fatty acids on the degree and direction of associations with blood lipids in humans.

Sergeant S, Ruczinski I, Ivester P, Lee TC, Morgan TM, Nicklas BJ, Mathias RA, Chilton FH.

Br J Nutr. 2016 Jan 28;115(2):251-61. doi: 10.1017/S0007114515004341. Epub 2015 Nov 30.

12.

The impact of polyunsaturated fatty acid-based dietary supplements on disease biomarkers in a metabolic syndrome/diabetes population.

Lee TC, Ivester P, Hester AG, Sergeant S, Case LD, Morgan T, Kouba EO, Chilton FH.

Lipids Health Dis. 2014 Dec 16;13:196. doi: 10.1186/1476-511X-13-196.

13.

LTC4 synthase polymorphism modifies efficacy of botanical seed oil combination in asthma.

Kazani S, Arm JP, Boyce J, Chhay H, Dutile S, Wechsler ME, Govindarajulu U, Ivester P, Ainsworth HC, Sergeant S, Chilton FH, Israel E.

Springerplus. 2014 Nov 6;3:661. doi: 10.1186/2193-1801-3-661. eCollection 2014.

14.
15.

Relationship between a common variant in the fatty acid desaturase (FADS) cluster and eicosanoid generation in humans.

Hester AG, Murphy RC, Uhlson CJ, Ivester P, Lee TC, Sergeant S, Miller LR, Howard TD, Mathias RA, Chilton FH.

J Biol Chem. 2014 Aug 8;289(32):22482-9. doi: 10.1074/jbc.M114.579557. Epub 2014 Jun 24.

16.

Diet-gene interactions and PUFA metabolism: a potential contributor to health disparities and human diseases.

Chilton FH, Murphy RC, Wilson BA, Sergeant S, Ainsworth H, Seeds MC, Mathias RA.

Nutrients. 2014 May 21;6(5):1993-2022. doi: 10.3390/nu6051993. Review.

17.

DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver.

Howard TD, Mathias RA, Seeds MC, Herrington DM, Hixson JE, Shimmin LC, Hawkins GA, Sellers M, Ainsworth HC, Sergeant S, Miller LR, Chilton FH.

PLoS One. 2014 May 19;9(5):e97510. doi: 10.1371/journal.pone.0097510. eCollection 2014.

18.

Impact of botanical oils on polyunsaturated fatty acid metabolism and leukotriene generation in mild asthmatics.

Arm JP, Boyce JA, Wang L, Chhay H, Zahid M, Patil V, Govindarajulu U, Ivester P, Weaver KL, Sergeant S, Israel E, Chilton FH.

Lipids Health Dis. 2013 Oct 2;12:141. doi: 10.1186/1476-511X-12-141.

19.

Stearidonic and γ-linolenic acids in echium oil improves glucose disposal in insulin resistant monkeys.

Kavanagh K, Flynn DM, Jenkins KA, Wilson MD, Chilton FH.

Prostaglandins Leukot Essent Fatty Acids. 2013 Jul;89(1):39-45. doi: 10.1016/j.plefa.2013.04.003. Epub 2013 May 7.

20.

Adaptive evolution of the FADS gene cluster within Africa.

Mathias RA, Fu W, Akey JM, Ainsworth HC, Torgerson DG, Ruczinski I, Sergeant S, Barnes KC, Chilton FH.

PLoS One. 2012;7(9):e44926. doi: 10.1371/journal.pone.0044926. Epub 2012 Sep 19.

21.

Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome.

Sergeant S, Hugenschmidt CE, Rudock ME, Ziegler JT, Ivester P, Ainsworth HC, Vaidya D, Case LD, Langefeld CD, Freedman BI, Bowden DW, Mathias RA, Chilton FH.

Br J Nutr. 2012 Feb;107(4):547-55. doi: 10.1017/S0007114511003230. Epub 2011 Jul 4.

22.

The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans.

Mathias RA, Sergeant S, Ruczinski I, Torgerson DG, Hugenschmidt CE, Kubala M, Vaidya D, Suktitipat B, Ziegler JT, Ivester P, Case D, Yanek LR, Freedman BI, Rudock ME, Barnes KC, Langefeld CD, Becker LC, Bowden DW, Becker DM, Chilton FH.

BMC Genet. 2011 May 20;12:50. doi: 10.1186/1471-2156-12-50.

23.

Dietary fish oil modestly attenuates the effect of age on diastolic function but has no effect on memory or brain inflammation in aged rats.

Sergeant S, McQuail JA, Riddle DR, Chilton FH, Ortmeier SB, Jessup JA, Groban L, Nicolle MM.

J Gerontol A Biol Sci Med Sci. 2011 May;66(5):521-33. doi: 10.1093/gerona/glr017. Epub 2011 Mar 10.

24.

Depression and altered serum lipids in cynomolgus monkeys consuming a Western diet.

Chilton FH, Lee TC, Willard SL, Ivester P, Sergeant S, Register TC, Shively CA.

Physiol Behav. 2011 Aug 3;104(2):222-7. doi: 10.1016/j.physbeh.2011.01.013. Epub 2011 Jan 20.

25.

FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population.

Mathias RA, Vergara C, Gao L, Rafaels N, Hand T, Campbell M, Bickel C, Ivester P, Sergeant S, Barnes KC, Chilton FH.

J Lipid Res. 2010 Sep;51(9):2766-74. doi: 10.1194/jlr.M008359. Epub 2010 Jun 19.

26.

Effect of a multifaceted, church-based wellness program on metabolic syndrome in 41 overweight or obese congregants.

Ivester P, Sergeant S, Danhauer SC, Case LD, Lamb A, Chilton BG, Delar B, Hollingshead ML, Weaver KL, Chilton FH.

Prev Chronic Dis. 2010 Jul;7(4):A81. Epub 2010 Jun 15.

27.

Nonpharmacologic treatment of dyslipidemia.

Houston MC, Fazio S, Chilton FH, Wise DE, Jones KB, Barringer TA, Bramlet DA.

Prog Cardiovasc Dis. 2009 Sep-Oct;52(2):61-94. doi: 10.1016/j.pcad.2009.02.002. Review. No abstract available.

PMID:
19732602
28.

Effect of dietary fatty acids on inflammatory gene expression in healthy humans.

Weaver KL, Ivester P, Seeds M, Case LD, Arm JP, Chilton FH.

J Biol Chem. 2009 Jun 5;284(23):15400-7. doi: 10.1074/jbc.M109.004861. Epub 2009 Apr 9.

29.

Regulation of arachidonate remodeling enzymes impacts eosinophil survival during allergic asthma.

Seeds MC, Peachman KK, Bowton DL, Sivertson KL, Chilton FH.

Am J Respir Cell Mol Biol. 2009 Sep;41(3):358-66. doi: 10.1165/rcmb.2008-0192OC. Epub 2009 Jan 16.

30.

Regarding favorable and unfavorable PUFA in fish.

Chilton FH.

J Am Diet Assoc. 2008 Oct;108(10):1614, 1616; author reply 1616. doi: 10.1016/j.jada.2008.08.031. No abstract available.

PMID:
18926120
31.

The content of favorable and unfavorable polyunsaturated fatty acids found in commonly eaten fish.

Weaver KL, Ivester P, Chilton JA, Wilson MD, Pandey P, Chilton FH.

J Am Diet Assoc. 2008 Jul;108(7):1178-85. doi: 10.1016/j.jada.2008.04.023. Erratum in: J Am Diet Assoc. 2008 Oct;108(10):1785.

PMID:
18589026
32.

Mechanisms by which botanical lipids affect inflammatory disorders.

Chilton FH, Rudel LL, Parks JS, Arm JP, Seeds MC.

Am J Clin Nutr. 2008 Feb;87(2):498S-503S. Review.

PMID:
18258646
33.

Technologies and experimental approaches at the National Institutes of Health Botanical Research Centers.

Barnes S, Birt DF, Cassileth BR, Cefalu WT, Chilton FH, Farnsworth NR, Raskin I, van Breemen RB, Weaver CM.

Am J Clin Nutr. 2008 Feb;87(2):476S-80S. Review.

34.

Arachidonic acid-induced gene expression in colon cancer cells.

Monjazeb AM, High KP, Connoy A, Hart LS, Koumenis C, Chilton FH.

Carcinogenesis. 2006 Oct;27(10):1950-60. Epub 2006 May 15.

PMID:
16704987
35.

Inhibitors of arachidonic acid metabolism act synergistically to signal apoptosis in neoplastic cells.

Monjazeb AM, High KP, Koumenis C, Chilton FH.

Prostaglandins Leukot Essent Fatty Acids. 2005 Dec;73(6):463-74. Epub 2005 Sep 16.

PMID:
16169197
36.
37.

Advanced age, but not anergy, is associated with altered serum polyunsaturated fatty acid levels.

High KP, Sinclair J, Easter LH, Case D, Chilton FH.

J Nutr Health Aging. 2003;7(6):378-84.

PMID:
14625615
38.
39.

Inhibition of leukotriene synthesis, pharmacokinetics, and tolerability of a novel dietary fatty acid formulation in healthy adult subjects.

Surette ME, Koumenis IL, Edens MB, Tramposch KM, Chilton FH.

Clin Ther. 2003 Mar;25(3):948-71.

PMID:
12852710
40.

15-Deoxy-delta12,14-prostaglandin J2-induced apoptosis does not require PPARgamma in breast cancer cells.

Clay CE, Monjazeb A, Thorburn J, Chilton FH, High KP.

J Lipid Res. 2002 Nov;43(11):1818-28.

41.

Antineoplastic properties of arachidonic acid and its metabolites.

Monjazeb AM, Clay CE, High KP, Chilton FH.

Prostaglandins Leukot Essent Fatty Acids. 2002 Jan;66(1):5-12. Review. No abstract available.

PMID:
12051952
42.

Early de novo gene expression is required for 15-deoxy-Delta 12,14-prostaglandin J2-induced apoptosis in breast cancer cells.

Clay CE, Atsumi GI, High KP, Chilton FH.

J Biol Chem. 2001 Dec 14;276(50):47131-5. Epub 2001 Nov 1.

43.

Enhancement of mast cell survival: a novel function of some secretory phospholipase A(2) isotypes.

Fonteh AN, Marion CR, Barham BJ, Edens MB, Atsumi G, Samet JM, High KP, Chilton FH.

J Immunol. 2001 Oct 15;167(8):4161-71.

44.

Magnitude of peroxisome proliferator-activated receptor-gamma activation is associated with important and seemingly opposite biological responses in breast cancer cells.

Clay CE, Namen AM, Atsumi G, Trimboli AJ, Fonteh AN, High KP, Chilton FH.

J Investig Med. 2001 Sep;49(5):413-20. doi: 10.2310/6650.2001.33786.

PMID:
11523697
45.
46.

15-deoxy-Delta(12,14)PGJ(2) induces diverse biological responses via PPARgamma activation in cancer cells.

Clay CE, Namen AM, Fonteh AN, Atsumi G, High KP, Chilton FH.

Prostaglandins Other Lipid Mediat. 2000 Jun;62(1):23-32. Review. No abstract available.

PMID:
10936413
47.

Addition of eicosapentaenoic acid to gamma-linolenic acid-supplemented diets prevents serum arachidonic acid accumulation in humans.

Barham JB, Edens MB, Fonteh AN, Johnson MM, Easter L, Chilton FH.

J Nutr. 2000 Aug;130(8):1925-31.

PMID:
10917903
48.

Influence of coenzyme A-independent transacylase and cyclooxygenase inhibitors on the proliferation of breast cancer cells.

Trimboli AJ, Waite BM, Atsumi G, Fonteh AN, Namen AM, Clay CE, Kute TE, High KP, Willingham MC, Chilton FH.

Cancer Res. 1999 Dec 15;59(24):6171-7.

49.

Influence of J series prostaglandins on apoptosis and tumorigenesis of breast cancer cells.

Clay CE, Namen AM, Atsumi G, Willingham MC, High KP, Kute TE, Trimboli AJ, Fonteh AN, Dawson PA, Chilton FH.

Carcinogenesis. 1999 Oct;20(10):1905-11.

PMID:
10506103
50.

Role of arachidonyl triglycerides within lipid bodies in eicosanoid formation by human polymorphonuclear cells.

Johnson MM, Vaughn B, Triggiani M, Swan DD, Fonteh AN, Chilton FH.

Am J Respir Cell Mol Biol. 1999 Aug;21(2):253-8.

PMID:
10423409

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