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Intrinsically disordered proteins access a range of hysteretic phase separation behaviors.

Garcia Quiroz F, Li NK, Roberts S, Weber P, Dzuricky M, Weitzhandler I, Yingling YG, Chilkoti A.

Sci Adv. 2019 Oct 18;5(10):eaax5177. doi: 10.1126/sciadv.aax5177. eCollection 2019 Oct.


Heuristics for the Optimal Presentation of Bioactive Peptides on Polypeptide Micelles.

Wang J, Saha S, Schaal JL, Yousefpour P, Li X, Chilkoti A.

Nano Lett. 2019 Oct 29. doi: 10.1021/acs.nanolett.9b03141. [Epub ahead of print]


Enzymatic synthesis and modification of high molecular weight DNA using terminal deoxynucleotidyl transferase.

Deshpande S, Yang Y, Chilkoti A, Zauscher S.

Methods Enzymol. 2019;627:163-188. doi: 10.1016/bs.mie.2019.07.044. Epub 2019 Aug 30.


Versatile biomanufacturing through stimulus-responsive cell-material feedback.

Dai Z, Lee AJ, Roberts S, Sysoeva TA, Huang S, Dzuricky M, Yang X, Zhang X, Liu Z, Chilkoti A, You L.

Nat Chem Biol. 2019 Oct;15(10):1017-1024. doi: 10.1038/s41589-019-0357-8. Epub 2019 Sep 16.


Genomically informed small-molecule drugs overcome resistance to a sustained-release formulation of an engineered death receptor agonist in patient-derived tumor models.

Manzari MT, Anderson GR, Lin KH, Soderquist RS, Çakir M, Zhang M, Moore CE, Skelton RN, Fèvre M, Li X, Bellucci JJ, Wardell SE, Costa SA, Wood KC, Chilkoti A.

Sci Adv. 2019 Sep 4;5(9):eaaw9162. doi: 10.1126/sciadv.aaw9162. eCollection 2019 Sep.


Nature of Amorphous Hydrophilic Block Affects Self-Assembly of an Artificial Viral Coat Polypeptide.

Willems L, van Westerveld L, Roberts S, Weitzhandler I, Calcines Cruz C, Hernandez-Garcia A, Chilkoti A, Mastrobattista E, van der Oost J, de Vries R.

Biomacromolecules. 2019 Oct 14;20(10):3641-3647. doi: 10.1021/acs.biomac.9b00512. Epub 2019 Aug 29.


Avidity and Cell Uptake of Integrin-Targeting Polypeptide Micelles is Strongly Shape-Dependent.

Dzuricky M, Xiong S, Weber P, Chilkoti A.

Nano Lett. 2019 Sep 11;19(9):6124-6132. doi: 10.1021/acs.nanolett.9b02095. Epub 2019 Aug 12.


Engineered Ribonucleoprotein Granules Inhibit Translation in Protocells.

Simon JR, Eghtesadi SA, Dzuricky M, You L, Chilkoti A.

Mol Cell. 2019 Jul 11;75(1):66-75.e5. doi: 10.1016/j.molcel.2019.05.010. Epub 2019 Jun 4.


Inducible Fibril Formation of Silk-Elastin Diblocks.

Willems L, Roberts S, Weitzhandler I, Chilkoti A, Mastrobattista E, van der Oost J, de Vries R.

ACS Omega. 2019 May 31;4(5):9135-9143. doi: 10.1021/acsomega.9b01025. Epub 2019 May 23.


Sediment challenge to promising ultra-low fouling hydrophilic surfaces in the marine environment.

Koc J, Simovich T, Schönemann E, Chilkoti A, Gardner H, Swain GW, Hunsucker K, Laschewsky A, Rosenhahn A.

Biofouling. 2019 Apr;35(4):454-462. doi: 10.1080/08927014.2019.1611790. Epub 2019 May 15.


Architectural Modification of Conformal PEG-Bottlebrush Coatings Minimizes Anti-PEG Antigenicity While Preserving Stealth Properties.

Joh DY, Zimmers Z, Avlani M, Heggestad JT, Aydin HB, Ganson N, Kumar S, Fontes CM, Achar RK, Hershfield MS, Hucknall AM, Chilkoti A.

Adv Healthc Mater. 2019 Apr;8(8):e1801177. doi: 10.1002/adhm.201801177. Epub 2019 Mar 25.


Molecular and Materials Engineering for Delivery of Peptide Drugs to Treat Type 2 Diabetes.

Varanko AK, Chilkoti A.

Adv Healthc Mater. 2019 Jun;8(12):e1801509. doi: 10.1002/adhm.201801509. Epub 2019 Feb 14. Review.


Conjugate of Doxorubicin to Albumin-Binding Peptide Outperforms Aldoxorubicin.

Yousefpour P, Ahn L, Tewksbury J, Saha S, Costa SA, Bellucci JJ, Li X, Chilkoti A.

Small. 2019 Mar;15(12):e1804452. doi: 10.1002/smll.201804452. Epub 2019 Feb 13.


Genetically Encoded Cholesterol-Modified Polypeptides.

Mozhdehi D, Luginbuhl KM, Dzuricky M, Costa SA, Xiong S, Huang FC, Lewis MM, Zelenetz SR, Colby CD, Chilkoti A.

J Am Chem Soc. 2019 Jan 16;141(2):945-951. doi: 10.1021/jacs.8b10687. Epub 2019 Jan 4.


Active Targeting of Cancer Cells by Nanobody Decorated Polypeptide Micelle with Bio-orthogonally Conjugated Drug.

Costa SA, Mozhdehi D, Dzuricky MJ, Isaacs FJ, Brustad EM, Chilkoti A.

Nano Lett. 2019 Jan 9;19(1):247-254. doi: 10.1021/acs.nanolett.8b03837. Epub 2018 Dec 14.


Long circulating genetically encoded intrinsically disordered zwitterionic polypeptides for drug delivery.

Banskota S, Yousefpour P, Kirmani N, Li X, Chilkoti A.

Biomaterials. 2019 Feb;192:475-485. doi: 10.1016/j.biomaterials.2018.11.012. Epub 2018 Nov 28.


Genetically Encoding Albumin Binding into Chemotherapeutic-loaded Polypeptide Nanoparticles Enhances Their Antitumor Efficacy.

Yousefpour P, McDaniel JR, Prasad V, Ahn L, Li X, Subrahmanyan R, Weitzhandler I, Suter S, Chilkoti A.

Nano Lett. 2018 Dec 12;18(12):7784-7793. doi: 10.1021/acs.nanolett.8b03558. Epub 2018 Nov 21.


Author Correction: Injectable tissue integrating networks from recombinant polypeptides with tunable order.

Roberts S, Harmon TS, Schaal JL, Miao V, Li KJ, Hunt A, Wen Y, Oas TG, Collier JH, Pappu RV, Chilkoti A.

Nat Mater. 2018 Dec;17(12):1164. doi: 10.1038/s41563-018-0233-z.


Injectable tissue integrating networks from recombinant polypeptides with tunable order.

Roberts S, Harmon TS, Schaal JL, Miao V, Li KJ, Hunt A, Wen Y, Oas TG, Collier JH, Pappu RV, Chilkoti A.

Nat Mater. 2018 Dec;17(12):1154-1163. doi: 10.1038/s41563-018-0182-6. Epub 2018 Oct 15. Erratum in: Nat Mater. 2018 Oct 31;:.


Engineering the Surface Properties of a Zwitterionic Polymer Brush to Enable the Simple Fabrication of Inkjet-Printed Point-of-Care Immunoassays.

Fontes CM, Achar RK, Joh DY, Ozer I, Bhattacharjee S, Hucknall A, Chilkoti A.

Langmuir. 2019 Feb 5;35(5):1379-1390. doi: 10.1021/acs.langmuir.8b01597. Epub 2018 Aug 21.


Enzymatic Synthesis of Nucleobase-Modified Single-Stranded DNA Offers Tunable Resistance to Nuclease Degradation.

Gu R, Oweida T, Yingling YG, Chilkoti A, Zauscher S.

Biomacromolecules. 2018 Aug 13;19(8):3525-3535. doi: 10.1021/acs.biomac.8b00816. Epub 2018 Jul 27.


Advances in Understanding Stimulus-Responsive Phase Behavior of Intrinsically Disordered Protein Polymers.

Ruff KM, Roberts S, Chilkoti A, Pappu RV.

J Mol Biol. 2018 Nov 2;430(23):4619-4635. doi: 10.1016/j.jmb.2018.06.031. Epub 2018 Jun 24. Review.


Convergence of Artificial Protein Polymers and Intrinsically Disordered Proteins.

Dzuricky M, Roberts S, Chilkoti A.

Biochemistry. 2018 May 1;57(17):2405-2414. doi: 10.1021/acs.biochem.8b00056. Epub 2018 Apr 23.


Sequence Directionality Dramatically Affects LCST Behavior of Elastin-Like Polypeptides.

Li NK, Roberts S, Quiroz FG, Chilkoti A, Yingling YG.

Biomacromolecules. 2018 Jul 9;19(7):2496-2505. doi: 10.1021/acs.biomac.8b00099. Epub 2018 Apr 30.


Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature-triggered hierarchical self-assembly.

Mozhdehi D, Luginbuhl KM, Simon JR, Dzuricky M, Berger R, Varol HS, Huang FC, Buehne KL, Mayne NR, Weitzhandler I, Bonn M, Parekh SH, Chilkoti A.

Nat Chem. 2018 May;10(5):496-505. doi: 10.1038/s41557-018-0005-z. Epub 2018 Mar 19.


Fusion of fibroblast growth factor 21 to a thermally responsive biopolymer forms an injectable depot with sustained anti-diabetic action.

Gilroy CA, Roberts S, Chilkoti A.

J Control Release. 2018 May 10;277:154-164. doi: 10.1016/j.jconrel.2018.03.015. Epub 2018 Mar 15.


Photo-Crosslinkable Unnatural Amino Acids Enable Facile Synthesis of Thermoresponsive Nano- to Microgels of Intrinsically Disordered Polypeptides.

Costa SA, Simon JR, Amiram M, Tang L, Zauscher S, Brustad EM, Isaacs FJ, Chilkoti A.

Adv Mater. 2018 Feb;30(5). doi: 10.1002/adma.201704878. Epub 2017 Dec 11.


Functional Modification of Silica through Enhanced Adsorption of Elastin-Like Polypeptide Block Copolymers.

Li L, Li NK, Tu Q, Im O, Mo CK, Han W, Fuss WH, Carroll NJ, Chilkoti A, Yingling YG, Zauscher S, López GP.

Biomacromolecules. 2018 Feb 12;19(2):298-306. doi: 10.1021/acs.biomac.7b01307. Epub 2017 Dec 12.


Nanoparticle formulation improves doxorubicin efficacy by enhancing host antitumor immunity.

Mastria EM, Cai LY, Kan MJ, Li X, Schaal JL, Fiering S, Gunn MD, Dewhirst MW, Nair SK, Chilkoti A.

J Control Release. 2018 Jan 10;269:364-373. doi: 10.1016/j.jconrel.2017.11.021. Epub 2017 Nov 13.


One-week glucose control via zero-order release kinetics from an injectable depot of glucagon-like peptide-1 fused to a thermosensitive biopolymer.

Luginbuhl KM, Schaal JL, Umstead B, Mastria EM, Li X, Banskota S, Arnold S, Feinglos M, D'Alessio D, Chilkoti A.

Nat Biomed Eng. 2017;1. pii: 0078. doi: 10.1038/s41551-017-0078. Epub 2017 Jun 5.


Recombinant Synthesis of Hybrid Lipid-Peptide Polymer Fusions that Self-Assemble and Encapsulate Hydrophobic Drugs.

Luginbuhl KM, Mozhdehi D, Dzuricky M, Yousefpour P, Huang FC, Mayne NR, Buehne KL, Chilkoti A.

Angew Chem Int Ed Engl. 2017 Nov 6;56(45):13979-13984. doi: 10.1002/anie.201704625. Epub 2017 Oct 9.


The Weak Link: Optimization of the Ligand-Nanoparticle Interface To Enhance Cancer Cell Targeting by Polymer Micelles.

Wang J, Dzuricky M, Chilkoti A.

Nano Lett. 2017 Oct 11;17(10):5995-6005. doi: 10.1021/acs.nanolett.7b02225. Epub 2017 Sep 5.


Niclosamide-conjugated polypeptide nanoparticles inhibit Wnt signaling and colon cancer growth.

Bhattacharyya J, Ren XR, Mook RA, Wang J, Spasojevic I, Premont RT, Li X, Chilkoti A, Chen W.

Nanoscale. 2017 Aug 31;9(34):12709-12717. doi: 10.1039/c7nr01973d.


Inkjet-printed point-of-care immunoassay on a nanoscale polymer brush enables subpicomolar detection of analytes in blood.

Joh DY, Hucknall AM, Wei Q, Mason KA, Lund ML, Fontes CM, Hill RT, Blair R, Zimmers Z, Achar RK, Tseng D, Gordan R, Freemark M, Ozcan A, Chilkoti A.

Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):E7054-E7062. doi: 10.1073/pnas.1703200114. Epub 2017 Aug 7. Erratum in: Proc Natl Acad Sci U S A. 2017 Sep 18;:.


A quantitative study of the intracellular fate of pH-responsive doxorubicin-polypeptide nanoparticles.

Wang J, Bhattacharyya J, Mastria E, Chilkoti A.

J Control Release. 2017 Aug 28;260:100-110. doi: 10.1016/j.jconrel.2017.05.032. Epub 2017 May 30.


Micellar Self-Assembly of Recombinant Resilin-/Elastin-Like Block Copolypeptides.

Weitzhandler I, Dzuricky M, Hoffmann I, Garcia Quiroz F, Gradzielski M, Chilkoti A.

Biomacromolecules. 2017 Aug 14;18(8):2419-2426. doi: 10.1021/acs.biomac.7b00589. Epub 2017 Jul 14.


Programming molecular self-assembly of intrinsically disordered proteins containing sequences of low complexity.

Simon JR, Carroll NJ, Rubinstein M, Chilkoti A, López GP.

Nat Chem. 2017 Jun;9(6):509-515. doi: 10.1038/nchem.2715. Epub 2017 Jan 30.


High-Molecular-Weight Polynucleotides by Transferase-Catalyzed Living Chain-Growth Polycondensation.

Tang L, Navarro LA Jr, Chilkoti A, Zauscher S.

Angew Chem Int Ed Engl. 2017 Jun 6;56(24):6778-6782. doi: 10.1002/anie.201700991. Epub 2017 May 15.


Self-assembled hybrid elastin-like polypeptide/silica nanoparticles enable triggered drug release.

Han W, Chilkoti A, López GP.

Nanoscale. 2017 May 11;9(18):6178-6186. doi: 10.1039/c7nr00172j.


Encapsulating a Hydrophilic Chemotherapeutic into Rod-like Nanoparticles of a Genetically Encoded Asymmetric Triblock Polypeptide Improves its Efficacy.

Bhattacharyya J, Weitzhandler I, Ho SB, McDaniel JR, Li X, Tang L, Liu J, Dewhirst M, Chilkoti A.

Adv Funct Mater. 2017 Mar 24;27(12). pii: 1605421. doi: 10.1002/adfm.201605421. Epub 2017 Feb 7.


Cargo self-assembly rescues affinity of cell-penetrating peptides to lipid membranes.

Weinberger A, Walter V, MacEwan SR, Schmatko T, Muller P, Schroder AP, Chilkoti A, Marques CM.

Sci Rep. 2017 Mar 6;7:43963. doi: 10.1038/srep43963.


Characterisation of hydration and nanophase separation during the temperature response in hydrophobic/hydrophilic elastin-like polypeptide (ELP) diblock copolymers.

Widder K, MacEwan SR, Garanger E, Núñez V, Lecommandoux S, Chilkoti A, Hinderberger D.

Soft Matter. 2017 Mar 1;13(9):1816-1822. doi: 10.1039/c6sm02427k.


Poly(oligo(ethylene glycol) methyl ether methacrylate) Brushes on High-κ Metal Oxide Dielectric Surfaces for Bioelectrical Environments.

Joh DY, McGuire F, Abedini-Nassab R, Andrews JB, Achar RK, Zimmers Z, Mozhdehi D, Blair R, Albarghouthi F, Oles W, Richter J, Fontes CM, Hucknall AM, Yellen BB, Franklin AD, Chilkoti A.

ACS Appl Mater Interfaces. 2017 Feb 15;9(6):5522-5529. doi: 10.1021/acsami.6b15836. Epub 2017 Feb 2.


Phase Behavior and Self-Assembly of Perfectly Sequence-Defined and Monodisperse Multiblock Copolypeptides.

MacEwan SR, Weitzhandler I, Hoffmann I, Genzer J, Gradzielski M, Chilkoti A.

Biomacromolecules. 2017 Feb 13;18(2):599-609. doi: 10.1021/acs.biomac.6b01759. Epub 2017 Jan 31.


Strong, Tough, Stretchable, and Self-Adhesive Hydrogels from Intrinsically Unstructured Proteins.

Gonzalez MA, Simon JR, Ghoorchian A, Scholl Z, Lin S, Rubinstein M, Marszalek P, Chilkoti A, López GP, Zhao X.

Adv Mater. 2017 Mar;29(10). doi: 10.1002/adma.201604743. Epub 2017 Jan 6.


Quantitative Mapping of the Spatial Distribution of Nanoparticles in Endo-Lysosomes by Local pH.

Wang J, MacEwan SR, Chilkoti A.

Nano Lett. 2017 Feb 8;17(2):1226-1232. doi: 10.1021/acs.nanolett.6b05041. Epub 2017 Jan 3.


From Composition to Cure: A Systems Engineering Approach to Anticancer Drug Carriers.

MacEwan SR, Chilkoti A.

Angew Chem Int Ed Engl. 2017 Jun 6;56(24):6712-6733. doi: 10.1002/anie.201610819. Epub 2017 May 2. Review.


Site-Specific and Stoichiometric Stealth Polymer Conjugates of Therapeutic Peptides and Proteins.

Ozer I, Chilkoti A.

Bioconjug Chem. 2017 Mar 15;28(3):713-723. doi: 10.1021/acs.bioconjchem.6b00652. Epub 2017 Jan 6. Review.


Cell-Based Biohybrid Drug Delivery Systems: The Best of the Synthetic and Natural Worlds.

Banskota S, Yousefpour P, Chilkoti A.

Macromol Biosci. 2017 Jan;17(1). doi: 10.1002/mabi.201600361. Epub 2016 Dec 7. Review.


Magnetophoretic transistors in a tri-axial magnetic field.

Abedini-Nassab R, Joh DY, Albarghouthi F, Chilkoti A, Murdoch DM, Yellen BB.

Lab Chip. 2016 Oct 18;16(21):4181-4188.

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