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Items: 1 to 50 of 142

1.

High and low doses of cocaine intake are differentially regulated by dopamine D2 receptors in the ventral tegmental area and the nucleus accumbens.

Chen R, McIntosh S, Hemby SE, Sun H, Sexton T, Martin TJ, Childers SR.

Neurosci Lett. 2018 Apr 3;671:133-139. doi: 10.1016/j.neulet.2018.02.026. Epub 2018 Feb 14.

2.

Regional differences in mu and kappa opioid receptor G-protein activation in brain in male and female prairie voles.

Martin TJ, Sexton T, Kim SA, Severino AL, Peters CM, Young LJ, Childers SR.

Neuroscience. 2015 Dec 17;311:422-9. doi: 10.1016/j.neuroscience.2015.10.047. Epub 2015 Oct 30.

3.

Increased Sensitivity to Cocaine Self-Administration in HIV-1 Transgenic Rats is Associated with Changes in Striatal Dopamine Transporter Binding.

McIntosh S, Sexton T, Pattison LP, Childers SR, Hemby SE.

J Neuroimmune Pharmacol. 2015 Sep;10(3):493-505. doi: 10.1007/s11481-015-9594-0. Epub 2015 Mar 10.

4.

Chronic baclofen desensitizes GABA(B)-mediated G-protein activation and stimulates phosphorylation of kinases in mesocorticolimbic rat brain.

Keegan BM, Beveridge TJ, Pezor JJ, Xiao R, Sexton T, Childers SR, Howlett AC.

Neuropharmacology. 2015 Aug;95:492-502. doi: 10.1016/j.neuropharm.2015.02.021. Epub 2015 Feb 25.

5.

Changes in dopamine transporter binding in nucleus accumbens following chronic self-administration cocaine: heroin combinations.

Pattison LP, McIntosh S, Sexton T, Childers SR, Hemby SE.

Synapse. 2014 Oct;68(10):437-44. doi: 10.1002/syn.21755. Epub 2014 Jun 19.

6.

Effect of Iboga alkaloids on µ-opioid receptor-coupled G protein activation.

Antonio T, Childers SR, Rothman RB, Dersch CM, King C, Kuehne M, Bornmann WG, Eshleman AJ, Janowsky A, Simon ER, Reith ME, Alper K.

PLoS One. 2013 Oct 16;8(10):e77262. doi: 10.1371/journal.pone.0077262. eCollection 2013.

7.

Striatal CB1 and D2 receptors regulate expression of each other, CRIP1A and δ opioid systems.

Blume LC, Bass CE, Childers SR, Dalton GD, Roberts DC, Richardson JM, Xiao R, Selley DE, Howlett AC.

J Neurochem. 2013 Mar;124(6):808-20. doi: 10.1111/jnc.12139. Epub 2013 Jan 31.

8.

Muscarinic receptor/G-protein coupling is reduced in the dorsomedial striatum of cognitively impaired aged rats.

Nieves-Martinez E, Haynes K, Childers SR, Sonntag WE, Nicolle MM.

Behav Brain Res. 2012 Feb 1;227(1):258-64. doi: 10.1016/j.bbr.2011.10.048. Epub 2011 Nov 7.

9.

Endocannabinoid tone versus constitutive activity of cannabinoid receptors.

Howlett AC, Reggio PH, Childers SR, Hampson RE, Ulloa NM, Deutsch DG.

Br J Pharmacol. 2011 Aug;163(7):1329-43. doi: 10.1111/j.1476-5381.2011.01364.x. Review.

10.

Involvement of the lateral amygdala in the antiallodynic and reinforcing effects of heroin in rats after peripheral nerve injury.

Martin TJ, Buechler NL, Kim SA, Ewan EE, Xiao R, Childers SR.

Anesthesiology. 2011 Mar;114(3):633-42. doi: 10.1097/ALN.0b013e318209aba7.

11.

1-Naphthyl and 4-indolyl arylalkylamines as selective monoamine reuptake inhibitors.

Manning JR, Sexton T, Childers SR, Davies HM.

Bioorg Med Chem Lett. 2009 Jan 1;19(1):58-61. doi: 10.1016/j.bmcl.2008.11.022. Epub 2008 Nov 13.

PMID:
19038547
12.

Dopamine uptake changes associated with cocaine self-administration.

Oleson EB, Talluri S, Childers SR, Smith JE, Roberts DC, Bonin KD, Budygin EA.

Neuropsychopharmacology. 2009 Apr;34(5):1174-84. doi: 10.1038/npp.2008.186. Epub 2008 Oct 15.

13.

In vivo characterization of a novel phenylisothiocyanate tropane analog at monoamine transporters in rat brain.

Murthy V, Martin TJ, Kim S, Davies HM, Childers SR.

J Pharmacol Exp Ther. 2008 Aug;326(2):587-95. doi: 10.1124/jpet.108.138842. Epub 2008 May 20.

PMID:
18492949
14.

Irreversible binding of a novel phenylisothiocyanate tropane analog to monoamine transporters in rat brain.

Murthy V, Davies HM, Hedley SJ, Childers SR.

Biochem Pharmacol. 2007 Jul 15;74(2):336-44. Epub 2007 Apr 27.

15.

Oral donepezil reduces hypersensitivity after nerve injury by a spinal muscarinic receptor mechanism.

Clayton BA, Hayashida K, Childers SR, Xiao R, Eisenach JC.

Anesthesiology. 2007 May;106(5):1019-25.

PMID:
17457135
16.
17.

Chronic activation of spinal adenosine A1 receptors results in hypersensitivity.

Martin TJ, Eisenach JC, Misler J, Childers SR.

Neuroreport. 2006 Oct 23;17(15):1619-22.

PMID:
17001280
18.
19.

The synthesis and biological evaluation of dopamine transporter inhibiting activity of substituted diphenylmethoxypiperidines.

Lapa GB, Byrd GD, Lapa AA, Budygin EA, Childers SR, Jones SR, Harp JJ.

Bioorg Med Chem Lett. 2005 Nov 15;15(22):4915-8.

PMID:
16165350
20.

Mechanisms of mu opioid receptor/G-protein desensitization in brain by chronic heroin administration.

Maher CE, Martin TJ, Childers SR.

Life Sci. 2005 Jul 22;77(10):1140-54.

PMID:
15890372
21.

Allosteric modulation of adenosine A1 receptor coupling to G-proteins in brain.

Childers SR, Li X, Xiao R, Eisenach JC.

J Neurochem. 2005 May;93(3):715-23.

22.

Spinal nerve ligation increases alpha2-adrenergic receptor G-protein coupling in the spinal cord.

Bantel C, Eisenach JC, Duflo F, Tobin JR, Childers SR.

Brain Res. 2005 Mar 15;1038(1):76-82.

PMID:
15748875
23.

Time-dependent changes in receptor/G-protein coupling in rat brain following chronic monoamine transporter blockade.

O'Connor KA, Porrino LJ, Davies HM, Childers SR.

J Pharmacol Exp Ther. 2005 May;313(2):510-7. Epub 2005 Jan 11.

24.

Effects of long-term biogenic amine transporter blockade on receptor/G-protein coupling in rat brain.

O'Connor KA, Gregg TC, Davies HM, Childers SR.

Neuropharmacology. 2005 Jan;48(1):62-71.

PMID:
15617728
25.

Cannabinoid physiology and pharmacology: 30 years of progress.

Howlett AC, Breivogel CS, Childers SR, Deadwyler SA, Hampson RE, Porrino LJ.

Neuropharmacology. 2004;47 Suppl 1:345-58. Review.

PMID:
15464149
26.

Cannabinoid signaling in rat cerebellar granule cells: G-protein activation, inhibition of glutamate release and endogenous cannabinoids.

Breivogel CS, Walker JM, Huang SM, Roy MB, Childers SR.

Neuropharmacology. 2004 Jul;47(1):81-91.

PMID:
15165836
27.

Repeated dosing with oral allosteric modulator of adenosine A1 receptor produces tolerance in rats with neuropathic pain.

Li X, Bantel C, Conklin D, Childers SR, Eisenach JC.

Anesthesiology. 2004 Apr;100(4):956-61.

PMID:
15087633
28.

Synthesis of methylphenidate analogues and their binding affinities at dopamine and serotonin transport sites.

Davies HM, Hopper DW, Hansen T, Liu Q, Childers SR.

Bioorg Med Chem Lett. 2004 Apr 5;14(7):1799-802.

PMID:
15026075
29.
30.

Cellular localization of cannabinoid receptors and activated G-proteins in rat anterior cingulate cortex.

Sim-Selley LJ, Vogt LJ, Vogt BA, Childers SR.

Life Sci. 2002 Sep 27;71(19):2217-26.

PMID:
12215369
31.

Role of adenosine receptors in spinal G-protein activation after peripheral nerve injury.

Bantel C, Childers SR, Eisenach JC.

Anesthesiology. 2002 Jun;96(6):1443-9.

PMID:
12170058
32.

Synthesis of iodinated 3beta-aryltropanes with selective binding to either the dopamine or serotonin transporters.

Davies HM, Ren P, Kong NX, Sexton T, Childers SR.

Bioorg Med Chem Lett. 2002 Mar 25;12(6):845-7.

PMID:
11958976
33.

Neuroanatomical localization of receptor-activated G proteins in brain.

Sim-Selley LJ, Childers SR.

Methods Enzymol. 2002;344:42-58. No abstract available.

PMID:
11771400
34.

Intrathecal adenosine following spinal nerve ligation in rat: short residence time in cerebrospinal fluid and no change in A(1) receptor binding.

Bantel C, Tobin JR, Li X, Childers SR, Chen SR, Eisenach JC.

Anesthesiology. 2002 Jan;96(1):103-8.

PMID:
11753009
35.

Colocalization of mu-opioid receptors and activated G-proteins in rat cingulate cortex.

Vogt LJ, Sim-Selley LJ, Childers SR, Wiley RG, Vogt BA.

J Pharmacol Exp Ther. 2001 Dec;299(3):840-8.

PMID:
11714867
36.

mu Opioid receptor-mediated G-protein activation by heroin metabolites: evidence for greater efficacy of 6-monoacetylmorphine compared with morphine.

Selley DE, Cao CC, Sexton T, Schwegel JA, Martin TJ, Childers SR.

Biochem Pharmacol. 2001 Aug 15;62(4):447-55.

PMID:
11448454
37.

Synthesis of 2beta-acyl-3beta-(substituted naphthyl)-8-azabicyclo[3.2.1]octanes and their binding affinities at dopamine and serotonin transport sites.

Davies HM, Gilliatt V, Kuhn LA, Saikali E, Ren P, Hammond PS, Sexton T, Childers SR.

J Med Chem. 2001 May 10;44(10):1509-15.

PMID:
11334561
38.

Functional and anatomical localization of mu opioid receptors in the striatum, amygdala, and extended amygdala of the nonhuman primate.

Daunais JB, Letchworth SR, Sim-Selley LJ, Smith HR, Childers SR, Porrino LJ.

J Comp Neurol. 2001 May 14;433(4):471-85.

PMID:
11304712
39.

Chronic intrathecal morphine administration produces homologous mu receptor/G-protein desensitization specifically in spinal cord.

Maher CE, Eisenach JC, Pan HL, Xiao R, Childers SR.

Brain Res. 2001 Mar 23;895(1-2):1-8.

PMID:
11259753
40.

Synthesis and monoamine transporter affinity of 3beta-(4-(2-pyrrolyl)phenyl)-8-azabicycl.

Davies HM, Ren P, Kong N, Sexton T, Childers SR.

Bioorg Med Chem Lett. 2001 Feb 26;11(4):487-9.

PMID:
11229754
41.

Relationship of mu opioid receptor binding to activation of G-proteins in specific rat brain regions.

Maher CE, Selley DE, Childers SR.

Biochem Pharmacol. 2000 Jun 1;59(11):1395-401.

PMID:
10751548
43.
44.

Fluorine-18-labeled tropane analogs for PET imaging studies of the dopamine transporter.

Mach RH, Nader MA, Ehrenkaufer RL, Gage HD, Childers SR, Hodges LM, Hodges MM, Davies HM.

Synapse. 2000 Aug;37(2):109-17.

PMID:
10881032
45.

Chronic heroin self-administration desensitizes mu opioid receptor-activated G-proteins in specific regions of rat brain.

Sim-Selley LJ, Selley DE, Vogt LJ, Childers SR, Martin TJ.

J Neurosci. 2000 Jun 15;20(12):4555-62.

46.
47.

Characterization of a tropane radioligand, [(3)H]2beta-propanoyl-3beta-(4-tolyl) tropane ([(3)H]PTT), for dopamine transport sites in rat brain.

Letchworth SR, Smith HR, Porrino LJ, Bennett BA, Davies HM, Sexton T, Childers SR.

J Pharmacol Exp Ther. 2000 May;293(2):686-96.

PMID:
10773045
48.

Sigma-2 receptors as a biomarker of proliferation in solid tumours.

Wheeler KT, Wang LM, Wallen CA, Childers SR, Cline JM, Keng PC, Mach RH.

Br J Cancer. 2000 Mar;82(6):1223-32.

49.

Region-specific changes in 5-HT(1A) receptor-activated G-proteins in rat brain following chronic buspirone.

Sim-Selley LJ, Vogt LJ, Xiao R, Childers SR, Selley DE.

Eur J Pharmacol. 2000 Feb 18;389(2-3):147-53.

PMID:
10688978
50.

Agonist-stimulated [35S]GTPgammaS binding in brain modulation by endogenous adenosine.

Moore RJ, Xiao R, Sim-Selley LJ, Childers SR.

Neuropharmacology. 2000 Jan 4;39(2):282-9.

PMID:
10670423

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