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Extraterrestrial ribose and other sugars in primitive meteorites.

Furukawa Y, Chikaraishi Y, Ohkouchi N, Ogawa NO, Glavin DP, Dworkin JP, Abe C, Nakamura T.

Proc Natl Acad Sci U S A. 2019 Dec 3;116(49):24440-24445. doi: 10.1073/pnas.1907169116. Epub 2019 Nov 18.


Omnivory in Bees: Elevated Trophic Positions among All Major Bee Families.

Steffan SA, Dharampal PS, Danforth BN, Gaines-Day HR, Takizawa Y, Chikaraishi Y.

Am Nat. 2019 Sep;194(3):414-421. doi: 10.1086/704281. Epub 2019 Jul 25.


Amino acid 15 N analysis reveals change in the importance of freshwater resources between the hunter-gatherer and farmer in the Neolithic upper Tigris.

Itahashi Y, Erdal YS, Tekin H, Omar L, Miyake Y, Chikaraishi Y, Ohkouchi N, Yoneda M.

Am J Phys Anthropol. 2019 Apr;168(4):676-686. doi: 10.1002/ajpa.23783. Epub 2019 Jan 28.


Trophic declines and decadal-scale foraging segregation in three pelagic seabirds.

Morra KE, Chikaraishi Y, Gandhi H, James HF, Rossman S, Wiley AE, Raine AF, Beck J, Ostrom PH.

Oecologia. 2019 Feb;189(2):395-406. doi: 10.1007/s00442-018-04330-8. Epub 2019 Jan 8.


Trophic structure and energy flow in a shallow-water hydrothermal vent: Insights from a stable isotope approach.

Chang NN, Lin LH, Tu TH, Jeng MS, Chikaraishi Y, Wang PL.

PLoS One. 2018 Oct 17;13(10):e0204753. doi: 10.1371/journal.pone.0204753. eCollection 2018.


Compound-specific isotope analysis of benthic foraminifer amino acids suggests microhabitat variability in rocky-shore environments.

Tsuchiya M, Chikaraishi Y, Nomaki H, Sasaki Y, Tame A, Uematsu K, Ohkouchi N.

Ecol Evol. 2018 Jul 24;8(16):8380-8395. doi: 10.1002/ece3.4358. eCollection 2018 Aug.


Insight into anaerobic methanotrophy from 13C/12C- amino acids and 14C/12C-ANME cells in seafloor microbial ecology.

Takano Y, Chikaraishi Y, Imachi H, Miyairi Y, Ogawa NO, Kaneko M, Yokoyama Y, Krüger M, Ohkouchi N.

Sci Rep. 2018 Sep 24;8(1):14070. doi: 10.1038/s41598-018-31004-5.


A primordial and reversible TCA cycle in a facultatively chemolithoautotrophic thermophile.

Nunoura T, Chikaraishi Y, Izaki R, Suwa T, Sato T, Harada T, Mori K, Kato Y, Miyazaki M, Shimamura S, Yanagawa K, Shuto A, Ohkouchi N, Fujita N, Takaki Y, Atomi H, Takai K.

Science. 2018 Feb 2;359(6375):559-563. doi: 10.1126/science.aao3407. Epub 2018 Feb 1.


Trophic position and dietary breadth of bats revealed by nitrogen isotopic composition of amino acids.

Campbell CJ, Nelson DM, Ogawa NO, Chikaraishi Y, Ohkouchi N.

Sci Rep. 2017 Nov 21;7(1):15932. doi: 10.1038/s41598-017-15440-3.


Reply to "Comment on "Ecological niche of Neanderthals from Spy Cave revealed by nitrogen isotopes of individual amino acids in collagen." [J. Hum. Evol. 93 (2016) 82-90]" [J. Hum. Evol. 117 (2018) 53-55].

Naito YI, Chikaraishi Y, Drucker DG, Ohkouchi N, Semal P, Wißing C, Bocherens H.

J Hum Evol. 2018 Apr;117:56-60. doi: 10.1016/j.jhevol.2017.09.008. Epub 2017 Oct 10. No abstract available.


Isotopic analyses suggest mammoth and plant in the diet of the oldest anatomically modern humans from far southeast Europe.

Drucker DG, Naito YI, Péan S, Prat S, Crépin L, Chikaraishi Y, Ohkouchi N, Puaud S, Lázničková-Galetová M, Patou-Mathis M, Yanevich A, Bocherens H.

Sci Rep. 2017 Jul 28;7(1):6833. doi: 10.1038/s41598-017-07065-3.


Integrated trophic position decreases in more diverse communities of stream food webs.

Ishikawa NF, Chikaraishi Y, Ohkouchi N, Murakami AR, Tayasu I, Togashi H, Okano JI, Sakai Y, Iwata T, Kondoh M, Okuda N.

Sci Rep. 2017 May 18;7(1):2130. doi: 10.1038/s41598-017-02155-8.


Unpacking brown food-webs: Animal trophic identity reflects rampant microbivory.

Steffan SA, Chikaraishi Y, Dharampal PS, Pauli JN, Guédot C, Ohkouchi N.

Ecol Evol. 2017 Apr 9;7(10):3532-3541. doi: 10.1002/ece3.2951. eCollection 2017 May.


Microbial Eukaryotes that Lack Sterols.

Takishita K, Chikaraishi Y, Tanifuji G, Ohkouchi N, Hashimoto T, Fujikura K, Roger AJ.

J Eukaryot Microbiol. 2017 Nov;64(6):897-900. doi: 10.1111/jeu.12426. Epub 2017 Jun 7.


Intra-trophic isotopic discrimination of 15N/14N for amino acids in autotrophs: Implications for nitrogen dynamics in ecological studies.

Takizawa Y, Dharampal PS, Steffan SA, Takano Y, Ohkouchi N, Chikaraishi Y.

Ecol Evol. 2017 Mar 22;7(9):2916-2924. doi: 10.1002/ece3.2866. eCollection 2017 May.


Genomic Evidence that Methanotrophic Endosymbionts Likely Provide Deep-Sea Bathymodiolus Mussels with a Sterol Intermediate in Cholesterol Biosynthesis.

Takishita K, Takaki Y, Chikaraishi Y, Ikuta T, Ozawa G, Yoshida T, Ohkouchi N, Fujikura K.

Genome Biol Evol. 2017 May 1;9(5):1148-1160. doi: 10.1093/gbe/evx082.


Broad-scale trophic shift in the pelagic North Pacific revealed by an oceanic seabird.

Ostrom PH, Wiley AE, James HF, Rossman S, Walker WA, Zipkin EF, Chikaraishi Y.

Proc Biol Sci. 2017 Mar 29;284(1851). pii: 20162436. doi: 10.1098/rspb.2016.2436.


Trophic discrimination factor of nitrogen isotopes within amino acids in the dobsonfly Protohermes grandis (Megaloptera: Corydalidae) larvae in a controlled feeding experiment.

Ishikawa NF, Hayashi F, Sasaki Y, Chikaraishi Y, Ohkouchi N.

Ecol Evol. 2017 Mar 12;7(6):1674-1679. doi: 10.1002/ece3.2728. eCollection 2017 Mar.


Ecological niche of Neanderthals from Spy Cave revealed by nitrogen isotopes of individual amino acids in collagen.

Naito YI, Chikaraishi Y, Drucker DG, Ohkouchi N, Semal P, Wißing C, Bocherens H.

J Hum Evol. 2016 Apr;93:82-90. doi: 10.1016/j.jhevol.2016.01.009. Epub 2016 Mar 12.


Organic Reference Materials for Hydrogen, Carbon, and Nitrogen Stable Isotope-Ratio Measurements: Caffeines, n-Alkanes, Fatty Acid Methyl Esters, Glycines, L-Valines, Polyethylenes, and Oils.

Schimmelmann A, Qi H, Coplen TB, Brand WA, Fong J, Meier-Augenstein W, Kemp HF, Toman B, Ackermann A, Assonov S, Aerts-Bijma AT, Brejcha R, Chikaraishi Y, Darwish T, Elsner M, Gehre M, Geilmann H, Gröning M, Hélie JF, Herrero-Martín S, Meijer HA, Sauer PE, Sessions AL, Werner RA.

Anal Chem. 2016 Apr 19;88(8):4294-302. doi: 10.1021/acs.analchem.5b04392. Epub 2016 Mar 31.


Microbes are trophic analogs of animals.

Steffan SA, Chikaraishi Y, Currie CR, Horn H, Gaines-Day HR, Pauli JN, Zalapa JE, Ohkouchi N.

Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15119-24. doi: 10.1073/pnas.1508782112. Epub 2015 Nov 23.


Diet quality influences isotopic discrimination among amino acids in an aquatic vertebrate.

Chikaraishi Y, Steffan SA, Takano Y, Ohkouchi N.

Ecol Evol. 2015 May;5(10):2048-59. doi: 10.1002/ece3.1491. Epub 2015 Apr 25.


High-resolution food webs based on nitrogen isotopic composition of amino acids.

Chikaraishi Y, Steffan SA, Ogawa NO, Ishikawa NF, Sasaki Y, Tsuchiya M, Ohkouchi N.

Ecol Evol. 2014 Jun;4(12):2423-49. doi: 10.1002/ece3.1103. Epub 2014 May 17.


Quantitative analysis of coenzyme F430 in environmental samples: a new diagnostic tool for methanogenesis and anaerobic methane oxidation.

Kaneko M, Takano Y, Chikaraishi Y, Ogawa NO, Asakawa S, Watanabe T, Shima S, Krüger M, Matsushita M, Kimura H, Ohkouchi N.

Anal Chem. 2014 Apr 1;86(7):3633-8. doi: 10.1021/ac500305j. Epub 2014 Mar 21.


Trophic hierarchies illuminated via amino acid isotopic analysis.

Steffan SA, Chikaraishi Y, Horton DR, Ohkouchi N, Singleton ME, Miliczky E, Hogg DB, Jones VP.

PLoS One. 2013 Sep 25;8(9):e76152. doi: 10.1371/journal.pone.0076152. eCollection 2013.


A low trophic position of Japanese eel larvae indicates feeding on marine snow.

Miller MJ, Chikaraishi Y, Ogawa NO, Yamada Y, Tsukamoto K, Ohkouchi N.

Biol Lett. 2013 Feb 23;9(1):20120826. doi: 10.1098/rsbl.2012.0826. Epub 2012 Nov 7.


Algivore or phototroph? Plakobranchus ocellatus (Gastropoda) continuously acquires kleptoplasts and nutrition from multiple algal species in nature.

Maeda T, Hirose E, Chikaraishi Y, Kawato M, Takishita K, Yoshida T, Verbruggen H, Tanaka J, Shimamura S, Takaki Y, Tsuchiya M, Iwai K, Maruyama T.

PLoS One. 2012;7(7):e42024. doi: 10.1371/journal.pone.0042024. Epub 2012 Jul 25.


Lateral transfer of tetrahymanol-synthesizing genes has allowed multiple diverse eukaryote lineages to independently adapt to environments without oxygen.

Takishita K, Chikaraishi Y, Leger MM, Kim E, Yabuki A, Ohkouchi N, Roger AJ.

Biol Direct. 2012 Feb 1;7:5. doi: 10.1186/1745-6150-7-5.


Mammalian DNA δ15N exhibits 40‰ intramolecular variation and is unresponsive to dietary protein level.

Strable MS, Tschanz CL, Varamini B, Chikaraishi Y, Ohkouchi N, Brenna JT.

Rapid Commun Mass Spectrom. 2011 Dec 15;25(23):3555-62. doi: 10.1002/rcm.5263.


Temperature effect on leaf water deuterium enrichment and isotopic fractionation during leaf lipid biosynthesis: results from controlled growth of C3 and C4 land plants.

Zhou Y, Grice K, Chikaraishi Y, Stuart-Williams H, Farquhar GD, Ohkouchi N.

Phytochemistry. 2011 Feb;72(2-3):207-13. doi: 10.1016/j.phytochem.2010.10.022. Epub 2010 Dec 15.


Isolation and desalting with cation-exchange chromatography for compound-specific nitrogen isotope analysis of amino acids: application to biogeochemical samples.

Takano Y, Kashiyama Y, Ogawa NO, Chikaraishi Y, Ohkouchi N.

Rapid Commun Mass Spectrom. 2010 Aug 30;24(16):2317-23. doi: 10.1002/rcm.4651.


Extracellular SOD and VEGF are increased in vitreous bodies from proliferative diabetic retinopathy patients.

Izuta H, Chikaraishi Y, Adachi T, Shimazawa M, Sugiyama T, Ikeda T, Hara H.

Mol Vis. 2009 Dec 10;15:2663-72.


Angiostatic effects of Brazilian green propolis and its chemical constituents.

Chikaraishi Y, Izuta H, Shimazawa M, Mishima S, Hara H.

Mol Nutr Food Res. 2010 Apr;54(4):566-75. doi: 10.1002/mnfr.200900115.


Ruboxistaurin, a PKCbeta inhibitor, inhibits retinal neovascularization via suppression of phosphorylation of ERK1/2 and Akt.

Nakamura S, Chikaraishi Y, Tsuruma K, Shimazawa M, Hara H.

Exp Eye Res. 2010 Jan;90(1):137-45. doi: 10.1016/j.exer.2009.09.022. Epub 2009 Oct 13.


Compound-specific nitrogen isotope analysis of D-alanine, L-alanine, and valine: application of diastereomer separation to delta15N and microbial peptidoglycan studies.

Takano Y, Chikaraishi Y, Ogawa NO, Kitazato H, Ohkouchi N.

Anal Chem. 2009 Jan 1;81(1):394-9. doi: 10.1021/ac802077v.


Vaccinium myrtillus (Bilberry) Extracts Reduce Angiogenesis In Vitro and In Vivo.

Matsunaga N, Chikaraishi Y, Shimazawa M, Yokota S, Hara H.

Evid Based Complement Alternat Med. 2010 Mar;7(1):47-56. doi: 10.1093/ecam/nem151. Epub 2007 Oct 27.


10-Hydroxy-2-decenoic acid, a major fatty acid from royal jelly, inhibits VEGF-induced angiogenesis in human umbilical vein endothelial cells.

Izuta H, Chikaraishi Y, Shimazawa M, Mishima S, Hara H.

Evid Based Complement Alternat Med. 2009 Dec;6(4):489-94. doi: 10.1093/ecam/nem152. Epub 2007 Oct 22.


Impact of non-homologous end-joining deficiency on random and targeted DNA integration: implications for gene targeting.

Iiizumi S, Kurosawa A, So S, Ishii Y, Chikaraishi Y, Ishii A, Koyama H, Adachi N.

Nucleic Acids Res. 2008 Nov;36(19):6333-42. doi: 10.1093/nar/gkn649. Epub 2008 Oct 3.


Role of soluble vascular endothelial growth factor receptor-1 in the vitreous in proliferative diabetic retinopathy.

Matsunaga N, Chikaraishi Y, Izuta H, Ogata N, Shimazawa M, Matsumura M, Hara H.

Ophthalmology. 2008 Nov;115(11):1916-22. doi: 10.1016/j.ophtha.2008.06.025. Epub 2008 Aug 21.


Evidence of global chlorophyll d.

Kashiyama Y, Miyashita H, Ohkubo S, Ogawa NO, Chikaraishi Y, Takano Y, Suga H, Toyofuku T, Nomaki H, Kitazato H, Nagata T, Ohkouchi N.

Science. 2008 Aug 1;321(5889):658. doi: 10.1126/science.1158761.


Geographical origin of polished rice based on multiple element and stable isotope analyses.

Suzuki Y, Chikaraishi Y, Ogawa NO, Ohkouchi N, Korenaga T.

Food Chem. 2008 Jul 15;109(2):470-5. doi: 10.1016/j.foodchem.2007.12.063. Epub 2008 Jan 9.


Stable carbon, nitrogen, and oxygen isotope analysis as a potential tool for verifying geographical origin of beef.

Nakashita R, Suzuki Y, Akamatsu F, Iizumi Y, Korenaga T, Chikaraishi Y.

Anal Chim Acta. 2008 Jun 9;617(1-2):148-52. doi: 10.1016/j.aca.2008.03.048. Epub 2008 Apr 3.


Rifampicin inhibits the retinal neovascularization in vitro and in vivo.

Chikaraishi Y, Matsunaga N, Shimazawa M, Hara H.

Exp Eye Res. 2008 Jan;86(1):131-7. Epub 2007 Oct 14.


[Evaluation system to search for inhibitory effect of retinal neovascularization in vitro and in vivo].

Chikaraishi Y, Shimazawa M, Hara H.

Nihon Yakurigaku Zasshi. 2007 Jun;129(6):451-6. Japanese. No abstract available.


New quantitative analysis, using high-resolution images, of oxygen-induced retinal neovascularization in mice.

Chikaraishi Y, Shimazawa M, Hara H.

Exp Eye Res. 2007 Mar;84(3):529-36. Epub 2007 Jan 17.


Novel method to identify illegal diesel fuel, I: use of adamantane or [1, 2-D2] n-tetradecane as chemical marker.

Suzuki Y, Ishioka S, Korenaga T, Chikaraishi Y.

Environ Sci. 2006;13(4):207-12.


Hydrogen, carbon and nitrogen isotopic fractionations during chlorophyll biosynthesis in C3 higher plants.

Chikaraishi Y, Matsumoto K, Ogawa NO, Suga H, Kitazato H, Ohkouchi N.

Phytochemistry. 2005 Apr;66(8):911-20.


Effect of humulus lupulus on gastric secretion in a rat pylorus-ligated model.

Kurasawa T, Chikaraishi Y, Naito A, Toyoda Y, Notsu Y.

Biol Pharm Bull. 2005 Feb;28(2):353-7.

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