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Items: 1 to 50 of 116

1.

Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus.

Yuan S, Chan JF, Ye ZW, Wen L, Tsang TG, Cao J, Huang J, Chan CC, Chik KK, Choi GK, Cai JP, Yin F, Chu H, Liang M, Jin DY, Yuen KY.

Viruses. 2019 Apr 25;11(4). pii: E385. doi: 10.3390/v11040385.

2.

Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus as a Host-Targeting Antiviral Strategy.

Zhu Z, Chu H, Wen L, Yuan S, Chik KK, Yuen TT, Yip CC, Wang D, Zhou J, Yin F, Jin DY, Kok KH, Yuen KY, Chan JF.

Int J Mol Sci. 2019 Jan 17;20(2). pii: E392. doi: 10.3390/ijms20020392.

3.

The celecoxib derivative kinase inhibitor AR-12 (OSU-03012) inhibits Zika virus via down-regulation of the PI3K/Akt pathway and protects Zika virus-infected A129 mice: A host-targeting treatment strategy.

Chan JF, Zhu Z, Chu H, Yuan S, Chik KK, Chan CC, Poon VK, Yip CC, Zhang X, Tsang JO, Zou Z, Tee KM, Shuai H, Lu G, Yuen KY.

Antiviral Res. 2018 Dec;160:38-47. doi: 10.1016/j.antiviral.2018.10.007. Epub 2018 Oct 13.

PMID:
30326204
4.
5.

Structure-based discovery of clinically approved drugs as Zika virus NS2B-NS3 protease inhibitors that potently inhibit Zika virus infection in vitro and in vivo.

Yuan S, Chan JF, den-Haan H, Chik KK, Zhang AJ, Chan CC, Poon VK, Yip CC, Mak WW, Zhu Z, Zou Z, Tee KM, Cai JP, Chan KH, de la Peña J, Pérez-Sánchez H, Cerón-Carrasco JP, Yuen KY.

Antiviral Res. 2017 Sep;145:33-43. doi: 10.1016/j.antiviral.2017.07.007. Epub 2017 Jul 14.

PMID:
28712942
6.

Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5'-untranslated region of Zika virus.

Chan JF, Yip CC, Tee KM, Zhu Z, Tsang JO, Chik KK, Tsang TG, Chan CC, Poon VK, Sridhar S, Yin F, Hung IF, Chau SK, Zhang AJ, Chan KH, Yuen KY.

Trop Med Int Health. 2017 May;22(5):594-603. doi: 10.1111/tmi.12857. Epub 2017 Mar 16.

7.

Novel antiviral activity and mechanism of bromocriptine as a Zika virus NS2B-NS3 protease inhibitor.

Chan JF, Chik KK, Yuan S, Yip CC, Zhu Z, Tee KM, Tsang JO, Chan CC, Poon VK, Lu G, Zhang AJ, Lai KK, Chan KH, Kao RY, Yuen KY.

Antiviral Res. 2017 May;141:29-37. doi: 10.1016/j.antiviral.2017.02.002. Epub 2017 Feb 7.

PMID:
28185815
8.

Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons.

Chan JF, Zhang AJ, Chan CC, Yip CC, Mak WW, Zhu H, Poon VK, Tee KM, Zhu Z, Cai JP, Tsang JO, Chik KK, Yin F, Chan KH, Kok KH, Jin DY, Au-Yeung RK, Yuen KY.

EBioMedicine. 2016 Dec;14:112-122. doi: 10.1016/j.ebiom.2016.11.017. Epub 2016 Nov 12.

9.

Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs.

Chan JF, Yip CC, Tsang JO, Tee KM, Cai JP, Chik KK, Zhu Z, Chan CC, Choi GK, Sridhar S, Zhang AJ, Lu G, Chiu K, Lo AC, Tsao SW, Kok KH, Jin DY, Chan KH, Yuen KY.

Emerg Microbes Infect. 2016 Aug 24;5:e93. doi: 10.1038/emi.2016.99.

10.

Hemagglutinin of influenza A virus binds specifically to cell surface nucleolin and plays a role in virus internalization.

Chan CM, Chu H, Zhang AJ, Leung LH, Sze KH, Kao RY, Chik KK, To KK, Chan JF, Chen H, Jin DY, Liu L, Yuen KY.

Virology. 2016 Jul;494:78-88. doi: 10.1016/j.virol.2016.04.008. Epub 2016 Apr 14.

11.

Feasibility of psychoeducational interventions in managing chemotherapy-associated nausea and vomiting (CANV) in pediatric oncology patients.

Chan CW, Lam LW, Li CK, Cheung JS, Cheng KK, Chik KW, Chan HY, So WK, Tang WP.

Eur J Oncol Nurs. 2015 Apr;19(2):182-90. doi: 10.1016/j.ejon.2014.09.002. Epub 2014 Oct 25.

PMID:
25445732
12.

Use of propranolol in infantile haemangioma among Chinese children.

Chik KK, Luk CK, Chan HB, Tan HY.

Hong Kong Med J. 2010 Oct;16(5):341-6.

13.

Foreign body aspiration in Hong Kong Chinese children.

Chik KK, Miu TY, Chan CW.

Hong Kong Med J. 2009 Feb;15(1):6-11.

14.

Psycho-educational intervention for chemotherapy-associated nausea and vomiting in paediatric oncology patients: a pilot study.

Chan CW, Cheng KK, Lam LW, Li CK, Chik KW, Cheung JS.

Hong Kong Med J. 2008 Oct;14(5 Suppl):32-5. No abstract available.

15.

Presence of donor-derived DNA and cells in the urine of sex-mismatched hematopoietic stem cell transplant recipients: implication for the transrenal hypothesis.

Hung EC, Shing TK, Chim SS, Yeung PC, Chan RW, Chik KW, Lee V, Tsui NB, Li CK, Wong CS, Chiu RW, Lo YM.

Clin Chem. 2009 Apr;55(4):715-22. doi: 10.1373/clinchem.2008.113530. Epub 2008 Oct 30.

16.

Humoral immune response after post-chemotherapy booster diphtheria-tetanus-pertussis vaccine in pediatric oncology patients.

Cheng FW, Leung TF, Chan PK, Lee V, Shing MK, Chik KW, Yuen PM, Li CK.

Pediatr Blood Cancer. 2009 Feb;52(2):248-53. doi: 10.1002/pbc.21792.

PMID:
18937325
17.

Hyperinsulinism and hyperammonaemia syndrome due to a novel missense mutation in the allosteric domain of the glutamate dehydrogenase 1 gene.

Chik KK, Chan CW, Lam CW, Ng KL.

J Paediatr Child Health. 2008 Sep;44(9):517-9. doi: 10.1111/j.1440-1754.2008.01361.x.

PMID:
18928469
18.

Minimal residual disease (MRD) analysis in the non-MRD-based ALL IC-BFM 2002 protocol for childhood ALL: is it possible to avoid MRD testing?

Fronkova E, Mejstrikova E, Avigad S, Chik KW, Castillo L, Manor S, Reznickova L, Valova T, Zdrahalova K, Hrusak O, Jabali Y, Schrappe M, Conter V, Izraeli S, Li CK, Stark B, Stary J, Trka J.

Leukemia. 2008 May;22(5):989-97. doi: 10.1038/leu.2008.22. Epub 2008 Feb 28.

PMID:
18305563
19.

Familial extrarenal Wilms tumor.

Houben CH, Tong JH, Chan AW, Chik KW, Lee KH, Sihoe JD, Tam YH, Yeung CK.

J Pediatr Surg. 2007 Nov;42(11):1826-30. Erratum in: J Pediatr Surg. 2008 May;43(5):970.

PMID:
18022431
20.

Use of a bone marrow transplantation model system to demonstrate the hematopoietic origin of plasma S100B mRNA.

Chan RW, Graham CA, Rainer TH, Lam NY, Chiu RW, Chik KW, Lee V, Lo YM.

Clin Chem. 2007 Oct;53(10):1874-6. No abstract available.

21.

Impact of SARS on development of childhood acute lymphoblastic leukaemia.

Li CK, Zee B, Lee J, Chik KW, Ha SY, Lee V.

Leukemia. 2007 Jul;21(7):1353-6. Review. No abstract available.

PMID:
17579654
22.

A malignant itch.

Hon KL, Lam MC, Leung TF, Chik KW, Leung AK.

J Natl Med Assoc. 2006 Dec;98(12):1992-4.

23.

A randomized controlled study evaluating the safety and efficacy of deferiprone treatment in thalassemia major patients from Hong Kong.

Ha SY, Chik KW, Ling SC, Lee AC, Luk CW, Lam CW, Ng IO, Chan GC.

Hemoglobin. 2006;30(2):263-74.

PMID:
16798652
24.

Clonal evolution of 8p11 stem cell syndrome in a 14-year-old Chinese boy: a review of literature of t(8;13) associated myeloproliferative diseases.

Wong WS, Cheng KC, Lau KM, Chan NP, Shing MM, Cheng SH, Chik KW, Li CK, Ng MH.

Leuk Res. 2007 Feb;31(2):235-8. Epub 2006 Jun 13.

PMID:
16777224
25.

Autoimmune hypothyroidism after unrelated haematopoietic stem cell transplantation in children.

Lee V, Cheng PS, Chik KW, Wong GW, Shing MM, Li CK.

J Pediatr Hematol Oncol. 2006 May;28(5):293-5.

PMID:
16772879
26.
27.

Improved outcome of acute lymphoblastic leukaemia treated by delayed intensification in Hong Kong children: HKALL97 study.

Li CK, Chik KW, Ha SY, Lee AC, Yuen HL, Ling SC, Lee V, Chan GC, Shing MM, Chan LC, Ng MH.

Hong Kong Med J. 2006 Feb;12(1):33-9.

28.

Critical airway obstruction, superior vena cava syndrome, and spontaneous cardiac arrest in a child with acute leukemia.

Hon KL, Leung A, Chik KW, Chu CW, Cheung KL, Fok TF.

Pediatr Emerg Care. 2005 Dec;21(12):844-6.

PMID:
16340761
29.

Partial neuroprotective effect of pretreatment with tanshinone IIA on neonatal hypoxia-ischemia brain damage.

Xia WJ, Yang M, Fok TF, Li K, Chan WY, Ng PC, Ng HK, Chik KW, Wang CC, Gu GJ, Woo KS, Fung KP.

Pediatr Res. 2005 Oct;58(4):784-90.

PMID:
16189210
30.

Arsenic trioxide mediates intrinsic and extrinsic pathways of apoptosis and cell cycle arrest in acute megakaryocytic leukemia.

Lam HK, Li K, Chik KW, Yang M, Liu VC, Li CK, Fok TF, Ng PC, Shing MM, Chuen CK, Yuen PM.

Int J Oncol. 2005 Aug;27(2):537-45.

PMID:
16010437
31.

Bone mineral density in children with thalassaemia major: determining factors and effects of bone marrow transplantation.

Leung TF, Hung EC, Lam CW, Li CK, Chu Y, Chik KW, Shing MM, Lee V, Yuen PM.

Bone Marrow Transplant. 2005 Aug;36(4):331-6.

PMID:
15968288
32.

Kinetic measurement by LC/MS of gamma-glutamylcysteine ligase activity.

Chikh K, Flourie F, Arab K, Steghens JP.

J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Nov 15;827(1):32-8. Erratum in: J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Apr 1;878(11-12):913. Chik, Karim [corrected to Chikh, Karim].

PMID:
15905141
33.

Role of imaging in management of hemophilic patients.

Ng WH, Chu WC, Shing MK, Lam WW, Chik KW, Li CK, Li CK, Ling SC.

AJR Am J Roentgenol. 2005 May;184(5):1619-23.

PMID:
15855127
34.

Preclinical ex vivo expansion of G-CSF-mobilized peripheral blood stem cells: effects of serum-free media, cytokine combinations and chemotherapy.

Li K, Li CK, Chuen CK, Tsang KS, Fok TF, James AE, Lee SM, Shing MM, Chik KW, Yuen PM.

Eur J Haematol. 2005 Feb;74(2):128-35.

PMID:
15654904
35.

Liver volume in thalassaemia major: relationship with body weight, serum ferritin, and liver function.

Chan YL, Li CK, Chik KW, Law MY, Howard R.

Pediatr Radiol. 2005 Feb;35(2):165-8. Epub 2004 Oct 8.

PMID:
15480619
36.

Neutrophil CD64 is a sensitive diagnostic marker for early-onset neonatal infection.

Ng PC, Li G, Chui KM, Chu WC, Li K, Wong RP, Chik KW, Wong E, Fok TF.

Pediatr Res. 2004 Nov;56(5):796-803. Epub 2004 Sep 15.

PMID:
15371562
37.

Identification of TPO receptors on central nervous system-a preliminary report.

Yang M, Xia WJ, Li K, Pong NH, Chik KW, Li CK, Ng MH, Ng HK, Fung KP, Fok TF.

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2004 Aug;12(4):494-7.

PMID:
15363139
38.

Childhood acute myeloid leukemia with CBFbeta-MYH11 rearrangement: study of incidence, morphology, cytogenetics, and clinical outcomes of Chinese in Hong Kong.

Chan NP, Wong WS, Ng MH, Tsang KS, Lau TT, Leung Y, Chik KW, Shing MM, Li CK.

Am J Hematol. 2004 Jul;76(3):300-3.

39.

Growth and endocrine function following bone marrow transplantation for thalassemia major.

Li CK, Chik KW, Wong GW, Cheng PS, Lee V, Shing MM.

Pediatr Hematol Oncol. 2004 Jul-Aug;21(5):411-9.

PMID:
15205084
40.

Oseltamivir prophylaxis during the influenza season in a paediatric cancer centre: prospective observational study.

Chik KW, Li CK, Chan PK, Shing MM, Lee V, Tam JS, Yuen PM.

Hong Kong Med J. 2004 Apr;10(2):103-6.

41.

Unrelated umbilical cord blood transplantation in children: experience of the Hong Kong Red Cross Blood Transfusion Service.

Li CK, Shing MM, Chik KW, Tsang KS, Tang NL, Chan PK, Chan NK, Lee V, Ng MH, Lin CK, Yuen PM.

Hong Kong Med J. 2004 Apr;10(2):89-95.

42.

Immunogenicity of a two-dose regime of varicella vaccine in children with cancers.

Leung TF, Li CK, Hung EC, Chan PK, Mo CW, Wong RP, Chik KW.

Eur J Haematol. 2004 May;72(5):353-7.

PMID:
15059071
43.

Risk factors and clinical consequences of human herpesvirus 7 infection in paediatric haematopoietic stem cell transplant recipients.

Chan PK, Li CK, Chik KW, Lee V, Shing MM, Ng KC, Cheung JL, Fok TF, Cheng AF.

J Med Virol. 2004 Apr;72(4):668-74.

PMID:
14981771
44.

Intraocular pressure profile of a child on a systemic corticosteroid.

Tham CC, Ng JS, Li RT, Chik KW, Lam DS.

Am J Ophthalmol. 2004 Jan;137(1):198-201.

PMID:
14700676
45.

Elevated serum interleukin-15 level in acute graft-versus-host disease after hematopoietic cell transplantation.

Chik KW, Li K, Pong H, Shing MM, Li CK, Yuen PM.

J Pediatr Hematol Oncol. 2003 Dec;25(12):960-4.

PMID:
14663280
46.

Thrombospondin-1 induces apoptosis in primary leukemia and cell lines mediated by CD36 and Caspase-3.

Li K, Yang M, Yuen PM, Chik KW, Li CK, Shing MM, Lam HK, Fok TF.

Int J Mol Med. 2003 Dec;12(6):995-1001.

PMID:
14612980
47.

White matter and cerebral metabolite changes in children undergoing treatment for acute lymphoblastic leukemia: longitudinal study with MR imaging and 1H MR spectroscopy.

Chu WC, Chik KW, Chan YL, Yeung DK, Roebuck DJ, Howard RG, Li CK, Metreweli C.

Radiology. 2003 Dec;229(3):659-69. Epub 2003 Oct 23.

PMID:
14576448
48.

Genetic variation of glycoproteins B and H of human herpesvirus 7 in Hong Kong.

Chan PK, Li CK, Chik KW, Shing MM, Lee V, Ng KC, Lam CW, Cheung JL, Cheng AF.

J Med Virol. 2003 Nov;71(3):429-33.

PMID:
12966550
49.

Imaging findings of paediatric oncology patients presenting with acute neurological symptoms.

Chu WC, Lee V, Howard RG, Roebuck DJ, Chik KW, Li CK.

Clin Radiol. 2003 Aug;58(8):589-603. Review.

PMID:
12887951
50.

Periorbital alveolar soft part sarcoma with radiologic features mimicking haemangioma.

Chu WC, Howard RG, Roebuck DJ, Chik KW, Li CK.

Med Pediatr Oncol. 2003 Aug;41(2):145-6. No abstract available.

PMID:
12825221

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