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Items: 43


Clioquinol: To harm or heal.

Perez DR, Sklar LA, Chigaev A.

Pharmacol Ther. 2019 Jul;199:155-163. doi: 10.1016/j.pharmthera.2019.03.009. Epub 2019 Mar 18. Review.


Methods for Investigating VLA-4 (CD49d/CD29) Expression and Activation in Chronic Lymphocytic Leukemia and Its Clinical Applications.

Zucchetto A, Tissino E, Chigaev A, Hartmann TN, Gattei V.

Methods Mol Biol. 2019;1881:101-112. doi: 10.1007/978-1-4939-8876-1_8.


Evaluating integrin activation with time-resolved flow cytometry.

Sambrano J, Chigaev A, Nichani KS, Smagley Y, Sklar LA, Houston JP.

J Biomed Opt. 2018 Jul;23(7):1-10. doi: 10.1117/1.JBO.23.7.075004.


High-Throughput Flow Cytometry Drug Combination Discovery with Novel Synergy Analysis Software, SynScreen.

Perez DR, Edwards BS, Sklar LA, Chigaev A.

SLAS Discov. 2018 Aug;23(7):751-760. doi: 10.1177/2472555218775913. Epub 2018 May 29.


High-Throughput Flow Cytometry Identifies Small-Molecule Inhibitors for Drug Repurposing in T-ALL.

Perez DR, Nickl CK, Waller A, Delgado-Martin C, Woods T, Sharma ND, Hermiston ML, Loh ML, Hunger SP, Winter SS, Chigaev A, Edwards B, Sklar LA, Matlawska-Wasowska K.

SLAS Discov. 2018 Aug;23(7):732-741. doi: 10.1177/2472555218774248. Epub 2018 May 10.


Functional and clinical relevance of VLA-4 (CD49d/CD29) in ibrutinib-treated chronic lymphocytic leukemia.

Tissino E, Benedetti D, Herman SEM, Ten Hacken E, Ahn IE, Chaffee KG, Rossi FM, Dal Bo M, Bulian P, Bomben R, Bayer E, Härzschel A, Gutjahr JC, Postorino M, Santinelli E, Ayed A, Zaja F, Chiarenza A, Pozzato G, Chigaev A, Sklar LA, Burger JA, Ferrajoli A, Shanafelt TD, Wiestner A, Del Poeta G, Hartmann TN, Gattei V, Zucchetto A.

J Exp Med. 2018 Feb 5;215(2):681-697. doi: 10.1084/jem.20171288. Epub 2018 Jan 4.


Ibrutinib Inhibits VLA-4-Dependent Adhesion in CLL-Letter.

Zucchetto A, Tissino E, Hartmann TN, Chigaev A, Del Poeta G, Colombatti A, Gattei V.

Clin Cancer Res. 2016 Jul 1;22(13):3410-1. doi: 10.1158/1078-0432.CCR-16-0050. No abstract available.


A High-Throughput Flow Cytometry Assay for Identification of Inhibitors of 3',5'-Cyclic Adenosine Monophosphate Efflux.

Perez D, Simons PC, Smagley Y, Sklar LA, Chigaev A.

Methods Mol Biol. 2016;1439:227-44. doi: 10.1007/978-1-4939-3673-1_15.


Cyclic AMP efflux inhibitors as potential therapeutic agents for leukemia.

Perez DR, Smagley Y, Garcia M, Carter MB, Evangelisti A, Matlawska-Wasowska K, Winter SS, Sklar LA, Chigaev A.

Oncotarget. 2016 Jun 7;7(23):33960-82. doi: 10.18632/oncotarget.8986.


Does aberrant membrane transport contribute to poor outcome in adult acute myeloid leukemia?

Chigaev A.

Front Pharmacol. 2015 Jul 2;6:134. doi: 10.3389/fphar.2015.00134. eCollection 2015.


CXCL12-induced VLA-4 activation is impaired in trisomy 12 chronic lymphocytic leukemia cells: a role for CCL21.

Ganghammer S, Hutterer E, Hinterseer E, Brachtl G, Asslaber D, Krenn PW, Girbl T, Berghammer P, Geisberger R, Egle A, Zucchetto A, Kruschinski A, Gattei V, Chigaev A, Greil R, Hartmann TN.

Oncotarget. 2015 May 20;6(14):12048-60.


Relationship of light scatter change and Cdc42-regulated actin status.

Hong L, Chavez S, Smagley Y, Chigaev A, Sklar LA.

Cytometry B Clin Cytom. 2016 Nov;90(6):499-505. doi: 10.1002/cyto.b.21223. Epub 2015 Jul 3.


The evaluation of thioridazine as a hematopoietic progenitor cell mobilizing agent in healthy human subjects.

Chigaev A, Sklar LA, Schrader R, Stephens N, Raissy H, Winter SS.

J Clin Pharmacol. 2015 May;55(5):512-6. doi: 10.1002/jcph.448. Epub 2015 Feb 4. No abstract available.


FRET detection of lymphocyte function-associated antigen-1 conformational extension.

Chigaev A, Smagley Y, Haynes MK, Ursu O, Bologa CG, Halip L, Oprea T, Waller A, Carter MB, Zhang Y, Wang W, Buranda T, Sklar LA.

Mol Biol Cell. 2015 Jan 1;26(1):43-54. doi: 10.1091/mbc.E14-06-1050. Epub 2014 Nov 5.


Carbon monoxide down-regulates α4β1 integrin-specific ligand binding and cell adhesion: a possible mechanism for cell mobilization.

Chigaev A, Smagley Y, Sklar LA.

BMC Immunol. 2014 Oct 31;15:52. doi: 10.1186/s12865-014-0052-1.


Characterization of a Cdc42 protein inhibitor and its use as a molecular probe.

Hong L, Kenney SR, Phillips GK, Simpson D, Schroeder CE, Nöth J, Romero E, Swanson S, Waller A, Strouse JJ, Carter M, Chigaev A, Ursu O, Oprea T, Hjelle B, Golden JE, Aubé J, Hudson LG, Buranda T, Sklar LA, Wandinger-Ness A.

J Biol Chem. 2013 Mar 22;288(12):8531-43. doi: 10.1074/jbc.M112.435941. Epub 2013 Feb 4. Erratum in: J Biol Chem. 2014 Mar 7;289(10):6837.


Aspects of VLA-4 and LFA-1 regulation that may contribute to rolling and firm adhesion.

Chigaev A, Sklar LA.

Front Immunol. 2012 Aug 2;3:242. doi: 10.3389/fimmu.2012.00242. eCollection 2012.


Drug Repurposing from an Academic Perspective.

Oprea TI, Bauman JE, Bologa CG, Buranda T, Chigaev A, Edwards BS, Jarvik JW, Gresham HD, Haynes MK, Hjelle B, Hromas R, Hudson L, Mackenzie DA, Muller CY, Reed JC, Simons PC, Smagley Y, Strouse J, Surviladze Z, Thompson T, Ursu O, Waller A, Wandinger-Ness A, Winter SS, Wu Y, Young SM, Larson RS, Willman C, Sklar LA.

Drug Discov Today Ther Strateg. 2011 Winter;8(3-4):61-69.


A miniature Couette to generate shear for flow cytometry: studying real-time modulation of intracellular calcium in monocytic cells.

Zwartz GJ, Chigaev A, Foutz TD, Edwards B, Sklar LA.

Cytometry A. 2011 Mar;79(3):233-40. doi: 10.1002/cyto.a.21027. Epub 2011 Feb 10.


Is prolonged stem cell mobilization detrimental for hematopoiesis?

Chigaev A, Winter SS, Sklar LA.

Med Hypotheses. 2011 Dec;77(6):1111-3. doi: 10.1016/j.mehy.2011.09.015. Epub 2011 Oct 2.


Overview: assays for studying integrin-dependent cell adhesion.

Chigaev A, Sklar LA.

Methods Mol Biol. 2012;757:3-14. doi: 10.1007/978-1-61779-166-6_1. Review.


Real-time analysis of the inside-out regulation of lymphocyte function-associated antigen-1 revealed similarities to and differences from very late antigen-4.

Chigaev A, Smagley Y, Zhang Y, Waller A, Haynes MK, Amit O, Wang W, Larson RS, Sklar LA.

J Biol Chem. 2011 Jun 10;286(23):20375-86. doi: 10.1074/jbc.M110.206185. Epub 2011 Apr 22.


Discovery of very late antigen-4 (VLA-4, alpha4beta1 integrin) allosteric antagonists.

Chigaev A, Wu Y, Williams DB, Smagley Y, Sklar LA.

J Biol Chem. 2011 Feb 18;286(7):5455-63. doi: 10.1074/jbc.M110.162636. Epub 2010 Dec 3.


Conformational mAb as a tool for integrin ligand discovery.

Njus BH, Chigaev A, Waller A, Wlodek D, Ostopovici-Halip L, Ursu O, Wang W, Oprea TI, Bologa CG, Sklar LA.

Assay Drug Dev Technol. 2009 Oct;7(5):507-15. doi: 10.1089/adt.2009.0203.


Real-time analysis of conformation-sensitive antibody binding provides new insights into integrin conformational regulation.

Chigaev A, Waller A, Amit O, Halip L, Bologa CG, Sklar LA.

J Biol Chem. 2009 May 22;284(21):14337-46. doi: 10.1074/jbc.M901178200. Epub 2009 Feb 27.


Galphas-coupled receptor signaling actively down-regulates alpha4beta1-integrin affinity: a possible mechanism for cell de-adhesion.

Chigaev A, Waller A, Amit O, Sklar LA.

BMC Immunol. 2008 Jun 5;9:26. doi: 10.1186/1471-2172-9-26.


Regulation of cell adhesion by affinity and conformational unbending of alpha4beta1 integrin.

Chigaev A, Waller A, Zwartz GJ, Buranda T, Sklar LA.

J Immunol. 2007 Jun 1;178(11):6828-39.


Dissociation of I domain and global conformational changes in LFA-1: refinement of small molecule-I domain structure-activity relationships.

Larson RS, Davis T, Bologa C, Semenuk G, Vijayan S, Li Y, Oprea T, Chigaev A, Buranda T, Wagner CR, Sklar LA.

Biochemistry. 2005 Mar 22;44(11):4322-31.


Real-time analysis of very late antigen-4 affinity modulation by shear.

Zwartz GJ, Chigaev A, Dwyer DC, Foutz TD, Edwards BS, Sklar LA.

J Biol Chem. 2004 Sep 10;279(37):38277-86. Epub 2004 Jun 28.


Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells.

Hernandez-Hansen V, Smith AJ, Surviladze Z, Chigaev A, Mazel T, Kalesnikoff J, Lowell CA, Krystal G, Sklar LA, Wilson BS, Oliver JM.

J Immunol. 2004 Jul 1;173(1):100-12.


Conformational regulation of alpha 4 beta 1-integrin affinity by reducing agents. "Inside-out" signaling is independent of and additive to reduction-regulated integrin activation.

Chigaev A, Zwartz GJ, Buranda T, Edwards BS, Prossnitz ER, Sklar LA.

J Biol Chem. 2004 Jul 30;279(31):32435-43. Epub 2004 May 27.


Relationship between molecular and cellular dissociation rates for VLA-4/VCAM-1 interaction in the absence of shear stress.

Zwartz G, Chigaev A, Foutz T, Larson RS, Posner R, Sklar LA.

Biophys J. 2004 Feb;86(2):1243-52.


FRET detection of cellular alpha4-integrin conformational activation.

Chigaev A, Buranda T, Dwyer DC, Prossnitz ER, Sklar LA.

Biophys J. 2003 Dec;85(6):3951-62.


Alpha4beta1 integrin affinity changes govern cell adhesion.

Chigaev A, Zwartz G, Graves SW, Dwyer DC, Tsuji H, Foutz TD, Edwards BS, Prossnitz ER, Larson RS, Sklar LA.

J Biol Chem. 2003 Oct 3;278(40):38174-82. Epub 2003 Jul 3.


VLA-4 affinity correlates with peripheral blood white cell count and DNA content in patients with precursor B-ALL.

Blenc AM, Chigaev A, Sklar L, Larson RS.

Leukemia. 2003 Mar;17(3):641-3. No abstract available. Erratum in: Leukemia. 2010 Mar;24(3):669. Chiagev, A [corrected to Chigaev, A].


Regulation of human basophil adhesion to endothelium under flow conditions: Different very late antigen 4 regulation on umbilical cord blood-derived and peripheral blood basophils.

Kepley CL, Andrews RP, Brown DC, Chigaev A, Sklar LA, Oliver JM, Larson RS.

J Allergy Clin Immunol. 2002 Sep;110(3):469-75.


Clustering patterns of cytotoxic T-lymphocyte epitopes in human immunodeficiency virus type 1 (HIV-1) proteins reveal imprints of immune evasion on HIV-1 global variation.

Yusim K, Kesmir C, Gaschen B, Addo MM, Altfeld M, Brunak S, Chigaev A, Detours V, Korber BT.

J Virol. 2002 Sep;76(17):8757-68.


Interactions of beta and gamma ENaC with Nedd4 can be facilitated by an ERK-mediated phosphorylation.

Shi H, Asher C, Chigaev A, Yung Y, Reuveny E, Seger R, Garty H.

J Biol Chem. 2002 Apr 19;277(16):13539-47. Epub 2002 Jan 22.


Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn(2+) or antibody activation.

Chigaev A, Blenc AM, Braaten JV, Kumaraswamy N, Kepley CL, Andrews RP, Oliver JM, Edwards BS, Prossnitz ER, Larson RS, Sklar LA.

J Biol Chem. 2001 Dec 28;276(52):48670-8. Epub 2001 Oct 18.


Characterization of interactions between Nedd4 and beta and gammaENaC using surface plasmon resonance.

Asher C, Chigaev A, Garty H.

Biochem Biophys Res Commun. 2001 Sep 7;286(5):1228-31.


In vitro phosphorylation of COOH termini of the epithelial Na(+) channel and its effects on channel activity in Xenopus oocytes.

Chigaev A, Lu G, Shi H, Asher C, Xu R, Latter H, Seger R, Garty H, Reuveny E.

Am J Physiol Renal Physiol. 2001 Jun;280(6):F1030-6.

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