Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 316

1.

Cell-mediated delivery of VEGF modified mRNA enhances blood vessel regeneration and ameliorates murine critical limb ischemia.

Yu Z, Witman N, Wang W, Li D, Yan B, Deng M, Wang X, Wang H, Zhou G, Liu W, Sahara M, Cao Y, Fritsche-Danielson R, Zhang W, Fu W, Chien KR.

J Control Release. 2019 Aug 16;310:103-114. doi: 10.1016/j.jconrel.2019.08.014. [Epub ahead of print]

PMID:
31425721
2.

Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes.

Gan LM, Lagerström-Fermér M, Carlsson LG, Arfvidsson C, Egnell AC, Rudvik A, Kjaer M, Collén A, Thompson JD, Joyal J, Chialda L, Koernicke T, Fuhr R, Chien KR, Fritsche-Danielson R.

Nat Commun. 2019 Feb 20;10(1):871. doi: 10.1038/s41467-019-08852-4.

3.

Regenerating the field of cardiovascular cell therapy.

Chien KR, Frisén J, Fritsche-Danielson R, Melton DA, Murry CE, Weissman IL.

Nat Biotechnol. 2019 Mar;37(3):232-237. doi: 10.1038/s41587-019-0042-1. Epub 2019 Feb 18. Review.

PMID:
30778231
4.

Population and Single-Cell Analysis of Human Cardiogenesis Reveals Unique LGR5 Ventricular Progenitors in Embryonic Outflow Tract.

Sahara M, Santoro F, Sohlmér J, Zhou C, Witman N, Leung CY, Mononen M, Bylund K, Gruber P, Chien KR.

Dev Cell. 2019 Feb 25;48(4):475-490.e7. doi: 10.1016/j.devcel.2019.01.005. Epub 2019 Jan 31.

PMID:
30713072
5.

Modified VEGF-A mRNA induces sustained multifaceted microvascular response and accelerates diabetic wound healing.

Sun N, Ning B, Hansson KM, Bruce AC, Seaman SA, Zhang C, Rikard M, DeRosa CA, Fraser CL, Wågberg M, Fritsche-Danielson R, Wikström J, Chien KR, Lundahl A, Hölttä M, Carlsson LG, Peirce SM, Hu S.

Sci Rep. 2018 Nov 30;8(1):17509. doi: 10.1038/s41598-018-35570-6.

6.

SMAD4 Is Essential for Human Cardiac Mesodermal Precursor Cell Formation.

Xu J, Gruber PJ, Chien KR.

Stem Cells. 2019 Feb;37(2):216-225. doi: 10.1002/stem.2943. Epub 2018 Dec 18.

PMID:
30376214
7.

Superselective endovascular tissue access using trans-vessel wall technique: feasibility study for treatment applications in heart, pancreas and kidney in swine.

Grankvist R, Jensen-Urstad M, Clarke J, Lehtinen M, Little P, Lundberg J, Arnberg F, Jonsson S, Chien KR, Holmin S.

J Intern Med. 2019 Apr;285(4):398-406. doi: 10.1111/joim.12841. Epub 2018 Oct 28.

PMID:
30289186
8.

Biocompatible, Purified VEGF-A mRNA Improves Cardiac Function after Intracardiac Injection 1 Week Post-myocardial Infarction in Swine.

Carlsson L, Clarke JC, Yen C, Gregoire F, Albery T, Billger M, Egnell AC, Gan LM, Jennbacken K, Johansson E, Linhardt G, Martinsson S, Sadiq MW, Witman N, Wang QD, Chen CH, Wang YP, Lin S, Ticho B, Hsieh PCH, Chien KR, Fritsche-Danielson R.

Mol Ther Methods Clin Dev. 2018 Apr 10;9:330-346. doi: 10.1016/j.omtm.2018.04.003. eCollection 2018 Jun 15.

9.

Lnc'ed in to Cardiogenesis.

Sahara M, Eroglu E, Chien KR.

Cell Stem Cell. 2018 Jun 1;22(6):787-789. doi: 10.1016/j.stem.2018.05.012.

10.

Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction.

Foo KS, Lehtinen ML, Leung CY, Lian X, Xu J, Keung W, Geng L, Kolstad TRS, Thams S, Wong AO, Wong N, Bylund K, Zhou C, He X, Jin SB, Clarke J, Lendahl U, Li RA, Louch WE, Chien KR.

Mol Ther. 2018 Jul 5;26(7):1644-1659. doi: 10.1016/j.ymthe.2018.02.012. Epub 2018 Feb 17.

11.

Heart Regeneration 4.0: Matrix Medicine.

Eroglu E, Chien KR.

Dev Cell. 2017 Jul 10;42(1):7-8. doi: 10.1016/j.devcel.2017.06.017.

12.

Insulin-Like Growth Factor 1 Receptor-Dependent Pathway Drives Epicardial Adipose Tissue Formation After Myocardial Injury.

Zangi L, Oliveira MS, Ye LY, Ma Q, Sultana N, Hadas Y, Chepurko E, Später D, Zhou B, Chew WL, Ebina W, Abrial M, Wang QD, Pu WT, Chien KR.

Circulation. 2017 Jan 3;135(1):59-72. doi: 10.1161/CIRCULATIONAHA.116.022064. Epub 2016 Nov 1.

13.

Corrigendum: Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells.

Soh BS, Ng SY, Wu H, Buac K, Park JH, Lian X, Xu J, Foo KS, Felldin U, He X, Nichane M, Yang H, Bu L, Li RA, Lim B, Chien KR.

Nat Commun. 2016 Jul 19;7:12118. doi: 10.1038/ncomms12118. No abstract available.

14.

Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells.

Soh BS, Ng SY, Wu H, Buac K, Park JH, Lian X, Xu J, Foo KS, Felldin U, He X, Nichane M, Yang H, Bu L, Li RA, Lim B, Chien KR.

Nat Commun. 2016 Mar 8;7:10774. doi: 10.1038/ncomms10774. Erratum in: Nat Commun. 2016 Jul 19;7:12118.

15.
16.

Programming and reprogramming a human heart cell.

Sahara M, Santoro F, Chien KR.

EMBO J. 2015 Mar 12;34(6):710-38. doi: 10.15252/embj.201490563. Epub 2015 Feb 20. Review.

17.

Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells.

Sahara M, Hansson EM, Wernet O, Lui KO, Später D, Chien KR.

Cell Res. 2015 Jan;25(1):148. doi: 10.1038/cr.2015.2. No abstract available.

18.

Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells.

Drawnel FM, Boccardo S, Prummer M, Delobel F, Graff A, Weber M, Gérard R, Badi L, Kam-Thong T, Bu L, Jiang X, Hoflack JC, Kiialainen A, Jeworutzki E, Aoyama N, Carlson C, Burcin M, Gromo G, Boehringer M, Stahlberg H, Hall BJ, Magnone MC, Kolaja K, Chien KR, Bailly J, Iacone R.

Cell Rep. 2014 Nov 6;9(3):810-21. doi: 10.1016/j.celrep.2014.09.055. Epub 2014 Oct 30.

19.

Tolerance induction to human stem cell transplants with extension to their differentiated progeny.

Lui KO, Howie D, Ng SW, Liu S, Chien KR, Waldmann H.

Nat Commun. 2014 Dec 1;5:5629. doi: 10.1038/ncomms6629.

PMID:
25434740
20.

How to make a cardiomyocyte.

Später D, Hansson EM, Zangi L, Chien KR.

Development. 2014 Dec;141(23):4418-31. doi: 10.1242/dev.091538. Epub 2014 Nov 18. Review.

21.

N-cadherin prevents the premature differentiation of anterior heart field progenitors in the pharyngeal mesodermal microenvironment.

Soh BS, Buac K, Xu H, Li E, Ng SY, Wu H, Chmielowiec J, Jiang X, Bu L, Li RA, Cowan C, Chien KR.

Cell Res. 2014 Dec;24(12):1420-32. doi: 10.1038/cr.2014.142. Epub 2014 Nov 4.

22.

Synthetic chemically modified mRNA (modRNA): toward a new technology platform for cardiovascular biology and medicine.

Chien KR, Zangi L, Lui KO.

Cold Spring Harb Perspect Med. 2014 Oct 9;5(1):a014035. doi: 10.1101/cshperspect.a014035. Review.

23.

Next-generation models of human cardiogenesis via genome editing.

Lian X, Xu J, Li J, Chien KR.

Cold Spring Harb Perspect Med. 2014 Sep 18;4(12):a013920. doi: 10.1101/cshperspect.a013920. Review.

24.

Cardiovascular regenerative therapeutics via synthetic paracrine factor modified mRNA.

Lui KO, Zangi L, Chien KR.

Stem Cell Res. 2014 Nov;13(3 Pt B):693-704. doi: 10.1016/j.scr.2014.06.007. Epub 2014 Jul 8. Review.

25.

Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies.

Wang G, McCain ML, Yang L, He A, Pasqualini FS, Agarwal A, Yuan H, Jiang D, Zhang D, Zangi L, Geva J, Roberts AE, Ma Q, Ding J, Chen J, Wang DZ, Li K, Wang J, Wanders RJ, Kulik W, Vaz FM, Laflamme MA, Murry CE, Chien KR, Kelley RI, Church GM, Parker KK, Pu WT.

Nat Med. 2014 Jun;20(6):616-23. doi: 10.1038/nm.3545. Epub 2014 May 11.

26.

Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells.

Sahara M, Hansson EM, Wernet O, Lui KO, Später D, Chien KR.

Cell Res. 2014 Jul;24(7):820-41. doi: 10.1038/cr.2014.59. Epub 2014 May 9. Erratum in: Cell Res. 2015 Jan;25(1):148. Erratum in: Cell Res. 2015 Jan;25(1):148.

27.

The muscle ankyrin repeat proteins CARP, Ankrd2, and DARP are not essential for normal cardiac development and function at basal conditions and in response to pressure overload.

Bang ML, Gu Y, Dalton ND, Peterson KL, Chien KR, Chen J.

PLoS One. 2014 Apr 15;9(4):e93638. doi: 10.1371/journal.pone.0093638. eCollection 2014. Erratum in: PLoS One. 2015;10(3):e0118523.

28.

Functional differences in engineered myocardium from embryonic stem cell-derived versus neonatal cardiomyocytes.

Feinberg AW, Ripplinger CM, van der Meer P, Sheehy SP, Domian I, Chien KR, Parker KK.

Stem Cell Reports. 2013 Nov 7;1(5):387-96. doi: 10.1016/j.stemcr.2013.10.004. eCollection 2013.

29.

Embryonic heart progenitors and cardiogenesis.

Brade T, Pane LS, Moretti A, Chien KR, Laugwitz KL.

Cold Spring Harb Perspect Med. 2013 Oct 1;3(10):a013847. doi: 10.1101/cshperspect.a013847. Review.

30.

Driving vascular endothelial cell fate of human multipotent Isl1+ heart progenitors with VEGF modified mRNA.

Lui KO, Zangi L, Silva EA, Bu L, Sahara M, Li RA, Mooney DJ, Chien KR.

Cell Res. 2013 Oct;23(10):1172-86. doi: 10.1038/cr.2013.112. Epub 2013 Sep 10.

31.

Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction.

Zangi L, Lui KO, von Gise A, Ma Q, Ebina W, Ptaszek LM, Später D, Xu H, Tabebordbar M, Gorbatov R, Sena B, Nahrendorf M, Briscoe DM, Li RA, Wagers AJ, Rossi DJ, Pu WT, Chien KR.

Nat Biotechnol. 2013 Oct;31(10):898-907. doi: 10.1038/nbt.2682. Epub 2013 Sep 8.

32.

Direct cardiomyocyte reprogramming: a new direction for cardiovascular regenerative medicine.

Yi BA, Mummery CL, Chien KR.

Cold Spring Harb Perspect Med. 2013 Sep 1;3(9):a014050. doi: 10.1101/cshperspect.a014050. Review.

33.

A HCN4+ cardiomyogenic progenitor derived from the first heart field and human pluripotent stem cells.

Später D, Abramczuk MK, Buac K, Zangi L, Stachel MW, Clarke J, Sahara M, Ludwig A, Chien KR.

Nat Cell Biol. 2013 Sep;15(9):1098-106. doi: 10.1038/ncb2824. Epub 2013 Aug 25.

PMID:
23974038
34.

The years of the monkey.

Lian X, Chien KR.

Cell Res. 2013 Oct;23(10):1161-2. doi: 10.1038/cr.2013.111. Epub 2013 Aug 20.

35.

Regenerative biology: heartbroken embryos heal.

Chien KR.

Nature. 2013 Jun 27;498(7455):439-40. doi: 10.1038/nature12262. Epub 2013 Jun 19. No abstract available.

PMID:
23783518
36.

Cardiac regenerative medicine 2.0.

Soh BS, Wu H, Chien KR.

Nat Biotechnol. 2013 Mar;31(3):209-11. doi: 10.1038/nbt.2524. No abstract available.

PMID:
23471068
37.

Reprogramming a broken heart.

Hansson EM, Chien KR.

Cell Stem Cell. 2012 Jul 6;11(1):3-4. doi: 10.1016/j.stem.2012.06.014.

38.

In vivo reprogramming for heart disease.

Xu H, Yi BA, Chien KR.

Cell Res. 2012 Nov;22(11):1521-3. doi: 10.1038/cr.2012.101. Epub 2012 Jul 3.

39.

Cardiomyocyte reprogramming and the new age of cellular alchemy.

Chien KR, Yi BA, Xu H, Mummery CL.

J Mol Cell Cardiol. 2012 Sep;53(3):311-3. doi: 10.1016/j.yjmcc.2012.06.010. Epub 2012 Jun 26. No abstract available.

PMID:
22749824
40.

Towards regenerative therapy for cardiac disease.

Ptaszek LM, Mansour M, Ruskin JN, Chien KR.

Lancet. 2012 Mar 10;379(9819):933-942. doi: 10.1016/S0140-6736(12)60075-0. Review.

PMID:
22405796
41.

Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature.

Xu H, Yi BA, Wu H, Bock C, Gu H, Lui KO, Park JH, Shao Y, Riley AK, Domian IJ, Hu E, Willette R, Lepore J, Meissner A, Wang Z, Chien KR.

Cell Res. 2012 Jan;22(1):142-54. doi: 10.1038/cr.2011.171. Epub 2011 Nov 8.

42.

A GPS for heart progenitor cell lineages.

Chmielowiec J, Chang YS, Chien KR.

Mol Ther. 2011 Sep;19(9):1576-8. doi: 10.1038/mt.2011.158. No abstract available.

43.

Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart.

Knöll R, Linke WA, Zou P, Miocic S, Kostin S, Buyandelger B, Ku CH, Neef S, Bug M, Schäfer K, Knöll G, Felkin LE, Wessels J, Toischer K, Hagn F, Kessler H, Didié M, Quentin T, Maier LS, Teucher N, Unsöld B, Schmidt A, Birks EJ, Gunkel S, Lang P, Granzier H, Zimmermann WH, Field LJ, Faulkner G, Dobbelstein M, Barton PJ, Sattler M, Wilmanns M, Chien KR.

Circ Res. 2011 Sep 16;109(7):758-69. doi: 10.1161/CIRCRESAHA.111.245787. Epub 2011 Jul 28.

44.

Bioengineering heart muscle: a paradigm for regenerative medicine.

Vunjak-Novakovic G, Lui KO, Tandon N, Chien KR.

Annu Rev Biomed Eng. 2011 Aug 15;13:245-67. doi: 10.1146/annurev-bioeng-071910-124701.

45.

Shortcuts to making cardiomyocytes.

Xu H, Yi BA, Chien KR.

Nat Cell Biol. 2011 Mar;13(3):191-3. doi: 10.1038/ncb0311-191.

PMID:
21364566
46.

Ablation of Nkx2-5 at mid-embryonic stage results in premature lethality and cardiac malformation.

Terada R, Warren S, Lu JT, Chien KR, Wessels A, Kasahara H.

Cardiovasc Res. 2011 Jul 15;91(2):289-99. doi: 10.1093/cvr/cvr037. Epub 2011 Feb 1.

47.

Cardiac origin of smooth muscle cells in the inflow tract.

Nakano H, Williams E, Hoshijima M, Sasaki M, Minamisawa S, Chien KR, Nakano A.

J Mol Cell Cardiol. 2011 Feb;50(2):337-45. doi: 10.1016/j.yjmcc.2010.10.009. Epub 2010 Oct 23.

48.

Stem cell models of cardiac development and disease.

Musunuru K, Domian IJ, Chien KR.

Annu Rev Cell Dev Biol. 2010;26:667-87. doi: 10.1146/annurev-cellbio-100109-103948. Review.

49.

Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511.

Rodin S, Domogatskaya A, Ström S, Hansson EM, Chien KR, Inzunza J, Hovatta O, Tryggvason K.

Nat Biotechnol. 2010 Jun;28(6):611-5. doi: 10.1038/nbt.1620. Epub 2010 May 30.

PMID:
20512123
50.

Targeted conditional gene knockout in human embryonic stem cells.

Bu L, Gao X, Jiang X, Chien KR, Wang Z.

Cell Res. 2010 Mar;20(3):379-82. doi: 10.1038/cr.2010.23. Epub 2010 Feb 9. No abstract available.

PMID:
20142843

Supplemental Content

Loading ...
Support Center