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Items: 18


Development of MGD007, a gpA33 x CD3-Bispecific DART Protein for T-Cell Immunotherapy of Metastatic Colorectal Cancer.

Moore PA, Shah K, Yang Y, Alderson R, Roberts P, Long V, Liu D, Li JC, Burke S, Ciccarone V, Li H, Fieger CB, Hooley J, Easton A, Licea M, Gorlatov S, King KL, Young P, Adami A, Loo D, Chichili GR, Liu L, Smith DH, Brown JG, Chen FZ, Koenig S, Mather J, Bonvini E, Johnson S.

Mol Cancer Ther. 2018 Aug;17(8):1761-1772. doi: 10.1158/1535-7163.MCT-17-1086. Epub 2018 Jun 4.


Tailoring CD19xCD3-DART exposure enhances T-cells to eradication of B-cell neoplasms.

Circosta P, Elia AR, Landra I, Machiorlatti R, Todaro M, Aliberti S, Brusa D, Deaglio S, Chiaretti S, Bruna R, Gottardi D, Massaia M, Giacomo FD, Guarini AR, Foà R, Kyriakides PW, Bareja R, Elemento O, Chichili GR, Monteleone E, Moore PA, Johnson S, Bonvini E, Cignetti A, Inghirami G.

Oncoimmunology. 2018 Feb 8;7(4):e1341032. doi: 10.1080/2162402X.2017.1341032. eCollection 2018.


Integrated Pharmacokinetic/Pharmacodynamic Model of a Bispecific CD3xCD123 DART Molecule in Nonhuman Primates: Evaluation of Activity and Impact of Immunogenicity.

Campagne O, Delmas A, Fouliard S, Chenel M, Chichili GR, Li H, Alderson R, Scherrmann JM, Mager DE.

Clin Cancer Res. 2018 Jun 1;24(11):2631-2641. doi: 10.1158/1078-0432.CCR-17-2265. Epub 2018 Feb 20.


First-in-human phase 1 study of margetuximab (MGAH22), an Fc-modified chimeric monoclonal antibody, in patients with HER2-positive advanced solid tumors.

Bang YJ, Giaccone G, Im SA, Oh DY, Bauer TM, Nordstrom JL, Li H, Chichili GR, Moore PA, Hong S, Stewart SJ, Baughman JE, Lechleider RJ, Burris HA.

Ann Oncol. 2017 Apr 1;28(4):855-861. doi: 10.1093/annonc/mdx002.


Development of PF-06671008, a Highly Potent Anti-P-cadherin/Anti-CD3 Bispecific DART Molecule with Extended Half-Life for the Treatment of Cancer.

Root AR, Cao W, Li B, LaPan P, Meade C, Sanford J, Jin M, O'Sullivan C, Cummins E, Lambert M, Sheehan AD, Ma W, Gatto S, Kerns K, Lam K, D'Antona AM, Zhu L, Brady WA, Benard S, King A, He T, Racie L, Arai M, Barrett D, Stochaj W, LaVallie ER, Apgar JR, Svenson K, Mosyak L, Yang Y, Chichili GR, Liu L, Li H, Burke S, Johnson S, Alderson R, Finlay WJJ, Lin L, Olland S, Somers W, Bonvini E, Gerber HP, May C, Moore PA, Tchistiakova L, Bloom L.

Antibodies (Basel). 2016 Mar 4;5(1). pii: E6. doi: 10.3390/antib5010006.


Targeting CD123 in acute myeloid leukemia using a T-cell-directed dual-affinity retargeting platform.

Al-Hussaini M, Rettig MP, Ritchey JK, Karpova D, Uy GL, Eissenberg LG, Gao F, Eades WC, Bonvini E, Chichili GR, Moore PA, Johnson S, Collins L, DiPersio JF.

Blood. 2016 Jan 7;127(1):122-31. doi: 10.1182/blood-2014-05-575704. Epub 2015 Nov 3.


A CD3xCD123 bispecific DART for redirecting host T cells to myelogenous leukemia: preclinical activity and safety in nonhuman primates.

Chichili GR, Huang L, Li H, Burke S, He L, Tang Q, Jin L, Gorlatov S, Ciccarone V, Chen F, Koenig S, Shannon M, Alderson R, Moore PA, Johnson S, Bonvini E.

Sci Transl Med. 2015 May 27;7(289):289ra82. doi: 10.1126/scitranslmed.aaa5693.


Cytoskeletal modulation of lipid interactions regulates Lck kinase activity.

Chichili GR, Cail RC, Rodgers W.

J Biol Chem. 2012 Jul 13;287(29):24186-94. doi: 10.1074/jbc.M111.320747. Epub 2012 May 21.


Cytoplasmic domain of P-selectin glycoprotein ligand-1 facilitates dimerization and export from the endoplasmic reticulum.

Miner JJ, Shao B, Wang Y, Chichili GR, Liu Z, Klopocki AG, Yago T, McDaniel JM, Rodgers W, Xia L, McEver RP.

J Biol Chem. 2011 Mar 18;286(11):9577-86. doi: 10.1074/jbc.M110.208777. Epub 2011 Jan 10.


T cell signal regulation by the actin cytoskeleton.

Chichili GR, Westmuckett AD, Rodgers W.

J Biol Chem. 2010 May 7;285(19):14737-46. doi: 10.1074/jbc.M109.097311. Epub 2010 Mar 1.


Cytoskeleton-membrane interactions in membrane raft structure.

Chichili GR, Rodgers W.

Cell Mol Life Sci. 2009 Jul;66(14):2319-28. doi: 10.1007/s00018-009-0022-6. Epub 2009 Apr 16. Review.


Compartmentalization of phosphatidylinositol 4,5-bisphosphate signaling evidenced using targeted phosphatases.

Johnson CM, Chichili GR, Rodgers W.

J Biol Chem. 2008 Oct 31;283(44):29920-8. doi: 10.1074/jbc.M805921200. Epub 2008 Aug 21.


Early and dynamic polarization of T cell membrane rafts and constituents prior to TCR stop signals.

Van Komen JS, Mishra S, Byrum J, Chichili GR, Yaciuk JC, Farris AD, Rodgers W.

J Immunol. 2007 Nov 15;179(10):6845-55.


Clustering of membrane raft proteins by the actin cytoskeleton.

Chichili GR, Rodgers W.

J Biol Chem. 2007 Dec 14;282(50):36682-91. Epub 2007 Oct 17.


Conversion of beta-carotene to retinal pigment.

Biesalski HK, Chichili GR, Frank J, von Lintig J, Nohr D.

Vitam Horm. 2007;75:117-30. Review.


Protective effects of tomato extract with elevated beta-carotene levels on oxidative stress in ARPE-19 cells.

Chichili GR, Nohr D, Frank J, Flaccus A, Fraser PD, Enfissi EM, Biesalski HK.

Br J Nutr. 2006 Oct;96(4):643-9.


beta-Carotene conversion into vitamin A in human retinal pigment epithelial cells.

Chichili GR, Nohr D, Schäffer M, von Lintig J, Biesalski HK.

Invest Ophthalmol Vis Sci. 2005 Oct;46(10):3562-9.


Multiplex polymerase chain reaction for the detection of herpes simplex virus, varicella-zoster virus and cytomegalovirus in ocular specimens.

Chichili GR, Athmanathan S, Farhatullah S, Gangopadhyay N, Jalali S, Pasricha G, Sharma S.

Curr Eye Res. 2003 Aug;27(2):85-90.


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