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Items: 46

1.

Synthesis, Microtubule-Binding Affinity, and Antiproliferative Activity of New Epothilone Analogs and of an EGFR-Targeted Epothilone-Peptide Conjugate.

Gaugaz FZ, Chicca A, Redondo-Horcajo M, Barasoain I, Díaz JF, Altmann KH.

Int J Mol Sci. 2019 Mar 5;20(5). pii: E1113. doi: 10.3390/ijms20051113.

2.

Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor.

Granchi C, Lapillo M, Glasmacher S, Bononi G, Licari C, Poli G, El Boustani M, Caligiuri I, Rizzolio F, Gertsch J, Macchia M, Minutolo F, Tuccinardi T, Chicca A.

J Med Chem. 2019 Feb 28;62(4):1932-1958. doi: 10.1021/acs.jmedchem.8b01483. Epub 2019 Feb 11.

PMID:
30715876
3.

Uncovering the psychoactivity of a cannabinoid from liverworts associated with a legal high.

Chicca A, Schafroth MA, Reynoso-Moreno I, Erni R, Petrucci V, Carreira EM, Gertsch J.

Sci Adv. 2018 Oct 24;4(10):eaat2166. doi: 10.1126/sciadv.aat2166. eCollection 2018 Oct.

4.

Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors.

Bononi G, Granchi C, Lapillo M, Giannotti M, Nieri D, Fortunato S, Boustani ME, Caligiuri I, Poli G, Carlson KE, Kim SH, Macchia M, Martinelli A, Rizzolio F, Chicca A, Katzenellenbogen JA, Minutolo F, Tuccinardi T.

Eur J Med Chem. 2018 Sep 5;157:817-836. doi: 10.1016/j.ejmech.2018.08.038. Epub 2018 Aug 16.

PMID:
30144699
5.

Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments.

Petrelli F, Dallérac G, Pucci L, Calì C, Zehnder T, Sultan S, Lecca S, Chicca A, Ivanov A, Asensio CS, Gundersen V, Toni N, Knott GW, Magara F, Gertsch J, Kirchhoff F, Déglon N, Giros B, Edwards RH, Mothet JP, Bezzi P.

Mol Psychiatry. 2018 Aug 20. doi: 10.1038/s41380-018-0226-y. [Epub ahead of print]

6.

The Endocannabinoid Reuptake Inhibitor WOBE437 Is Orally Bioavailable and Exerts Indirect Polypharmacological Effects via Different Endocannabinoid Receptors.

Reynoso-Moreno I, Chicca A, Flores-Soto ME, Viveros-Paredes JM, Gertsch J.

Front Mol Neurosci. 2018 May 28;11:180. doi: 10.3389/fnmol.2018.00180. eCollection 2018.

7.

Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system.

Chicca A, Arena C, Bertini S, Gado F, Ciaglia E, Abate M, Digiacomo M, Lapillo M, Poli G, Bifulco M, Macchia M, Tuccinardi T, Gertsch J, Manera C.

Eur J Med Chem. 2018 Jun 25;154:155-171. doi: 10.1016/j.ejmech.2018.05.019. Epub 2018 May 14.

PMID:
29793210
8.

Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.

Aghazadeh Tabrizi M, Baraldi PG, Baraldi S, Ruggiero E, De Stefano L, Rizzolio F, Di Cesare Mannelli L, Ghelardini C, Chicca A, Lapillo M, Gertsch J, Manera C, Macchia M, Martinelli A, Granchi C, Minutolo F, Tuccinardi T.

J Med Chem. 2018 Feb 8;61(3):1340-1354. doi: 10.1021/acs.jmedchem.7b01845. Epub 2018 Jan 22.

PMID:
29309142
9.

Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor.

Bertini S, Chicca A, Gado F, Arena C, Nieri D, Digiacomo M, Saccomanni G, Zhao P, Abood ME, Macchia M, Gertsch J, Manera C.

Bioorg Med Chem. 2017 Dec 15;25(24):6427-6434. doi: 10.1016/j.bmc.2017.10.015. Epub 2017 Oct 16.

10.

Pepcan-12 (RVD-hemopressin) is a CB2 receptor positive allosteric modulator constitutively secreted by adrenals and in liver upon tissue damage.

Petrucci V, Chicca A, Glasmacher S, Paloczi J, Cao Z, Pacher P, Gertsch J.

Sci Rep. 2017 Aug 25;7(1):9560. doi: 10.1038/s41598-017-09808-8.

11.

4-O'-methylhonokiol protects from alcohol/carbon tetrachloride-induced liver injury in mice.

Patsenker E, Chicca A, Petrucci V, Moghadamrad S, de Gottardi A, Hampe J, Gertsch J, Semmo N, Stickel F.

J Mol Med (Berl). 2017 Oct;95(10):1077-1089. doi: 10.1007/s00109-017-1556-y. Epub 2017 Jul 8.

12.

Chemical probes to potently and selectively inhibit endocannabinoid cellular reuptake.

Chicca A, Nicolussi S, Bartholomäus R, Blunder M, Aparisi Rey A, Petrucci V, Reynoso-Moreno IDC, Viveros-Paredes JM, Dalghi Gens M, Lutz B, Schiöth HB, Soeberdt M, Abels C, Charles RP, Altmann KH, Gertsch J.

Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):E5006-E5015. doi: 10.1073/pnas.1704065114. Epub 2017 Jun 5.

13.

Biological evaluation of pyridone alkaloids on the endocannabinoid system.

Chicca A, Berg R, Jessen HJ, Marck N, Schmid F, Burch P, Gertsch J, Gademann K.

Bioorg Med Chem. 2017 Nov 15;25(22):6102-6114. doi: 10.1016/j.bmc.2017.02.031. Epub 2017 Feb 17.

PMID:
28284861
14.

β-Caryophyllene protects against alcoholic steatohepatitis by attenuating inflammation and metabolic dysregulation in mice.

Varga ZV, Matyas C, Erdelyi K, Cinar R, Nieri D, Chicca A, Nemeth BT, Paloczi J, Lajtos T, Corey L, Hasko G, Gao B, Kunos G, Gertsch J, Pacher P.

Br J Pharmacol. 2018 Jan;175(2):320-334. doi: 10.1111/bph.13722. Epub 2017 Feb 22.

15.

Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity.

Soethoudt M, Grether U, Fingerle J, Grim TW, Fezza F, de Petrocellis L, Ullmer C, Rothenhäusler B, Perret C, van Gils N, Finlay D, MacDonald C, Chicca A, Gens MD, Stuart J, de Vries H, Mastrangelo N, Xia L, Alachouzos G, Baggelaar MP, Martella A, Mock ED, Deng H, Heitman LH, Connor M, Di Marzo V, Gertsch J, Lichtman AH, Maccarrone M, Pacher P, Glass M, van der Stelt M.

Nat Commun. 2017 Jan 3;8:13958. doi: 10.1038/ncomms13958.

16.
17.

Assay of Endocannabinoid Uptake.

Rau M, Nicolussi S, Chicca A, Gertsch J.

Methods Mol Biol. 2016;1412:191-203. doi: 10.1007/978-1-4939-3539-0_20.

PMID:
27245905
18.

Synthetic Cannabinoid Receptor Agonists and Antagonists: Implication in CNS Disorders.

Manera C, Arena C, Chicca A.

Recent Pat CNS Drug Discov. 2016;10(2):142-156. Review.

PMID:
27193072
19.

Synthesis and pharmacological evaluation of new biphenylic derivatives as CB2 receptor ligands.

Bertini S, Chicca A, Arena C, Chicca S, Saccomanni G, Gertsch J, Manera C, Macchia M.

Eur J Med Chem. 2016 Jun 30;116:252-266. doi: 10.1016/j.ejmech.2016.03.072. Epub 2016 Mar 30.

PMID:
27078864
20.

Reactions of CF3-enones with arenes under superelectrophilic activation: a pathway to trans-1,3-diaryl-1-CF3-indanes, new cannabinoid receptor ligands.

Iakovenko RO, Kazakova AN, Muzalevskiy VM, Ivanov AY, Boyarskaya IA, Chicca A, Petrucci V, Gertsch J, Krasavin M, Starova GL, Zolotarev AA, Avdontceva MS, Nenajdenko VG, Vasilyev AV.

Org Biomol Chem. 2015 Sep 7;13(33):8827-42. doi: 10.1039/c5ob01072a. Epub 2015 Jul 17.

PMID:
26186675
21.

4'-O-methylhonokiol increases levels of 2-arachidonoyl glycerol in mouse brain via selective inhibition of its COX-2-mediated oxygenation.

Chicca A, Gachet MS, Petrucci V, Schuehly W, Charles RP, Gertsch J.

J Neuroinflammation. 2015 May 13;12:89. doi: 10.1186/s12974-015-0307-7.

22.

Elevated levels of endocannabinoids in chronic hepatitis C may modulate cellular immune response and hepatic stellate cell activation.

Patsenker E, Sachse P, Chicca A, Gachet MS, Schneider V, Mattsson J, Lanz C, Worni M, de Gottardi A, Semmo M, Hampe J, Schafmayer C, Brenneisen R, Gertsch J, Stickel F, Semmo N.

Int J Mol Sci. 2015 Mar 27;16(4):7057-76. doi: 10.3390/ijms16047057.

23.

Splice variants of activation induced deaminase (AID) do not affect the efficiency of class switch recombination in murine CH12F3 cells.

Sala C, Mattiuz G, Pietrobono S, Chicca A, Conticello SG.

PLoS One. 2015 Mar 24;10(3):e0121719. doi: 10.1371/journal.pone.0121719. eCollection 2015.

24.

Development of an HPLC/UV assay for the evaluation of inhibitors of human recombinant monoacylglycerol lipase.

Del Carlo S, Manera C, Chicca A, Arena C, Bertini S, Burgalassi S, Tampucci S, Gertsch J, Macchia M, Saccomanni G.

J Pharm Biomed Anal. 2015 Apr 10;108:113-21. doi: 10.1016/j.jpba.2015.02.007. Epub 2015 Feb 13.

PMID:
25743577
25.

Correlating FAAH and anandamide cellular uptake inhibition using N-alkylcarbamate inhibitors: from ultrapotent to hyperpotent.

Nicolussi S, Chicca A, Rau M, Rihs S, Soeberdt M, Abels C, Gertsch J.

Biochem Pharmacol. 2014 Dec 15;92(4):669-89. doi: 10.1016/j.bcp.2014.09.020. Epub 2014 Nov 4.

PMID:
25283614
26.

One-pot heterogeneous synthesis of Δ(3)-tetrahydrocannabinol analogues and xanthenes showing differential binding to CB(1) and CB(2) receptors.

Rosati O, Messina F, Pelosi A, Curini M, Petrucci V, Gertsch J, Chicca A.

Eur J Med Chem. 2014 Oct 6;85:77-86. doi: 10.1016/j.ejmech.2014.07.062. Epub 2014 Jul 19.

PMID:
25072877
27.

Functionally Optimized Neuritogenic Farinosone C Analogs: SAR-Study and Investigations on Their Mode of Action.

Burch P, Chicca A, Gertsch J, Gademann K.

ACS Med Chem Lett. 2013 Dec 6;5(2):172-7. doi: 10.1021/ml400435h. eCollection 2014 Feb 13.

28.

Functionalization of β-caryophyllene generates novel polypharmacology in the endocannabinoid system.

Chicca A, Caprioglio D, Minassi A, Petrucci V, Appendino G, Taglialatela-Scafati O, Gertsch J.

ACS Chem Biol. 2014 Jul 18;9(7):1499-507. doi: 10.1021/cb500177c. Epub 2014 May 15.

PMID:
24831513
29.

Anticancer activity of anandamide in human cutaneous melanoma cells.

Adinolfi B, Romanini A, Vanni A, Martinotti E, Chicca A, Fogli S, Nieri P.

Eur J Pharmacol. 2013 Oct 15;718(1-3):154-9. doi: 10.1016/j.ejphar.2013.08.039. Epub 2013 Sep 13.

PMID:
24041928
30.

Identification and quantification of a new family of peptide endocannabinoids (Pepcans) showing negative allosteric modulation at CB1 receptors.

Bauer M, Chicca A, Tamborrini M, Eisen D, Lerner R, Lutz B, Poetz O, Pluschke G, Gertsch J.

J Biol Chem. 2012 Oct 26;287(44):36944-67. doi: 10.1074/jbc.M112.382481. Epub 2012 Sep 5.

31.

Synthesis and cytotoxic activity of non-naturally substituted 4-oxycoumarin derivatives.

Serra S, Chicca A, Delogu G, Vázquez-Rodríguez S, Santana L, Uriarte E, Casu L, Gertsch J.

Bioorg Med Chem Lett. 2012 Sep 15;22(18):5791-4. doi: 10.1016/j.bmcl.2012.07.099. Epub 2012 Aug 5. Erratum in: Bioorg Med Chem Lett. 2012 Nov 1;22(21):6775.

PMID:
22901895
32.

Evidence for bidirectional endocannabinoid transport across cell membranes.

Chicca A, Marazzi J, Nicolussi S, Gertsch J.

J Biol Chem. 2012 Oct 5;287(41):34660-82. doi: 10.1074/jbc.M112.373241. Epub 2012 Aug 9.

33.

The antinociceptive triterpene β-amyrin inhibits 2-arachidonoylglycerol (2-AG) hydrolysis without directly targeting cannabinoid receptors.

Chicca A, Marazzi J, Gertsch J.

Br J Pharmacol. 2012 Dec;167(8):1596-608. doi: 10.1111/j.1476-5381.2012.02059.x.

34.

Anti-proliferative activity of aguerin B and a new rare nor-guaianolide lactone isolated from the aerial parts of Centaurea deflexa.

Chicca A, Tebano M, Adinolfi B, Ertugrul K, Flamini G, Nieri P.

Eur J Med Chem. 2011 Jul;46(7):3066-70. doi: 10.1016/j.ejmech.2011.03.011. Epub 2011 Mar 15.

PMID:
21458113
35.

Analysis of reptilian APOBEC1 suggests that RNA editing may not be its ancestral function.

Severi F, Chicca A, Conticello SG.

Mol Biol Evol. 2011 Mar;28(3):1125-9. doi: 10.1093/molbev/msq338. Epub 2010 Dec 15.

PMID:
21172829
36.

Cytotoxic activity and G1 cell cycle arrest of a Dienynone from Echinacea pallida.

Chicca A, Adinolfi B, Pellati F, Orlandini G, Benvenuti S, Nieri P.

Planta Med. 2010 Mar;76(5):444-6. doi: 10.1055/s-0029-1186224. Epub 2009 Oct 20.

PMID:
19844866
37.

Synergistic immunomopharmacological effects of N-alkylamides in Echinacea purpurea herbal extracts.

Chicca A, Raduner S, Pellati F, Strompen T, Altmann KH, Schoop R, Gertsch J.

Int Immunopharmacol. 2009 Jul;9(7-8):850-8. doi: 10.1016/j.intimp.2009.03.006. Epub 2009 Mar 19.

PMID:
19303464
38.

Cytotoxic activity of polyacetylenes and polyenes isolated from roots of Echinacea pallida.

Chicca A, Pellati F, Adinolfi B, Matthias A, Massarelli I, Benvenuti S, Martinotti E, Bianucci AM, Bone K, Lehmann R, Nieri P.

Br J Pharmacol. 2008 Mar;153(5):879-85. doi: 10.1038/sj.bjp.0707639. Epub 2008 Jan 14.

39.

Sequence characterized amplified region (SCAR) analysis on DNA from the three medicinal Echinacea species.

Adinolfi B, Chicca A, Martinotti E, Breschi MC, Nieri P.

Fitoterapia. 2007 Jan;78(1):43-5. Epub 2006 Sep 23.

PMID:
17067760
40.

Cytotoxic effects of Echinacea root hexanic extracts on human cancer cell lines.

Chicca A, Adinolfi B, Martinotti E, Fogli S, Breschi MC, Pellati F, Benvenuti S, Nieri P.

J Ethnopharmacol. 2007 Mar 1;110(1):148-53. Epub 2006 Sep 23.

PMID:
17052874
41.

Modulation of P-glycoprotein activity by cannabinoid molecules in HK-2 renal cells.

Nieri P, Romiti N, Adinolfi B, Chicca A, Massarelli I, Chieli E.

Br J Pharmacol. 2006 Jul;148(5):682-7. Epub 2006 May 22.

42.

Cannabinoid derivatives induce cell death in pancreatic MIA PaCa-2 cells via a receptor-independent mechanism.

Fogli S, Nieri P, Chicca A, Adinolfi B, Mariotti V, Iacopetti P, Breschi MC, Pellegrini S.

FEBS Lett. 2006 Mar 20;580(7):1733-9. Epub 2006 Feb 20.

43.

Role of endothelin-1 in carrageenin-induced inflammation.

Bertelli A, Clerico A, Chicca A, Giovannini L, Gorio A, Romano MA.

Int J Tissue React. 1992;14(5):225-30.

PMID:
1300308
44.

Neutralizing antibodies against 33 human adenoviruses in normal children in Rome.

D'Ambrosio E, Del Grosso N, Chicca A, Midulla M.

J Hyg (Lond). 1982 Aug;89(1):155-61.

45.

[Prenatal viral infections and congenital heart diseases].

Assensio AM, Chiesa C, Colloridi V, Bastianon V, Chicca A, Balducci L, Midulla M.

Minerva Pediatr. 1979 Jul 31;31(14):1077-84. Italian. No abstract available.

PMID:
224301
46.

[Epidemic parotitis in Italy: results of a 1st vaccination trial].

Midulla M, Tamburello O, Balducci L, Assensio AM, Finocchiaro M, Chicca A, Sabatino G.

Ann Sclavo. 1977 Mar-Apr;19(2):177-86. Italian.

PMID:
603264

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