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Items: 40


Phosphatidylinositol 3 monophosphate metabolizing enzymes in blood platelet production and in thrombosis.

Bellio M, Caux M, Vauclard A, Chicanne G, Gratacap MP, Terrisse AD, Severin S, Payrastre B.

Adv Biol Regul. 2019 Oct 7:100664. doi: 10.1016/j.jbior.2019.100664. [Epub ahead of print] Review.


Profiling of phosphoinositide molecular species in human and mouse platelets identifies new species increasing following stimulation.

Mujalli A, Chicanne G, Bertrand-Michel J, Viars F, Stephens L, Hawkins P, Viaud J, Gaits-Iacovoni F, Severin S, Gratacap MP, Terrisse AD, Payrastre B.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Sep;1863(9):1121-1131. doi: 10.1016/j.bbalip.2018.06.009. Epub 2018 Jun 12.


Phosphoinositides regulate the TCR/CD3 complex membrane dynamics and activation.

Chouaki-Benmansour N, Ruminski K, Sartre AM, Phelipot MC, Salles A, Bergot E, Wu A, Chicanne G, Fallet M, Brustlein S, Billaudeau C, Formisano A, Mailfert S, Payrastre B, Marguet D, Brasselet S, Hamon Y, He HT.

Sci Rep. 2018 Mar 21;8(1):4966. doi: 10.1038/s41598-018-23109-8.


Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism.

Bilanges B, Alliouachene S, Pearce W, Morelli D, Szabadkai G, Chung YL, Chicanne G, Valet C, Hill JM, Voshol PJ, Collinson L, Peddie C, Ali K, Ghazaly E, Rajeeve V, Trichas G, Srinivas S, Chaussade C, Salamon RS, Backer JM, Scudamore CL, Whitehead MA, Keaney EP, Murphy LO, Semple RK, Payrastre B, Tooze SA, Vanhaesebroeck B.

Nat Commun. 2017 Nov 27;8(1):1804. doi: 10.1038/s41467-017-01969-4.


The importance of blood platelet lipid signaling in thrombosis and in sepsis.

Vardon Bounes F, Mujalli A, Cenac C, Severin S, Le Faouder P, Chicanne G, Gaits-Iacovoni F, Minville V, Gratacap MP, Payrastre B.

Adv Biol Regul. 2018 Jan;67:66-73. doi: 10.1016/j.jbior.2017.09.011. Epub 2017 Sep 29. Review.


A dual role for the class III PI3K, Vps34, in platelet production and thrombus growth.

Valet C, Levade M, Chicanne G, Bilanges B, Cabou C, Viaud J, Gratacap MP, Gaits-Iacovoni F, Vanhaesebroeck B, Payrastre B, Severin S.

Blood. 2017 Nov 2;130(18):2032-2042. doi: 10.1182/blood-2017-04-781641. Epub 2017 Sep 13.


Mass Assays to Quantify Bioactive PtdIns3P and PtdIns5P During Autophagic Responses.

Viaud J, Chicanne G, Solinhac R, Hnia K, Gaits-Iacovoni F, Payrastre B.

Methods Enzymol. 2017;587:293-310. doi: 10.1016/bs.mie.2016.09.061. Epub 2016 Nov 18.


Trans-inhibition of activation and proliferation signals by Fc receptors in mast cells and basophils.

Malbec O, Cassard L, Albanesi M, Jönsson F, Mancardi D, Chicanne G, Payrastre B, Dubreuil P, Vivier E, Daëron M.

Sci Signal. 2016 Dec 20;9(459):ra126. doi: 10.1126/scisignal.aag1401.


Functional Characterization and Rescue of a Deep Intronic Mutation in OCRL Gene Responsible for Lowe Syndrome.

Rendu J, Montjean R, Coutton C, Suri M, Chicanne G, Petiot A, Brocard J, Grunwald D, Pietri Rouxel F, Payrastre B, Lunardi J, Dorseuil O, Marty I, Fauré J.

Hum Mutat. 2017 Feb;38(2):152-159. doi: 10.1002/humu.23139. Epub 2016 Nov 21.


PLIF: A rapid, accurate method to detect and quantitatively assess protein-lipid interactions.

Ceccato L, Chicanne G, Nahoum V, Pons V, Payrastre B, Gaits-Iacovoni F, Viaud J.

Sci Signal. 2016 Mar 29;9(421):rs2. doi: 10.1126/scisignal.aad4337.


Cdc42-dependent F-actin dynamics drive structuration of the demarcation membrane system in megakaryocytes.

Antkowiak A, Viaud J, Severin S, Zanoun M, Ceccato L, Chicanne G, Strassel C, Eckly A, Leon C, Gachet C, Payrastre B, Gaits-Iacovoni F.

J Thromb Haemost. 2016 Jun;14(6):1268-84. doi: 10.1111/jth.13318. Epub 2016 Apr 21.


The role of class I, II and III PI 3-kinases in platelet production and activation and their implication in thrombosis.

Valet C, Severin S, Chicanne G, Laurent PA, Gaits-Iacovoni F, Gratacap MP, Payrastre B.

Adv Biol Regul. 2016 May;61:33-41. doi: 10.1016/j.jbior.2015.11.008. Epub 2015 Dec 2. Review.


Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity.

Alliouachene S, Bilanges B, Chicanne G, Anderson KE, Pearce W, Ali K, Valet C, Posor Y, Low PC, Chaussade C, Scudamore CL, Salamon RS, Backer JM, Stephens L, Hawkins PT, Payrastre B, Vanhaesebroeck B.

Cell Rep. 2015 Dec 1;13(9):1881-94. doi: 10.1016/j.celrep.2015.10.052. Epub 2015 Nov 19.


Phosphoinositides: Important lipids in the coordination of cell dynamics.

Viaud J, Mansour R, Antkowiak A, Mujalli A, Valet C, Chicanne G, Xuereb JM, Terrisse AD, Séverin S, Gratacap MP, Gaits-Iacovoni F, Payrastre B.

Biochimie. 2016 Jun;125:250-8. doi: 10.1016/j.biochi.2015.09.005. Epub 2015 Sep 25. Review.


Essential role of class II PI3K-C2α in platelet membrane morphology.

Valet C, Chicanne G, Severac C, Chaussade C, Whitehead MA, Cabou C, Gratacap MP, Gaits-Iacovoni F, Vanhaesebroeck B, Payrastre B, Severin S.

Blood. 2015 Aug 27;126(9):1128-37. doi: 10.1182/blood-2015-03-636670. Epub 2015 Jun 24.


TOM1 is a PI5P effector involved in the regulation of endosomal maturation.

Boal F, Mansour R, Gayral M, Saland E, Chicanne G, Xuereb JM, Marcellin M, Burlet-Schiltz O, Sansonetti PJ, Payrastre B, Tronchère H.

J Cell Sci. 2015 Feb 15;128(4):815-27. doi: 10.1242/jcs.166314. Epub 2015 Jan 14.


SHP-1-mediated inhibitory signals promote responsiveness and anti-tumour functions of natural killer cells.

Viant C, Fenis A, Chicanne G, Payrastre B, Ugolini S, Vivier E.

Nat Commun. 2014 Oct 30;5:5108. doi: 10.1038/ncomms6108.


Phosphatidylinositol 5-phosphate regulates invasion through binding and activation of Tiam1.

Viaud J, Lagarrigue F, Ramel D, Allart S, Chicanne G, Ceccato L, Courilleau D, Xuereb JM, Pertz O, Payrastre B, Gaits-Iacovoni F.

Nat Commun. 2014 Jun 6;5:4080. doi: 10.1038/ncomms5080.


cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease.

Fant X, Durieu E, Chicanne G, Payrastre B, Sbrissa D, Shisheva A, Limanton E, Carreaux F, Bazureau JP, Meijer L.

Mol Pharmacol. 2014 Mar;85(3):441-50. doi: 10.1124/mol.113.090837. Epub 2013 Dec 23.


Myotubularin and PtdIns3P remodel the sarcoplasmic reticulum in muscle in vivo.

Amoasii L, Hnia K, Chicanne G, Brech A, Cowling BS, Müller MM, Schwab Y, Koebel P, Ferry A, Payrastre B, Laporte J.

J Cell Sci. 2013 Apr 15;126(Pt 8):1806-19. doi: 10.1242/jcs.118505. Epub 2013 Feb 26.


Phosphatase-dead myotubularin ameliorates X-linked centronuclear myopathy phenotypes in mice.

Amoasii L, Bertazzi DL, Tronchère H, Hnia K, Chicanne G, Rinaldi B, Cowling BS, Ferry A, Klaholz B, Payrastre B, Laporte J, Friant S.

PLoS Genet. 2012;8(10):e1002965. doi: 10.1371/journal.pgen.1002965. Epub 2012 Oct 11.


A novel mass assay to quantify the bioactive lipid PtdIns3P in various biological samples.

Chicanne G, Severin S, Boscheron C, Terrisse AD, Gratacap MP, Gaits-Iacovoni F, Tronchère H, Payrastre B.

Biochem J. 2012 Oct 1;447(1):17-23. doi: 10.1042/BJ20120945.


Focal adhesion kinase splice variants maintain primitive acute myeloid leukemia cells through altered Wnt signaling.

Despeaux M, Chicanne G, Rouer E, De Toni-Costes F, Bertrand J, Mansat-De Mas V, Vergnolle N, Eaves C, Payrastre B, Girault JA, Racaud-Sultan C.

Stem Cells. 2012 Aug;30(8):1597-610. doi: 10.1002/stem.1157.


Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers.

de Saint-Jean M, Delfosse V, Douguet D, Chicanne G, Payrastre B, Bourguet W, Antonny B, Drin G.

J Cell Biol. 2011 Dec 12;195(6):965-78. doi: 10.1083/jcb.201104062.


Genetic interaction between MTMR2 and FIG4 phospholipid phosphatases involved in Charcot-Marie-Tooth neuropathies.

Vaccari I, Dina G, Tronchère H, Kaufman E, Chicanne G, Cerri F, Wrabetz L, Payrastre B, Quattrini A, Weisman LS, Meisler MH, Bolino A.

PLoS Genet. 2011 Oct;7(10):e1002319. doi: 10.1371/journal.pgen.1002319. Epub 2011 Oct 20.


Molecular networks linked by Moesin drive remodeling of the cell cortex during mitosis.

Roubinet C, Decelle B, Chicanne G, Dorn JF, Payrastre B, Payre F, Carreno S.

J Cell Biol. 2011 Oct 3;195(1):99-112. doi: 10.1083/jcb.201106048.


Shigella flexneri infection generates the lipid PI5P to alter endocytosis and prevent termination of EGFR signaling.

Ramel D, Lagarrigue F, Pons V, Mounier J, Dupuis-Coronas S, Chicanne G, Sansonetti PJ, Gaits-Iacovoni F, Tronchère H, Payrastre B.

Sci Signal. 2011 Sep 20;4(191):ra61. doi: 10.1126/scisignal.2001619.


The nucleophosmin-anaplastic lymphoma kinase oncogene interacts, activates, and uses the kinase PIKfyve to increase invasiveness.

Dupuis-Coronas S, Lagarrigue F, Ramel D, Chicanne G, Saland E, Gaits-Iacovoni F, Payrastre B, Tronchère H.

J Biol Chem. 2011 Sep 16;286(37):32105-14. doi: 10.1074/jbc.M111.227512. Epub 2011 Jul 7.


Phosphatidylinositol 3-monophosphate is involved in toxoplasma apicoplast biogenesis.

Tawk L, Dubremetz JF, Montcourrier P, Chicanne G, Merezegue F, Richard V, Payrastre B, Meissner M, Vial HJ, Roy C, Wengelnik K, Lebrun M.

PLoS Pathog. 2011 Feb;7(2):e1001286. doi: 10.1371/journal.ppat.1001286. Epub 2011 Feb 17.


Regulation and roles of PI3Kβ, a major actor in platelet signaling and functions.

Gratacap MP, Guillermet-Guibert J, Martin V, Chicanne G, Tronchère H, Gaits-Iacovoni F, Payrastre B.

Adv Enzyme Regul. 2011;51(1):106-16. doi: 10.1016/j.advenzreg.2010.09.011. Epub 2010 Oct 28. Review.


Phosphatidylinositol 3-phosphate, an essential lipid in Plasmodium, localizes to the food vacuole membrane and the apicoplast.

Tawk L, Chicanne G, Dubremetz JF, Richard V, Payrastre B, Vial HJ, Roy C, Wengelnik K.

Eukaryot Cell. 2010 Oct;9(10):1519-30. doi: 10.1128/EC.00124-10. Epub 2010 Aug 13.


A central role of GPIb-IX in the procoagulant function of platelets that is independent of the 45-kDa GPIbalpha N-terminal extracellular domain.

Ravanat C, Strassel C, Hechler B, Schuhler S, Chicanne G, Payrastre B, Gachet C, Lanza F.

Blood. 2010 Aug 19;116(7):1157-64. doi: 10.1182/blood-2010-01-266080. Epub 2010 May 10.


Deletion of the p110beta isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo.

Martin V, Guillermet-Guibert J, Chicanne G, Cabou C, Jandrot-Perrus M, Plantavid M, Vanhaesebroeck B, Payrastre B, Gratacap MP.

Blood. 2010 Mar 11;115(10):2008-13. doi: 10.1182/blood-2009-04-217224. Epub 2010 Jan 11.


Rac1 inactivation by lethal toxin from Clostridium sordellii modifies focal adhesions upstream of actin depolymerization.

Geny B, Grassart A, Manich M, Chicanne G, Payrastre B, Sauvonnet N, Popoff MR.

Cell Microbiol. 2010 Feb;12(2):217-32. doi: 10.1111/j.1462-5822.2009.01392.x. Epub 2009 Oct 13.


PtdIns5P protects Akt from dephosphorylation through PP2A inhibition.

Ramel D, Lagarrigue F, Dupuis-Coronas S, Chicanne G, Leslie N, Gaits-Iacovoni F, Payrastre B, Tronchère H.

Biochem Biophys Res Commun. 2009 Sep 11;387(1):127-31. doi: 10.1016/j.bbrc.2009.06.139. Epub 2009 Jul 1.


Elevated levels of PtdIns5P in NPM-ALK transformed cells: implication of PIKfyve.

Coronas S, Lagarrigue F, Ramel D, Chicanne G, Delsol G, Payrastre B, Tronchère H.

Biochem Biophys Res Commun. 2008 Jul 25;372(2):351-5. doi: 10.1016/j.bbrc.2008.05.062. Epub 2008 May 22.


Different roles of SHIP1 according to the cell context: the example of blood platelets.

Gratacap MP, Séverin S, Chicanne G, Plantavid M, Payrastre B.

Adv Enzyme Regul. 2008;48:240-52. Epub 2007 Nov 19. Review. No abstract available.


Expression of beta-catenin by acute myeloid leukemia cells predicts enhanced clonogenic capacities and poor prognosis.

Ysebaert L, Chicanne G, Demur C, De Toni F, Prade-Houdellier N, Ruidavets JB, Mansat-De Mas V, Rigal-Huguet F, Laurent G, Payrastre B, Manenti S, Racaud-Sultan C.

Leukemia. 2006 Jul;20(7):1211-6. Epub 2006 May 11.


A crosstalk between the Wnt and the adhesion-dependent signaling pathways governs the chemosensitivity of acute myeloid leukemia.

De Toni F, Racaud-Sultan C, Chicanne G, Mas VM, Cariven C, Mesange F, Salles JP, Demur C, Allouche M, Payrastre B, Manenti S, Ysebaert L.

Oncogene. 2006 May 25;25(22):3113-22.


Antileukemic activity of rapamycin in acute myeloid leukemia.

Récher C, Beyne-Rauzy O, Demur C, Chicanne G, Dos Santos C, Mas VM, Benzaquen D, Laurent G, Huguet F, Payrastre B.

Blood. 2005 Mar 15;105(6):2527-34. Epub 2004 Nov 18.


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