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Fabrication of psoralen-loaded lipid-polymer hybrid nanoparticles and their reversal effect on drug resistance of cancer cells.

Yuan Y, Chiba P, Cai T, Callaghan R, Bai L, Cole SPC, Cai Y.

Oncol Rep. 2018 Aug;40(2):1055-1063. doi: 10.3892/or.2018.6492. Epub 2018 Jun 14.


An unsuspected role for organic cation transporter 3 in the actions of amphetamine.

Mayer FP, Schmid D, Owens WA, Gould GG, Apuschkin M, Kudlacek O, Salzer I, Boehm S, Chiba P, Williams PH, Wu HH, Gether U, Koek W, Daws LC, Sitte HH.

Neuropsychopharmacology. 2018 Nov;43(12):2408-2417. doi: 10.1038/s41386-018-0053-5. Epub 2018 Apr 6.


Dissecting the Forces that Dominate Dimerization of the Nucleotide Binding Domains of ABCB1.

Szöllősi D, Szakács G, Chiba P, Stockner T.

Biophys J. 2018 Jan 23;114(2):331-342. doi: 10.1016/j.bpj.2017.11.022.


Molecular Mechanism of Taurocholate Transport by the Bile Salt Export Pump, an ABC Transporter Associated with Intrahepatic Cholestasis.

Sohail MI, Schmid D, Wlcek K, Spork M, Szakács G, Trauner M, Stockner T, Chiba P.

Mol Pharmacol. 2017 Oct;92(4):401-413. doi: 10.1124/mol.117.108688. Epub 2017 Aug 7.


Folding correction of ABC-transporter ABCB1 by pharmacological chaperones: a mechanistic concept.

Spork M, Sohail MI, Schmid D, Ecker GF, Freissmuth M, Chiba P, Stockner T.

Pharmacol Res Perspect. 2017 May 26;5(3):e00325. doi: 10.1002/prp2.325. eCollection 2017 Jun.


Metabolic preconditioning protects BSEP/ABCB11-/- mice against cholestatic liver injury.

Fuchs CD, Paumgartner G, Wahlström A, Schwabl P, Reiberger T, Leditznig N, Stojakovic T, Rohr-Udilova N, Chiba P, Marschall HU, Trauner M.

J Hepatol. 2017 Jan;66(1):95-101. doi: 10.1016/j.jhep.2016.08.017. Epub 2016 Sep 1.


Nanoparticle delivery of anticancer drugs overcomes multidrug resistance in breast cancer.

Yuan Y, Cai T, Xia X, Zhang R, Chiba P, Cai Y.

Drug Deliv. 2016 Nov;23(9):3350-3357. Epub 2016 May 29. Review.


Subtle Structural Differences Trigger Inhibitory Activity of Propafenone Analogues at the Two Polyspecific ABC Transporters: P-Glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP).

Schwarz T, Montanari F, Cseke A, Wlcek K, Visvader L, Palme S, Chiba P, Kuchler K, Urban E, Ecker GF.

ChemMedChem. 2016 Jun 20;11(12):1380-94. doi: 10.1002/cmdc.201500592. Epub 2016 Mar 10.


Flagging Drugs That Inhibit the Bile Salt Export Pump.

Montanari F, Pinto M, Khunweeraphong N, Wlcek K, Sohail MI, Noeske T, Boyer S, Chiba P, Stieger B, Kuchler K, Ecker GF.

Mol Pharm. 2016 Jan 4;13(1):163-71. doi: 10.1021/acs.molpharmaceut.5b00594. Epub 2015 Dec 21.


Pharmacological correction of misfolding of ABC proteins.

Rudashevskaya EL, Stockner T, Trauner M, Freissmuth M, Chiba P.

Drug Discov Today Technol. 2014 Jun;12:e87-94. doi: 10.1016/j.ddtec.2014.03.009. Review.


The Q loops of the human multidrug resistance transporter ABCB1 are necessary to couple drug binding to the ATP catalytic cycle.

Zolnerciks JK, Akkaya BG, Snippe M, Chiba P, Seelig A, Linton KJ.

FASEB J. 2014 Oct;28(10):4335-46. doi: 10.1096/fj.13-245639. Epub 2014 Jul 11.


Synthesis, biological evaluation and 3D-QSAR studies of new chalcone derivatives as inhibitors of human P-glycoprotein.

Parveen Z, Brunhofer G, Jabeen I, Erker T, Chiba P, Ecker GF.

Bioorg Med Chem. 2014 Apr 1;22(7):2311-9. doi: 10.1016/j.bmc.2014.02.005. Epub 2014 Feb 15.


Pore-exposed tyrosine residues of P-glycoprotein are important hydrogen-bonding partners for drugs.

Dönmez Cakil Y, Khunweeraphong N, Parveen Z, Schmid D, Artaker M, Ecker GF, Sitte HH, Pusch O, Stockner T, Chiba P.

Mol Pharmacol. 2014 Mar;85(3):420-8. doi: 10.1124/mol.113.088526. Epub 2013 Dec 23.


Clinical application of transcriptional activators of bile salt transporters.

Baghdasaryan A, Chiba P, Trauner M.

Mol Aspects Med. 2014 Jun;37:57-76. doi: 10.1016/j.mam.2013.12.001. Epub 2013 Dec 12. Review.


Defining the blanks--pharmacochaperoning of SLC6 transporters and ABC transporters.

Chiba P, Freissmuth M, Stockner T.

Pharmacol Res. 2014 May;83:63-73. doi: 10.1016/j.phrs.2013.11.009. Epub 2013 Dec 6. Review.


Simvastatin-induced compartmentalisation of doxorubicin sharpens up nuclear topoisomerase II inhibition in human rhabdomyosarcoma cells.

Werner M, Atil B, Sieczkowski E, Chiba P, Hohenegger M.

Naunyn Schmiedebergs Arch Pharmacol. 2013 Jul;386(7):605-17. doi: 10.1007/s00210-013-0859-y. Epub 2013 Apr 7.


2D- and 3D-QSAR studies of a series of benzopyranes and benzopyrano[3,4b][1,4]-oxazines as inhibitors of the multidrug transporter P-glycoprotein.

Jabeen I, Wetwitayaklung P, Chiba P, Pastor M, Ecker GF.

J Comput Aided Mol Des. 2013 Feb;27(2):161-71. doi: 10.1007/s10822-013-9635-9. Epub 2013 Feb 12.


Interaction of HM30181 with P-glycoprotein at the murine blood-brain barrier assessed with positron emission tomography.

Bauer F, Wanek T, Mairinger S, Stanek J, Sauberer M, Kuntner C, Parveen Z, Chiba P, Müller M, Langer O, Erker T.

Eur J Pharmacol. 2012 Dec 5;696(1-3):18-27. doi: 10.1016/j.ejphar.2012.09.013. Epub 2012 Sep 26.


Synthesis and preclinical evaluation of the radiolabeled P-glycoprotein inhibitor [(11)C]MC113.

Mairinger S, Wanek T, Kuntner C, Doenmez Y, Strommer S, Stanek J, Capparelli E, Chiba P, Müller M, Colabufo NA, Langer O.

Nucl Med Biol. 2012 Nov;39(8):1219-25. doi: 10.1016/j.nucmedbio.2012.08.005. Epub 2012 Sep 13.


Structure-activity relationships, ligand efficiency, and lipophilic efficiency profiles of benzophenone-type inhibitors of the multidrug transporter P-glycoprotein.

Jabeen I, Pleban K, Rinner U, Chiba P, Ecker GF.

J Med Chem. 2012 Apr 12;55(7):3261-73. doi: 10.1021/jm201705f. Epub 2012 Mar 27.


Antiplasmodial activity of flavonol quercetin and its analogues in Plasmodium falciparum: evidence from clinical isolates in Bangladesh and standardized parasite clones.

Ganesh D, Fuehrer HP, Starzengrüber P, Swoboda P, Khan WA, Reismann JA, Mueller MS, Chiba P, Noedl H.

Parasitol Res. 2012 Jun;110(6):2289-95. doi: 10.1007/s00436-011-2763-z. Epub 2012 Jan 4.


Glibenclamide reduces proinflammatory cytokines in an ex vivo model of human endotoxinaemia under hypoxaemic conditions.

Schmid D, Svoboda M, Sorgner A, Moravcevic I, Thalhammer T, Chiba P, Möslinger T.

Life Sci. 2011 Nov 7;89(19-20):725-34. doi: 10.1016/j.lfs.2011.08.017. Epub 2011 Sep 10.


Synthesis, structures and anti-malaria activity of some gold(I) phosphine complexes containing seleno- and thiosemicarbazonato ligands.

Molter A, Rust J, Lehmann CW, Deepa G, Chiba P, Mohr F.

Dalton Trans. 2011 Oct 14;40(38):9810-20. doi: 10.1039/c1dt10885a. Epub 2011 Aug 30.


An abundant, truncated human sulfonylurea receptor 1 splice variant has prodiabetic properties and impairs sulfonylurea action.

Schmid D, Stolzlechner M, Sorgner A, Bentele C, Assinger A, Chiba P, Moeslinger T.

Cell Mol Life Sci. 2012 Jan;69(1):129-48. doi: 10.1007/s00018-011-0739-x. Epub 2011 Jun 14.


Exhaustive sampling of docking poses reveals binding hypotheses for propafenone type inhibitors of P-glycoprotein.

Klepsch F, Chiba P, Ecker GF.

PLoS Comput Biol. 2011 May;7(5):e1002036. doi: 10.1371/journal.pcbi.1002036. Epub 2011 May 12.


Radiosynthesis and in vivo evaluation of 1-[18F]fluoroelacridar as a positron emission tomography tracer for P-glycoprotein and breast cancer resistance protein.

Dörner B, Kuntner C, Bankstahl JP, Wanek T, Bankstahl M, Stanek J, Müllauer J, Bauer F, Mairinger S, Löscher W, Miller DW, Chiba P, Müller M, Erker T, Langer O.

Bioorg Med Chem. 2011 Apr 1;19(7):2190-8. doi: 10.1016/j.bmc.2011.02.039. Epub 2011 Feb 26.


Molecular dissection of dual pseudosymmetric solute translocation pathways in human P-glycoprotein.

Parveen Z, Stockner T, Bentele C, Pferschy S, Kraupp M, Freissmuth M, Ecker GF, Chiba P.

Mol Pharmacol. 2011 Mar;79(3):443-52. doi: 10.1124/mol.110.067611. Epub 2010 Dec 21.


Probing the stereoselectivity of P-glycoprotein-synthesis, biological activity and ligand docking studies of a set of enantiopure benzopyrano[3,4-b][1,4]oxazines.

Jabeen I, Wetwitayaklung P, Klepsch F, Parveen Z, Chiba P, Ecker GF.

Chem Commun (Camb). 2011 Mar 7;47(9):2586-8. doi: 10.1039/c0cc03075a. Epub 2010 Dec 21.


Using structural and mechanistic information to design novel inhibitors/substrates of P-glycoprotein.

Klepsch F, Stockner T, Erker T, Müller M, Chiba P, Ecker GF.

Curr Top Med Chem. 2010;10(17):1769-74. Review.


Concentration-dependent effects and intracellular accumulation of HIV protease inhibitors in cultured CD4 T cells and primary human lymphocytes.

Janneh O, Bray PG, Jones E, Wyen C, Chiba P, Back DJ, Khoo SH.

J Antimicrob Chemother. 2010 May;65(5):906-16. doi: 10.1093/jac/dkq082. Epub 2010 Mar 17.


Pharmacoinformatic approaches to design natural product type ligands of ABC-transporters.

Klepsch F, Jabeen I, Chiba P, Ecker GF.

Curr Pharm Des. 2010 May;16(15):1742-52. Review.


The SYBR Green I malaria drug sensitivity assay: performance in low parasitemia samples.

Vossen MG, Pferschy S, Chiba P, Noedl H.

Am J Trop Med Hyg. 2010 Mar;82(3):398-401. doi: 10.4269/ajtmh.2010.09-0417.


Synthesis and biological studies of some gold(I) complexes containing functionalised alkynes.

Schuh E, Valiahdi SM, Jakupec MA, Keppler BK, Chiba P, Mohr F.

Dalton Trans. 2009 Dec 28;(48):10841-5. doi: 10.1039/b911234k. Epub 2009 Oct 8.


Aqueous extracts of Cimicifuga racemosa and phenolcarboxylic constituents inhibit production of proinflammatory cytokines in LPS-stimulated human whole blood.

Schmid D, Woehs F, Svoboda M, Thalhammer T, Chiba P, Moeslinger T.

Can J Physiol Pharmacol. 2009 Nov;87(11):963-72. doi: 10.1139/y09-091.


Pinacidil-primed ATP-sensitive potassium channels mediate feedback control of mechanical power output in isolated myocardium of rats and guinea pigs.

Schmid D, Staudacher DL, Plass CA, Loew HG, Fritz E, Steurer G, Chiba P, Moeslinger T.

Eur J Pharmacol. 2010 Feb 25;628(1-3):116-27. doi: 10.1016/j.ejphar.2009.11.013. Epub 2009 Nov 17.


P-glycoprotein, multidrug resistance-associated proteins and human organic anion transporting polypeptide influence the intracellular accumulation of atazanavir.

Janneh O, Anwar T, Jungbauer C, Kopp S, Khoo SH, Back DJ, Chiba P.

Antivir Ther. 2009;14(7):965-74. doi: 10.3851/IMP1399.


A pilot study to assess the efficacy of tariquidar to inhibit P-glycoprotein at the human blood-brain barrier with (R)-11C-verapamil and PET.

Wagner CC, Bauer M, Karch R, Feurstein T, Kopp S, Chiba P, Kletter K, Löscher W, Müller M, Zeitlinger M, Langer O.

J Nucl Med. 2009 Dec;50(12):1954-61. doi: 10.2967/jnumed.109.063289. Epub 2009 Nov 12.


Antimalarial and antitrypanosomal activity of a series of amide and sulfonamide derivatives of a 2,5-diaminobenzophenone.

Altenkämper M, Bechem B, Perruchon J, Heinrich S, Mädel A, Ortmann R, Dahse HM, Freunscht E, Wang Y, Rath J, Stich A, Hitzler M, Chiba P, Lanzer M, Schlitzer M.

Bioorg Med Chem. 2009 Nov 15;17(22):7690-7. doi: 10.1016/j.bmc.2009.09.043. Epub 2009 Sep 25.


Interactions between ABC-transport proteins and the secondary Fusarium metabolites enniatin and beauvericin.

Dornetshuber R, Heffeter P, Sulyok M, Schumacher R, Chiba P, Kopp S, Koellensperger G, Micksche M, Lemmens-Gruber R, Berger W.

Mol Nutr Food Res. 2009 Jul;53(7):904-20. doi: 10.1002/mnfr.200800384.


Data-driven homology modelling of P-glycoprotein in the ATP-bound state indicates flexibility of the transmembrane domains.

Stockner T, de Vries SJ, Bonvin AM, Ecker GF, Chiba P.

FEBS J. 2009 Feb;276(4):964-72. doi: 10.1111/j.1742-4658.2008.06832.x.


Computational models for prediction of interactions with ABC-transporters.

Ecker GF, Stockner T, Chiba P.

Drug Discov Today. 2008 Apr;13(7-8):311-7. doi: 10.1016/j.drudis.2007.12.012. Epub 2008 Mar 14. Review.


Multispecificity of drug transporters: probing inhibitor selectivity for the human drug efflux transporters ABCB1 and ABCG2.

Cramer J, Kopp S, Bates SE, Chiba P, Ecker GF.

ChemMedChem. 2007 Dec;2(12):1783-8.


Catalytic cycle of ATP hydrolysis by P-glycoprotein: evidence for formation of the E.S reaction intermediate with ATP-gamma-S, a nonhydrolyzable analogue of ATP.

Sauna ZE, Kim IW, Nandigama K, Kopp S, Chiba P, Ambudkar SV.

Biochemistry. 2007 Dec 4;46(48):13787-99. Epub 2007 Nov 8.


Future directions for drug transporter modelling.

Ekins S, Ecker GF, Chiba P, Swaan PW.

Xenobiotica. 2007 Oct-Nov;37(10-11):1152-70. Review.


Attachment of VLDL receptors to an icosahedral virus along the 5-fold symmetry axis: multiple binding modes evidenced by fluorescence correlation spectroscopy.

Wruss J, Rünzler D, Steiger C, Chiba P, Köhler G, Blaas D.

Biochemistry. 2007 May 29;46(21):6331-9. Epub 2007 May 2.


Multidrug-resistant cancer cells are preferential targets of the new antineoplastic lanthanum compound KP772 (FFC24).

Heffeter P, Jakupec MA, Körner W, Chiba P, Pirker C, Dornetshuber R, Elbling L, Sutterlüty H, Micksche M, Keppler BK, Berger W.

Biochem Pharmacol. 2007 Jun 15;73(12):1873-86. Epub 2007 Mar 12.


Self-organizing maps for identification of new inhibitors of P-glycoprotein.

Kaiser D, Terfloth L, Kopp S, Schulz J, de Laet R, Chiba P, Ecker GF, Gasteiger J.

J Med Chem. 2007 Apr 5;50(7):1698-702. Epub 2007 Mar 13.


Characterization of a novel class of antimalarials and its applicability to plasmodial target identification.

Tasanor O, Ernst M, Thriemer K, Ecker GF, Noedl H, Chiba P.

Wien Klin Wochenschr. 2007;119(19-20 Suppl 3):83-7. Erratum in: Wien Klin Wochenschr. 2009 Oct;121 Suppl 3:following 56.


Interaction field based and hologram based QSAR analysis of propafenone-type modulators of multidrug resistance.

Kaiser D, Smiesko M, Kopp S, Chiba P, Ecker GF.

Med Chem. 2005 Sep;1(5):431-44.


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