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Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma.

Hu K, Li K, Lv J, Feng J, Chen J, Wu H, Cheng F, Jiang W, Wang J, Pei H, Chiao PJ, Cai Z, Chen Y, Liu M, Pang X.

J Clin Invest. 2019 Dec 24. pii: 124049. doi: 10.1172/JCI124049. [Epub ahead of print]


Modulation of Redox Homeostasis by Inhibition of MTHFD2 in Colorectal Cancer: Mechanisms and Therapeutic Implications.

Ju HQ, Lu YX, Chen DL, Zuo ZX, Liu ZX, Wu QN, Mo HY, Wang ZX, Wang DS, Pu HY, Zeng ZL, Li B, Xie D, Huang P, Hung MC, Chiao PJ, Xu RH.

J Natl Cancer Inst. 2018 Dec 8. doi: 10.1093/jnci/djy160. [Epub ahead of print]


Amyloid beta-positive subjects exhibit longitudinal network-specific reductions in spontaneous brain activity.

Avants BB, Hutchison RM, Mikulskis A, Salinas-Valenzuela C, Hargreaves R, Beaver J, Chiao P; Alzheimer's Disease Neuroimaging Initiative.

Neurobiol Aging. 2019 Feb;74:191-201. doi: 10.1016/j.neurobiolaging.2018.10.002. Epub 2018 Oct 11.


Suppression of stromal-derived Dickkopf-3 (DKK3) inhibits tumor progression and prolongs survival in pancreatic ductal adenocarcinoma.

Zhou L, Husted H, Moore T, Lu M, Deng D, Liu Y, Ramachandran V, Arumugam T, Niehrs C, Wang H, Chiao P, Ling J, Curran MA, Maitra A, Hung MC, Lee JE, Logsdon CD, Hwang RF.

Sci Transl Med. 2018 Oct 24;10(464). pii: eaat3487. doi: 10.1126/scitranslmed.aat3487.


Identification of cisplatin sensitizers through high-throughput combinatorial screening.

Sun Y, Jiang W, Lu W, Song M, Liu K, Chen P, Chang A, Ling J, Chiao PJ, Hu Y, Huang P.

Int J Oncol. 2018 Sep;53(3):1237-1246. doi: 10.3892/ijo.2018.4447. Epub 2018 Jun 19.


Impact of Reference and Target Region Selection on Amyloid PET SUV Ratios in the Phase 1b PRIME Study of Aducanumab.

Chiao P, Bedell BJ, Avants B, Zijdenbos AP, Grand'Maison M, O'Neill P, O'Gorman J, Chen T, Koeppe R.

J Nucl Med. 2019 Jan;60(1):100-106. doi: 10.2967/jnumed.118.209130. Epub 2018 May 18.


Noninvasive PK11195-PET Image Analysis Techniques Can Detect Abnormal Cerebral Microglial Activation in Parkinson's Disease.

Kang Y, Mozley PD, Verma A, Schlyer D, Henchcliffe C, Gauthier SA, Chiao PC, He B, Nikolopoulou A, Logan J, Sullivan JM, Pryor KO, Hesterman J, Kothari PJ, Vallabhajosula S.

J Neuroimaging. 2018 Sep;28(5):496-505. doi: 10.1111/jon.12519. Epub 2018 May 4.


The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1.

Zhang B, Fu D, Xu Q, Cong X, Wu C, Zhong X, Ma Y, Lv Z, Chen F, Han L, Qian M, Chin YE, Lam EW, Chiao P, Sun Y.

Nat Commun. 2018 Apr 30;9(1):1723. doi: 10.1038/s41467-018-04010-4.


Immune Cell Production of Interleukin 17 Induces Stem Cell Features of Pancreatic Intraepithelial Neoplasia Cells.

Zhang Y, Zoltan M, Riquelme E, Xu H, Sahin I, Castro-Pando S, Montiel MF, Chang K, Jiang Z, Ling J, Gupta S, Horne W, Pruski M, Wang H, Sun SC, Lozano G, Chiao P, Maitra A, Leach SD, Kolls JK, Vilar E, Wang TC, Bailey JM, McAllister F.

Gastroenterology. 2018 Jul;155(1):210-223.e3. doi: 10.1053/j.gastro.2018.03.041. Epub 2018 Mar 29.


EGFR-Induced and PKCε Monoubiquitylation-Dependent NF-κB Activation Upregulates PKM2 Expression and Promotes Tumorigenesis.

Yang W, Xia Y, Cao Y, Zheng Y, Bu W, Zhang L, You MJ, Koh MY, Cote G, Aldape K, Li Y, Verma IM, Chiao PJ, Lu Z.

Mol Cell. 2018 Jan 18;69(2):347. doi: 10.1016/j.molcel.2017.12.034. No abstract available.


Long non-coding RNA UICLM promotes colorectal cancer liver metastasis by acting as a ceRNA for microRNA-215 to regulate ZEB2 expression.

Chen DL, Lu YX, Zhang JX, Wei XL, Wang F, Zeng ZL, Pan ZZ, Yuan YF, Wang FH, Pelicano H, Chiao PJ, Huang P, Xie D, Li YH, Ju HQ, Xu RH.

Theranostics. 2017 Oct 17;7(19):4836-4849. doi: 10.7150/thno.20942. eCollection 2017.


Clinical Development of Aducanumab, an Anti-Aβ Human Monoclonal Antibody Being Investigated for the Treatment of Early Alzheimer's Disease.

Budd Haeberlein S, O'Gorman J, Chiao P, Bussière T, von Rosenstiel P, Tian Y, Zhu Y, von Hehn C, Gheuens S, Skordos L, Chen T, Sandrock A.

J Prev Alzheimers Dis. 2017;4(4):255-263. doi: 10.14283/jpad.2017.39.


TAK-ing aim at chemoresistance: The emerging role of MAP3K7 as a target for cancer therapy.

Santoro R, Carbone C, Piro G, Chiao PJ, Melisi D.

Drug Resist Updat. 2017 Nov;33-35:36-42. doi: 10.1016/j.drup.2017.10.004. Epub 2017 Nov 3.


Concordance Between Different Amyloid Immunoassays and Visual Amyloid Positron Emission Tomographic Assessment.

Janelidze S, Pannee J, Mikulskis A, Chiao P, Zetterberg H, Blennow K, Hansson O.

JAMA Neurol. 2017 Dec 1;74(12):1492-1501. doi: 10.1001/jamaneurol.2017.2814.


SOX9 activity is induced by oncogenic Kras to affect MDC1 and MCMs expression in pancreatic cancer.

Zhou H, Qin Y, Ji S, Ling J, Fu J, Zhuang Z, Fan X, Song L, Yu X, Chiao PJ.

Oncogene. 2018 Feb 15;37(7):912-923. doi: 10.1038/onc.2017.393. Epub 2017 Oct 23.


NEMO peptide inhibits the growth of pancreatic ductal adenocarcinoma by blocking NF-κB activation.

Zhuang Z, Li H, Lee H, Aguilar M, Gocho T, Ju H, Iida T, Ling J, Fu J, Wu M, Sun Y, Lu Y, Chiao PJ.

Cancer Lett. 2017 Dec 28;411:44-56. doi: 10.1016/j.canlet.2017.09.018. Epub 2017 Sep 23.


Addendum: The antibody aducanumab reduces Aβ plaques in Alzheimer's disease.

Sevigny J, Chiao P, Bussière T, Weinreb PH, Williams L, Maier M, Dunstan R, Salloway S, Chen T, Ling Y, O'Gorman J, Qian F, Arastu M, Li M, Chollate S, Brennan MS, Quintero-Monzon O, Scannevin RH, Arnold HM, Engber T, Rhodes K, Ferrero J, Hang Y, Mikulskis A, Grimm J, Hock C, Nitsch RM, Sandrock A.

Nature. 2017 Jun 21;546(7659):564. doi: 10.1038/nature22809.


Inhibition of Pancreatic Cancer by RhIL1RA-Response.

Chiao PJ, Ling J, Fu J, Lu Y, Sun YC.

Clin Cancer Res. 2017 Jun 15;23(12):3224. doi: 10.1158/1078-0432.CCR-17-0083. No abstract available.


Implementation of a pragmatic randomized trial of screening for chronic kidney disease to improve care among non-diabetic hypertensive veterans.

Peralta CA, Frigaard M, Rubinsky AD, Rolon L, Lo L, Voora S, Seal K, Tuot D, Chao S, Lui K, Chiao P, Powe N, Shlipak M.

BMC Nephrol. 2017 Apr 12;18(1):132. doi: 10.1186/s12882-017-0541-6.


A New Comprehensive Short-form Health Literacy Survey Tool for Patients in General.

Duong TV, Chang PW, Yang SH, Chen MC, Chao WT, Chen T, Chiao P, Huang HL.

Asian Nurs Res (Korean Soc Nurs Sci). 2017 Mar;11(1):30-35. doi: 10.1016/j.anr.2017.02.001. Epub 2017 Feb 11.


Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma.

Ju HQ, Ying H, Tian T, Ling J, Fu J, Lu Y, Wu M, Yang L, Achreja A, Chen G, Zhuang Z, Wang H, Nagrath D, Yao J, Hung MC, DePinho RA, Huang P, Xu RH, Chiao PJ.

Nat Commun. 2017 Feb 24;8:14437. doi: 10.1038/ncomms14437.


IGFBP2 Activates the NF-κB Pathway to Drive Epithelial-Mesenchymal Transition and Invasive Character in Pancreatic Ductal Adenocarcinoma.

Gao S, Sun Y, Zhang X, Hu L, Liu Y, Chua CY, Phillips LM, Ren H, Fleming JB, Wang H, Chiao PJ, Hao J, Zhang W.

Cancer Res. 2016 Nov 15;76(22):6543-6554. doi: 10.1158/0008-5472.CAN-16-0438. Epub 2016 Sep 22.


The antibody aducanumab reduces Aβ plaques in Alzheimer's disease.

Sevigny J, Chiao P, Bussière T, Weinreb PH, Williams L, Maier M, Dunstan R, Salloway S, Chen T, Ling Y, O'Gorman J, Qian F, Arastu M, Li M, Chollate S, Brennan MS, Quintero-Monzon O, Scannevin RH, Arnold HM, Engber T, Rhodes K, Ferrero J, Hang Y, Mikulskis A, Grimm J, Hock C, Nitsch RM, Sandrock A.

Nature. 2016 Sep 1;537(7618):50-6. doi: 10.1038/nature19323. Update in: Nature. 2017 Jun 21;546(7659):564.


Regulation of the Nampt-mediated NAD salvage pathway and its therapeutic implications in pancreatic cancer.

Ju HQ, Zhuang ZN, Li H, Tian T, Lu YX, Fan XQ, Zhou HJ, Mo HY, Sheng H, Chiao PJ, Xu RH.

Cancer Lett. 2016 Aug 28;379(1):1-11. doi: 10.1016/j.canlet.2016.05.024. Epub 2016 May 24.


Transforming Growth Factor-β Limits Secretion of Lumican by Activated Stellate Cells within Primary Pancreatic Adenocarcinoma Tumors.

Kang Y, Roife D, Lee Y, Lv H, Suzuki R, Ling J, Rios Perez MV, Li X, Dai B, Pratt M, Truty MJ, Chatterjee D, Wang H, Thomas RM, Wang Y, Koay EJ, Chiao PJ, Katz MH, Fleming JB.

Clin Cancer Res. 2016 Oct 1;22(19):4934-4946. Epub 2016 Apr 28.


FBW7 (F-box and WD Repeat Domain-Containing 7) Negatively Regulates Glucose Metabolism by Targeting the c-Myc/TXNIP (Thioredoxin-Binding Protein) Axis in Pancreatic Cancer.

Ji S, Qin Y, Liang C, Huang R, Shi S, Liu J, Jin K, Liang D, Xu W, Zhang B, Liu L, Liu C, Xu J, Ni Q, Chiao PJ, Li M, Yu X.

Clin Cancer Res. 2016 Aug 1;22(15):3950-60. doi: 10.1158/1078-0432.CCR-15-2380. Epub 2016 Mar 16.


Amphiregulin in Cancer: New Insights for Translational Medicine.

Xu Q, Chiao P, Sun Y.

Trends Cancer. 2016 Mar;2(3):111-113. doi: 10.1016/j.trecan.2016.02.002. Epub 2016 Mar 2.


Amyloid PET Screening for Enrichment of Early-Stage Alzheimer Disease Clinical Trials: Experience in a Phase 1b Clinical Trial.

Sevigny J, Suhy J, Chiao P, Chen T, Klein G, Purcell D, Oh J, Verma A, Sampat M, Barakos J.

Alzheimer Dis Assoc Disord. 2016 Jan-Mar;30(1):1-7. doi: 10.1097/WAD.0000000000000144.


MicroRNA Signaling Pathway Network in Pancreatic Ductal Adenocarcinoma.

Sun L, Chua CYX, Tian W, Zhang Z, Chiao PJ, Zhang W.

J Genet Genomics. 2015 Oct 20;42(10):563-577. doi: 10.1016/j.jgg.2015.07.003. Epub 2015 Aug 6. Review.


IL1 Receptor Antagonist Inhibits Pancreatic Cancer Growth by Abrogating NF-κB Activation.

Zhuang Z, Ju HQ, Aguilar M, Gocho T, Li H, Iida T, Lee H, Fan X, Zhou H, Ling J, Li Z, Fu J, Wu M, Li M, Melisi D, Iwakura Y, Xu K, Fleming JB, Chiao PJ.

Clin Cancer Res. 2016 Mar 15;22(6):1432-44. doi: 10.1158/1078-0432.CCR-14-3382. Epub 2015 Oct 23. Erratum in: Clin Cancer Res. 2017 Feb 1;23 (3):868.


Melatonin overcomes gemcitabine resistance in pancreatic ductal adenocarcinoma by abrogating nuclear factor-κB activation.

Ju HQ, Li H, Tian T, Lu YX, Bai L, Chen LZ, Sheng H, Mo HY, Zeng JB, Deng W, Chiao PJ, Xu RH.

J Pineal Res. 2016 Jan;60(1):27-38. doi: 10.1111/jpi.12285. Epub 2015 Oct 17.


Towards the identification of multi-parametric quantitative MRI biomarkers in lupus nephritis.

Rapacchi S, Smith RX, Wang Y, Yan L, Sigalov V, Krasileva KE, Karpouzas G, Plotnik A, Sayre J, Hernandez E, Verma A, Burkly L, Wisniacki N, Torrington J, He X, Hu P, Chiao PC, Wang DJJ.

Magn Reson Imaging. 2015 Nov;33(9):1066-1074. doi: 10.1016/j.mri.2015.06.019. Epub 2015 Jun 25.


Micro-RNA-155 is induced by K-Ras oncogenic signal and promotes ROS stress in pancreatic cancer.

Wang P, Zhu CF, Ma MZ, Chen G, Song M, Zeng ZL, Lu WH, Yang J, Wen S, Chiao PJ, Hu Y, Huang P.

Oncotarget. 2015 Aug 28;6(25):21148-58.


Optimizing Central Nervous System Drug Development Using Molecular Imaging.

Hargreaves RJ, Hoppin J, Sevigny J, Patel S, Chiao P, Klimas M, Verma A.

Clin Pharmacol Ther. 2015 Jul;98(1):47-60. doi: 10.1002/cpt.132. Epub 2015 May 19. Review.


ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer.

Ji S, Qin Y, Shi S, Liu X, Hu H, Zhou H, Gao J, Zhang B, Xu W, Liu J, Liang D, Liu L, Liu C, Long J, Zhou H, Chiao PJ, Xu J, Ni Q, Gao D, Yu X.

Cell Res. 2015 May;25(5):561-73. doi: 10.1038/cr.2015.30. Epub 2015 Mar 10.


Mechanisms of Overcoming Intrinsic Resistance to Gemcitabine in Pancreatic Ductal Adenocarcinoma through the Redox Modulation.

Ju HQ, Gocho T, Aguilar M, Wu M, Zhuang ZN, Fu J, Yanaga K, Huang P, Chiao PJ.

Mol Cancer Ther. 2015 Mar;14(3):788-98. doi: 10.1158/1535-7163.MCT-14-0420. Epub 2014 Dec 19.


The influence of biological and technical factors on quantitative analysis of amyloid PET: Points to consider and recommendations for controlling variability in longitudinal data.

Schmidt ME, Chiao P, Klein G, Matthews D, Thurfjell L, Cole PE, Margolin R, Landau S, Foster NL, Mason NS, De Santi S, Suhy J, Koeppe RA, Jagust W; Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement. 2015 Sep;11(9):1050-68. doi: 10.1016/j.jalz.2014.09.004. Epub 2014 Nov 24. Review.


An angiopoietin-like protein 2 autocrine signaling promotes EMT during pancreatic ductal carcinogenesis.

Carbone C, Piro G, Fassan M, Tamburrino A, Mina MM, Zanotto M, Chiao PJ, Bassi C, Scarpa A, Tortora G, Melisi D.

Oncotarget. 2015 May 30;6(15):13822-34.


SMAD4 regulates cell motility through transcription of N-cadherin in human pancreatic ductal epithelium.

Kang Y, Ling J, Suzuki R, Roife D, Chopin-Laly X, Truty MJ, Chatterjee D, Wang H, Thomas RM, Katz MH, Chiao PJ, Fleming JB.

PLoS One. 2014 Sep 29;9(9):e107948. doi: 10.1371/journal.pone.0107948. eCollection 2014.


Cooperativity of oncogenic K-ras and downregulated p16/INK4A in human pancreatic tumorigenesis.

Chang Z, Ju H, Ling J, Zhuang Z, Li Z, Wang H, Fleming JB, Freeman JW, Yu D, Huang P, Chiao PJ.

PLoS One. 2014 Jul 16;9(7):e101452. doi: 10.1371/journal.pone.0101452. eCollection 2014.


Activation of the transcription factor c-Maf in T cells is dependent on the CARMA1-IKKβ signaling cascade.

Blonska M, Joo D, Nurieva RI, Zhao X, Chiao P, Sun SC, Dong C, Lin X.

Sci Signal. 2013 Dec 17;6(306):ra110. doi: 10.1126/scisignal.2004273.


Oncogenic K-Ras and loss of Smad4 mediate invasion by activating an EGFR/NF-κB Axis that induces expression of MMP9 and uPA in human pancreas progenitor cells.

Bera A, Zhao S, Cao L, Chiao PJ, Freeman JW.

PLoS One. 2013 Dec 5;8(12):e82282. doi: 10.1371/journal.pone.0082282. eCollection 2013.


A novel epigenetic CREB-miR-373 axis mediates ZIP4-induced pancreatic cancer growth.

Zhang Y, Yang J, Cui X, Chen Y, Zhu VF, Hagan JP, Wang H, Yu X, Hodges SE, Fang J, Chiao PJ, Logsdon CD, Fisher WE, Brunicardi FC, Chen C, Yao Q, Fernandez-Zapico ME, Li M.

EMBO Mol Med. 2013 Sep;5(9):1322-34. doi: 10.1002/emmm.201302507. Epub 2013 Jul 16.


Deciphering the mechanisms of tumorigenesis in human pancreatic ductal epithelial cells.

Chang Z, Li Z, Wang X, Kang Y, Yuan Y, Niu J, Wang H, Chatterjee D, Fleming JB, Li M, Abbruzzese JL, Chiao PJ.

Clin Cancer Res. 2013 Feb 1;19(3):549-59. doi: 10.1158/1078-0432.CCR-12-0032. Epub 2013 Jan 22.


Desensitization of NFκB for overcoming chemoresistance of pancreatic cancer cells to TNF-α or paclitaxel.

Fujioka S, Son K, Onda S, Schmidt C, Scrabas GM, Okamoto T, Fujita T, Chiao PJ, Yanaga K.

Anticancer Res. 2012 Nov;32(11):4813-21.


Study human pancreatic cancer in mice: how close are they?

Zhang Y, Chen L, Yang J, Fleming JB, Chiao PJ, Logsdon CD, Li M.

Biochim Biophys Acta. 2013 Jan;1835(1):110-8. doi: 10.1016/j.bbcan.2012.11.001. Epub 2012 Nov 9. Review.


EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis.

Yang W, Xia Y, Cao Y, Zheng Y, Bu W, Zhang L, You MJ, Koh MY, Cote G, Aldape K, Li Y, Verma IM, Chiao PJ, Lu Z.

Mol Cell. 2012 Dec 14;48(5):771-84. doi: 10.1016/j.molcel.2012.09.028. Epub 2012 Nov 1. Erratum in: Mol Cell. 2018 Jan 18;69(2):347.


Kras, Pten, NF-κB, and inflammation: dangerous liaisons.

Chiao PJ, Ling J.

Cancer Discov. 2011 Jul;1(2):103-5. doi: 10.1158/2159-8290.CD-11-0115.

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