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Items: 1 to 50 of 73

1.

A community-based lung cancer rapid tissue donation protocol provides high-quality drug-resistant specimens for proteogenomic analyses.

Boyle TA, Quinn GP, Schabath MB, Muñoz-Antonia T, Saller JJ, Duarte LF, Hair LS, Teer JK, Chiang DY, Leary R, Wong CC, Savchenko A, Singh AP, Charette L, Mendell K, Gorgun G, Antonia SJ, Chiappori AA, Creelan BC, Gray JE, Haura EB.

Cancer Med. 2020 Jan;9(1):225-237. doi: 10.1002/cam4.2670. Epub 2019 Nov 20.

2.

LITAF (Lipopolysaccharide-Induced Tumor Necrosis Factor) Regulates Cardiac L-Type Calcium Channels by Modulating NEDD (Neural Precursor Cell Expressed Developmentally Downregulated Protein) 4-1 Ubiquitin Ligase.

Moshal KS, Roder K, Kabakov AY, Werdich AA, Chiang DY, Turan NN, Xie A, Kim TY, Cooper LL, Lu Y, Zhong M, Li W, Terentyev D, Choi BR, Karma A, MacRae CA, Koren G.

Circ Genom Precis Med. 2019 Sep;12(9):407-420. doi: 10.1161/CIRCGEN.119.002641. Epub 2019 Aug 28.

PMID:
31462068
3.

Loss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes Atrial Fibrillation.

Alsina KM, Hulsurkar M, Brandenburg S, Kownatzki-Danger D, Lenz C, Urlaub H, Abu-Taha I, Kamler M, Chiang DY, Lahiri SK, Reynolds JO, Quick AP, Scott L Jr, Word TA, Gelves MD, Heck AJR, Li N, Dobrev D, Lehnart SE, Wehrens XHT.

Circulation. 2019 Aug 20;140(8):681-693. doi: 10.1161/CIRCULATIONAHA.119.039642. Epub 2019 Jun 12.

PMID:
31185731
4.

Elucidating therapeutic molecular targets in premenopausal Asian women with recurrent breast cancers.

Yap YS, Singh AP, Lim JHC, Ahn JH, Jung KH, Kim J, Dent RA, Ng RCH, Kim SB, Chiang DY.

NPJ Breast Cancer. 2018 Jul 26;4:19. doi: 10.1038/s41523-018-0070-x. eCollection 2018.

5.

Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression.

Chiang DY, Alsina KM, Corradini E, Fitzpatrick M, Ni L, Lahiri SK, Reynolds JO, Pan X, Scott L Jr, Heck AJR, Wehrens XHT.

Circulation. 2018 Oct 9;138(15):1569-1581. doi: 10.1161/CIRCULATIONAHA.118.034361.

6.

Oxidized CaMKII (Ca2+/Calmodulin-Dependent Protein Kinase II) Is Essential for Ventricular Arrhythmia in a Mouse Model of Duchenne Muscular Dystrophy.

Wang Q, Quick AP, Cao S, Reynolds J, Chiang DY, Beavers D, Li N, Wang G, Rodney GG, Anderson ME, Wehrens XHT.

Circ Arrhythm Electrophysiol. 2018 Apr;11(4):e005682. doi: 10.1161/CIRCEP.117.005682.

7.

Wounds That Would Not Heal: Pyoderma Gangrenosum.

Pinard J, Chiang DY, Mostaghimi A, Granter SR, Merola JF, Barkoudah E.

Am J Med. 2018 Apr;131(4):377-379. doi: 10.1016/j.amjmed.2017.12.009. Epub 2017 Dec 25. No abstract available.

PMID:
29284112
8.

Genomic Analysis of Nasopharyngeal Carcinoma Reveals TME-Based Subtypes.

Zhang L, MacIsaac KD, Zhou T, Huang PY, Xin C, Dobson JR, Yu K, Chiang DY, Fan Y, Pelletier M, Wang Y, Jaeger S, Krishnamurthy Radhakrishnan V, JeBailey L, Skewes-Cox P, Zhang J, Fang W, Huang Y, Zhao H, Zhao Y, Li E, Peng B, Huang A, Dranoff G, Hammerman PS, Engelman J, Bitter H, Zeng YX, Yao Y.

Mol Cancer Res. 2017 Dec;15(12):1722-1732. doi: 10.1158/1541-7786.MCR-17-0134. Epub 2017 Aug 29.

9.

Progress towards molecular patient stratification of hepatocellular carcinoma: Lost in translation?

Chiang DY, Villanueva A.

J Hepatol. 2017 Nov;67(5):893-895. doi: 10.1016/j.jhep.2017.07.031. Epub 2017 Aug 31. No abstract available.

PMID:
28837834
10.

PureCN: copy number calling and SNV classification using targeted short read sequencing.

Riester M, Singh AP, Brannon AR, Yu K, Campbell CD, Chiang DY, Morrissey MP.

Source Code Biol Med. 2016 Dec 15;11:13. doi: 10.1186/s13029-016-0060-z. eCollection 2016.

11.

SPEG (Striated Muscle Preferentially Expressed Protein Kinase) Is Essential for Cardiac Function by Regulating Junctional Membrane Complex Activity.

Quick AP, Wang Q, Philippen LE, Barreto-Torres G, Chiang DY, Beavers D, Wang G, Khalid M, Reynolds JO, Campbell HM, Showell J, McCauley MD, Scholten A, Wehrens XH.

Circ Res. 2017 Jan 6;120(1):110-119. doi: 10.1161/CIRCRESAHA.116.309977. Epub 2016 Oct 11.

12.

Regulating the regulator: Insights into the cardiac protein phosphatase 1 interactome.

Chiang DY, Heck AJ, Dobrev D, Wehrens XH.

J Mol Cell Cardiol. 2016 Dec;101:165-172. doi: 10.1016/j.yjmcc.2016.09.009. Epub 2016 Sep 20. Review.

13.

Integrative biomarker analyses indicate etiological variations in hepatocellular carcinoma.

Zhu AX, Chen D, He W, Kanai M, Voi M, Chen LT, Daniele B, Furuse J, Kang YK, Poon RT, Vogel A, Chiang DY.

J Hepatol. 2016 Aug;65(2):296-304. doi: 10.1016/j.jhep.2016.04.015. Epub 2016 Apr 27.

PMID:
27130844
14.

Relation of Cardiac Dysfunction to Rhythm Abnormalities in Patients With Duchenne or Becker Muscular Dystrophies.

Chiang DY, Allen HD, Kim JJ, Valdes SO, Wang Y, Pignatelli RH, Lotze TE, Miyake CY.

Am J Cardiol. 2016 Apr 15;117(8):1349-54. doi: 10.1016/j.amjcard.2016.01.031. Epub 2016 Jan 28.

PMID:
26952271
15.

High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response.

Gao H, Korn JM, Ferretti S, Monahan JE, Wang Y, Singh M, Zhang C, Schnell C, Yang G, Zhang Y, Balbin OA, Barbe S, Cai H, Casey F, Chatterjee S, Chiang DY, Chuai S, Cogan SM, Collins SD, Dammassa E, Ebel N, Embry M, Green J, Kauffmann A, Kowal C, Leary RJ, Lehar J, Liang Y, Loo A, Lorenzana E, Robert McDonald E 3rd, McLaughlin ME, Merkin J, Meyer R, Naylor TL, Patawaran M, Reddy A, Röelli C, Ruddy DA, Salangsang F, Santacroce F, Singh AP, Tang Y, Tinetto W, Tobler S, Velazquez R, Venkatesan K, Von Arx F, Wang HQ, Wang Z, Wiesmann M, Wyss D, Xu F, Bitter H, Atadja P, Lees E, Hofmann F, Li E, Keen N, Cozens R, Jensen MR, Pryer NK, Williams JA, Sellers WR.

Nat Med. 2015 Nov;21(11):1318-25. doi: 10.1038/nm.3954. Epub 2015 Oct 19.

PMID:
26479923
16.

Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation.

Glasscock E, Voigt N, McCauley MD, Sun Q, Li N, Chiang DY, Zhou XB, Molina CE, Thomas D, Schmidt C, Skapura DG, Noebels JL, Dobrev D, Wehrens XH.

Basic Res Cardiol. 2015 Sep;110(5):505. doi: 10.1007/s00395-015-0505-6. Epub 2015 Jul 11.

17.

Loss-of-Function SCN5A Mutations Associated With Sinus Node Dysfunction, Atrial Arrhythmias, and Poor Pacemaker Capture.

Chiang DY, Kim JJ, Valdes SO, de la Uz C, Fan Y, Orcutt J, Domino M, Smith M, Wehrens XH, Miyake CY.

Circ Arrhythm Electrophysiol. 2015 Oct;8(5):1105-12. doi: 10.1161/CIRCEP.115.003098. Epub 2015 Jun 25.

18.

Studying clonal dynamics in response to cancer therapy using high-complexity barcoding.

Bhang HE, Ruddy DA, Krishnamurthy Radhakrishna V, Caushi JX, Zhao R, Hims MM, Singh AP, Kao I, Rakiec D, Shaw P, Balak M, Raza A, Ackley E, Keen N, Schlabach MR, Palmer M, Leary RJ, Chiang DY, Sellers WR, Michor F, Cooke VG, Korn JM, Stegmeier F.

Nat Med. 2015 May;21(5):440-8. doi: 10.1038/nm.3841. Epub 2015 Apr 13.

PMID:
25849130
19.

Von Hippel-Lindau status influences phenotype of liver cancers arising from PTEN loss.

Sendor AB, Hacker KE, Chen S, Corona AL, Sen O, Chiang DY, Snavely A, Rogers AB, Montgomery SA, Rathmell WK, McRee AJ.

Gastrointest Cancer. 2015 Feb 1;5:61-71.

20.

Promoted decomposition of NOx in automotive diesel-like exhausts by electro-catalytic honeycombs.

Huang TJ, Chiang DY, Shih C, Lee CC, Mao CW, Wang BC.

Environ Sci Technol. 2015 Mar 17;49(6):3711-7. doi: 10.1021/acs.est.5b00226. Epub 2015 Mar 4.

PMID:
25719390
21.

Identification of microRNA-mRNA dysregulations in paroxysmal atrial fibrillation.

Chiang DY, Zhang M, Voigt N, Alsina KM, Jakob H, Martin JF, Dobrev D, Wehrens XH, Li N.

Int J Cardiol. 2015 Apr 1;184:190-7. doi: 10.1016/j.ijcard.2015.01.075. Epub 2015 Jan 28.

22.

Alterations in the interactome of serine/threonine protein phosphatase type-1 in atrial fibrillation patients.

Chiang DY, Lebesgue N, Beavers DL, Alsina KM, Damen JM, Voigt N, Dobrev D, Wehrens XH, Scholten A.

J Am Coll Cardiol. 2015 Jan 20;65(2):163-73. doi: 10.1016/j.jacc.2014.10.042.

23.

Loss of microRNA-106b-25 cluster promotes atrial fibrillation by enhancing ryanodine receptor type-2 expression and calcium release.

Chiang DY, Kongchan N, Beavers DL, Alsina KM, Voigt N, Neilson JR, Jakob H, Martin JF, Dobrev D, Wehrens XH, Li N.

Circ Arrhythm Electrophysiol. 2014 Dec;7(6):1214-22. doi: 10.1161/CIRCEP.114.001973. Epub 2014 Nov 11.

24.

Genetic deletion of Rnd3/RhoE results in mouse heart calcium leakage through upregulation of protein kinase A signaling.

Yang X, Wang T, Lin X, Yue X, Wang Q, Wang G, Fu Q, Ai X, Chiang DY, Miyake CY, Wehrens XHT, Chang J.

Circ Res. 2015 Jan 2;116(1):e1-e10. doi: 10.1161/CIRCRESAHA.116.304940. Epub 2014 Oct 27.

25.

Emerging roles of junctophilin-2 in the heart and implications for cardiac diseases.

Beavers DL, Landstrom AP, Chiang DY, Wehrens XH.

Cardiovasc Res. 2014 Jul 15;103(2):198-205. doi: 10.1093/cvr/cvu151. Epub 2014 Jun 15. Review.

26.

Impaired local regulation of ryanodine receptor type 2 by protein phosphatase 1 promotes atrial fibrillation.

Chiang DY, Li N, Wang Q, Alsina KM, Quick AP, Reynolds JO, Wang G, Skapura D, Voigt N, Dobrev D, Wehrens XH.

Cardiovasc Res. 2014 Jul 1;103(1):178-87. doi: 10.1093/cvr/cvu123. Epub 2014 May 8.

27.

Targeted next generation sequencing identifies clinically actionable mutations in patients with melanoma.

Jeck WR, Parker J, Carson CC, Shields JM, Sambade MJ, Peters EC, Burd CE, Thomas NE, Chiang DY, Liu W, Eberhard DA, Ollila D, Grilley-Olson J, Moschos S, Neil Hayes D, Sharpless NE.

Pigment Cell Melanoma Res. 2014 Jul;27(4):653-63. doi: 10.1111/pcmr.12238. Epub 2014 Apr 7.

28.

Mutations of isocitrate dehydrogenase 1 and 2 in intrahepatic cholangiocarcinoma.

Grassian AR, Pagliarini R, Chiang DY.

Curr Opin Gastroenterol. 2014 May;30(3):295-302. doi: 10.1097/MOG.0000000000000050. Review.

PMID:
24569570
29.

Ryanodine receptor-mediated calcium leak drives progressive development of an atrial fibrillation substrate in a transgenic mouse model.

Li N, Chiang DY, Wang S, Wang Q, Sun L, Voigt N, Respress JL, Ather S, Skapura DG, Jordan VK, Horrigan FT, Schmitz W, Müller FU, Valderrabano M, Nattel S, Dobrev D, Wehrens XHT.

Circulation. 2014 Mar 25;129(12):1276-1285. doi: 10.1161/CIRCULATIONAHA.113.006611. Epub 2014 Jan 7.

30.

A coregulatory network of NR2F1 and microRNA-140.

Chiang DY, Cuthbertson DW, Ruiz FR, Li N, Pereira FA.

PLoS One. 2013 Dec 3;8(12):e83358. doi: 10.1371/journal.pone.0083358. eCollection 2013.

31.

Cellular and molecular mechanisms of atrial arrhythmogenesis in patients with paroxysmal atrial fibrillation.

Voigt N, Heijman J, Wang Q, Chiang DY, Li N, Karck M, Wehrens XHT, Nattel S, Dobrev D.

Circulation. 2014 Jan 14;129(2):145-156. doi: 10.1161/CIRCULATIONAHA.113.006641. Epub 2013 Nov 18.

32.

Identification of driver genes in hepatocellular carcinoma by exome sequencing.

Cleary SP, Jeck WR, Zhao X, Chen K, Selitsky SR, Savich GL, Tan TX, Wu MC, Getz G, Lawrence MS, Parker JS, Li J, Powers S, Kim H, Fischer S, Guindi M, Ghanekar A, Chiang DY.

Hepatology. 2013 Nov;58(5):1693-702. doi: 10.1002/hep.26540. Epub 2013 Sep 24.

33.

Junctophilin-2 is necessary for T-tubule maturation during mouse heart development.

Reynolds JO, Chiang DY, Wang W, Beavers DL, Dixit SS, Skapura DG, Landstrom AP, Song LS, Ackerman MJ, Wehrens XH.

Cardiovasc Res. 2013 Oct 1;100(1):44-53. doi: 10.1093/cvr/cvt133. Epub 2013 May 27.

34.

Chronic exercise: a contributing factor to atrial fibrillation?

Wehrens XH, Chiang DY, Li N.

J Am Coll Cardiol. 2013 Jul 2;62(1):78-80. doi: 10.1016/j.jacc.2013.02.070. Epub 2013 Apr 9. No abstract available.

35.

Effects of CaMKII-mediated phosphorylation of ryanodine receptor type 2 on islet calcium handling, insulin secretion, and glucose tolerance.

Dixit SS, Wang T, Manzano EJ, Yoo S, Lee J, Chiang DY, Ryan N, Respress JL, Yechoor VK, Wehrens XH.

PLoS One. 2013;8(3):e58655. doi: 10.1371/journal.pone.0058655. Epub 2013 Mar 13.

36.

A robust method for transcript quantification with RNA-seq data.

Huang Y, Hu Y, Jones CD, MacLeod JN, Chiang DY, Liu Y, Prins JF, Liu J.

J Comput Biol. 2013 Mar;20(3):167-87. doi: 10.1089/cmb.2012.0230.

37.

iReckon: simultaneous isoform discovery and abundance estimation from RNA-seq data.

Mezlini AM, Smith EJ, Fiume M, Buske O, Savich GL, Shah S, Aparicio S, Chiang DY, Goldenberg A, Brudno M.

Genome Res. 2013 Mar;23(3):519-29. doi: 10.1101/gr.142232.112. Epub 2012 Nov 29.

38.

DiffSplice: the genome-wide detection of differential splicing events with RNA-seq.

Hu Y, Huang Y, Du Y, Orellana CF, Singh D, Johnson AR, Monroy A, Kuan PF, Hammond SM, Makowski L, Randell SH, Chiang DY, Hayes DN, Jones C, Liu Y, Prins JF, Liu J.

Nucleic Acids Res. 2013 Jan;41(2):e39. doi: 10.1093/nar/gks1026. Epub 2012 Nov 15.

39.

Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas.

Wang P, Dong Q, Zhang C, Kuan PF, Liu Y, Jeck WR, Andersen JB, Jiang W, Savich GL, Tan TX, Auman JT, Hoskins JM, Misher AD, Moser CD, Yourstone SM, Kim JW, Cibulskis K, Getz G, Hunt HV, Thorgeirsson SS, Roberts LR, Ye D, Guan KL, Xiong Y, Qin LX, Chiang DY.

Oncogene. 2013 Jun 20;32(25):3091-100. doi: 10.1038/onc.2012.315. Epub 2012 Jul 23.

40.

Crystallization mechanisms of phase change (GeSbSn)(100-x)Co(x) optical recording films.

Ou SL, Kuo PC, Ma SH, Shen CL, Tsai TL, Chen SC, Chiang DY, Lee CT.

J Nanosci Nanotechnol. 2011 Dec;11(12):11138-41.

PMID:
22409072
41.

Microstructure and crystallization kinetics analysis of the (In15Sb85)(100-x)Zn(x) phase change recording thin films.

Ou SL, Kuo PC, Sheu SC, Shen CL, Tsai TL, Chen SC, Chiang DY.

J Nanosci Nanotechnol. 2011 Dec;11(12):10922-5.

PMID:
22409026
42.

Integrating prior knowledge in multiple testing under dependence with applications to detecting differential DNA methylation.

Kuan PF, Chiang DY.

Biometrics. 2012 Sep;68(3):774-83. doi: 10.1111/j.1541-0420.2011.01730.x. Epub 2012 Jan 19.

43.

Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion.

Bass AJ, Lawrence MS, Brace LE, Ramos AH, Drier Y, Cibulskis K, Sougnez C, Voet D, Saksena G, Sivachenko A, Jing R, Parkin M, Pugh T, Verhaak RG, Stransky N, Boutin AT, Barretina J, Solit DB, Vakiani E, Shao W, Mishina Y, Warmuth M, Jimenez J, Chiang DY, Signoretti S, Kaelin WG Jr, Spardy N, Hahn WC, Hoshida Y, Ogino S, DePinho RA, Chin L, Garraway LA, Fuchs CS, Baselga J, Tabernero J, Gabriel S, Lander ES, Getz G, Meyerson M.

Nat Genet. 2011 Sep 4;43(10):964-968. doi: 10.1038/ng.936.

44.

FDM: a graph-based statistical method to detect differential transcription using RNA-seq data.

Singh D, Orellana CF, Hu Y, Jones CD, Liu Y, Chiang DY, Liu J, Prins JF.

Bioinformatics. 2011 Oct 1;27(19):2633-40. doi: 10.1093/bioinformatics/btr458. Epub 2011 Aug 8.

45.

Nuclear factor I/B is an oncogene in small cell lung cancer.

Dooley AL, Winslow MM, Chiang DY, Banerji S, Stransky N, Dayton TL, Snyder EL, Senna S, Whittaker CA, Bronson RT, Crowley D, Barretina J, Garraway L, Meyerson M, Jacks T.

Genes Dev. 2011 Jul 15;25(14):1470-5. doi: 10.1101/gad.2046711.

46.

Suppression of lung adenocarcinoma progression by Nkx2-1.

Winslow MM, Dayton TL, Verhaak RG, Kim-Kiselak C, Snyder EL, Feldser DM, Hubbard DD, DuPage MJ, Whittaker CA, Hoersch S, Yoon S, Crowley D, Bronson RT, Chiang DY, Meyerson M, Jacks T.

Nature. 2011 May 5;473(7345):101-4. doi: 10.1038/nature09881. Epub 2011 Apr 6.

47.

MicroRNA-based classification of hepatocellular carcinoma and oncogenic role of miR-517a.

Toffanin S, Hoshida Y, Lachenmayer A, Villanueva A, Cabellos L, Minguez B, Savic R, Ward SC, Thung S, Chiang DY, Alsinet C, Tovar V, Roayaie S, Schwartz M, Bruix J, Waxman S, Friedman SL, Golub T, Mazzaferro V, Llovet JM.

Gastroenterology. 2011 May;140(5):1618-28.e16. doi: 10.1053/j.gastro.2011.02.009. Epub 2011 Feb 13.

48.

MapSplice: accurate mapping of RNA-seq reads for splice junction discovery.

Wang K, Singh D, Zeng Z, Coleman SJ, Huang Y, Savich GL, He X, Mieczkowski P, Grimm SA, Perou CM, MacLeod JN, Chiang DY, Prins JF, Liu J.

Nucleic Acids Res. 2010 Oct;38(18):e178. doi: 10.1093/nar/gkq622. Epub 2010 Aug 27.

49.

Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy.

Barretina J, Taylor BS, Banerji S, Ramos AH, Lagos-Quintana M, Decarolis PL, Shah K, Socci ND, Weir BA, Ho A, Chiang DY, Reva B, Mermel CH, Getz G, Antipin Y, Beroukhim R, Major JE, Hatton C, Nicoletti R, Hanna M, Sharpe T, Fennell TJ, Cibulskis K, Onofrio RC, Saito T, Shukla N, Lau C, Nelander S, Silver SJ, Sougnez C, Viale A, Winckler W, Maki RG, Garraway LA, Lash A, Greulich H, Root DE, Sellers WR, Schwartz GK, Antonescu CR, Lander ES, Varmus HE, Ladanyi M, Sander C, Meyerson M, Singer S.

Nat Genet. 2010 Aug;42(8):715-21. doi: 10.1038/ng.619. Epub 2010 Jul 4.

50.

A probabilistic framework for aligning paired-end RNA-seq data.

Hu Y, Wang K, He X, Chiang DY, Prins JF, Liu J.

Bioinformatics. 2010 Aug 15;26(16):1950-7. doi: 10.1093/bioinformatics/btq336. Epub 2010 Jun 23.

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