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Knockout of the Hmt1p arginine methyltransferase in Saccharomyces cerevisiae leads to the dysregulation of phosphate-associated genes and processes.

Chia SZ, Lai YW, Yagoub D, Lev S, Hamey JJ, Pang CNI, Desmarini D, Chen Z, Djordjevic JT, Erce MA, Hart-Smith G, Wilkins MR.

Mol Cell Proteomics. 2018 Sep 11. pii: mcp.RA117.000214. doi: 10.1074/mcp.RA117.000214. [Epub ahead of print]


Turning cold tumours hot: oncolytic virotherapy gets up close and personal with other therapeutics at the 11th Oncolytic Virus Conference.

Dyer A, Baugh R, Chia SL, Frost S, Iris, Jacobus EJ, Khalique H, Pokrovska TD, Scott EM, Taverner WK, Seymour LW, Lei J.

Cancer Gene Ther. 2018 Sep 4. doi: 10.1038/s41417-018-0042-1. [Epub ahead of print]


Near-White Light Emission from Lead(II) Metal-Organic Frameworks.

Peedikakkal AMP, Quah HS, Chia S, Jalilov AS, Shaikh AR, Al-Mohsin HA, Yadava K, Ji W, Vittal JJ.

Inorg Chem. 2018 Sep 17;57(18):11341-11348. doi: 10.1021/acs.inorgchem.8b00637. Epub 2018 Aug 29.


Asymmetrical meta-methoxylated diarylpentanoids: Rational design, synthesis and anti-cancer evaluation in-vitro.

Leong SW, Chia SL, Abas F, Yusoff K.

Eur J Med Chem. 2018 Aug 16;157:716-728. doi: 10.1016/j.ejmech.2018.08.039. [Epub ahead of print]


Dose-Dependent Increase in Unconjugated Cinnamic Acid Concentration in Plasma Following Acute Consumption of Polyphenol Rich Curry in the Polyspice Study.

Haldar S, Lee SH, Tan JJ, Chia SC, Henry CJ, Chan ECY.

Nutrients. 2018 Jul 20;10(7). pii: E934. doi: 10.3390/nu10070934.


Food waste compost as an organic nutrient source for the cultivation of Chlorella vulgaris.

Chew KW, Chia SR, Show PL, Ling TC, Arya SS, Chang JS.

Bioresour Technol. 2018 Nov;267:356-362. doi: 10.1016/j.biortech.2018.07.069. Epub 2018 Jul 20.


Understanding adjuvant endocrine therapy persistence in breast Cancer survivors.

Lambert LK, Balneaves LG, Howard AF, Chia SK, Gotay CC.

BMC Cancer. 2018 Jul 11;18(1):732. doi: 10.1186/s12885-018-4644-7.


Reducing protein oxidation reverses lung fibrosis.

Anathy V, Lahue KG, Chapman DG, Chia SB, Casey DT, Aboushousha R, van der Velden JLJ, Elko E, Hoffman SM, McMillan DH, Jones JT, Nolin JD, Abdalla S, Schneider R, Seward DJ, Roberson EC, Liptak MD, Cousins ME, Butnor KJ, Taatjes DJ, Budd RC, Irvin CG, Ho YS, Hakem R, Brown KK, Matsui R, Bachschmid MM, Gomez JL, Kaminski N, van der Vliet A, Janssen-Heininger YMW.

Nat Med. 2018 Aug;24(8):1128-1135. doi: 10.1038/s41591-018-0090-y. Epub 2018 Jul 9.


Stabilization and Characterization of Cytotoxic Aβ40 Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions.

Mannini B, Habchi J, Chia S, Ruggeri FS, Perni M, Knowles TPJ, Dobson CM, Vendruscolo M.

ACS Chem Neurosci. 2018 Aug 10. doi: 10.1021/acschemneuro.8b00141. [Epub ahead of print]


Cost Effectiveness of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Management of Colorectal Peritoneal Carcinomatosis.

Lee ZJ, Chia SL, Tan G, Soo KC, Teo CCM.

Ann Surg Oncol. 2018 Aug;25(8):2340-2346. doi: 10.1245/s10434-018-6508-4. Epub 2018 Jun 8.


Hormone receptor-positive, HER2-negative metastatic breast cancer: redrawing the lines.

Matutino A, Joy AA, Brezden-Masley C, Chia S, Verma S.

Curr Oncol. 2018 Jun;25(Suppl 1):S131-S141. doi: 10.3747/co.25.4000. Epub 2018 Jun 13. Review.


Clinical application and utility of genomic assays in early-stage breast cancer: key lessons learned to date.

Chia SKL.

Curr Oncol. 2018 Jun;25(Suppl 1):S125-S130. doi: 10.3747/co.25.3814. Epub 2018 Jun 13. Review.


Phase III Randomized Study of Ribociclib and Fulvestrant in Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer: MONALEESA-3.

Slamon DJ, Neven P, Chia S, Fasching PA, De Laurentiis M, Im SA, Petrakova K, Bianchi GV, Esteva FJ, Martín M, Nusch A, Sonke GS, De la Cruz-Merino L, Beck JT, Pivot X, Vidam G, Wang Y, Rodriguez Lorenc K, Miller M, Taran T, Jerusalem G.

J Clin Oncol. 2018 Aug 20;36(24):2465-2472. doi: 10.1200/JCO.2018.78.9909. Epub 2018 Jun 3.


Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes.

Habchi J, Chia S, Galvagnion C, Michaels TCT, Bellaiche MMJ, Ruggeri FS, Sanguanini M, Idini I, Kumita JR, Sparr E, Linse S, Dobson CM, Knowles TPJ, Vendruscolo M.

Nat Chem. 2018 Jun;10(6):673-683. doi: 10.1038/s41557-018-0031-x. Epub 2018 May 7.


Pathway level alterations rather than mutations in single genes predict response to HER2-targeted therapies in the neo-ALTTO trial.

Shi W, Jiang T, Nuciforo P, Hatzis C, Holmes E, Harbeck N, Sotiriou C, Peña L, Loi S, Rosa DD, Chia S, Wardley A, Ueno T, Rossari J, Eidtmann H, Armour A, Piccart-Gebhart M, Rimm DL, Baselga J, Pusztai L.

Ann Oncol. 2018 Apr 26. doi: 10.1093/annonc/mdx805. [Epub ahead of print] No abstract available.


The influence of obesity on functional outcome and quality of life after total knee arthroplasty.

Xu S, Chen JY, Lo NN, Chia SL, Tay DKJ, Pang HN, Hao Y, Yeo SJ.

Bone Joint J. 2018 May 1;100-B(5):579-583. doi: 10.1302/0301-620X.100B5.BJJ-2017-1263.R1.


Sustainable approach in phlorotannin recovery from macroalgae.

Chia SR, Show PL, Phang SM, Ling TC, Ong HC.

J Biosci Bioeng. 2018 Aug;126(2):220-225. doi: 10.1016/j.jbiosc.2018.02.015. Epub 2018 Apr 16.


Newcastle disease virus strain AF2240 as an oncolytic virus: A review.

Kalyanasundram J, Hamid A, Yusoff K, Chia SL.

Acta Trop. 2018 Jul;183:126-133. doi: 10.1016/j.actatropica.2018.04.007. Epub 2018 Apr 4. Review.


De novo reconstruction of human adipose transcriptome reveals conserved lncRNAs as regulators of brown adipogenesis.

Ding C, Lim YC, Chia SY, Walet ACE, Xu S, Lo KA, Zhao Y, Zhu D, Shan Z, Chen Q, Leow MK, Xu D, Sun L.

Nat Commun. 2018 Apr 6;9(1):1329. doi: 10.1038/s41467-018-03754-3.


Effects of Two Doses of Curry Prepared with Mixed Spices on Postprandial Ghrelin and Subjective Appetite Responses-A Randomized Controlled Crossover Trial.

Haldar S, Lim J, Chia SC, Ponnalagu S, Henry CJ.

Foods. 2018 Mar 26;7(4). pii: E47. doi: 10.3390/foods7040047.


Upper Airway Stimulation for Obstructive Sleep Apnea: Results from the ADHERE Registry.

Boon M, Huntley C, Steffen A, Maurer JT, Sommer JU, Schwab R, Thaler E, Soose R, Chou C, Strollo P, Kezirian EJ, Chia S, Withrow K, Weidenbecher M, Strohl K, Doghramji K, Hofauer B, Heiser C; ADHERE Registry Investigators.

Otolaryngol Head Neck Surg. 2018 Aug;159(2):379-385. doi: 10.1177/0194599818764896. Epub 2018 Mar 20.


Oral water soluble contrast for malignant bowel obstruction.

Syrmis W, Richard R, Jenkins-Marsh S, Chia SC, Good P.

Cochrane Database Syst Rev. 2018 Mar 7;3:CD012014. doi: 10.1002/14651858.CD012014.pub2. Review.


Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation.

Michaels TCT, Šarić A, Habchi J, Chia S, Meisl G, Vendruscolo M, Dobson CM, Knowles TPJ.

Annu Rev Phys Chem. 2018 Apr 20;69:273-298. doi: 10.1146/annurev-physchem-050317-021322. Epub 2018 Feb 28. Review.


Comparison of hepatic and serum lipid signatures in hepatocellular carcinoma patients leads to the discovery of diagnostic and prognostic biomarkers.

Lu Y, Chen J, Huang C, Li N, Zou L, Chia SE, Chen S, Yu K, Ling Q, Cheng Q, Zhu M, Zhang W, Chen M, Ong CN.

Oncotarget. 2017 Dec 13;9(4):5032-5043. doi: 10.18632/oncotarget.23494. eCollection 2018 Jan 12.


Patient preferences for types of community-based cardiac rehabilitation programme.

Chia S, Wong XY, Toon ML, Seah Y, Yap AF, Lim C, Tay HY, Fong W, Low LL, Kwan YH.

Heart Asia. 2018 Jan 26;10(1):e010976. doi: 10.1136/heartasia-2017-010976. eCollection 2018.


Comparison of the outcome measures from different pathways post total knee arthroplasty.

Chan HY, Sultana R, Yeo SJ, Chia SL, Pang HN, Lo NN.

Singapore Med J. 2018 Jan 26. doi: 10.11622/smedj.2018011. [Epub ahead of print]


Analysis of Economic and Environmental Aspects of Microalgae Biorefinery for Biofuels Production: A Review.

Chia SR, Chew KW, Show PL, Yap YJ, Ong HC, Ling TC, Chang JS.

Biotechnol J. 2018 Jun;13(6):e1700618. doi: 10.1002/biot.201700618. Epub 2018 Feb 9.


Polyphenol-rich curry made with mixed spices and vegetables increases postprandial plasma GLP-1 concentration in a dose-dependent manner.

Haldar S, Chia SC, Henry CJ.

Eur J Clin Nutr. 2018 Feb;72(2):297-300. doi: 10.1038/s41430-017-0069-7. Epub 2017 Dec 28.


Tailoring the mechanical and biodegradable properties of binary blends of biomedical thermoplastic elastomer.

Ang HY, Chan J, Toong D, Venkatraman SS, Chia SJ, Huang YY.

J Mech Behav Biomed Mater. 2018 Mar;79:64-72. doi: 10.1016/j.jmbbm.2017.12.013. Epub 2017 Dec 15.


Homologous Recombination Deficiency and Platinum-Based Therapy Outcomes in Advanced Breast Cancer.

Zhao EY, Shen Y, Pleasance E, Kasaian K, Leelakumari S, Jones M, Bose P, Ch'ng C, Reisle C, Eirew P, Corbett R, Mungall KL, Thiessen N, Ma Y, Schein JE, Mungall AJ, Zhao Y, Moore RA, Den Brok W, Wilson S, Villa D, Shenkier T, Lohrisch C, Chia S, Yip S, Gelmon K, Lim H, Renouf D, Sun S, Schrader KA, Young S, Bosdet I, Karsan A, Laskin J, Marra MA, Jones SJM.

Clin Cancer Res. 2017 Dec 15;23(24):7521-7530. doi: 10.1158/1078-0432.CCR-17-1941.


Polyphenol-rich curry made with mixed spices and vegetables benefits glucose homeostasis in Chinese males (Polyspice Study): a dose-response randomized controlled crossover trial.

Haldar S, Chia SC, Lee SH, Lim J, Leow MK, Chan ECY, Henry CJ.

Eur J Nutr. 2017 Dec 13. doi: 10.1007/s00394-017-1594-9. [Epub ahead of print]


Long-term efficacy analysis of the randomised, phase II TRYPHAENA cardiac safety study: Evaluating pertuzumab and trastuzumab plus standard neoadjuvant anthracycline-containing and anthracycline-free chemotherapy regimens in patients with HER2-positive early breast cancer.

Schneeweiss A, Chia S, Hickish T, Harvey V, Eniu A, Waldron-Lynch M, Eng-Wong J, Kirk S, Cortés J.

Eur J Cancer. 2018 Jan;89:27-35. doi: 10.1016/j.ejca.2017.10.021. Epub 2017 Dec 8.


Predictors of Midterm Outcomes after Medial Unicompartmental Knee Arthroplasty in Asians.

Bin Abd Razak HR, Acharyya S, Tan SM, Pang HN, Tay KD, Chia SL, Lo NN, Yeo SJ.

Clin Orthop Surg. 2017 Dec;9(4):432-438. doi: 10.4055/cios.2017.9.4.432. Epub 2017 Nov 10.


Change in Body Mass Index After Total Knee Arthroplasty and Its Influence on Functional Outcome.

Chen JY, Xu S, Pang HN, Tay DKJ, Chia SL, Lo NN, Yeo SJ.

J Arthroplasty. 2018 Mar;33(3):718-722. doi: 10.1016/j.arth.2017.10.046. Epub 2017 Oct 31.


Factors affecting compliance with confirmatory colonoscopy after a positive fecal immunochemical test in a national colorectal screening program.

Cheng SY, Li MC, Chia SL, Huang KC, Chiu TY, Chan DC, Chiu HM.

Cancer. 2018 Mar 1;124(5):907-915. doi: 10.1002/cncr.31145. Epub 2017 Nov 22.


Age and ejection fraction modify the impact of atrial fibrillation on acute heart failure outcomes.

Go YY, Sugimoto T, Bulluck H, Acharyya S, Allen JC, Chia SY, Jaufeerally FR, Sim D, Lim TK, Liew R, Lam CSP.

Eur J Heart Fail. 2018 Apr;20(4):821-822. doi: 10.1002/ejhf.1075. Epub 2017 Nov 16. No abstract available.


Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial.

Martin M, Holmes FA, Ejlertsen B, Delaloge S, Moy B, Iwata H, von Minckwitz G, Chia SKL, Mansi J, Barrios CH, Gnant M, Tomašević Z, Denduluri N, Šeparović R, Gokmen E, Bashford A, Ruiz Borrego M, Kim SB, Jakobsen EH, Ciceniene A, Inoue K, Overkamp F, Heijns JB, Armstrong AC, Link JS, Joy AA, Bryce R, Wong A, Moran S, Yao B, Xu F, Auerbach A, Buyse M, Chan A; ExteNET Study Group.

Lancet Oncol. 2017 Dec;18(12):1688-1700. doi: 10.1016/S1470-2045(17)30717-9. Epub 2017 Nov 13.


IL-1/inhibitory κB kinase ε-induced glycolysis augment epithelial effector function and promote allergic airways disease.

Qian X, Aboushousha R, van de Wetering C, Chia SB, Amiel E, Schneider RW, van der Velden JLJ, Lahue KG, Hoagland DA, Casey DT, Daphtary N, Ather JL, Randall MJ, Aliyeva M, Black KE, Chapman DG, Lundblad LKA, McMillan DH, Dixon AE, Anathy V, Irvin CG, Poynter ME, Wouters EFM, Vacek PM, Henket M, Schleich F, Louis R, van der Vliet A, Janssen-Heininger YMW.

J Allergy Clin Immunol. 2018 Aug;142(2):435-450.e10. doi: 10.1016/j.jaci.2017.08.043. Epub 2017 Nov 3.


Management of penile cancer in a Singapore tertiary hospital.

Tan TW, Chia SJ, Chong KT.

Arab J Urol. 2017 Mar 30;15(2):123-130. doi: 10.1016/j.aju.2017.03.001. eCollection 2017 Jun.


LAG-3+ tumor infiltrating lymphocytes in breast cancer: clinical correlates and association with PD-1/PD-L1+ tumors.

Burugu S, Gao D, Leung S, Chia SK, Nielsen TO.

Ann Oncol. 2017 Dec 1;28(12):2977-2984. doi: 10.1093/annonc/mdx557.


Postoperative fixed flexion deformity greater than 10° lead to poorer functional outcome 10 years after unicompartmental knee arthroplasty.

Yeh JZY, Chen JY, Lim JW, Pang HN, Tay DKJ, Chia SL, Lo NN, Yeo SJ.

Knee Surg Sports Traumatol Arthrosc. 2018 Jun;26(6):1723-1727. doi: 10.1007/s00167-017-4749-6. Epub 2017 Oct 9.


RNA Binding Protein Ybx2 Regulates RNA Stability During Cold-Induced Brown Fat Activation.

Xu D, Xu S, Kyaw AMM, Lim YC, Chia SY, Chee Siang DT, Alvarez-Dominguez JR, Chen P, Leow MK, Sun L.

Diabetes. 2017 Dec;66(12):2987-3000. doi: 10.2337/db17-0655. Epub 2017 Sep 29.


Revision total knee arthroplasty for failed high tibial osteotomy and unicompartmental knee arthroplasty have similar patient-reported outcome measures in a two-year follow-up study.

Lim JBT, Chong HC, Pang HN, Tay KJD, Chia SL, Lo NN, Yeo SJ.

Bone Joint J. 2017 Oct;99-B(10):1329-1334. doi: 10.1302/0301-620X.99B10.BJJ-2017-0034.R1.


Successful targeting of the NRG1 pathway indicates novel treatment strategy for metastatic cancer.

Jones MR, Lim H, Shen Y, Pleasance E, Ch'ng C, Reisle C, Leelakumari S, Zhao C, Yip S, Ho J, Zhong E, Ng T, Ionescu D, Schaeffer DF, Mungall AJ, Mungall KL, Zhao Y, Moore RA, Ma Y, Chia S, Ho C, Renouf DJ, Gelmon K, Jones SJM, Marra MA, Laskin J.

Ann Oncol. 2017 Dec 1;28(12):3092-3097. doi: 10.1093/annonc/mdx523.


No Difference in Functional Outcomes after Total Knee Arthroplasty with or without Pinless Navigation.

Zhu M, Chen JY, Chong HC, Pang HN, Tay DKJ, Chia SL, Lo NN, Yeo SJ.

J Knee Surg. 2018 Aug;31(7):649-653. doi: 10.1055/s-0037-1606375. Epub 2017 Sep 8.


Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time.

Chia S, Low JL, Zhang X, Kwang XL, Chong FT, Sharma A, Bertrand D, Toh SY, Leong HS, Thangavelu MT, Hwang JSG, Lim KH, Skanthakumar T, Tan HK, Su Y, Hui Choo S, Hentze H, Tan IBH, Lezhava A, Tan P, Tan DSW, Periyasamy G, Koh JLY, Gopalakrishna Iyer N, DasGupta R.

Nat Commun. 2017 Sep 5;8(1):435. doi: 10.1038/s41467-017-00451-5.


Development of a Multiplexed Assay for Oral Cancer Candidate Biomarkers Using Peptide Immunoaffinity Enrichment and Targeted Mass Spectrometry.

Hsiao YC, Chi LM, Chien KY, Chiang WF, Chen SF, Chuang YN, Lin SY, Wu CC, Chang YT, Chu LJ, Chen YT, Chia SL, Chien CY, Chang KP, Chang YS, Yu JS.

Mol Cell Proteomics. 2017 Oct;16(10):1829-1849. doi: 10.1074/mcp.RA117.000147. Epub 2017 Aug 18.


Dynamic transcriptome changes during adipose tissue energy expenditure reveal critical roles for long noncoding RNA regulators.

Bai Z, Chai XR, Yoon MJ, Kim HJ, Lo KA, Zhang ZC, Xu D, Siang DTC, Walet ACE, Xu SH, Chia SY, Chen P, Yang H, Ghosh S, Sun L.

PLoS Biol. 2017 Aug 1;15(8):e2002176. doi: 10.1371/journal.pbio.2002176. eCollection 2017 Aug.


Ectopic parathyroid adenoma in the pyriform sinus.

Kim J, Cubangbang M, Adkins L, Chia S, DeKlotz TR, Boyle L, Davidson B.

Head Neck. 2017 Oct;39(10):E110-E113. doi: 10.1002/hed.24878. Epub 2017 Jul 25.


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