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Items: 34


Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins.

Jemth P, Karlsson E, Vögeli B, Guzovsky B, Andersson E, Hultqvist G, Dogan J, Güntert P, Riek R, Chi CN.

Sci Adv. 2018 Oct 24;4(10):eaau4130. doi: 10.1126/sciadv.aau4130. eCollection 2018 Oct.


Backbone and side-chain chemical shift assignments of full-length, apo, human Pin1, a phosphoprotein regulator with interdomain allostery.

Born A, Nichols PJ, Henen MA, Chi CN, Strotz D, Bayer P, Tate SI, Peng JW, Vögeli B.

Biomol NMR Assign. 2019 Apr;13(1):85-89. doi: 10.1007/s12104-018-9857-9. Epub 2018 Oct 23.


Proteome-wide analysis of phospho-regulated PDZ domain interactions.

Sundell GN, Arnold R, Ali M, Naksukpaiboon P, Orts J, Güntert P, Chi CN, Ivarsson Y.

Mol Syst Biol. 2018 Aug 20;14(8):e8129. doi: 10.15252/msb.20178129.


NOE-Derived Methyl Distances from a 360 kDa Proteasome Complex.

Chi CN, Strotz D, Riek R, Vögeli B.

Chemistry. 2018 Feb 9;24(9):2270-2276. doi: 10.1002/chem.201705551. Epub 2018 Jan 17.


eNORA2 Exact NOE Analysis Program.

Strotz D, Orts J, Chi CN, Riek R, Vögeli B.

J Chem Theory Comput. 2017 Sep 12;13(9):4336-4346. doi: 10.1021/acs.jctc.7b00436. Epub 2017 Aug 3.


The Exact Nuclear Overhauser Enhancement: Recent Advances.

Nichols PJ, Born A, Henen MA, Strotz D, Orts J, Olsson S, Güntert P, Chi CN, Vögeli B.

Molecules. 2017 Jul 14;22(7). pii: E1176. doi: 10.3390/molecules22071176. Review.


Emergence and evolution of an interaction between intrinsically disordered proteins.

Hultqvist G, Åberg E, Camilloni C, Sundell GN, Andersson E, Dogan J, Chi CN, Vendruscolo M, Jemth P.

Elife. 2017 Apr 11;6. pii: e16059. doi: 10.7554/eLife.16059.


Solution structure of discoidal high-density lipoprotein particles with a shortened apolipoprotein A-I.

Bibow S, Polyhach Y, Eichmann C, Chi CN, Kowal J, Albiez S, McLeod RA, Stahlberg H, Jeschke G, Güntert P, Riek R.

Nat Struct Mol Biol. 2017 Feb;24(2):187-193. doi: 10.1038/nsmb.3345. Epub 2016 Dec 26.


Ligand binding to the PDZ domains of postsynaptic density protein 95.

Toto A, Pedersen SW, Karlsson OA, Moran GE, Andersson E, Chi CN, Strømgaard K, Gianni S, Jemth P.

Protein Eng Des Sel. 2016 May;29(5):169-75. doi: 10.1093/protein/gzw004. Epub 2016 Mar 2.


Enzyme Selectivity Fine-Tuned through Dynamic Control of a Loop.

Vögeli B, Bibow S, Chi CN.

Angew Chem Int Ed Engl. 2016 Feb 24;55(9):3096-100. doi: 10.1002/anie.201511476. Epub 2016 Jan 28.


A Structural Ensemble for the Enzyme Cyclophilin Reveals an Orchestrated Mode of Action at Atomic Resolution.

Chi CN, Vögeli B, Bibow S, Strotz D, Orts J, Güntert P, Riek R.

Angew Chem Int Ed Engl. 2015 Sep 28;54(40):11657-61. doi: 10.1002/anie.201503698. Epub 2015 Aug 10.


Design of a PDZbody, a bivalent binder of the E6 protein from human papillomavirus.

Karlsson OA, Ramirez J, Öberg D, Malmqvist T, Engström Å, Friberg M, Chi CN, Widersten M, Travé G, Nilsson MT, Jemth P.

Sci Rep. 2015 Mar 23;5:9382. doi: 10.1038/srep09382.


Extending the eNOE data set of large proteins by evaluation of NOEs with unresolved diagonals.

Chi CN, Strotz D, Riek R, Vögeli B.

J Biomol NMR. 2015 May;62(1):63-9. doi: 10.1007/s10858-015-9917-8. Epub 2015 Mar 8.


Contribution of specific residues of the β-solenoid fold to HET-s prion function, amyloid structure and stability.

Daskalov A, Gantner M, Wälti MA, Schmidlin T, Chi CN, Wasmer C, Schütz A, Ceschin J, Clavé C, Cescau S, Meier B, Riek R, Saupe SJ.

PLoS Pathog. 2014 Jun 12;10(6):e1004158. doi: 10.1371/journal.ppat.1004158. eCollection 2014 Jun.


Energetic pathway sampling in a protein interaction domain.

Hultqvist G, Haq SR, Punekar AS, Chi CN, Engström Å, Bach A, Strømgaard K, Selmer M, Gianni S, Jemth P.

Structure. 2013 Jul 2;21(7):1193-1202.


Tolerance of protein folding to a circular permutation in a PDZ domain.

Hultqvist G, Punekar AS, Morrone A, Chi CN, Engström A, Selmer M, Gianni S, Jemth P.

PLoS One. 2012;7(11):e50055. doi: 10.1371/journal.pone.0050055. Epub 2012 Nov 21.


Interactions outside the boundaries of the canonical binding groove of a PDZ domain influence ligand binding.

Chi CN, Haq SR, Rinaldo S, Dogan J, Cutruzzolà F, Engström Å, Gianni S, Lundström P, Jemth P.

Biochemistry. 2012 Nov 6;51(44):8971-9. doi: 10.1021/bi300792h. Epub 2012 Oct 23.


Ligand binding by PDZ domains.

Chi CN, Bach A, Strømgaard K, Gianni S, Jemth P.

Biofactors. 2012 Sep-Oct;38(5):338-48. doi: 10.1002/biof.1031. Epub 2012 Jun 7. Review.


An expanded view of the protein folding landscape of PDZ domains.

Hultqvist G, Pedersen SW, Chi CN, Strømgaard K, Gianni S, Jemth P.

Biochem Biophys Res Commun. 2012 May 11;421(3):550-3. doi: 10.1016/j.bbrc.2012.04.042. Epub 2012 Apr 13.


A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage.

Bach A, Clausen BH, Møller M, Vestergaard B, Chi CN, Round A, Sørensen PL, Nissen KB, Kastrup JS, Gajhede M, Jemth P, Kristensen AS, Lundström P, Lambertsen KL, Strømgaard K.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3317-22. doi: 10.1073/pnas.1113761109. Epub 2012 Feb 17.


The transition state of coupled folding and binding for a flexible β-finger.

Karlsson OA, Chi CN, Engström A, Jemth P.

J Mol Biol. 2012 Mar 30;417(3):253-61. doi: 10.1016/j.jmb.2012.01.042. Epub 2012 Jan 30.


Side-chain interactions form late and cooperatively in the binding reaction between disordered peptides and PDZ domains.

Haq SR, Chi CN, Bach A, Dogan J, Engström Å, Hultqvist G, Karlsson OA, Lundström P, Montemiglio LC, Strømgaard K, Gianni S, Jemth P.

J Am Chem Soc. 2012 Jan 11;134(1):599-605. doi: 10.1021/ja209341w. Epub 2011 Dec 16.


Sequence-specific long range networks in PSD-95/discs large/ZO-1 (PDZ) domains tune their binding selectivity.

Gianni S, Haq SR, Montemiglio LC, Jürgens MC, Engström Å, Chi CN, Brunori M, Jemth P.

J Biol Chem. 2011 Aug 5;286(31):27167-75. doi: 10.1074/jbc.M111.239541. Epub 2011 Jun 8.


Biophysical characterization of the complex between human papillomavirus E6 protein and synapse-associated protein 97.

Chi CN, Bach A, Engström Å, Strømgaard K, Lundström P, Ferguson N, Jemth P.

J Biol Chem. 2011 Feb 4;286(5):3597-606. doi: 10.1074/jbc.M110.190264. Epub 2010 Nov 27.


Deciphering the kinetic binding mechanism of dimeric ligands using a potent plasma-stable dimeric inhibitor of postsynaptic density protein-95 as an example.

Chi CN, Bach A, Gottschalk M, Kristensen AS, Strømgaard K, Jemth P.

J Biol Chem. 2010 Sep 3;285(36):28252-60. doi: 10.1074/jbc.M110.124040. Epub 2010 Jun 24.


The plastic energy landscape of protein folding: a triangular folding mechanism with an equilibrium intermediate for a small protein domain.

Haq SR, Jürgens MC, Chi CN, Koh CS, Elfström L, Selmer M, Gianni S, Jemth P.

J Biol Chem. 2010 Jun 4;285(23):18051-9. doi: 10.1074/jbc.M110.110833. Epub 2010 Mar 30.


Design and synthesis of highly potent and plasma-stable dimeric inhibitors of the PSD-95-NMDA receptor interaction.

Bach A, Chi CN, Pang GF, Olsen L, Kristensen AS, Jemth P, Strømgaard K.

Angew Chem Int Ed Engl. 2009;48(51):9685-9. doi: 10.1002/anie.200904741. No abstract available.


A sequential binding mechanism in a PDZ domain.

Chi CN, Bach A, Engström A, Wang H, Strømgaard K, Gianni S, Jemth P.

Biochemistry. 2009 Aug 4;48(30):7089-97. doi: 10.1021/bi900559k.


Comparison of successive transition states for folding reveals alternative early folding pathways of two homologous proteins.

Calosci N, Chi CN, Richter B, Camilloni C, Engström A, Eklund L, Travaglini-Allocatelli C, Gianni S, Vendruscolo M, Jemth P.

Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19241-6. doi: 10.1073/pnas.0804774105. Epub 2008 Nov 25.


Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction.

Bach A, Chi CN, Olsen TB, Pedersen SW, Røder MU, Pang GF, Clausen RP, Jemth P, Strømgaard K.

J Med Chem. 2008 Oct 23;51(20):6450-9. doi: 10.1021/jm800836w. Epub 2008 Sep 24.


Reassessing a sparse energetic network within a single protein domain.

Chi CN, Elfström L, Shi Y, Snäll T, Engström A, Jemth P.

Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4679-84. doi: 10.1073/pnas.0711732105. Epub 2008 Mar 13.


A conserved folding mechanism for PDZ domains.

Chi CN, Gianni S, Calosci N, Travaglini-Allocatelli C, Engström K, Jemth P.

FEBS Lett. 2007 Mar 20;581(6):1109-13. Epub 2007 Feb 15.


Two conserved residues govern the salt and pH dependencies of the binding reaction of a PDZ domain.

Chi CN, Engström A, Gianni S, Larsson M, Jemth P.

J Biol Chem. 2006 Dec 1;281(48):36811-8. Epub 2006 Oct 2.

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