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Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics.

Davies MR, McIntyre L, Mutreja A, Lacey JA, Lees JA, Towers RJ, Duchêne S, Smeesters PR, Frost HR, Price DJ, Holden MTG, David S, Giffard PM, Worthing KA, Seale AC, Berkley JA, Harris SR, Rivera-Hernandez T, Berking O, Cork AJ, Torres RSLA, Lithgow T, Strugnell RA, Bergmann R, Nitsche-Schmitz P, Chhatwal GS, Bentley SD, Fraser JD, Moreland NJ, Carapetis JR, Steer AC, Parkhill J, Saul A, Williamson DA, Currie BJ, Tong SYC, Dougan G, Walker MJ.

Nat Genet. 2019 Jun;51(6):1035-1043. doi: 10.1038/s41588-019-0417-8. Epub 2019 May 27.


Linoleic and palmitoleic acid block streptokinase-mediated plasminogen activation and reduce severity of invasive group A streptococcal infection.

Rox K, Jansen R, Loof TG, Gillen CM, Bernecker S, Walker MJ, Chhatwal GS, Müller R.

Sci Rep. 2017 Sep 18;7(1):11798. doi: 10.1038/s41598-017-11276-z.


Disorazoles Block Group A Streptococcal Invasion into Epithelial Cells Via Interference with the Host Factor Ezrin.

Rox K, Rohde M, Chhatwal GS, Müller R.

Cell Chem Biol. 2017 Feb 16;24(2):159-170. doi: 10.1016/j.chembiol.2016.12.011. Epub 2017 Jan 12.


Whole genome sequence typing and microarray profiling of nasal and blood stream methicillin-resistant Staphylococcus aureus isolates: Clues to phylogeny and invasiveness.

Hamed M, Nitsche-Schmitz DP, Ruffing U, Steglich M, Dordel J, Nguyen D, Brink JH, Chhatwal GS, Herrmann M, Nübel U, Helms V, von Müller L.

Infect Genet Evol. 2015 Dec;36:475-482. doi: 10.1016/j.meegid.2015.08.020. Epub 2015 Aug 20.


Expression of group B protective surface protein (BPS) by invasive and colonizing isolates of group B streptococci.

Flores AE, Chhatwal GS, Hillier SL, Baker CJ, Ferrieri P.

Curr Microbiol. 2014 Dec;69(6):894-8. doi: 10.1007/s00284-014-0673-x. Epub 2014 Aug 10.


Differences in virulence repertoire and cell invasive potential of group A Streptococcus emm1-2 in comparison to emm1 genotype.

Sagar V, Bergmann R, Nerlich A, McMillan DJ, Nitsche-Schmitz DP, Fulde M, Talay S, Geffers R, Hoe N, Kumar R, Rohde M, Chakraborti A, Chhatwal GS.

Int J Med Microbiol. 2014 Jul;304(5-6):685-95. doi: 10.1016/j.ijmm.2014.04.011. Epub 2014 May 6.


The M1 protein of Streptococcus pyogenes triggers an innate uptake mechanism into polarized human endothelial cells.

Ochel A, Rohde M, Chhatwal GS, Talay SR.

J Innate Immun. 2014;6(5):585-96. doi: 10.1159/000358085. Epub 2014 Jan 31.


Factors that cause trimethoprim resistance in Streptococcus pyogenes.

Bergmann R, van der Linden M, Chhatwal GS, Nitsche-Schmitz DP.

Antimicrob Agents Chemother. 2014;58(4):2281-8. doi: 10.1128/AAC.02282-13. Epub 2014 Feb 3.


Distribution of small native plasmids in Streptococcus pyogenes in India.

Bergmann R, Nerlich A, Chhatwal GS, Nitsche-Schmitz DP.

Int J Med Microbiol. 2014 May;304(3-4):370-8. doi: 10.1016/j.ijmm.2013.12.001. Epub 2013 Dec 21.


Pneumococcal phosphoglycerate kinase interacts with plasminogen and its tissue activator.

Fulde M, Bernardo-García N, Rohde M, Nachtigall N, Frank R, Preissner KT, Klett J, Morreale A, Chhatwal GS, Hermoso JA, Bergmann S.

Thromb Haemost. 2014 Mar 3;111(3):401-16. doi: 10.1160/TH13-05-0421. Epub 2013 Nov 7.


Structure-informed design of an enzymatically inactive vaccine component for group A Streptococcus.

Henningham A, Ericsson DJ, Langer K, Casey LW, Jovcevski B, Chhatwal GS, Aquilina JA, Batzloff MR, Kobe B, Walker MJ.

MBio. 2013 Aug 6;4(4). pii: e00509-13. doi: 10.1128/mBio.00509-13.


Cooperative plasminogen recruitment to the surface of Streptococcus canis via M protein and enolase enhances bacterial survival.

Fulde M, Rohde M, Polok A, Preissner KT, Chhatwal GS, Bergmann S.

MBio. 2013 Mar 12;4(2):e00629-12. doi: 10.1128/mBio.00629-12.


Host-pathogen interactions in streptococcal immune sequelae.

Nitsche-Schmitz DP, Chhatwal GS.

Curr Top Microbiol Immunol. 2013;368:155-71. doi: 10.1007/82_2012_296. Review.


Adherence and invasion of streptococci to eukaryotic cells and their role in disease pathogenesis.

Rohde M, Chhatwal GS.

Curr Top Microbiol Immunol. 2013;368:83-110. doi: 10.1007/82_2012_281. Review.


Identification of potential universal vaccine candidates against group A Streptococcus by using high throughput in silico and proteomics approach.

Sharma A, Arya DK, Sagar V, Bergmann R, Chhatwal GS, Johri AK.

J Proteome Res. 2013 Jan 4;12(1):336-46. doi: 10.1021/pr3005265. Epub 2012 Dec 12.


Identification and characterization of the arginine deiminase system of Streptococcus canis.

Hitzmann A, Bergmann S, Rohde M, Chhatwal GS, Fulde M.

Vet Microbiol. 2013 Feb 22;162(1):270-7. doi: 10.1016/j.vetmic.2012.08.004. Epub 2012 Aug 16.


Nano-technology for targeted drug delivery to combat antibiotic resistance.

Sharma A, Kumar Arya D, Dua M, Chhatwal GS, Johri AK.

Expert Opin Drug Deliv. 2012 Nov;9(11):1325-32. doi: 10.1517/17425247.2012.717927. Epub 2012 Aug 28.


first detection of trimethoprim resistance determinant dfrG in Streptococcus pyogenes clinical isolates in India.

Bergmann R, Sagar V, Nitsche-Schmitz DP, Chhatwal GS.

Antimicrob Agents Chemother. 2012 Oct;56(10):5424-5. doi: 10.1128/AAC.01284-12. Epub 2012 Aug 13. No abstract available.


Conserved anchorless surface proteins as group A streptococcal vaccine candidates.

Henningham A, Chiarot E, Gillen CM, Cole JN, Rohde M, Fulde M, Ramachandran V, Cork AJ, Hartas J, Magor G, Djordjevic SP, Cordwell SJ, Kobe B, Sriprakash KS, Nizet V, Chhatwal GS, Margarit IY, Batzloff MR, Walker MJ.

J Mol Med (Berl). 2012 Oct;90(10):1197-207. doi: 10.1007/s00109-012-0897-9. Epub 2012 Apr 14.


Clinical and microbiologic characteristics of invasive Streptococcus pyogenes infections in north and south India.

Haggar A, Nerlich A, Kumar R, Abraham VJ, Brahmadathan KN, Ray P, Dhanda V, Joshua JM, Mehra N, Bergmann R, Chhatwal GS, Norrby-Teglund A.

J Clin Microbiol. 2012 May;50(5):1626-31. doi: 10.1128/JCM.06697-11. Epub 2012 Feb 22.


Tumor necrosis factor alpha modulates the dynamics of the plasminogen-mediated early interaction between Bifidobacterium animalis subsp. lactis and human enterocytes.

Centanni M, Bergmann S, Turroni S, Hammerschmidt S, Chhatwal GS, Brigidi P, Candela M.

Appl Environ Microbiol. 2012 Apr;78(7):2465-9. doi: 10.1128/AEM.07883-11. Epub 2012 Jan 27.


Region specific and worldwide distribution of collagen-binding M proteins with PARF motifs among human pathogenic streptococcal isolates.

Reissmann S, Gillen CM, Fulde M, Bergmann R, Nerlich A, Rajkumari R, Brahmadathan KN, Chhatwal GS, Nitsche-Schmitz DP.

PLoS One. 2012;7(1):e30122. doi: 10.1371/journal.pone.0030122. Epub 2012 Jan 11.


Streptococcus pneumoniae induces exocytosis of Weibel-Palade bodies in pulmonary endothelial cells.

Lüttge M, Fulde M, Talay SR, Nerlich A, Rohde M, Preissner KT, Hammerschmidt S, Steinert M, Mitchell TJ, Chhatwal GS, Bergmann S.

Cell Microbiol. 2012 Feb;14(2):210-25. doi: 10.1111/j.1462-5822.2011.01712.x. Epub 2011 Nov 3.


The FbaB-type fibronectin-binding protein of Streptococcus pyogenes promotes specific invasion into endothelial cells.

Amelung S, Nerlich A, Rohde M, Spellerberg B, Cole JN, Nizet V, Chhatwal GS, Talay SR.

Cell Microbiol. 2011 Aug;13(8):1200-11. doi: 10.1111/j.1462-5822.2011.01610.x. Epub 2011 May 25.


Virulence gene pool detected in bovine group C Streptococcus dysgalactiae subsp. dysgalactiae isolates by use of a group A S. pyogenes virulence microarray.

Rato MG, Nerlich A, Bergmann R, Bexiga R, Nunes SF, Vilela CL, Santos-Sanches I, Chhatwal GS.

J Clin Microbiol. 2011 Jul;49(7):2470-9. doi: 10.1128/JCM.00008-11. Epub 2011 Apr 27.


SCM, a novel M-like protein from Streptococcus canis, binds (mini)-plasminogen with high affinity and facilitates bacterial transmigration.

Fulde M, Rohde M, Hitzmann A, Preissner KT, Nitsche-Schmitz DP, Nerlich A, Chhatwal GS, Bergmann S.

Biochem J. 2011 Mar 15;434(3):523-35. doi: 10.1042/BJ20101121.


Caveolin limits membrane microdomain mobility and integrin-mediated uptake of fibronectin-binding pathogens.

Hoffmann C, Berking A, Agerer F, Buntru A, Neske F, Chhatwal GS, Ohlsen K, Hauck CR.

J Cell Sci. 2010 Dec 15;123(Pt 24):4280-91. doi: 10.1242/jcs.064006. Epub 2010 Nov 23.


Contribution of plasminogen activation towards the pathogenic potential of oral streptococci.

Itzek A, Gillen CM, Fulde M, Friedrichs C, Rodloff AC, Chhatwal GS, Nitsche-Schmitz DP.

PLoS One. 2010 Nov 3;5(11):e13826. doi: 10.1371/journal.pone.0013826.


Differences in the aromatic domain of homologous streptococcal fibronectin-binding proteins trigger different cell invasion mechanisms and survival rates.

Rohde M, Graham RM, Branitzki-Heinemann K, Borchers P, Preuss C, Schleicher I, Zähner D, Talay SR, Fulde M, Dinkla K, Chhatwal GS.

Cell Microbiol. 2011 Mar;13(3):450-68. doi: 10.1111/j.1462-5822.2010.01547.x. Epub 2010 Nov 24. Erratum in: Cell Microbiol. 2012 Jan;14(1):147-8.


Biological functions of GCS3, a novel plasminogen-binding protein of Streptococcus dysgalactiae ssp. equisimilis.

Bergmann R, Dinkla K, Nitsche-Schmitz DP, Graham RM, Lüttge M, Sanderson-Smith ML, Nerlich A, Rohde M, Chhatwal GS.

Int J Med Microbiol. 2011 Feb;301(2):157-64. doi: 10.1016/j.ijmm.2010.06.007. Epub 2010 Oct 15.


Parameters governing invasive disease propensity of non-M1 serotype group A streptococci.

Maamary PG, Sanderson-Smith ML, Aziz RK, Hollands A, Cole JN, McKay FC, McArthur JD, Kirk JK, Cork AJ, Keefe RJ, Kansal RG, Sun H, Taylor WL, Chhatwal GS, Ginsburg D, Nizet V, Kotb M, Walker MJ.

J Innate Immun. 2010;2(6):596-606. doi: 10.1159/000317640. Epub 2010 Sep 2.


The CXC chemokine-degrading protease SpyCep of Streptococcus pyogenes promotes its uptake into endothelial cells.

Kaur SJ, Nerlich A, Bergmann S, Rohde M, Fulde M, Zähner D, Hanski E, Zinkernagel A, Nizet V, Chhatwal GS, Talay SR.

J Biol Chem. 2010 Sep 3;285(36):27798-805. doi: 10.1074/jbc.M109.098053. Epub 2010 Jun 18.


Microevolution of group A streptococci in vivo: capturing regulatory networks engaged in sociomicrobiology, niche adaptation, and hypervirulence.

Aziz RK, Kansal R, Aronow BJ, Taylor WL, Rowe SL, Kubal M, Chhatwal GS, Walker MJ, Kotb M.

PLoS One. 2010 Apr 14;5(4):e9798. doi: 10.1371/journal.pone.0009798.


Contribution of Streptococcus anginosus to infections caused by groups C and G streptococci, southern India.

Reissmann S, Friedrichs C, Rajkumari R, Itzek A, Fulde M, Rodloff AC, Brahmadathan KN, Chhatwal GS, Nitsche-Schmitz DP.

Emerg Infect Dis. 2010 Apr;16(4):656-63. doi: 10.3201/eid1604.090448.


Autoantigens identified by screening a human heart cDNA library with acute rheumatic fever sera.

Towers RJ, Bolm M, Currie BJ, Chhatwal GS, Fagan PK.

Ann N Y Acad Sci. 2009 Sep;1173:83-91. doi: 10.1111/j.1749-6632.2009.04653.x.


Identification of active variants of PARF in human pathogenic group C and group G streptococci leads to an amended description of its consensus motif.

Barroso V, Rohde M, Davies MR, Gillen CM, Nitsche-Schmitz DP, Dinkla K, Chhatwal GS.

Int J Med Microbiol. 2009 Dec;299(8):547-53. doi: 10.1016/j.ijmm.2009.04.004. Epub 2009 Jun 11.


Invasion of endothelial cells by tissue-invasive M3 type group A streptococci requires Src kinase and activation of Rac1 by a phosphatidylinositol 3-kinase-independent mechanism.

Nerlich A, Rohde M, Talay SR, Genth H, Just I, Chhatwal GS.

J Biol Chem. 2009 Jul 24;284(30):20319-28. doi: 10.1074/jbc.M109.016501. Epub 2009 May 27.


Crucial role of the CB3-region of collagen IV in PARF-induced acute rheumatic fever.

Dinkla K, Talay SR, Mörgelin M, Graham RM, Rohde M, Nitsche-Schmitz DP, Chhatwal GS.

PLoS One. 2009;4(3):e4666. doi: 10.1371/journal.pone.0004666. Epub 2009 Mar 2.


More than one tandem repeat domain of the extracellular adherence protein of Staphylococcus aureus is required for aggregation, adherence, and host cell invasion but not for leukocyte activation.

Hussain M, Haggar A, Peters G, Chhatwal GS, Herrmann M, Flock JI, Sinha B.

Infect Immun. 2008 Dec;76(12):5615-23. doi: 10.1128/IAI.00480-08. Epub 2008 Sep 15.


Evaluation of the potential of animal streptococcal isolates belonging to serogroups C and G to elicit acute rheumatic fever.

Barroso V, Rohde M, Dinkla K, Chhatwal GS.

Am J Vet Res. 2008 Sep;69(9):1183-7. doi: 10.2460/ajvr.69.9.1183.


M protein-mediated plasminogen binding is essential for the virulence of an invasive Streptococcus pyogenes isolate.

Sanderson-Smith ML, Dinkla K, Cole JN, Cork AJ, Maamary PG, McArthur JD, Chhatwal GS, Walker MJ.

FASEB J. 2008 Aug;22(8):2715-22. doi: 10.1096/fj.07-105643. Epub 2008 May 8.


The contribution of dendritic cells to host defenses against Streptococcus pyogenes.

Loof TG, Rohde M, Chhatwal GS, Jung S, Medina E.

J Infect Dis. 2007 Dec 15;196(12):1794-803. doi: 10.1086/523647.


Opacity factor activity and epithelial cell binding by the serum opacity factor protein of Streptococcus pyogenes are functionally discrete.

Gillen CM, Courtney HS, Schulze K, Rohde M, Wilson MR, Timmer AM, Guzman CA, Nizet V, Chhatwal GS, Walker MJ.

J Biol Chem. 2008 Mar 7;283(10):6359-66. doi: 10.1074/jbc.M706739200. Epub 2008 Jan 7.


Invasion mechanisms of Gram-positive pathogenic cocci.

Nitsche-Schmitz DP, Rohde M, Chhatwal GS.

Thromb Haemost. 2007 Sep;98(3):488-96. Review.


DNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infection.

Walker MJ, Hollands A, Sanderson-Smith ML, Cole JN, Kirk JK, Henningham A, McArthur JD, Dinkla K, Aziz RK, Kansal RG, Simpson AJ, Buchanan JT, Chhatwal GS, Kotb M, Nizet V.

Nat Med. 2007 Aug;13(8):981-5. Epub 2007 Jul 15.


Rapid identification of viridans streptococci by mass spectrometric discrimination.

Friedrichs C, Rodloff AC, Chhatwal GS, Schellenberger W, Eschrich K.

J Clin Microbiol. 2007 Aug;45(8):2392-7. Epub 2007 Jun 6.


Transcriptome analysis of murine macrophages in response to infection with Streptococcus pyogenes reveals an unusual activation program.

Goldmann O, von Köckritz-Blickwede M, Höltje C, Chhatwal GS, Geffers R, Medina E.

Infect Immun. 2007 Aug;75(8):4148-57. Epub 2007 May 25.


Virulence profiling of Streptococcus dysgalactiae subspecies equisimilis isolated from infected humans reveals 2 distinct genetic lineages that do not segregate with their phenotypes or propensity to cause diseases.

Davies MR, McMillan DJ, Beiko RG, Barroso V, Geffers R, Sriprakash KS, Chhatwal GS.

Clin Infect Dis. 2007 Jun 1;44(11):1442-54. Epub 2007 Apr 19.


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