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Items: 1 to 50 of 72

1.

5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due to Staphylococcus aureus.

Zapotoczna M, Murray EJ, Hogan S, O'Gara JP, Chhabra SR, Chan WC, O'Neill E, Williams P.

J Antimicrob Chemother. 2017 Mar 1;72(3):744-753. doi: 10.1093/jac/dkw482.

2.

Bacterial Interactomes: Interacting Protein Partners Share Similar Function and Are Validated in Independent Assays More Frequently Than Previously Reported.

Shatsky M, Allen S, Gold BL, Liu NL, Juba TR, Reveco SA, Elias DA, Prathapam R, He J, Yang W, Szakal ED, Liu H, Singer ME, Geller JT, Lam BR, Saini A, Trotter VV, Hall SC, Fisher SJ, Brenner SE, Chhabra SR, Hazen TC, Wall JD, Witkowska HE, Biggin MD, Chandonia JM, Butland G.

Mol Cell Proteomics. 2016 May;15(5):1539-55. doi: 10.1074/mcp.M115.054692. Epub 2016 Feb 12.

3.

Biotic inactivation of the Pseudomonas aeruginosa quinolone signal molecule.

Soh EY, Chhabra SR, Halliday N, Heeb S, Müller C, Birmes FS, Fetzner S, Cámara M, Chan KG, Williams P.

Environ Microbiol. 2015 Nov;17(11):4352-65. doi: 10.1111/1462-2920.12857. Epub 2015 Apr 28.

PMID:
25809238
4.

Targeting Staphylococcus aureus quorum sensing with nonpeptidic small molecule inhibitors.

Murray EJ, Crowley RC, Truman A, Clarke SR, Cottam JA, Jadhav GP, Steele VR, O'Shea P, Lindholm C, Cockayne A, Chhabra SR, Chan WC, Williams P.

J Med Chem. 2014 Mar 27;57(6):2813-9. doi: 10.1021/jm500215s. Epub 2014 Mar 13.

5.

Substrate-assisted O2 activation in a cofactor-independent dioxygenase.

Thierbach S, Bui N, Zapp J, Chhabra SR, Kappl R, Fetzner S.

Chem Biol. 2014 Feb 20;21(2):217-25. doi: 10.1016/j.chembiol.2013.11.013. Epub 2014 Jan 2.

6.

Development of a broad-host synthetic biology toolbox for Ralstonia eutropha and its application to engineering hydrocarbon biofuel production.

Bi C, Su P, Müller J, Yeh YC, Chhabra SR, Beller HR, Singer SW, Hillson NJ.

Microb Cell Fact. 2013 Nov 13;12:107. doi: 10.1186/1475-2859-12-107.

7.

Biochemical and structural studies of NADH-dependent FabG used to increase the bacterial production of fatty acids under anaerobic conditions.

Javidpour P, Pereira JH, Goh EB, McAndrew RP, Ma SM, Friedland GD, Keasling JD, Chhabra SR, Adams PD, Beller HR.

Appl Environ Microbiol. 2014 Jan;80(2):497-505. doi: 10.1128/AEM.03194-13. Epub 2013 Nov 8.

8.

Structural basis for native agonist and synthetic inhibitor recognition by the Pseudomonas aeruginosa quorum sensing regulator PqsR (MvfR).

Ilangovan A, Fletcher M, Rampioni G, Pustelny C, Rumbaugh K, Heeb S, Cámara M, Truman A, Chhabra SR, Emsley J, Williams P.

PLoS Pathog. 2013;9(7):e1003508. doi: 10.1371/journal.ppat.1003508. Epub 2013 Jul 25.

9.

Engineering of Ralstonia eutropha H16 for autotrophic and heterotrophic production of methyl ketones.

Müller J, MacEachran D, Burd H, Sathitsuksanoh N, Bi C, Yeh YC, Lee TS, Hillson NJ, Chhabra SR, Singer SW, Beller HR.

Appl Environ Microbiol. 2013 Jul;79(14):4433-9. doi: 10.1128/AEM.00973-13. Epub 2013 May 17.

10.

Functionalizing bacterial cell surfaces with a phage protein.

Yeh YC, Müller J, Bi C, Hillson NJ, Beller HR, Chhabra SR, Singer SW.

Chem Commun (Camb). 2013 Jan 30;49(9):910-2. doi: 10.1039/c2cc37883c.

PMID:
23247551
11.

Manipulation of the carbon storage regulator system for metabolite remodeling and biofuel production in Escherichia coli.

McKee AE, Rutherford BJ, Chivian DC, Baidoo EK, Juminaga D, Kuo D, Benke PI, Dietrich JA, Ma SM, Arkin AP, Petzold CJ, Adams PD, Keasling JD, Chhabra SR.

Microb Cell Fact. 2012 Jun 13;11:79.

12.

Tracing determinants of dual substrate specificity in glycoside hydrolase family 5.

Chen Z, Friedland GD, Pereira JH, Reveco SA, Chan R, Park JI, Thelen MP, Adams PD, Arkin AP, Keasling JD, Blanch HW, Simmons BA, Sale KL, Chivian D, Chhabra SR.

J Biol Chem. 2012 Jul 20;287(30):25335-43. doi: 10.1074/jbc.M112.362640. Epub 2012 May 29.

13.

Generalized schemes for high-throughput manipulation of the Desulfovibrio vulgaris genome.

Chhabra SR, Butland G, Elias DA, Chandonia JM, Fok OY, Juba TR, Gorur A, Allen S, Leung CM, Keller KL, Reveco S, Zane GM, Semkiw E, Prathapam R, Gold B, Singer M, Ouellet M, Szakal ED, Jorgens D, Price MN, Witkowska HE, Beller HR, Arkin AP, Hazen TC, Biggin MD, Auer M, Wall JD, Keasling JD.

Appl Environ Microbiol. 2011 Nov;77(21):7595-604. doi: 10.1128/AEM.05495-11. Epub 2011 Sep 9.

14.

Optimization of a heterologous mevalonate pathway through the use of variant HMG-CoA reductases.

Ma SM, Garcia DE, Redding-Johanson AM, Friedland GD, Chan R, Batth TS, Haliburton JR, Chivian D, Keasling JD, Petzold CJ, Lee TS, Chhabra SR.

Metab Eng. 2011 Sep;13(5):588-97. doi: 10.1016/j.ymben.2011.07.001. Epub 2011 Jul 28.

PMID:
21810477
15.

Towards a rigorous network of protein-protein interactions of the model sulfate reducer Desulfovibrio vulgaris Hildenborough.

Chhabra SR, Joachimiak MP, Petzold CJ, Zane GM, Price MN, Reveco SA, Fok V, Johanson AR, Batth TS, Singer M, Chandonia JM, Joyner D, Hazen TC, Arkin AP, Wall JD, Singh AK, Keasling JD.

PLoS One. 2011;6(6):e21470. doi: 10.1371/journal.pone.0021470. Epub 2011 Jun 28.

16.

Synthesis and biotransformation of 2-alkyl-4(1H)-quinolones by recombinant Pseudomonas putida KT2440.

Niewerth H, Bergander K, Chhabra SR, Williams P, Fetzner S.

Appl Microbiol Biotechnol. 2011 Sep;91(5):1399-408. doi: 10.1007/s00253-011-3378-0. Epub 2011 Jun 14.

PMID:
21670979
17.

Immunosuppressive but non-LasR-inducing analogues of the Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-l-homoserine lactone.

Jadhav GP, Chhabra SR, Telford G, Hooi DS, Righetti K, Williams P, Kellam B, Pritchard DI, Fischer PM.

J Med Chem. 2011 May 12;54(9):3348-59. doi: 10.1021/jm2001019. Epub 2011 Apr 13.

PMID:
21488685
18.
19.

Simultaneous quantitative profiling of N-acyl-L-homoserine lactone and 2-alkyl-4(1H)-quinolone families of quorum-sensing signaling molecules using LC-MS/MS.

Ortori CA, Dubern JF, Chhabra SR, Cámara M, Hardie K, Williams P, Barrett DA.

Anal Bioanal Chem. 2011 Jan;399(2):839-50. doi: 10.1007/s00216-010-4341-0. Epub 2010 Oct 28.

PMID:
21046079
20.

Quinolones: from antibiotics to autoinducers.

Heeb S, Fletcher MP, Chhabra SR, Diggle SP, Williams P, Cámara M.

FEMS Microbiol Rev. 2011 Mar;35(2):247-74. doi: 10.1111/j.1574-6976.2010.00247.x. Review.

21.

Biochemical characterization and crystal structure of endoglucanase Cel5A from the hyperthermophilic Thermotoga maritima.

Pereira JH, Chen Z, McAndrew RP, Sapra R, Chhabra SR, Sale KL, Simmons BA, Adams PD.

J Struct Biol. 2010 Dec;172(3):372-9. doi: 10.1016/j.jsb.2010.06.018. Epub 2010 Jul 3.

PMID:
20599513
22.

Dioxygenase-mediated quenching of quinolone-dependent quorum sensing in Pseudomonas aeruginosa.

Pustelny C, Albers A, Büldt-Karentzopoulos K, Parschat K, Chhabra SR, Cámara M, Williams P, Fetzner S.

Chem Biol. 2009 Dec 24;16(12):1259-67. doi: 10.1016/j.chembiol.2009.11.013.

23.

Genome-wide transposon mutagenesis identifies a role for host neuroendocrine stress hormones in regulating the expression of virulence genes in Salmonella.

Spencer H, Karavolos MH, Bulmer DM, Aldridge P, Chhabra SR, Winzer K, Williams P, Khan CM.

J Bacteriol. 2010 Feb;192(3):714-24. doi: 10.1128/JB.01329-09. Epub 2009 Nov 20.

24.

N-Acylhomoserine lactone-mediated quorum sensing: a twist in the tail and a blow for host immunity.

Cooley M, Chhabra SR, Williams P.

Chem Biol. 2008 Nov 24;15(11):1141-7. doi: 10.1016/j.chembiol.2008.10.010. Review.

25.

A dual biosensor for 2-alkyl-4-quinolone quorum-sensing signal molecules.

Fletcher MP, Diggle SP, Crusz SA, Chhabra SR, Cámara M, Williams P.

Environ Microbiol. 2007 Nov;9(11):2683-93.

PMID:
17922753
26.

The immunomodulatory Pseudomonas aeruginosa signalling molecule N-(3-oxododecanoyl)-L-homoserine lactone enters mammalian cells in an unregulated fashion.

Ritchie AJ, Whittall C, Lazenby JJ, Chhabra SR, Pritchard DI, Cooley MA.

Immunol Cell Biol. 2007 Nov-Dec;85(8):596-602. Epub 2007 Jul 3.

PMID:
17607318
27.

The Pseudomonas aeruginosa 4-quinolone signal molecules HHQ and PQS play multifunctional roles in quorum sensing and iron entrapment.

Diggle SP, Matthijs S, Wright VJ, Fletcher MP, Chhabra SR, Lamont IL, Kong X, Hider RC, Cornelis P, Cámara M, Williams P.

Chem Biol. 2007 Jan;14(1):87-96.

28.

N-acyl homoserine lactones are degraded via an amidolytic activity in Comamonas sp. strain D1.

Uroz S, Oger P, Chhabra SR, Cámara M, Williams P, Dessaux Y.

Arch Microbiol. 2007 Mar;187(3):249-56. Epub 2006 Nov 29.

PMID:
17136382
29.

Comprehensive profiling of N-acylhomoserine lactones produced by Yersinia pseudotuberculosis using liquid chromatography coupled to hybrid quadrupole-linear ion trap mass spectrometry.

Ortori CA, Atkinson S, Chhabra SR, Cámara M, Williams P, Barrett DA.

Anal Bioanal Chem. 2007 Jan;387(2):497-511. Epub 2006 Sep 12.

PMID:
16967185
30.

Functional genetic analysis reveals a 2-Alkyl-4-quinolone signaling system in the human pathogen Burkholderia pseudomallei and related bacteria.

Diggle SP, Lumjiaktase P, Dipilato F, Winzer K, Kunakorn M, Barrett DA, Chhabra SR, Cámara M, Williams P.

Chem Biol. 2006 Jul;13(7):701-10.

31.

Global analysis of heat shock response in Desulfovibrio vulgaris Hildenborough.

Chhabra SR, He Q, Huang KH, Gaucher SP, Alm EJ, He Z, Hadi MZ, Hazen TC, Wall JD, Zhou J, Arkin AP, Singh AK.

J Bacteriol. 2006 Mar;188(5):1817-28.

32.

N-acylhomoserine lactones antagonize virulence gene expression and quorum sensing in Staphylococcus aureus.

Qazi S, Middleton B, Muharram SH, Cockayne A, Hill P, O'Shea P, Chhabra SR, Cámara M, Williams P.

Infect Immun. 2006 Feb;74(2):910-9.

33.
34.

An expression-driven approach to the prediction of carbohydrate transport and utilization regulons in the hyperthermophilic bacterium Thermotoga maritima.

Conners SB, Montero CI, Comfort DA, Shockley KR, Johnson MR, Chhabra SR, Kelly RM.

J Bacteriol. 2005 Nov;187(21):7267-82.

35.

N-Acylhomoserine lactone quorum-sensing molecules are modified and degraded by Rhodococcus erythropolis W2 by both amidolytic and novel oxidoreductase activities.

Uroz S, Chhabra SR, Cámara M, Williams P, Oger P, Dessaux Y.

Microbiology. 2005 Oct;151(Pt 10):3313-22.

PMID:
16207914
36.

Differential immune modulatory activity of Pseudomonas aeruginosa quorum-sensing signal molecules.

Hooi DS, Bycroft BW, Chhabra SR, Williams P, Pritchard DI.

Infect Immun. 2004 Nov;72(11):6463-70.

37.

Biosynthesis of carbapenem antibiotics: new carbapenam substrates for carbapenem synthase (CarC).

Sleeman MC, Smith P, Kellam B, Chhabra SR, Bycroft BW, Schofield CJ.

Chembiochem. 2004 Jun 7;5(6):879-82. No abstract available.

PMID:
15174175
38.

Bacterial N-acylhomoserine lactone-induced apoptosis in breast carcinoma cells correlated with down-modulation of STAT3.

Li L, Hooi D, Chhabra SR, Pritchard D, Shaw PE.

Oncogene. 2004 Jun 17;23(28):4894-902. Erratum in: Oncogene. 2004 Dec 16;9450.

PMID:
15064716
39.

Recent progress in the design of selectin inhibitors.

Chhabra SR, Rahim AS, Kellam B.

Mini Rev Med Chem. 2003 Nov;3(7):679-87. Review.

PMID:
14529509
41.

Heat shock response by the hyperthermophilic archaeon Pyrococcus furiosus.

Shockley KR, Ward DE, Chhabra SR, Conners SB, Montero CI, Kelly RM.

Appl Environ Microbiol. 2003 Apr;69(4):2365-71.

42.

Synthetic analogues of the bacterial signal (quorum sensing) molecule N-(3-oxododecanoyl)-L-homoserine lactone as immune modulators.

Chhabra SR, Harty C, Hooi DS, Daykin M, Williams P, Telford G, Pritchard DI, Bycroft BW.

J Med Chem. 2003 Jan 2;46(1):97-104.

PMID:
12502363
43.

Carbohydrate-induced differential gene expression patterns in the hyperthermophilic bacterium Thermotoga maritima.

Chhabra SR, Shockley KR, Conners SB, Scott KL, Wolfinger RD, Kelly RM.

J Biol Chem. 2003 Feb 28;278(9):7540-52. Epub 2002 Dec 9.

45.

The growth response of Escherichia coli to neurotransmitters and related catecholamine drugs requires a functional enterobactin biosynthesis and uptake system.

Burton CL, Chhabra SR, Swift S, Baldwin TJ, Withers H, Hill SJ, Williams P.

Infect Immun. 2002 Nov;70(11):5913-23.

46.

N-acylhomoserine lactones undergo lactonolysis in a pH-, temperature-, and acyl chain length-dependent manner during growth of Yersinia pseudotuberculosis and Pseudomonas aeruginosa.

Yates EA, Philipp B, Buckley C, Atkinson S, Chhabra SR, Sockett RE, Goldner M, Dessaux Y, Cámara M, Smith H, Williams P.

Infect Immun. 2002 Oct;70(10):5635-46.

47.

Homochiral 4-azalysine building blocks: syntheses and applications in solid-phase chemistry.

Chhabra SR, Mahajan A, Chan WC.

J Org Chem. 2002 Jun 14;67(12):4017-29.

PMID:
12054934
48.

raiIR genes are part of a quorum-sensing network controlled by cinI and cinR in Rhizobium leguminosarum.

Wisniewski-Dyé F, Jones J, Chhabra SR, Downie JA.

J Bacteriol. 2002 Mar;184(6):1597-606.

49.
50.

Galactomannanases Man2 and Man5 from Thermotoga species: growth physiology on galactomannans, gene sequence analysis, and biochemical properties of recombinant enzymes.

Parker KN, Chhabra SR, Lam D, Callen W, Duffaud GD, Snead MA, Short JM, Mathur EJ, Kelly RM.

Biotechnol Bioeng. 2001 Nov 5;75(3):322-33.

PMID:
11590605

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