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Items: 35


Predominance of the heterozygous CCR5 delta-24 deletion in African individuals resistant to HIV infection might be related to a defect in CCR5 addressing at the cell surface.

Arendt V, Amand M, Iserentant G, Lemaire M, Masquelier C, Ndayisaba GF, Verhofstede C, Karita E, Allen S, Chevigné A, Schmit JC, Bercoff DP, Seguin-Devaux C.

J Int AIDS Soc. 2019 Sep;22(9):e25384. doi: 10.1002/jia2.25384.


The Distinct Roles of CXCR3 Variants and Their Ligands in the Tumor Microenvironment.

Reynders N, Abboud D, Baragli A, Noman MZ, Rogister B, Niclou SP, Heveker N, Janji B, Hanson J, Szpakowska M, Chevigné A.

Cells. 2019 Jun 18;8(6). pii: E613. doi: 10.3390/cells8060613. Review.


A Novel ACKR2-Dependent Role of Fibroblast-Derived CXCL14 in Epithelial-to-Mesenchymal Transition and Metastasis of Breast Cancer.

Sjöberg E, Meyrath M, Milde L, Herrera M, Lövrot J, Hägerstrand D, Frings O, Bartish M, Rolny C, Sonnhammer E, Chevigné A, Augsten M, Östman A.

Clin Cancer Res. 2019 Jun 15;25(12):3702-3717. doi: 10.1158/1078-0432.CCR-18-1294. Epub 2019 Mar 8.


Driving Cytotoxic Natural Killer Cells into Melanoma: If CCL5 Plays the Music, Autophagy Calls the Shots.

Xiao M, Noman MZ, Menard L, Chevigne A, Szpakowska M, Bosseler M, Ollert M, Berchem G, Janji B.

Crit Rev Oncog. 2018;23(5-6):321-332. doi: 10.1615/CritRevOncog.2018027526. Review.


Aurora A plays a dual role in migration and survival of human glioblastoma cells according to the CXCL12 concentration.

Willems E, Dedobbeleer M, Digregorio M, Lombard A, Goffart N, Lumapat PN, Lambert J, Van den Ackerveken P, Szpakowska M, Chevigné A, Scholtes F, Rogister B.

Oncogene. 2019 Jan;38(1):73-87. doi: 10.1038/s41388-018-0437-3. Epub 2018 Aug 6.


Emerging roles of the protease allergen Der p 1 in house dust mite-induced airway inflammation.

Chevigné A, Jacquet A.

J Allergy Clin Immunol. 2018 Aug;142(2):398-400. doi: 10.1016/j.jaci.2018.05.027. Epub 2018 Jun 12. Review. No abstract available.


Development of Mimokines, chemokine N terminus-based CXCR4 inhibitors optimized by phage display and rational design.

Fievez V, Szpakowska M, Mosbah A, Arumugam K, Mathu J, Counson M, Beaupain N, Seguin-Devaux C, Deroo S, Baudy-Floc'h M, Chevigné A.

J Leukoc Biol. 2018 Aug;104(2):343-357. doi: 10.1002/JLB.3MA0118-007. Epub 2018 Mar 23.


Mutational analysis of the extracellular disulphide bridges of the atypical chemokine receptor ACKR3/CXCR7 uncovers multiple binding and activation modes for its chemokine and endogenous non-chemokine agonists.

Szpakowska M, Meyrath M, Reynders N, Counson M, Hanson J, Steyaert J, Chevigné A.

Biochem Pharmacol. 2018 Jul;153:299-309. doi: 10.1016/j.bcp.2018.03.007. Epub 2018 Mar 9.


Different contributions of chemokine N-terminal features attest to a different ligand binding mode and a bias towards activation of ACKR3/CXCR7 compared with CXCR4 and CXCR3.

Szpakowska M, Nevins AM, Meyrath M, Rhainds D, D'huys T, Guité-Vinet F, Dupuis N, Gauthier PA, Counson M, Kleist A, St-Onge G, Hanson J, Schols D, Volkman BF, Heveker N, Chevigné A.

Br J Pharmacol. 2018 May;175(9):1419-1438. doi: 10.1111/bph.14132. Epub 2018 Mar 23.


Profiling the Extended Cleavage Specificity of the House Dust Mite Protease Allergens Der p 1, Der p 3 and Der p 6 for the Prediction of New Cell Surface Protein Substrates.

Jacquet A, Campisi V, Szpakowska M, Dumez ME, Galleni M, Chevigné A.

Int J Mol Sci. 2017 Jun 27;18(7). pii: E1373. doi: 10.3390/ijms18071373.


The Lys-Asp-Tyr Triad within the Mite Allergen Der p 1 Propeptide Is a Critical Structural Element for the pH-Dependent Initiation of the Protease Maturation.

Chevigné A, Campizi V, Szpakowska M, Bourry D, Dumez ME, Martins JC, Matagne A, Galleni M, Jacquet A.

Int J Mol Sci. 2017 May 20;18(5). pii: E1087. doi: 10.3390/ijms18051087.


Activation of the Orphan G Protein-Coupled Receptor GPR27 by Surrogate Ligands Promotes β-Arrestin 2 Recruitment.

Dupuis N, Laschet C, Franssen D, Szpakowska M, Gilissen J, Geubelle P, Soni A, Parent AS, Pirotte B, Chevigné A, Twizere JC, Hanson J.

Mol Pharmacol. 2017 Jun;91(6):595-608. doi: 10.1124/mol.116.107714. Epub 2017 Mar 17.


GPCRs in immunity: Atypical receptors and novel concepts.

Hanson J, Chevigné A.

Biochem Pharmacol. 2016 Aug 15;114:1-2. doi: 10.1016/j.bcp.2016.06.017. Epub 2016 Jun 29. No abstract available.


Human herpesvirus 8-encoded chemokine vCCL2/vMIP-II is an agonist of the atypical chemokine receptor ACKR3/CXCR7.

Szpakowska M, Dupuis N, Baragli A, Counson M, Hanson J, Piette J, Chevigné A.

Biochem Pharmacol. 2016 Aug 15;114:14-21. doi: 10.1016/j.bcp.2016.05.012. Epub 2016 May 27.


New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model.

Kleist AB, Getschman AE, Ziarek JJ, Nevins AM, Gauthier PA, Chevigné A, Szpakowska M, Volkman BF.

Biochem Pharmacol. 2016 Aug 15;114:53-68. doi: 10.1016/j.bcp.2016.04.007. Epub 2016 Apr 19. Review.


Isolation of an HIV-1 neutralizing peptide mimicking the CXCR4 and CCR5 surface from the heavy-chain complementary determining region 3 repertoire of a viremic controller.

Chevigne A, Delhalle S, Counson M, Beaupain N, Rybicki A, Verschueren C, Staub T, Schmit JC, Seguin-Devaux C, Deroo S.

AIDS. 2016 Jan 28;30(3):377-82. doi: 10.1097/QAD.0000000000000925.


vCCL2/vMIP-II, the viral master KEYmokine.

Szpakowska M, Chevigné A.

J Leukoc Biol. 2016 Jun;99(6):893-900. doi: 10.1189/jlb.2MR0815-383R. Epub 2015 Dec 23. Review.


Development of recombinant stable house dust mite allergen Der p 3 molecules for component-resolved diagnosis and specific immunotherapy.

Bouaziz A, Walgraffe D, Bouillot C, Herman J, Foguenne J, Gothot A, Louis R, Hentges F, Jacquet A, Mailleux AC, Chevigné A, Galleni M, Adam E, Dumez ME.

Clin Exp Allergy. 2015 Apr;45(4):823-34. doi: 10.1111/cea.12452.


Closing the ring: a fourth extracellular loop in chemokine receptors.

Szpakowska M, Perez Bercoff D, Chevigné A.

Sci Signal. 2014 Sep 2;7(341):pe21. doi: 10.1126/scisignal.2005664.


Orchestration of an uncommon maturation cascade of the house dust mite protease allergen quartet.

Dumez ME, Herman J, Campizi V, Galleni M, Jacquet A, Chevigné A.

Front Immunol. 2014 Mar 31;5:138. doi: 10.3389/fimmu.2014.00138. eCollection 2014. Review.


Neutralising properties of peptides derived from CXCR4 extracellular loops towards CXCL12 binding and HIV-1 infection.

Chevigné A, Fievez V, Szpakowska M, Fischer A, Counson M, Plesséria JM, Schmit JC, Deroo S.

Biochim Biophys Acta. 2014 May;1843(5):1031-41. doi: 10.1016/j.bbamcr.2014.01.017. Epub 2014 Jan 27.


Der p 1 is the primary activator of Der p 3, Der p 6 and Der p 9 the proteolytic allergens produced by the house dust mite Dermatophagoides pteronyssinus.

Herman J, Thelen N, Smargiasso N, Mailleux AC, Luxen A, Cloes M, De Pauw E, Chevigné A, Galleni M, Dumez ME.

Biochim Biophys Acta. 2014 Mar;1840(3):1117-24. doi: 10.1016/j.bbagen.2013.11.017. Epub 2013 Nov 27.


The proline-rich motif of the proDer p 3 allergen propeptide is crucial for protease-protease interaction.

Dumez ME, Herman J, Campisi V, Bouaziz A, Rosu F, Luxen A, Vandenberghe I, de Pauw E, Frère JM, Matagne A, Chevigné A, Galleni M.

PLoS One. 2013 Sep 20;8(9):e68014. doi: 10.1371/journal.pone.0068014. eCollection 2013.


Structure prediction of GPCRs using piecewise homologs and application to the human CCR5 chemokine receptor: validation through agonist and antagonist docking.

Arumugam K, Crouzy S, Chevigne A, Seguin-Devaux C, Schmit JC.

J Biomol Struct Dyn. 2014;32(8):1274-89. doi: 10.1080/07391102.2013.817952. Epub 2013 Jul 22.


Allosteric inhibition of VIM metallo-β-lactamases by a camelid nanobody.

Sohier JS, Laurent C, Chevigné A, Pardon E, Srinivasan V, Wernery U, Lassaux P, Steyaert J, Galleni M.

Biochem J. 2013 Mar 15;450(3):477-86. doi: 10.1042/BJ20121305.


Function, diversity and therapeutic potential of the N-terminal domain of human chemokine receptors.

Szpakowska M, Fievez V, Arumugan K, van Nuland N, Schmit JC, Chevigné A.

Biochem Pharmacol. 2012 Nov 15;84(10):1366-80. doi: 10.1016/j.bcp.2012.08.008. Epub 2012 Aug 21. Review.


Inhibition of the keratinolytic subtilisin protease Sub3 from Microsporum canis by its propeptide (proSub3) and evaluation of the capacity of proSub3 to inhibit fungal adherence to feline epidermis.

Baldo A, Chevigné A, Dumez ME, Mathy A, Power P, Tabart J, Cambier L, Galleni M, Mignon B.

Vet Microbiol. 2012 Oct 12;159(3-4):479-84. doi: 10.1016/j.vetmic.2012.04.041. Epub 2012 May 8.


Phages and HIV-1: from display to interplay.

Delhalle S, Schmit JC, Chevigné A.

Int J Mol Sci. 2012;13(4):4727-94. doi: 10.3390/ijms13044727. Epub 2012 Apr 13. Review.


Engineering and screening the N-terminus of chemokines for drug discovery.

Chevigné A, Fievez V, Schmit JC, Deroo S.

Biochem Pharmacol. 2011 Nov 15;82(10):1438-56. doi: 10.1016/j.bcp.2011.07.091. Epub 2011 Jul 30. Review.


Selection of a CXCR4 antagonist from a human heavy chain CDR3-derived phage library.

Chevigné A, Fischer A, Mathu J, Counson M, Beaupain N, Plesséria JM, Schmit JC, Deroo S.

FEBS J. 2011 Aug;278(16):2867-78. doi: 10.1111/j.1742-4658.2011.08208.x. Epub 2011 Jun 27.


Comparative study of mature and zymogen mite cysteine protease stability and pH unfolding.

Chevigné A, Dumez ME, Dumoulin M, Matagne A, Jacquet A, Galleni M.

Biochim Biophys Acta. 2010 Sep;1800(9):937-45. doi: 10.1016/j.bbagen.2010.05.011. Epub 2010 Jun 8.


Activation mechanism of recombinant Der p 3 allergen zymogen: contribution of cysteine protease Der p 1 and effect of propeptide glycosylation.

Dumez ME, Teller N, Mercier F, Tanaka T, Vandenberghe I, Vandenbranden M, Devreese B, Luxen A, Frère JM, Matagne A, Jacquet A, Galleni M, Chevigné A.

J Biol Chem. 2008 Nov 7;283(45):30606-17. doi: 10.1074/jbc.M803041200. Epub 2008 Aug 25.


Relationship between propeptide pH unfolding and inhibitory ability during ProDer p 1 activation mechanism.

Chevigné A, Barumandzadeh R, Groslambert S, Cloes B, Dehareng D, Filée P, Marx JC, Frère JM, Matagne A, Jacquet A, Galleni M.

J Mol Biol. 2007 Nov 16;374(1):170-85. Epub 2007 Aug 21.


Use of bifunctional hybrid beta-lactamases for epitope mapping and immunoassay development.

Chevigné A, Yilmaz N, Gaspard G, Giannotta F, François JM, Frère JM, Galleni M, Filée P.

J Immunol Methods. 2007 Mar 30;320(1-2):81-93. Epub 2007 Jan 22.


New integrative method to generate Bacillus subtilis recombinant strains free of selection markers.

Brans A, Filée P, Chevigné A, Claessens A, Joris B.

Appl Environ Microbiol. 2004 Dec;70(12):7241-50.

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