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Items: 7

1.

2-Hydroxypyridine-N-oxide (HOPO): Equivocal in the ames assay.

Dobo KL, Cheung JR, Gunther WC, Kenyon MO.

Environ Mol Mutagen. 2018 May;59(4):312-321. doi: 10.1002/em.22179. Epub 2018 Feb 26.

PMID:
29481708
2.

Resolution of contradiction between in silico predictions and Ames test results for four pharmaceutically relevant impurities.

Gunther WC, Kenyon MO, Cheung JR, Dugger RW, Dobo KL.

Regul Toxicol Pharmacol. 2017 Dec;91:68-76. doi: 10.1016/j.yrtph.2017.10.011. Epub 2017 Oct 20.

PMID:
29061373
3.

Histone markers identify the mode of action for compounds positive in the TK6 micronucleus assay.

Cheung JR, Dickinson DA, Moss J, Schuler MJ, Spellman RA, Heard PL.

Mutat Res Genet Toxicol Environ Mutagen. 2015 Jan 1;777:7-16. doi: 10.1016/j.mrgentox.2014.11.002. Epub 2014 Nov 15.

PMID:
25726170
4.

Development and validation of an in vitro micronucleus assay platform in TK6 cells.

Sobol Z, Homiski ML, Dickinson DA, Spellman RA, Li D, Scott A, Cheung JR, Coffing SL, Munzner JB, Sanok KE, Gunther WC, Dobo KL, Schuler M.

Mutat Res. 2012 Jul 4;746(1):29-34. doi: 10.1016/j.mrgentox.2012.02.005. Epub 2012 Mar 13.

PMID:
22445949
5.

Bioluminescent Salmonella reverse mutation assay: a screen for detecting mutagenicity with high throughput attributes.

Aubrecht J, Osowski JJ, Persaud P, Cheung JR, Ackerman J, Lopes SH, Ku WW.

Mutagenesis. 2007 Sep;22(5):335-42. Epub 2007 Jul 26.

PMID:
17656636
6.

An evaluation of the sensitivity of the Ames assay to discern low-level mutagenic impurities.

Kenyon MO, Cheung JR, Dobo KL, Ku WW.

Regul Toxicol Pharmacol. 2007 Jun;48(1):75-86. Epub 2007 Feb 4.

PMID:
17379368
7.

Genotoxicity of 2-(3-chlorobenzyloxy)-6-(piperazinyl)pyrazine, a novel 5-hydroxytryptamine2c receptor agonist for the treatment of obesity: role of metabolic activation.

Kalgutkar AS, Dalvie DK, Aubrecht J, Smith EB, Coffing SL, Cheung JR, Vage C, Lame ME, Chiang P, McClure KF, Maurer TS, Coelho RV Jr, Soliman VF, Schildknegt K.

Drug Metab Dispos. 2007 Jun;35(6):848-58. Epub 2007 Mar 7.

PMID:
17344339

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