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X-ray Scattering and Coarse-Grained Simulations for Clustering and Interactions of Monoclonal Antibodies at High Concentrations.

Dear BJ, Bollinger JA, Chowdhury A, Hung JJ, Wilks LR, Karouta CA, Ramachandran K, Shay TY, Nieto MP, Sharma A, Cheung JK, Nykypanchuk D, Godfrin PD, Johnston KP, Truskett TM.

J Phys Chem B. 2019 May 30. doi: 10.1021/acs.jpcb.9b04478. [Epub ahead of print]


Protein-Protein Interactions of Highly Concentrated Monoclonal Antibody Solutions via Static Light Scattering and Influence on the Viscosity.

Hung JJ, Dear BJ, Karouta CA, Chowdhury AA, Godfrin PD, Bollinger JA, Nieto MP, Wilks LR, Shay TY, Ramachandran K, Sharma A, Cheung JK, Truskett TM, Johnston KP.

J Phys Chem B. 2019 Jan 31;123(4):739-755. doi: 10.1021/acs.jpcb.8b09527. Epub 2019 Jan 18.


Structure, heterogeneity and developability assessment of therapeutic antibodies.

Xu Y, Wang D, Mason B, Rossomando T, Li N, Liu D, Cheung JK, Xu W, Raghava S, Katiyar A, Nowak C, Xiang T, Dong DD, Sun J, Beck A, Liu H.

MAbs. 2019 Feb/Mar;11(2):239-264. doi: 10.1080/19420862.2018.1553476. Epub 2018 Dec 17.


Concurrent Host-Pathogen Transcriptional Responses in a Clostridium perfringens Murine Myonecrosis Infection.

Low LY, Harrison PF, Gould J, Powell DR, Choo JM, Forster SC, Chapman R, Gearing LJ, Cheung JK, Hertzog P, Rood JI.

MBio. 2018 Mar 27;9(2). pii: e00473-18. doi: 10.1128/mBio.00473-18.


Surveillance of drug abuse in Hong Kong by hair analysis using LC-MS/MS.

Leung KW, Wong ZCF, Ho JYM, Yip AWS, Cheung JKH, Ho KKL, Duan R, Tsim KWK.

Drug Test Anal. 2018 Jun;10(6):977-983. doi: 10.1002/dta.2345. Epub 2017 Dec 18.


Isotope-coded protein label based quantitative proteomic analysis reveals significant up-regulation of apolipoprotein A1 and ovotransferrin in the myopic chick vitreous.

Yu FJ, Lam TC, Liu LQ, Chun RK, Cheung JK, Li KK, To CH.

Sci Rep. 2017 Oct 4;7(1):12649. doi: 10.1038/s41598-017-12650-7.


The NEAT Domain-Containing Proteins of Clostridium perfringens Bind Heme.

Choo JM, Cheung JK, Wisniewski JA, Steer DL, Bulach DM, Hiscox TJ, Chakravorty A, Smith AI, Gell DA, Rood JI, Awad MM.

PLoS One. 2016 Sep 16;11(9):e0162981. doi: 10.1371/journal.pone.0162981. eCollection 2016.


CdtR Regulates TcdA and TcdB Production in Clostridium difficile.

Lyon SA, Hutton ML, Rood JI, Cheung JK, Lyras D.

PLoS Pathog. 2016 Jul 14;12(7):e1005758. doi: 10.1371/journal.ppat.1005758. eCollection 2016 Jul.


Analysis of the virulence-associated RevSR two-component signal transduction system of Clostridium perfringens.

Cheung JK, Wisniewski JA, Adams VM, Quinsey NS, Rood JI.

Int J Med Microbiol. 2016 Sep;306(6):429-42. doi: 10.1016/j.ijmm.2016.05.011. Epub 2016 May 20.


RNA-seq analysis of virR and revR mutants of Clostridium perfringens.

Low LY, Harrison PF, Lin YH, Boyce JD, Rood JI, Cheung JK.

BMC Genomics. 2016 May 23;17:391. doi: 10.1186/s12864-016-2706-2.


A comparison of biophysical characterization techniques in predicting monoclonal antibody stability.

Thiagarajan G, Semple A, James JK, Cheung JK, Shameem M.

MAbs. 2016 Aug-Sep;8(6):1088-97. doi: 10.1080/19420862.2016.1189048. Epub 2016 May 21.


Functional analysis of an feoB mutant in Clostridium perfringens strain 13.

Awad MM, Cheung JK, Tan JE, McEwan AG, Lyras D, Rood JI.

Anaerobe. 2016 Oct;41:10-17. doi: 10.1016/j.anaerobe.2016.05.005. Epub 2016 May 10.


A 3-arm randomized controlled trial on the effects of dance movement intervention and exercises on elderly with early dementia.

Ho RT, Cheung JK, Chan WC, Cheung IK, Lam LC.

BMC Geriatr. 2015 Oct 19;15:127. doi: 10.1186/s12877-015-0123-z.


NanR, a Transcriptional Regulator That Binds to the Promoters of Genes Involved in Sialic Acid Metabolism in the Anaerobic Pathogen Clostridium perfringens.

Therit B, Cheung JK, Rood JI, Melville SB.

PLoS One. 2015 Jul 21;10(7):e0133217. doi: 10.1371/journal.pone.0133217. eCollection 2015.


Prediction of viral filtration performance of monoclonal antibodies based on biophysical properties of feed.

Rayfield WJ, Roush DJ, Chmielowski RA, Tugcu N, Barakat S, Cheung JK.

Biotechnol Prog. 2015 May-Jun;31(3):765-74. doi: 10.1002/btpr.2094. Epub 2015 May 19.


Animal models to study the pathogenesis of human and animal Clostridium perfringens infections.

Uzal FA, McClane BA, Cheung JK, Theoret J, Garcia JP, Moore RJ, Rood JI.

Vet Microbiol. 2015 Aug 31;179(1-2):23-33. doi: 10.1016/j.vetmic.2015.02.013. Epub 2015 Feb 25. Review.


The pore-forming α-toxin from clostridium septicum activates the MAPK pathway in a Ras-c-Raf-dependent and independent manner.

Chakravorty A, Awad MM, Cheung JK, Hiscox TJ, Lyras D, Rood JI.

Toxins (Basel). 2015 Feb 10;7(2):516-34. doi: 10.3390/toxins7020516.


Nanoparticulate Impurities in Pharmaceutical-Grade Sugars and their Interference with Light Scattering-Based Analysis of Protein Formulations.

Weinbuch D, Cheung JK, Ketelaars J, Filipe V, Hawe A, den Engelsman J, Jiskoot W.

Pharm Res. 2015 Jul;32(7):2419-27. doi: 10.1007/s11095-015-1634-1. Epub 2015 Jan 30.


Complex disposition of methylthioninium redox forms determines efficacy in tau aggregation inhibitor therapy for Alzheimer's disease.

Baddeley TC, McCaffrey J, Storey JM, Cheung JK, Melis V, Horsley D, Harrington CR, Wischik CM.

J Pharmacol Exp Ther. 2015 Jan;352(1):110-8. doi: 10.1124/jpet.114.219352. Epub 2014 Oct 15.


Improving monoclonal antibody selection and engineering using measurements of colloidal protein interactions.

Geng SB, Cheung JK, Narasimhan C, Shameem M, Tessier PM.

J Pharm Sci. 2014 Nov;103(11):3356-3363. doi: 10.1002/jps.24130. Epub 2014 Sep 10. Review.


Identification of a two-component signal transduction system that regulates maltose genes in Clostridium perfringens.

Hiscox TJ, Ohtani K, Shimizu T, Cheung JK, Rood JI.

Anaerobe. 2014 Dec;30:199-204. doi: 10.1016/j.anaerobe.2014.08.006. Epub 2014 Aug 23.


Utility of the clostridial site-specific recombinase TnpX to clone toxic-product-encoding genes and selectively remove genomic DNA fragments.

Adams V, Bantwal R, Stevenson L, Cheung JK, Awad MM, Nicholson J, Carter GP, Mackin KE, Rood JI, Lyras D.

Appl Environ Microbiol. 2014 Jun;80(12):3597-3603.


Regulation of toxin production in the pathogenic clostridia.

Carter GP, Cheung JK, Larcombe S, Lyras D.

Mol Microbiol. 2014 Jan;91(2):221-31. Review.


Opioid analgesics stop the development of clostridial gas gangrene.

Chakravorty A, Awad MM, Hiscox TJ, Cheung JK, Choo JM, Lyras D, Rood JI.

J Infect Dis. 2014 Aug 1;210(3):483-92. doi: 10.1093/infdis/jiu101. Epub 2014 Feb 18.


Effect of pegylation on self-association of IFN-α2b.

Mohs A, Ambrogelly A, Yang X, Haverick M, Cheung JK, Narasimhan C, Shameem M.

Mol Pharm. 2014 Jan 6;11(1):158-63. doi: 10.1021/mp400343b. Epub 2013 Dec 6.


Regulation of sialidase production in Clostridium perfringens by the orphan sensor histidine kinase ReeS.

Hiscox TJ, Harrison PF, Chakravorty A, Choo JM, Ohtani K, Shimizu T, Cheung JK, Rood JI.

PLoS One. 2013 Sep 4;8(9):e73525. doi: 10.1371/journal.pone.0073525. eCollection 2013.


Structural and functional analysis of the pore-forming toxin NetB from Clostridium perfringens.

Yan XX, Porter CJ, Hardy SP, Steer D, Smith AI, Quinsey NS, Hughes V, Cheung JK, Keyburn AL, Kaldhusdal M, Moore RJ, Bannam TL, Whisstock JC, Rood JI.

MBio. 2013 Feb 5;4(1):e00019-13. doi: 10.1128/mBio.00019-13.


Solution pH that minimizes self-association of three monoclonal antibodies is strongly dependent on ionic strength.

Sule SV, Cheung JK, Antochshuk V, Bhalla AS, Narasimhan C, Blaisdell S, Shameem M, Tessier PM.

Mol Pharm. 2012 Apr 2;9(4):744-51. doi: 10.1021/mp200448j. Epub 2012 Feb 17.


Necrotic enteritis-derived Clostridium perfringens strain with three closely related independently conjugative toxin and antibiotic resistance plasmids.

Bannam TL, Yan XX, Harrison PF, Seemann T, Keyburn AL, Stubenrauch C, Weeramantri LH, Cheung JK, McClane BA, Boyce JD, Moore RJ, Rood JI.

MBio. 2011 Sep 27;2(5). pii: e00190-11. doi: 10.1128/mBio.00190-11. Print 2011.


The cysteine protease α-clostripain is not essential for the pathogenesis of Clostridium perfringens-mediated myonecrosis.

Chakravorty A, Awad MM, Hiscox TJ, Cheung JK, Carter GP, Choo JM, Lyras D, Rood JI.

PLoS One. 2011;6(7):e22762. doi: 10.1371/journal.pone.0022762. Epub 2011 Jul 29.


Regulation of virulence by the RevR response regulator in Clostridium perfringens.

Hiscox TJ, Chakravorty A, Choo JM, Ohtani K, Shimizu T, Cheung JK, Rood JI.

Infect Immun. 2011 Jun;79(6):2145-53. doi: 10.1128/IAI.00060-11. Epub 2011 Mar 14.


The VirSR two-component signal transduction system regulates NetB toxin production in Clostridium perfringens.

Cheung JK, Keyburn AL, Carter GP, Lanckriet AL, Van Immerseel F, Moore RJ, Rood JI.

Infect Immun. 2010 Jul;78(7):3064-72. doi: 10.1128/IAI.00123-10. Epub 2010 May 10.


Insights into crowding effects on protein stability from a coarse-grained model.

Shen VK, Cheung JK, Errington JR, Truskett TM.

J Biomech Eng. 2009 Jul;131(7):071002. doi: 10.1115/1.3127259.


Functional analysis of the VirSR phosphorelay from Clostridium perfringens.

Cheung JK, Awad MM, McGowan S, Rood JI.

PLoS One. 2009 Jun 9;4(6):e5849. doi: 10.1371/journal.pone.0005849.


Cordysinocan, a polysaccharide isolated from cultured Cordyceps, activates immune responses in cultured T-lymphocytes and macrophages: signaling cascade and induction of cytokines.

Cheung JK, Li J, Cheung AW, Zhu Y, Zheng KY, Bi CW, Duan R, Choi RC, Lau DT, Dong TT, Lau BW, Tsim KW.

J Ethnopharmacol. 2009 Jul 6;124(1):61-8. doi: 10.1016/j.jep.2009.04.010. Epub 2009 Apr 11.


Cross-complementation of Clostridium perfringens PLC and Clostridium septicum alpha-toxin mutants reveals PLC is sufficient to mediate gas gangrene.

Kennedy CL, Lyras D, Cheung JK, Hiscox TJ, Emmins JJ, Rood JI.

Microbes Infect. 2009 Mar;11(3):413-8. doi: 10.1016/j.micinf.2009.01.002. Epub 2009 Jan 20.


A chinese herbal decoction, danggui buxue tang, stimulates proliferation, differentiation and gene expression of cultured osteosarcoma cells: genomic approach to reveal specific gene activation.

Choi RC, Gao QT, Cheung AW, Zhu JT, Lau FT, Li J, Li WZ, Chu GK, Duan R, Cheung JK, Ding AW, Zhao KJ, Dong TT, Tsim KW.

Evid Based Complement Alternat Med. 2011;2011:307548. doi: 10.1093/ecam/nen085. Epub 2011 Jun 18.


A Chinese herbal decoction prepared from Radix Astragali and Radix Angelicae Sinensis induces the expression of erythropoietin in cultured Hep3B cells.

Gao QT, Cheung JK, Choi RC, Cheung AW, Li J, Jiang ZY, Duan R, Zhao KJ, Ding AW, Dong TT, Tsim KW.

Planta Med. 2008 Mar;74(4):392-5. doi: 10.1055/s-2008-1034322.


A Chinese herbal decoction, Danggui Buxue Tang, activates extracellular signal-regulated kinase in cultured T-lymphocytes.

Gao QT, Cheung JK, Li J, Jiang ZY, Chu GK, Duan R, Cheung AW, Zhao KJ, Choi RC, Dong TT, Tsim KW.

FEBS Lett. 2007 Oct 30;581(26):5087-93. Epub 2007 Oct 2.


Environmental fate of endocrine-disrupting dimethyl phthalate esters (DMPE) under sulfate-reducing condition.

Cheung JK, Lam RK, Shi MY, Gu JD.

Sci Total Environ. 2007 Aug 1;381(1-3):126-33. Epub 2007 Apr 26.


Coarse-grained strategy for modeling protein stability in concentrated solutions. III: directional protein interactions.

Cheung JK, Shen VK, Errington JR, Truskett TM.

Biophys J. 2007 Jun 15;92(12):4316-24. Epub 2007 Mar 30.


Danggui buxue tang--a Chinese herbal decoction activates the phosphorylations of extracellular signal-regulated kinase and estrogen receptor alpha in cultured MCF-7 cells.

Gao QT, Choi RC, Cheung AW, Zhu JT, Li J, Chu GK, Duan R, Cheung JK, Jiang ZY, Dong XB, Zhao KJ, Dong TT, Tsim KW.

FEBS Lett. 2007 Jan 23;581(2):233-40. Epub 2006 Dec 14.


Analytical model for studying how environmental factors influence protein conformational stability in solution.

Cheung JK, Raverkar PS, Truskett TM.

J Chem Phys. 2006 Dec 14;125(22):224903.


Construction and analysis of chromosomal Clostridium difficile mutants.

O'Connor JR, Lyras D, Farrow KA, Adams V, Powell DR, Hinds J, Cheung JK, Rood JI.

Mol Microbiol. 2006 Sep;61(5):1335-51.


A Chinese herbal decoction, Danggui Buxue Tang, prepared from Radix Astragali and Radix Angelicae Sinensis stimulates the immune responses.

Gao QT, Cheung JK, Li J, Chu GK, Duan R, Cheung AW, Zhao KJ, Dong TT, Tsim KW.

Planta Med. 2006 Oct;72(13):1227-31. Epub 2006 Aug 10.


Heteropolymer collapse theory for protein folding in the pressure-temperature plane.

Cheung JK, Shah P, Truskett TM.

Biophys J. 2006 Oct 1;91(7):2427-35. Epub 2006 Jul 14.


Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens.

Myers GS, Rasko DA, Cheung JK, Ravel J, Seshadri R, DeBoy RT, Ren Q, Varga J, Awad MM, Brinkac LM, Daugherty SC, Haft DH, Dodson RJ, Madupu R, Nelson WC, Rosovitz MJ, Sullivan SA, Khouri H, Dimitrov GI, Watkins KL, Mulligan S, Benton J, Radune D, Fisher DJ, Atkins HS, Hiscox T, Jost BH, Billington SJ, Songer JG, McClane BA, Titball RW, Rood JI, Melville SB, Paulsen IT.

Genome Res. 2006 Aug;16(8):1031-40. Epub 2006 Jul 6.


Coarse-grained strategy for modeling protein stability in concentrated solutions. II: phase behavior.

Shen VK, Cheung JK, Errington JR, Truskett TM.

Biophys J. 2006 Mar 15;90(6):1949-60. Epub 2005 Dec 30.


Coarse-grained strategy for modeling protein stability in concentrated solutions.

Cheung JK, Truskett TM.

Biophys J. 2005 Oct;89(4):2372-84. Epub 2005 Jul 22.

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