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Items: 46


Role of Phenol-Soluble Modulins in Staphylococcus epidermidis Biofilm Formation and Infection of Indwelling Medical Devices.

Le KY, Villaruz AE, Zheng Y, He L, Fisher EL, Nguyen TH, Ho TV, Yeh AJ, Joo HS, Cheung GYC, Otto M.

J Mol Biol. 2019 Apr 5. pii: S0022-2836(19)30180-9. doi: 10.1016/j.jmb.2019.03.030. [Epub ahead of print]


Resistance to leukocytes ties benefits of quorum sensing dysfunctionality to biofilm infection.

He L, Le KY, Khan BA, Nguyen TH, Hunt RL, Bae JS, Kabat J, Zheng Y, Cheung GYC, Li M, Otto M.

Nat Microbiol. 2019 Jul;4(7):1114-1119. doi: 10.1038/s41564-019-0413-x. Epub 2019 Apr 1.


Pathogen elimination by probiotic Bacillus via signalling interference.

Piewngam P, Zheng Y, Nguyen TH, Dickey SW, Joo HS, Villaruz AE, Glose KA, Fisher EL, Hunt RL, Li B, Chiou J, Pharkjaksu S, Khongthong S, Cheung GYC, Kiratisin P, Otto M.

Nature. 2018 Oct;562(7728):532-537. doi: 10.1038/s41586-018-0616-y. Epub 2018 Oct 10.


Do antimicrobial peptides and antimicrobial-peptide resistance play important roles during bacterial infection?

Cheung GY, Otto M.

Future Microbiol. 2018 Aug;13:1073-1075. doi: 10.2217/fmb-2018-0138. Epub 2018 Aug 16. No abstract available.


Basis of Virulence in Enterotoxin-Mediated Staphylococcal Food Poisoning.

Fisher EL, Otto M, Cheung GYC.

Front Microbiol. 2018 Mar 13;9:436. doi: 10.3389/fmicb.2018.00436. eCollection 2018. Review.


Antimicrobial Peptide Resistance Mechanism Contributes to Staphylococcus aureus Infection.

Cheung GYC, Fisher EL, McCausland JW, Choi J, Collins JWM, Dickey SW, Otto M.

J Infect Dis. 2018 Mar 13;217(7):1153-1159. doi: 10.1093/infdis/jiy024.


Phenol-Soluble Modulin Toxins of Staphylococcus haemolyticus.

Da F, Joo HS, Cheung GYC, Villaruz AE, Rohde H, Luo X, Otto M.

Front Cell Infect Microbiol. 2017 May 24;7:206. doi: 10.3389/fcimb.2017.00206. eCollection 2017.


Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance.

Dickey SW, Cheung GYC, Otto M.

Nat Rev Drug Discov. 2017 Jul;16(7):457-471. doi: 10.1038/nrd.2017.23. Epub 2017 Mar 24. Review.


Toxin Mediates Sepsis Caused by Methicillin-Resistant Staphylococcus epidermidis.

Qin L, Da F, Fisher EL, Tan DC, Nguyen TH, Fu CL, Tan VY, McCausland JW, Sturdevant DE, Joo HS, Queck SY, Cheung GY, Otto M.

PLoS Pathog. 2017 Feb 2;13(2):e1006153. doi: 10.1371/journal.ppat.1006153. eCollection 2017 Feb.


Bacterial Abscess Formation Is Controlled by the Stringent Stress Response and Can Be Targeted Therapeutically.

Mansour SC, Pletzer D, de la Fuente-Núñez C, Kim P, Cheung GYC, Joo HS, Otto M, Hancock REW.

EBioMedicine. 2016 Oct;12:219-226. doi: 10.1016/j.ebiom.2016.09.015. Epub 2016 Sep 17.


PSM-Mec-A Virulence Determinant that Connects Transcriptional Regulation, Virulence, and Antibiotic Resistance in Staphylococci.

Qin L, McCausland JW, Cheung GY, Otto M.

Front Microbiol. 2016 Aug 22;7:1293. doi: 10.3389/fmicb.2016.01293. eCollection 2016. Review.


Key Role of α-Toxin in Fatal Pneumonia Caused by Staphylococcus aureus Sequence Type 398.

Bonesso MF, Yeh AJ, Villaruz AE, Joo HS, McCausland J, Fortaleza CM, Cavalcante RS, Sobrinho MT, Ronchi CF, Cheung GY, Cunha ML, Otto M.

Am J Respir Crit Care Med. 2016 Jan 15;193(2):217-20. doi: 10.1164/rccm.201506-1225LE. No abstract available.


Adenoviral Expression of a Bispecific VHH-Based Neutralizing Agent That Targets Protective Antigen Provides Prophylactic Protection from Anthrax in Mice.

Moayeri M, Tremblay JM, Debatis M, Dmitriev IP, Kashentseva EA, Yeh AJ, Cheung GY, Curiel DT, Leppla S, Shoemaker CB.

Clin Vaccine Immunol. 2016 Jan 6;23(3):213-8. doi: 10.1128/CVI.00611-15.


Activator of G-Protein Signaling 3-Induced Lysosomal Biogenesis Limits Macrophage Intracellular Bacterial Infection.

Vural A, Al-Khodor S, Cheung GY, Shi CS, Srinivasan L, McQuiston TJ, Hwang IY, Yeh AJ, Blumer JB, Briken V, Williamson PR, Otto M, Fraser ID, Kehrl JH.

J Immunol. 2016 Jan 15;196(2):846-56. doi: 10.4049/jimmunol.1501595. Epub 2015 Dec 14.


Functional characteristics of the Staphylococcus aureus δ-toxin allelic variant G10S.

Cheung GY, Yeh AJ, Kretschmer D, Duong AC, Tuffuor K, Fu CL, Joo HS, Diep BA, Li M, Nakamura Y, Nunez G, Peschel A, Otto M.

Sci Rep. 2015 Dec 10;5:18023. doi: 10.1038/srep18023.


Investigational drugs to treat methicillin-resistant Staphylococcus aureus.

Vuong C, Yeh AJ, Cheung GY, Otto M.

Expert Opin Investig Drugs. 2016;25(1):73-93. doi: 10.1517/13543784.2016.1109077. Epub 2015 Nov 4. Review.


Role of Phenol-Soluble Modulins in Formation of Staphylococcus aureus Biofilms in Synovial Fluid.

Dastgheyb SS, Villaruz AE, Le KY, Tan VY, Duong AC, Chatterjee SS, Cheung GY, Joo HS, Hickok NJ, Otto M.

Infect Immun. 2015 Jul;83(7):2966-75. doi: 10.1128/IAI.00394-15. Epub 2015 May 11.


Neutrophil recruitment to lymph nodes limits local humoral response to Staphylococcus aureus.

Kamenyeva O, Boularan C, Kabat J, Cheung GY, Cicala C, Yeh AJ, Chan JL, Periasamy S, Otto M, Kehrl JH.

PLoS Pathog. 2015 Apr 17;11(4):e1004827. doi: 10.1371/journal.ppat.1004827. eCollection 2015 Apr.


Investigational therapies targeting quorum-sensing for the treatment of Staphylococcus aureus infections.

Khan BA, Yeh AJ, Cheung GY, Otto M.

Expert Opin Investig Drugs. 2015 May;24(5):689-704. doi: 10.1517/13543784.2015.1019062. Epub 2015 Feb 23. Review.


Microbiology: Diverted on the way to memory.

Cheung GY, Otto M.

Nature. 2015 Jan 1;517(7532):28-9. doi: 10.1038/nature14083. Epub 2014 Dec 10. No abstract available.


Production of an attenuated phenol-soluble modulin variant unique to the MRSA clonal complex 30 increases severity of bloodstream infection.

Cheung GY, Kretschmer D, Duong AC, Yeh AJ, Ho TV, Chen Y, Joo HS, Kreiswirth BN, Peschel A, Otto M.

PLoS Pathog. 2014 Aug 21;10(8):e1004298. doi: 10.1371/journal.ppat.1004298. eCollection 2014 Aug.


Basis of virulence in a Panton-Valentine leukocidin-negative community-associated methicillin-resistant Staphylococcus aureus strain.

Chen Y, Yeh AJ, Cheung GY, Villaruz AE, Tan VY, Joo HS, Chatterjee SS, Yu Y, Otto M.

J Infect Dis. 2015 Feb 1;211(3):472-80. doi: 10.1093/infdis/jiu462. Epub 2014 Aug 19.


Genome-wide analysis of the regulatory function mediated by the small regulatory psm-mec RNA of methicillin-resistant Staphylococcus aureus.

Cheung GY, Villaruz AE, Joo HS, Duong AC, Yeh AJ, Nguyen TH, Sturdevant DE, Queck SY, Otto M.

Int J Med Microbiol. 2014 Jul;304(5-6):637-44. doi: 10.1016/j.ijmm.2014.04.008. Epub 2014 Apr 28. Erratum in: Int J Med Microbiol. 2015 Jun-Aug;305(4-5):491.


Phenol-soluble modulins--critical determinants of staphylococcal virulence.

Cheung GY, Joo HS, Chatterjee SS, Otto M.

FEMS Microbiol Rev. 2014 Jul;38(4):698-719. doi: 10.1111/1574-6976.12057. Epub 2014 Jan 16. Review.


Staphylococcus δ-toxin induces allergic skin disease by activating mast cells.

Nakamura Y, Oscherwitz J, Cease KB, Chan SM, Muñoz-Planillo R, Hasegawa M, Villaruz AE, Cheung GY, McGavin MJ, Travers JB, Otto M, Inohara N, Núñez G.

Nature. 2013 Nov 21;503(7476):397-401. doi: 10.1038/nature12655. Epub 2013 Oct 30.


Insight into structure-function relationship in phenol-soluble modulins using an alanine screen of the phenol-soluble modulin (PSM) α3 peptide.

Cheung GY, Kretschmer D, Queck SY, Joo HS, Wang R, Duong AC, Nguyen TH, Bach TH, Porter AR, DeLeo FR, Peschel A, Otto M.

FASEB J. 2014 Jan;28(1):153-61. doi: 10.1096/fj.13-232041. Epub 2013 Sep 5.


Essential Staphylococcus aureus toxin export system.

Chatterjee SS, Joo HS, Duong AC, Dieringer TD, Tan VY, Song Y, Fischer ER, Cheung GY, Li M, Otto M.

Nat Med. 2013 Mar;19(3):364-7. doi: 10.1038/nm.3047. Epub 2013 Feb 10.


Phenol-soluble modulins in staphylococci: What are they originally for?

Periasamy S, Chatterjee SS, Cheung GY, Otto M.

Commun Integr Biol. 2012 May 1;5(3):275-7. doi: 10.4161/cib.19420.


The potential use of toxin antibodies as a strategy for controlling acute Staphylococcus aureus infections.

Cheung GY, Otto M.

Expert Opin Ther Targets. 2012 Jun;16(6):601-12. doi: 10.1517/14728222.2012.682573. Epub 2012 Apr 25. Review.


How Staphylococcus aureus biofilms develop their characteristic structure.

Periasamy S, Joo HS, Duong AC, Bach TH, Tan VY, Chatterjee SS, Cheung GY, Otto M.

Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1281-6. doi: 10.1073/pnas.1115006109. Epub 2012 Jan 9.


Interaction of phenol-soluble modulins with phosphatidylcholine vesicles.

Duong AC, Cheung GY, Otto M.

Pathogens. 2012 Jul 20;1(1):3-11. doi: 10.3390/pathogens1010003.


Direct and synergistic hemolysis caused by Staphylococcus phenol-soluble modulins: implications for diagnosis and pathogenesis.

Cheung GY, Duong AC, Otto M.

Microbes Infect. 2012 Apr;14(4):380-6. doi: 10.1016/j.micinf.2011.11.013. Epub 2011 Dec 7.


Distribution and regulation of the mobile genetic element-encoded phenol-soluble modulin PSM-mec in methicillin-resistant Staphylococcus aureus.

Chatterjee SS, Chen L, Joo HS, Cheung GY, Kreiswirth BN, Otto M.

PLoS One. 2011;6(12):e28781. doi: 10.1371/journal.pone.0028781. Epub 2011 Dec 12.


Role of the accessory gene regulator agr in community-associated methicillin-resistant Staphylococcus aureus pathogenesis.

Cheung GY, Wang R, Khan BA, Sturdevant DE, Otto M.

Infect Immun. 2011 May;79(5):1927-35. doi: 10.1128/IAI.00046-11. Epub 2011 Mar 14.


Antimicrobial activity of community-associated methicillin-resistant Staphylococcus aureus is caused by phenol-soluble modulin derivatives.

Joo HS, Cheung GY, Otto M.

J Biol Chem. 2011 Mar 18;286(11):8933-40. doi: 10.1074/jbc.M111.221382. Epub 2011 Jan 28.


Staphylococcus epidermidis surfactant peptides promote biofilm maturation and dissemination of biofilm-associated infection in mice.

Wang R, Khan BA, Cheung GY, Bach TH, Jameson-Lee M, Kong KF, Queck SY, Otto M.

J Clin Invest. 2011 Jan;121(1):238-48. doi: 10.1172/JCI42520. Epub 2010 Dec 6.


Comparative analysis of virulence and toxin expression of global community-associated methicillin-resistant Staphylococcus aureus strains.

Li M, Cheung GY, Hu J, Wang D, Joo HS, Deleo FR, Otto M.

J Infect Dis. 2010 Dec 15;202(12):1866-76. doi: 10.1086/657419. Epub 2010 Nov 4.


Staphylococcus epidermidis strategies to avoid killing by human neutrophils.

Cheung GY, Rigby K, Wang R, Queck SY, Braughton KR, Whitney AR, Teintze M, DeLeo FR, Otto M.

PLoS Pathog. 2010 Oct 7;6(10):e1001133. doi: 10.1371/journal.ppat.1001133.


Understanding the significance of Staphylococcus epidermidis bacteremia in babies and children.

Cheung GY, Otto M.

Curr Opin Infect Dis. 2010 Jun;23(3):208-16. doi: 10.1097/QCO.0b013e328337fecb. Review.


Bordetella pertussis commits human dendritic cells to promote a Th1/Th17 response through the activity of adenylate cyclase toxin and MAPK-pathways.

Fedele G, Spensieri F, Palazzo R, Nasso M, Cheung GY, Coote JG, Ausiello CM.

PLoS One. 2010 Jan 15;5(1):e8734. doi: 10.1371/journal.pone.0008734.


Codon-optimized fluorescent proteins designed for expression in low-GC gram-positive bacteria.

Sastalla I, Chim K, Cheung GY, Pomerantsev AP, Leppla SH.

Appl Environ Microbiol. 2009 Apr;75(7):2099-110. doi: 10.1128/AEM.02066-08. Epub 2009 Jan 30.


Functional and structural studies on different forms of the adenylate cyclase toxin of Bordetella pertussis.

Cheung GY, Kelly SM, Jess TJ, Prior S, Price NC, Parton R, Coote JG.

Microb Pathog. 2009 Jan;46(1):36-42. doi: 10.1016/j.micpath.2008.10.005. Epub 2008 Nov 1.


Transcriptional responses of murine macrophages to the adenylate cyclase toxin of Bordetella pertussis.

Cheung GY, Dickinson P, Sing G, Craigon M, Ghazal P, Parton R, Coote JG.

Microb Pathog. 2008 Jan;44(1):61-70. Epub 2007 Aug 14.


Effect of different forms of adenylate cyclase toxin of Bordetella pertussis on protection afforded by an acellular pertussis vaccine in a murine model.

Cheung GY, Xing D, Prior S, Corbel MJ, Parton R, Coote JG.

Infect Immun. 2006 Dec;74(12):6797-805. Epub 2006 Sep 18.


A case of bioprosthetic mitral valve dysfunction presenting as haemolytic anaemia.

Chan DK, Cheung GY.

Aust N Z J Med. 1995 Oct;25(5):543. No abstract available.


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