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Items: 1 to 50 of 223

1.

The Toxin-Antitoxin MazEF Drives Staphylococcus aureus Biofilm Formation, Antibiotic Tolerance, and Chronic Infection.

Ma D, Mandell JB, Donegan NP, Cheung AL, Ma W, Rothenberger S, Shanks RMQ, Richardson AR, Urish KL.

MBio. 2019 Nov 26;10(6). pii: e01658-19. doi: 10.1128/mBio.01658-19.

2.

Interspecies interactions induce exploratory motility in Pseudomonas aeruginosa.

Limoli DH, Warren EA, Yarrington KD, Donegan NP, Cheung AL, O'Toole G.

Elife. 2019 Nov 12;8. pii: e47365. doi: 10.7554/eLife.47365. [Epub ahead of print]

3.

MicroRNA-338-5p reverses chemoresistance and inhibits invasion of esophageal squamous cell carcinoma cells by targeting Id-1.

Han L, Cui D, Li B, Xu WW, Lam AKY, Chan KT, Zhu Y, Lee NPY, Law SYK, Guan XY, Qin YR, Chan KW, Ma S, Tsao SW, Cheung ALM.

Cancer Sci. 2019 Dec;110(12):3677-3688. doi: 10.1111/cas.14220. Epub 2019 Nov 17.

4.

CspA regulation of Staphylococcus aureus carotenoid levels and σB activity is controlled by YjbH and Spx.

Donegan NP, Manna AC, Tseng CW, Liu GY, Cheung AL.

Mol Microbiol. 2019 Aug;112(2):532-551. doi: 10.1111/mmi.14273. Epub 2019 May 22.

PMID:
31074903
5.

Quorum sensing between bacterial species on the skin protects against epidermal injury in atopic dermatitis.

Williams MR, Costa SK, Zaramela LS, Khalil S, Todd DA, Winter HL, Sanford JA, O'Neill AM, Liggins MC, Nakatsuji T, Cech NB, Cheung AL, Zengler K, Horswill AR, Gallo RL.

Sci Transl Med. 2019 May 1;11(490). pii: eaat8329. doi: 10.1126/scitranslmed.aat8329.

PMID:
31043573
6.

Identification of miR-29c and its Target FBXO31 as a Key Regulatory Mechanism in Esophageal Cancer Chemoresistance: Functional Validation and Clinical Significance.

Li B, Hong P, Zheng CC, Dai W, Chen WY, Yang QS, Han L, Tsao SW, Chan KT, Lee NPY, Law S, Xu LY, Li EM, Chan KW, Qin YR, Guan XY, Lung ML, He QY, Xu WW, Cheung AL.

Theranostics. 2019 Feb 28;9(6):1599-1613. doi: 10.7150/thno.30372. eCollection 2019.

7.

mTORC2-mediated PDHE1α nuclear translocation links EBV-LMP1 reprogrammed glucose metabolism to cancer metastasis in nasopharyngeal carcinoma.

Zhang J, Jia L, Liu T, Yip YL, Tang WC, Lin W, Deng W, Lo KW, You C, Lung ML, Lung HL, Cheung AL, Tsao SW, Tsang CM.

Oncogene. 2019 Jun;38(24):4669-4684. doi: 10.1038/s41388-019-0749-y. Epub 2019 Feb 11.

8.

YpdA, a putative bacillithiol disulfide reductase, contributes to cellular redox homeostasis and virulence in Staphylococcus aureus.

Mikheyeva IV, Thomas JM, Kolar SL, Corvaglia AR, Gaϊa N, Leo S, Francois P, Liu GY, Rawat M, Cheung AL.

Mol Microbiol. 2019 Apr;111(4):1039-1056. doi: 10.1111/mmi.14207. Epub 2019 Feb 17.

PMID:
30636083
9.

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials.

Antonova-Koch Y, Meister S, Abraham M, Luth MR, Ottilie S, Lukens AK, Sakata-Kato T, Vanaerschot M, Owen E, Jado JC, Maher SP, Calla J, Plouffe D, Zhong Y, Chen K, Chaumeau V, Conway AJ, McNamara CW, Ibanez M, Gagaring K, Serrano FN, Eribez K, Taggard CM, Cheung AL, Lincoln C, Ambachew B, Rouillier M, Siegel D, Nosten F, Kyle DE, Gamo FJ, Zhou Y, Llinás M, Fidock DA, Wirth DF, Burrows J, Campo B, Winzeler EA.

Science. 2018 Dec 7;362(6419). pii: eaat9446. doi: 10.1126/science.aat9446.

10.

Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma.

Lin W, Yip YL, Jia L, Deng W, Zheng H, Dai W, Ko JMY, Lo KW, Chung GTY, Yip KY, Lee SD, Kwan JS, Zhang J, Liu T, Chan JY, Kwong DL, Lee VH, Nicholls JM, Busson P, Liu X, Chiang AKS, Hui KF, Kwok H, Cheung ST, Cheung YC, Chan CK, Li B, Cheung AL, Hau PM, Zhou Y, Tsang CM, Middeldorp J, Chen H, Lung ML, Tsao SW.

Nat Commun. 2018 Nov 7;9(1):4663. doi: 10.1038/s41467-018-06889-5.

11.

IGF2 induces CD133 expression in esophageal cancer cells to promote cancer stemness.

Xu WW, Li B, Zhao JF, Yang JG, Li JQ, Tsao SW, He QY, Cheung ALM.

Cancer Lett. 2018 Jul 1;425:88-100. doi: 10.1016/j.canlet.2018.03.039. Epub 2018 Mar 29.

PMID:
29604392
12.

Two inhibitors of yeast plasma membrane ATPase 1 (ScPma1p): toward the development of novel antifungal therapies.

Ottilie S, Goldgof GM, Cheung AL, Walker JL, Vigil E, Allen KE, Antonova-Koch Y, Slayman CW, Suzuki Y, Durrant JD.

J Cheminform. 2018 Feb 20;10(1):6. doi: 10.1186/s13321-018-0261-3.

13.

Correlation of defective mitotic checkpoint with aberrantly reduced expression of MAD2 protein in nasopharyngeal carcinoma cells.

Wang X, Jin DY, Wong YC, Cheung ALM, Chun ACS, Lo AKF, Liu Y, Tsao SW.

Carcinogenesis. 2018 Feb 9;39(2):305. doi: 10.1093/carcin/bgx127. No abstract available.

PMID:
29267852
14.

Small RNA teg49 Is Derived from a sarA Transcript and Regulates Virulence Genes Independent of SarA in Staphylococcus aureus.

Manna AC, Kim S, Cengher L, Corvaglia A, Leo S, Francois P, Cheung AL.

Infect Immun. 2018 Jan 22;86(2). pii: e00635-17. doi: 10.1128/IAI.00635-17. Print 2018 Feb.

15.

Corrigendum: Correlation of defective mitotic checkpoint with aberrantly reduced expression of MAD2 protein in nasopharyngeal carcinoma cells.

Wang X, Jin DY, Wong YC, Cheung ALM, Chun ACS, Lo AKF, Liu Y, Tsao SW.

Carcinogenesis. 2017 Oct 26;38(11):1155. doi: 10.1093/carcin/bgx086. No abstract available. Erratum in: Carcinogenesis. 2018 Feb 9;39(2):305.

PMID:
29028969
16.

Overexpression of F-box only protein 31 predicts poor prognosis and deregulates p38α- and JNK-mediated apoptosis in esophageal squamous cell carcinoma.

Liu J, Lv L, Gong J, Tan Y, Zhu Y, Dai Y, Pan X, Huen MSY, Li B, Tsao SW, Huo J, Cheung ALM.

Int J Cancer. 2018 Jan 1;142(1):145-155. doi: 10.1002/ijc.31040. Epub 2017 Sep 28.

17.

FSTL1 Promotes Metastasis and Chemoresistance in Esophageal Squamous Cell Carcinoma through NFκB-BMP Signaling Cross-talk.

Lau MC, Ng KY, Wong TL, Tong M, Lee TK, Ming XY, Law S, Lee NP, Cheung AL, Qin YR, Chan KW, Ning W, Guan XY, Ma S.

Cancer Res. 2017 Nov 1;77(21):5886-5899. doi: 10.1158/0008-5472.CAN-17-1411. Epub 2017 Sep 7.

18.

α-Toxin Regulates Local Granulocyte Expansion from Hematopoietic Stem and Progenitor Cells in Staphylococcus aureus-Infected Wounds.

Falahee PC, Anderson LS, Reynolds MB, Pirir M, McLaughlin BE, Dillen CA, Cheung AL, Miller LS, Simon SI.

J Immunol. 2017 Sep 1;199(5):1772-1782. doi: 10.4049/jimmunol.1700649. Epub 2017 Jul 21.

19.

Bypassing the Restriction System To Improve Transformation of Staphylococcus epidermidis.

Costa SK, Donegan NP, Corvaglia AR, François P, Cheung AL.

J Bacteriol. 2017 Jul 25;199(16). pii: e00271-17. doi: 10.1128/JB.00271-17. Print 2017 Aug 15.

20.

Significance of PI3K/AKT signaling pathway in metastasis of esophageal squamous cell carcinoma and its potential as a target for anti-metastasis therapy.

Li B, Xu WW, Lam AKY, Wang Y, Hu HF, Guan XY, Qin YR, Saremi N, Tsao SW, He QY, Cheung ALM.

Oncotarget. 2017 Jun 13;8(24):38755-38766. doi: 10.18632/oncotarget.16333.

21.

MicroRNA-377 suppresses initiation and progression of esophageal cancer by inhibiting CD133 and VEGF.

Li B, Xu WW, Han L, Chan KT, Tsao SW, Lee NPY, Law S, Xu LY, Li EM, Chan KW, Qin YR, Guan XY, He QY, Cheung ALM.

Oncogene. 2017 Jul 13;36(28):3986-4000. doi: 10.1038/onc.2017.29. Epub 2017 Mar 13.

22.

A viral protease relocalizes in the presence of the vector to promote vector performance.

Bak A, Cheung AL, Yang C, Whitham SA, Casteel CL.

Nat Commun. 2017 Feb 16;8:14493. doi: 10.1038/ncomms14493.

23.

Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression.

Xu WW, Li B, Guan XY, Chung SK, Wang Y, Yip YL, Law SY, Chan KT, Lee NP, Chan KW, Xu LY, Li EM, Tsao SW, He QY, Cheung AL.

Nat Commun. 2017 Feb 10;8:14399. doi: 10.1038/ncomms14399.

24.

Persister formation in Staphylococcus aureus is associated with ATP depletion.

Conlon BP, Rowe SE, Gandt AB, Nuxoll AS, Donegan NP, Zalis EA, Clair G, Adkins JN, Cheung AL, Lewis K.

Nat Microbiol. 2016 Apr 18;1:16051. doi: 10.1038/nmicrobiol.2016.51.

PMID:
27572649
25.

Persister formation in Staphylococcus aureus is associated with ATP depletion.

Conlon BP, Rowe SE, Gandt AB, Nuxoll AS, Donegan NP, Zalis EA, Clair G, Adkins JN, Cheung AL, Lewis K.

Nat Microbiol. 2016;1. pii: 16051. Epub 2016 Apr 18.

26.

Effect of clpP and clpC deletion on persister cell number in Staphylococcus aureus.

Springer MT, Singh VK, Cheung AL, Donegan NP, Chamberlain NR.

J Med Microbiol. 2016 Aug;65(8):848-57. doi: 10.1099/jmm.0.000304. Epub 2016 Jul 1.

PMID:
27375177
27.

Extremely stringent activation of p16INK4a prevents immortalization of uterine cervical epithelial cells without human papillomavirus oncogene expression.

Hang S, Tiwari AF, Ngan HY, Yip YL, Cheung AL, Tsao SW, Deng W.

Oncotarget. 2016 Jul 19;7(29):45656-45670. doi: 10.18632/oncotarget.10120.

28.

Dysregulation of mprF and dltABCD expression among daptomycin-non-susceptible MRSA clinical isolates.

Bayer AS, Mishra NN, Cheung AL, Rubio A, Yang SJ.

J Antimicrob Chemother. 2016 Aug;71(8):2100-4. doi: 10.1093/jac/dkw142. Epub 2016 Apr 27.

29.

Neuropilin-2 promotes tumourigenicity and metastasis in oesophageal squamous cell carcinoma through ERK-MAPK-ETV4-MMP-E-cadherin deregulation.

Fung TM, Ng KY, Tong M, Chen JN, Chai S, Chan KT, Law S, Lee NP, Choi MY, Li B, Cheung AL, Tsao SW, Qin YR, Guan XY, Chan KW, Ma S.

J Pathol. 2016 Jul;239(3):309-19. doi: 10.1002/path.4728. Epub 2016 May 5.

PMID:
27063000
30.

The GraS Sensor in Staphylococcus aureus Mediates Resistance to Host Defense Peptides Differing in Mechanisms of Action.

Chaili S, Cheung AL, Bayer AS, Xiong YQ, Waring AJ, Memmi G, Donegan N, Yang SJ, Yeaman MR.

Infect Immun. 2015 Nov 23;84(2):459-66. doi: 10.1128/IAI.01030-15. Print 2016 Feb.

31.

Role of AMPK signaling in mediating the anticancer effects of silibinin in esophageal squamous cell carcinoma.

Li J, Li B, Xu WW, Chan KW, Guan XY, Qin YR, Lee NP, Chan KT, Law S, Tsao SW, Cheung AL.

Expert Opin Ther Targets. 2016;20(1):7-18. doi: 10.1517/14728222.2016.1121236. Epub 2015 Dec 15.

PMID:
26568207
32.

Competitive Binding Between Id1 and E2F1 to Cdc20 Regulates E2F1 Degradation and Thymidylate Synthase Expression to Promote Esophageal Cancer Chemoresistance.

Li B, Xu WW, Guan XY, Qin YR, Law S, Lee NP, Chan KT, Tam PY, Li YY, Chan KW, Yuen HF, Tsao SW, He QY, Cheung AL.

Clin Cancer Res. 2016 Mar 1;22(5):1243-55. doi: 10.1158/1078-0432.CCR-15-1196. Epub 2015 Oct 16.

33.

Significance of NF-κB activation in immortalization of nasopharyngeal epithelial cells.

Zhu DD, Zhang J, Deng W, Yip YL, Lung HL, Tsang CM, Law WT, Yang J, Lau VM, Shuen WH, Lung ML, Cheung AL, Tsao SW.

Int J Cancer. 2016 Mar 1;138(5):1175-85. doi: 10.1002/ijc.29850. Epub 2015 Oct 13.

34.

Epstein-Barr virus BZLF1 protein impairs accumulation of host DNA damage proteins at damage sites in response to DNA damage.

Yang J, Deng W, Hau PM, Liu J, Lau VM, Cheung AL, Huen MS, Tsao SW.

Lab Invest. 2015 Aug;95(8):937-50. doi: 10.1038/labinvest.2015.69. Epub 2015 Jun 1.

35.

Sigma Factor SigB Is Crucial to Mediate Staphylococcus aureus Adaptation during Chronic Infections.

Tuchscherr L, Bischoff M, Lattar SM, Noto Llana M, Pförtner H, Niemann S, Geraci J, Van de Vyver H, Fraunholz MJ, Cheung AL, Herrmann M, Völker U, Sordelli DO, Peters G, Löffler B.

PLoS Pathog. 2015 Apr 29;11(4):e1004870. doi: 10.1371/journal.ppat.1004870. eCollection 2015 Apr.

36.

Improving transformation of Staphylococcus aureus belonging to the CC1, CC5 and CC8 clonal complexes.

Jones MJ, Donegan NP, Mikheyeva IV, Cheung AL.

PLoS One. 2015 Mar 25;10(3):e0119487. doi: 10.1371/journal.pone.0119487. eCollection 2015.

37.

Oncogenic mutation profiling in new lung cancer and mesothelioma cell lines.

Lam DC, Luo SY, Deng W, Kwan JSh, Rodriguez-Canales J, Cheung AL, Cheng GH, Lin CH, Wistuba II, Sham PC, Wan TS, Tsao SW.

Onco Targets Ther. 2015 Jan 16;8:195-209. doi: 10.2147/OTT.S71242. eCollection 2015.

38.

Targeting VEGFR1- and VEGFR2-expressing non-tumor cells is essential for esophageal cancer therapy.

Xu WW, Li B, Lam AK, Tsao SW, Law SY, Chan KW, Yuan QJ, Cheung AL.

Oncotarget. 2015 Jan 30;6(3):1790-805.

39.

Characterization of a novel small molecule that potentiates β-lactam activity against gram-positive and gram-negative pathogens.

Nair DR, Monteiro JM, Memmi G, Thanassi J, Pucci M, Schwartzman J, Pinho MG, Cheung AL.

Antimicrob Agents Chemother. 2015 Apr;59(4):1876-85. doi: 10.1128/AAC.04164-14. Epub 2015 Jan 12.

40.

Suppression of esophageal tumor growth and chemoresistance by directly targeting the PI3K/AKT pathway.

Li B, Li J, Xu WW, Guan XY, Qin YR, Zhang LY, Law S, Tsao SW, Cheung AL.

Oncotarget. 2014 Nov 30;5(22):11576-87.

41.

Site-specific mutation of the sensor kinase GraS in Staphylococcus aureus alters the adaptive response to distinct cationic antimicrobial peptides.

Cheung AL, Bayer AS, Yeaman MR, Xiong YQ, Waring AJ, Memmi G, Donegan N, Chaili S, Yang SJ.

Infect Immun. 2014 Dec;82(12):5336-45. doi: 10.1128/IAI.02480-14. Epub 2014 Oct 6.

42.

Role of adaptor TrfA and ClpPC in controlling levels of SsrA-tagged proteins and antitoxins in Staphylococcus aureus.

Donegan NP, Marvin JS, Cheung AL.

J Bacteriol. 2014 Dec;196(23):4140-51. doi: 10.1128/JB.02222-14. Epub 2014 Sep 15.

43.

p21/Cyclin E pathway modulates anticlastogenic function of Bmi-1 in cancer cells.

Deng W, Zhou Y, Tiwari AF, Su H, Yang J, Zhu D, Lau VM, Hau PM, Yip YL, Cheung AL, Guan XY, Tsao SW.

Int J Cancer. 2015 Mar 15;136(6):1361-70. doi: 10.1002/ijc.29114. Epub 2014 Aug 7.

44.

Water extract from Pleurotus pulmonarius with antioxidant activity exerts in vivo chemoprophylaxis and chemosensitization for liver cancer.

Xu WW, Li B, Lai ET, Chen L, Huang JJ, Cheung AL, Cheung PC.

Nutr Cancer. 2014;66(6):989-98. doi: 10.1080/01635581.2014.936950. Epub 2014 Jul 29.

PMID:
25072857
45.

Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance.

Sully EK, Malachowa N, Elmore BO, Alexander SM, Femling JK, Gray BM, DeLeo FR, Otto M, Cheung AL, Edwards BS, Sklar LA, Horswill AR, Hall PR, Gresham HD.

PLoS Pathog. 2014 Jun 12;10(6):e1004174. doi: 10.1371/journal.ppat.1004174. eCollection 2014 Jun.

46.

F-box only protein 31 (FBXO31) negatively regulates p38 mitogen-activated protein kinase (MAPK) signaling by mediating lysine 48-linked ubiquitination and degradation of mitogen-activated protein kinase kinase 6 (MKK6).

Liu J, Han L, Li B, Yang J, Huen MS, Pan X, Tsao SW, Cheung AL.

J Biol Chem. 2014 Aug 1;289(31):21508-18. doi: 10.1074/jbc.M114.560342. Epub 2014 Jun 16.

47.

Id1-induced IGF-II and its autocrine/endocrine promotion of esophageal cancer progression and chemoresistance--implications for IGF-II and IGF-IR-targeted therapy.

Li B, Tsao SW, Chan KW, Ludwig DL, Novosyadlyy R, Li YY, He QY, Cheung AL.

Clin Cancer Res. 2014 May 15;20(10):2651-62. doi: 10.1158/1078-0432.CCR-13-2735. Epub 2014 Mar 5.

48.

Enhanced IL-6/IL-6R signaling promotes growth and malignant properties in EBV-infected premalignant and cancerous nasopharyngeal epithelial cells.

Zhang G, Tsang CM, Deng W, Yip YL, Lui VW, Wong SC, Cheung AL, Hau PM, Zeng M, Lung ML, Chen H, Lo KW, Takada K, Tsao SW.

PLoS One. 2013 May 1;8(5):e62284. doi: 10.1371/journal.pone.0062284. Print 2013.

49.

Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice.

Cho JS, Guo Y, Ramos RI, Hebroni F, Plaisier SB, Xuan C, Granick JL, Matsushima H, Takashima A, Iwakura Y, Cheung AL, Cheng G, Lee DJ, Simon SI, Miller LS.

PLoS Pathog. 2012;8(11):e1003047. doi: 10.1371/journal.ppat.1003047. Epub 2012 Nov 29.

50.

In vivo bioluminescence imaging to evaluate systemic and topical antibiotics against community-acquired methicillin-resistant Staphylococcus aureus-infected skin wounds in mice.

Guo Y, Ramos RI, Cho JS, Donegan NP, Cheung AL, Miller LS.

Antimicrob Agents Chemother. 2013 Feb;57(2):855-63. doi: 10.1128/AAC.01003-12. Epub 2012 Dec 3.

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