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Inactivation of GAP-43 due to the depletion of cellular calcium by the Pb and amyloid peptide induced toxicity: An in vitro approach.

Ayyalasomayajula N, Bandaru M, Dixit PK, Ajumeera R, Chetty CS, Challa S.

Chem Biol Interact. 2019 Dec 13;316:108927. doi: 10.1016/j.cbi.2019.108927. [Epub ahead of print]


Deleterious effects of combination of lead and β-amyloid peptides in inducing apoptosis and altering cell cycle in human neuroblastoma cells.

Neelima A, Rajanna A, Bhanuprakash RG, Chetty CS, Suresh C.

Interdiscip Toxicol. 2017 Nov;10(3):93-98. doi: 10.1515/intox-2017-0015. Epub 2018 Feb 14.


Intraperitoneal injection of MSC-derived exosomes prevent experimental bronchopulmonary dysplasia.

Braun RK, Chetty C, Balasubramaniam V, Centanni R, Haraldsdottir K, Hematti P, Eldridge MW.

Biochem Biophys Res Commun. 2018 Sep 18;503(4):2653-2658. doi: 10.1016/j.bbrc.2018.08.019. Epub 2018 Aug 7.


Knockdown of LRP/LR induces apoptosis in pancreatic cancer and neuroblastoma cells through activation of caspases.

Chetty CJ, Ferreira E, Jovanovic K, Weiss SFT.

Exp Cell Res. 2017 Nov 15;360(2):264-272. doi: 10.1016/j.yexcr.2017.09.016. Epub 2017 Sep 10.


Anti-LRP/LR specific antibody IgG1-iS18 significantly impedes adhesion and invasion in early and late stage colorectal carcinoma cells.

Vania L, Chetty CJ, Ferreira E, Weiss SFT.

Mol Med. 2016 Oct;22:664-673. doi: 10.2119/molmed.2016.00169. Epub 2016 Sep 8.


Novel patented therapeutic approaches targeting the 37/67 kDa laminin receptor for treatment of cancer and Alzheimer's disease.

Jovanovic K, Chetty CJ, Khumalo T, Da Costa Dias B, Ferreira E, Malindisa ST, Caveney R, Letsolo BT, Weiss SF.

Expert Opin Ther Pat. 2015 May;25(5):567-82. doi: 10.1517/13543776.2015.1014802. Epub 2015 Mar 8. Review.


miR-let-7f-1 regulates SPARC mediated cisplatin resistance in medulloblastoma cells.

Pannuru P, Dontula R, Khan AA, Herbert E, Ozer H, Chetty C, Lakka SS.

Cell Signal. 2014 Oct;26(10):2193-201. doi: 10.1016/j.cellsig.2014.06.014. Epub 2014 Jul 8.


Anti-LRP/LR specific antibody IgG1-iS18 impedes adhesion and invasion of liver cancer cells.

Chetty C, Khumalo T, Da Costa Dias B, Reusch U, Knackmuss S, Little M, Weiss SF.

PLoS One. 2014 May 5;9(5):e96268. doi: 10.1371/journal.pone.0096268. eCollection 2014.


Development and in vitro permeation studies of proniosomal based transdermal delivery system of Atenolol.

Ramkanth S, Chetty CM, Sudhakar Y.

Pak J Pharm Sci. 2014 Jan;27(1):115-20.


Involvement of nitric oxide synthase in matrix metalloproteinase-9- and/or urokinase plasminogen activator receptor-mediated glioma cell migration.

Zhuang T, Chelluboina B, Ponnala S, Velpula KK, Rehman AA, Chetty C, Zakharian E, Rao JS, Veeravalli KK.

BMC Cancer. 2013 Dec 11;13:590. doi: 10.1186/1471-2407-13-590.


Hepatoprotective activity of Ficus religiosa leaves against isoniazid+rifampicin and paracetamol induced hepatotoxicity.

Parameswari SA, Chetty CM, Chandrasekhar KB.

Pharmacognosy Res. 2013 Oct;5(4):271-6. doi: 10.4103/0974-8490.118828.


MicroRNA 203 Modulates Glioma Cell Migration via Robo1/ERK/MMP-9 Signaling.

Dontula R, Dinasarapu A, Chetty C, Pannuru P, Herbert E, Ozer H, Lakka SS.

Genes Cancer. 2013 Jul;4(7-8):285-96. doi: 10.1177/1947601913500141.


Tumor-associated soluble uPAR-directed endothelial cell motility and tumor angiogenesis.

Rao JS, Gujrati M, Chetty C.

Oncogenesis. 2013 Jun 24;2:e53. doi: 10.1038/oncsis.2013.19.


Suppression of tumor cell invasiveness and in vivo tumor growth by microRNA-874 in non-small cell lung cancer.

Kesanakurti D, Maddirela DR, Chittivelu S, Rao JS, Chetty C.

Biochem Biophys Res Commun. 2013 May 10;434(3):627-33. doi: 10.1016/j.bbrc.2013.03.132. Epub 2013 Apr 10.


Functional cooperativity by direct interaction between PAK4 and MMP-2 in the regulation of anoikis resistance, migration and invasion in glioma.

Kesanakurti D, Chetty C, Rajasekhar Maddirela D, Gujrati M, Rao JS.

Cell Death Dis. 2012 Dec 20;3:e445. doi: 10.1038/cddis.2012.182.


Epigenetic regulation of miRNA-211 by MMP-9 governs glioma cell apoptosis, chemosensitivity and radiosensitivity.

Asuthkar S, Velpula KK, Chetty C, Gorantla B, Rao JS.

Oncotarget. 2012 Nov;3(11):1439-54.


Essential role of cooperative NF-κB and Stat3 recruitment to ICAM-1 intronic consensus elements in the regulation of radiation-induced invasion and migration in glioma.

Kesanakurti D, Chetty C, Rajasekhar Maddirela D, Gujrati M, Rao JS.

Oncogene. 2013 Oct 24;32(43):5144-55. doi: 10.1038/onc.2012.546. Epub 2012 Nov 26.


The secreted protein acidic and rich in cysteine (SPARC) induces endoplasmic reticulum stress leading to autophagy-mediated apoptosis in neuroblastoma.

Sailaja GS, Bhoopathi P, Gorantla B, Chetty C, Gogineni VR, Velpula KK, Gondi CS, Rao JS.

Int J Oncol. 2013 Jan;42(1):188-96. doi: 10.3892/ijo.2012.1678. Epub 2012 Oct 24.


Notch signaling regulates tumor-induced angiogenesis in SPARC-overexpressed neuroblastoma.

Gorantla B, Bhoopathi P, Chetty C, Gogineni VR, Sailaja GS, Gondi CS, Rao JS.

Angiogenesis. 2013 Jan;16(1):85-100. doi: 10.1007/s10456-012-9301-1. Epub 2012 Sep 6.


Empowering biotechnology in southern Africa: establishment of a robust transformation platform for the production of transgenic industry-preferred cassava.

Chetty CC, Rossin CB, Gruissem W, Vanderschuren H, Rey ME.

N Biotechnol. 2013 Jan 25;30(2):136-43. doi: 10.1016/j.nbt.2012.04.006. Epub 2012 Jun 6.


Synergistic effects of amyloid peptides and lead on human neuroblastoma cells.

Suresh C, Johnson J, Mohan R, Chetty CS.

Cell Mol Biol Lett. 2012 Sep;17(3):408-21. doi: 10.2478/s11658-012-0018-3. Epub 2012 May 18.


Blockade of SOX4 mediated DNA repair by SPARC enhances radioresponse in medulloblastoma.

Chetty C, Dontula R, Gujrati M, Dinh DH, Lakka SS.

Cancer Lett. 2012 Oct 28;323(2):188-98. doi: 10.1016/j.canlet.2012.04.014. Epub 2012 Apr 24.


Role of MMP-2 in the regulation of IL-6/Stat3 survival signaling via interaction with α5β1 integrin in glioma.

Kesanakurti D, Chetty C, Dinh DH, Gujrati M, Rao JS.

Oncogene. 2013 Jan 17;32(3):327-40. doi: 10.1038/onc.2012.52. Epub 2012 Feb 20.


HIV incidence and prevalence among cohorts of women with higher risk behaviour in Bloemfontein and Rustenburg, South Africa: a prospective study.

Feldblum PJ, Latka MH, Lombaard J, Chetty C, Chen PL, Sexton C, Fischer S.

BMJ Open. 2012 Feb 13;2(1):e000626. doi: 10.1136/bmjopen-2011-000626. Print 2012.


New ionic derivatives of betulinic acid as highly potent anti-cancer agents.

Suresh C, Zhao H, Gumbs A, Chetty CS, Bose HS.

Bioorg Med Chem Lett. 2012 Feb 15;22(4):1734-8. doi: 10.1016/j.bmcl.2011.12.102. Epub 2011 Dec 28.


SPARC expression induces cell cycle arrest via STAT3 signaling pathway in medulloblastoma cells.

Chetty C, Dontula R, Ganji PN, Gujrati M, Lakka SS.

Biochem Biophys Res Commun. 2012 Jan 13;417(2):874-9. doi: 10.1016/j.bbrc.2011.12.065. Epub 2011 Dec 20.


Development and evaluation of novel-trans-buccoadhesive films of Famotidine.

Alagusundaram M, Chetty CM, Dhachinamoorthi D.

J Adv Pharm Technol Res. 2011 Jan;2(1):17-23. doi: 10.4103/2231-4040.79800.


Metabolic remodeling precedes mitochondrial outer membrane permeabilization in human glioma xenograft cells.

Ponnala S, Chetty C, Veeravalli KK, Dinh DH, Klopfenstein JD, Rao JS.

Int J Oncol. 2012 Feb;40(2):509-18. doi: 10.3892/ijo.2011.1255. Epub 2011 Nov 7.


Developmental delay of infants and young children with and without fetal alcohol spectrum disorder in the Northern Cape Province, South Africa.

Davies L, Dunn M, Chersich M, Urban M, Chetty C, Olivier L, Viljoen D.

Afr J Psychiatry (Johannesbg). 2011 Sep;14(4):298-305. doi:


Universal prevention is associated with lower prevalence of fetal alcohol spectrum disorders in Northern Cape, South Africa: a multicentre before-after study.

Chersich MF, Urban M, Olivier L, Davies LA, Chetty C, Viljoen D.

Alcohol Alcohol. 2012 Jan-Feb;47(1):67-74. doi: 10.1093/alcalc/agr145. Epub 2011 Oct 27.


MMP-9 induces CD44 cleavage and CD44 mediated cell migration in glioblastoma xenograft cells.

Chetty C, Vanamala SK, Gondi CS, Dinh DH, Gujrati M, Rao JS.

Cell Signal. 2012 Feb;24(2):549-59. doi: 10.1016/j.cellsig.2011.10.008. Epub 2011 Oct 17.


Regulation of DNA repair mechanism in human glioma xenograft cells both in vitro and in vivo in nude mice.

Ponnala S, Veeravalli KK, Chetty C, Dinh DH, Rao JS.

PLoS One. 2011;6(10):e26191. doi: 10.1371/journal.pone.0026191. Epub 2011 Oct 14.


Integrin α9β1-mediated cell migration in glioblastoma via SSAT and Kir4.2 potassium channel pathway.

Veeravalli KK, Ponnala S, Chetty C, Tsung AJ, Gujrati M, Rao JS.

Cell Signal. 2012 Jan;24(1):272-81. doi: 10.1016/j.cellsig.2011.09.011. Epub 2011 Sep 17.


MMP-9 silencing regulates hTERT expression via β1 integrin-mediated FAK signaling and induces senescence in glioma xenograft cells.

Ponnala S, Chetty C, Veeravalli KK, Dinh DH, Klopfenstein JD, Rao JS.

Cell Signal. 2011 Dec;23(12):2065-75. doi: 10.1016/j.cellsig.2011.08.001. Epub 2011 Aug 9. Erratum in: Cell Signal. 2013 Aug;25(8):1729.


Formulation and evaluation of bucco-adhesive tablets of sumatriptan succinate.

Prasanna RI, Anitha P, Chetty CM.

Int J Pharm Investig. 2011 Jul;1(3):182-91. doi: 10.4103/2230-973X.85971.


MMP-2 siRNA inhibits radiation-enhanced invasiveness in glioma cells.

Badiga AV, Chetty C, Kesanakurti D, Are D, Gujrati M, Klopfenstein JD, Dinh DH, Rao JS.

PLoS One. 2011;6(6):e20614. doi: 10.1371/journal.pone.0020614. Epub 2011 Jun 16.


SPARC stimulates neuronal differentiation of medulloblastoma cells via the Notch1/STAT3 pathway.

Bhoopathi P, Chetty C, Dontula R, Gujrati M, Dinh DH, Rao JS, Lakka SS.

Cancer Res. 2011 Jul 15;71(14):4908-19. doi: 10.1158/0008-5472.CAN-10-3395. Epub 2011 May 25.


Suppression of MMP-2 attenuates TNF-α induced NF-κB activation and leads to JNK mediated cell death in glioma.

Kesanakurti D, Chetty C, Bhoopathi P, Lakka SS, Gorantla B, Tsung AJ, Rao JS.

PLoS One. 2011 May 4;6(5):e19341. doi: 10.1371/journal.pone.0019341.


Matrix metalloproteinase pharmacogenomics in non-small-cell lung carcinoma.

Chetty C, Rao JS, Lakka SS.

Pharmacogenomics. 2011 Apr;12(4):535-46. doi: 10.2217/pgs.10.207. Review.


MMP-2 mediates mesenchymal stem cell tropism towards medulloblastoma tumors.

Bhoopathi P, Chetty C, Gogineni VR, Gujrati M, Dinh DH, Rao JS, Lakka SS.

Gene Ther. 2011 Jul;18(7):692-701. doi: 10.1038/gt.2011.14. Epub 2011 Mar 3.


uPAR/cathepsin B overexpression reverse angiogenesis by rescuing FAK phosphorylation in uPAR/cathepsin B down regulated meningioma.

Gupta R, Nalla AK, Gogineni VR, Chetty C, Bhoopathi P, Klopfenstein JD, Tsung AJ, Mohanam S, Rao JS.

PLoS One. 2011 Feb 11;6(2):e17123. doi: 10.1371/journal.pone.0017123.


Oncogenic role of p53 is suppressed by si-RNA bicistronic construct of uPA, uPAR and cathepsin-B in meningiomas both in vitro and in vivo.

Gupta R, Rao Gogineni V, Nalla AK, Chetty C, Klopfenstein JD, Tsung AJ, Mohanam S, Rao JS.

Int J Oncol. 2011 Apr;38(4):973-83. doi: 10.3892/ijo.2011.934. Epub 2011 Feb 2.


Downregulation of uPA/uPAR inhibits intermittent hypoxia-induced epithelial-mesenchymal transition (EMT) in DAOY and D283 medulloblastoma cells.

Gupta R, Chetty C, Bhoopathi P, Lakka S, Mohanam S, Rao JS, Dinh DE.

Int J Oncol. 2011 Mar;38(3):733-44. doi: 10.3892/ijo.2010.883. Epub 2010 Dec 22.


Urokinase plasminogen activator receptor and/or matrix metalloproteinase-9 inhibition induces apoptosis signaling through lipid rafts in glioblastoma xenograft cells.

Chetty C, Lakka SS, Bhoopathi P, Gondi CS, Veeravalli KK, Fassett D, Klopfenstein JD, Dinh DH, Gujrati M, Rao JS.

Mol Cancer Ther. 2010 Sep;9(9):2605-17. doi: 10.1158/1535-7163.MCT-10-0245. Epub 2010 Aug 17.


MMP-9, uPAR and cathepsin B silencing downregulate integrins in human glioma xenograft cells in vitro and in vivo in nude mice.

Veeravalli KK, Chetty C, Ponnala S, Gondi CS, Lakka SS, Fassett D, Klopfenstein JD, Dinh DH, Gujrati M, Rao JS.

PLoS One. 2010 Jul 15;5(7):e11583. doi: 10.1371/journal.pone.0011583.


Induction of apoptosis in glioma cells requires cell-to-cell contact with human umbilical cord blood stem cells.

Gondi CS, Gogineni VR, Chetty C, Dasari VR, Gorantla B, Gujrati M, Dinh DH, Rao JS.

Int J Oncol. 2010 May;36(5):1165-73.


Cathepsin B facilitates autophagy-mediated apoptosis in SPARC overexpressed primitive neuroectodermal tumor cells.

Bhoopathi P, Chetty C, Gujrati M, Dinh DH, Rao JS, Lakka S.

Cell Death Differ. 2010 Oct;17(10):1529-39. doi: 10.1038/cdd.2010.28. Epub 2010 Mar 26.


The role of MMP-9 in the anti-angiogenic effect of secreted protein acidic and rich in cysteine.

Bhoopathi P, Chetty C, Gujrati M, Dinh DH, Rao JS, Lakka SS.

Br J Cancer. 2010 Feb 2;102(3):530-40. doi: 10.1038/sj.bjc.6605538. Epub 2010 Jan 19.

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