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Items: 1 to 50 of 62

1.

Moving Metabolism to Make Inroads in a Model of Mitochondrial Epilepsy.

Lyman KA, Chetkovich DM.

Epilepsy Curr. 2019 Sep 9:1535759719873360. doi: 10.1177/1535759719873360. [Epub ahead of print]

PMID:
31495198
2.

Phosphorylation of the HCN channel auxiliary subunit TRIP8b is altered in an animal model of temporal lobe epilepsy and modulates channel function.

Foote KM, Lyman KA, Han Y, Michailidis IE, Heuermann RJ, Mandikian D, Trimmer JS, Swanson GT, Chetkovich DM.

J Biol Chem. 2019 Sep 5. pii: jbc.RA119.010027. doi: 10.1074/jbc.RA119.010027. [Epub ahead of print]

3.

Oligodendrocyte Kir4.1 Channels Clear Out Congested K.

Lyman KA, Chetkovich DM.

Epilepsy Curr. 2019 Aug 13:1535759719868185. doi: 10.1177/1535759719868185. [Epub ahead of print]

PMID:
31409147
4.

Current Opinions and Consensus for Studying Tremor in Animal Models.

Kuo SH, Louis ED, Faust PL, Handforth A, Chang SY, Avlar B, Lang EJ, Pan MK, Miterko LN, Brown AM, Sillitoe RV, Anderson CJ, Pulst SM, Gallagher MJ, Lyman KA, Chetkovich DM, Clark LN, Tio M, Tan EK, Elble RJ.

Cerebellum. 2019 May 23. doi: 10.1007/s12311-019-01037-1. [Epub ahead of print]

PMID:
31124049
5.

CRAFTing a New Approach to Antiepileptic Drug Discovery.

Lyman KA, Chetkovich DM.

Epilepsy Curr. 2019 May-Jun;19(3):182-183. doi: 10.1177/1535759719842148. Epub 2019 Apr 29.

6.

PUMILIO1 Links Epilepsy to Spinocerebellar Ataxia.

Lyman KA, Chetkovich DM.

Epilepsy Curr. 2019 Mar-Apr;19(2):122-123. doi: 10.1177/1535759719835354.

7.

Pannexin1 as a Possible Panacea for Intractable Epilepsy.

Lyman KA, Chetkovich DM.

Epilepsy Curr. 2018 Nov-Dec;18(6):396-397. doi: 10.5698/1535-7597.18.6.396. No abstract available.

8.

Axonal organization defects in the hippocampus of adult conditional BACE1 knockout mice.

Ou-Yang MH, Kurz JE, Nomura T, Popovic J, Rajapaksha TW, Dong H, Contractor A, Chetkovich DM, Tourtellotte WG, Vassar R.

Sci Transl Med. 2018 Sep 19;10(459). pii: eaao5620. doi: 10.1126/scitranslmed.aao5620.

PMID:
30232227
9.

HCN channels in the hippocampus regulate active coping behavior.

Fisher DW, Han Y, Lyman KA, Heuermann RJ, Bean LA, Ybarra N, Foote KM, Dong H, Nicholson DA, Chetkovich DM.

J Neurochem. 2018 Sep;146(6):753-766. doi: 10.1111/jnc.14539. Epub 2018 Aug 9.

10.

Molecular Mimicry may Underlie a Worm-Associated Epilepsy Syndrome.

Lyman KA, Chetkovich DM.

Epilepsy Curr. 2018 May-Jun;18(3):180-181. doi: 10.5698/1535-7597.18.3.180. No abstract available.

11.

Publisher Correction: Stimulation of entorhinal cortex-dentate gyrus circuitry is antidepressive.

Yun S, Reynolds RP, Petrof I, White A, Rivera PD, Segev A, Gibson AD, Suarez M, DeSalle MJ, Ito N, Mukherjee S, Richardson DR, Kang CE, Ahrens-Nicklas RC, Soler I, Chetkovich DM, Kourrich S, Coulter DA, Eisch AJ.

Nat Med. 2018 Sep;24(9):1482. doi: 10.1038/s41591-018-0084-9.

PMID:
29934536
12.

Store depletion-induced h-channel plasticity rescues a channelopathy linked to Alzheimer's disease.

Musial TF, Molina-Campos E, Bean LA, Ybarra N, Borenstein R, Russo ML, Buss EW, Justus D, Neuman KM, Ayala GD, Mullen SA, Voskobiynyk Y, Tulisiak CT, Fels JA, Corbett NJ, Carballo G, Kennedy CD, Popovic J, Ramos-Franco J, Fill M, Pergande MR, Borgia JA, Corbett GT, Pahan K, Han Y, Chetkovich DM, Vassar RJ, Byrne RW, Matthew Oh M, Stoub TR, Remy S, Disterhoft JF, Nicholson DA.

Neurobiol Learn Mem. 2018 Oct;154:141-157. doi: 10.1016/j.nlm.2018.06.004. Epub 2018 Jun 12.

13.

Stimulation of entorhinal cortex-dentate gyrus circuitry is antidepressive.

Yun S, Reynolds RP, Petrof I, White A, Rivera PD, Segev A, Gibson AD, Suarez M, DeSalle MJ, Ito N, Mukherjee S, Richardson DR, Kang CE, Ahrens-Nicklas RC, Soler I, Chetkovich DM, Kourrich S, Coulter DA, Eisch AJ.

Nat Med. 2018 May;24(5):658-666. doi: 10.1038/s41591-018-0002-1. Epub 2018 Apr 16. Erratum in: Nat Med. 2018 Sep;24(9):1482.

14.

Loss of HCN2 leads to delayed gastrointestinal motility and reduced energy intake in mice.

Fisher DW, Luu P, Agarwal N, Kurz JE, Chetkovich DM.

PLoS One. 2018 Feb 21;13(2):e0193012. doi: 10.1371/journal.pone.0193012. eCollection 2018.

15.

Understanding Network Connections Connects Genotype to Epilepsy Phenotype.

Kurz JE, Chetkovich DM.

Epilepsy Curr. 2017 Jul-Aug;17(4):239-240. doi: 10.5698/1535-7597.17.4.239. No abstract available.

16.

Excitatory Synaptic Input to Hilar Mossy Cells under Basal and Hyperexcitable Conditions.

Hedrick TP, Nobis WP, Foote KM, Ishii T, Chetkovich DM, Swanson GT.

eNeuro. 2017 Dec 4;4(6). pii: ENEURO.0364-17.2017. doi: 10.1523/ENEURO.0364-17.2017. eCollection 2017 Nov-Dec.

17.

Modulation of thalamocortical oscillations by TRIP8b, an auxiliary subunit for HCN channels.

Zobeiri M, Chaudhary R, Datunashvili M, Heuermann RJ, Lüttjohann A, Narayanan V, Balfanz S, Meuth P, Chetkovich DM, Pape HC, Baumann A, van Luijtelaar G, Budde T.

Brain Struct Funct. 2018 Apr;223(3):1537-1564. doi: 10.1007/s00429-017-1559-z. Epub 2017 Nov 22.

18.

Allostery between two binding sites in the ion channel subunit TRIP8b confers binding specificity to HCN channels.

Lyman KA, Han Y, Heuermann RJ, Cheng X, Kurz JE, Lyman RE, Van Veldhoven PP, Chetkovich DM.

J Biol Chem. 2017 Oct 27;292(43):17718-17730. doi: 10.1074/jbc.M117.802256. Epub 2017 Sep 8.

19.

Mutant IDH1 and seizures in patients with glioma.

Chen H, Judkins J, Thomas C, Wu M, Khoury L, Benjamin CG, Pacione D, Golfinos JG, Kumthekar P, Ghamsari F, Chen L, Lein P, Chetkovich DM, Snuderl M, Horbinski C.

Neurology. 2017 May 9;88(19):1805-1813. doi: 10.1212/WNL.0000000000003911. Epub 2017 Apr 12.

20.

Animal models suggest the TRIP8b-HCN interaction is a therapeutic target for major depressive disorder.

Lyman KA, Han Y, Chetkovich DM.

Expert Opin Ther Targets. 2017 Mar;21(3):235-237. doi: 10.1080/14728222.2017.1287899. No abstract available.

21.

Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b.

Han Y, Lyman KA, Clutter M, Schiltz GE, Ismail QA, Cheng X, Luan CH, Chetkovich DM.

J Vis Exp. 2016 Nov 11;(117). doi: 10.3791/54540.

22.

HCN-channel dendritic targeting requires bipartite interaction with TRIP8b and regulates antidepressant-like behavioral effects.

Han Y, Heuermann RJ, Lyman KA, Fisher D, Ismail QA, Chetkovich DM.

Mol Psychiatry. 2017 Mar;22(3):458-465. doi: 10.1038/mp.2016.99. Epub 2016 Jul 12.

23.

A Time and Place for Everything: Early-Life Seizures at Different Developmental Epochs Have Distinct Effects on Adult Hippocampal Structure and Function.

Kurz JE, Chetkovich DM.

Epilepsy Curr. 2016 Mar-Apr;16(2):106-7. doi: 10.5698/1535-7511-16.2.106. No abstract available.

24.

Reduction of thalamic and cortical Ih by deletion of TRIP8b produces a mouse model of human absence epilepsy.

Heuermann RJ, Jaramillo TC, Ying SW, Suter BA, Lyman KA, Han Y, Lewis AS, Hampton TG, Shepherd GMG, Goldstein PA, Chetkovich DM.

Neurobiol Dis. 2016 Jan;85:81-92. doi: 10.1016/j.nbd.2015.10.005. Epub 2015 Oct 14.

25.

Identification of Small-Molecule Inhibitors of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels.

Han Y, Lyman K, Clutter M, Schiltz GE, Ismail QA, Prados DB, Luan CH, Chetkovich DM.

J Biomol Screen. 2015 Oct;20(9):1124-31. doi: 10.1177/1087057115589590. Epub 2015 Jun 4.

26.

Cortical Compass: EML1 Helps Point the Way in Neuronal Migration.

Lyman KA, Chetkovich DM.

Epilepsy Curr. 2015 Jan-Feb;15(1):43-4. doi: 10.5698/1535-7597-15.1.43. No abstract available.

27.

Nedd4-2 regulates surface expression and may affect N-glycosylation of hyperpolarization-activated cyclic nucleotide-gated (HCN)-1 channels.

Wilkars W, Wollberg J, Mohr E, Han M, Chetkovich DM, Bähring R, Bender RA.

FASEB J. 2014 May;28(5):2177-90. doi: 10.1096/fj.13-242032. Epub 2014 Jan 22.

PMID:
24451387
28.

TRIP8b is required for maximal expression of HCN1 in the mouse retina.

Pan Y, Bhattarai S, Modestou M, Drack AV, Chetkovich DM, Baker SA.

PLoS One. 2014 Jan 7;9(1):e85850. doi: 10.1371/journal.pone.0085850. eCollection 2014.

29.

Short- and long-term plasticity in CA1 neurons from mice lacking h-channel auxiliary subunit TRIP8b.

Brager DH, Lewis AS, Chetkovich DM, Johnston D.

J Neurophysiol. 2013 Nov;110(10):2350-7. doi: 10.1152/jn.00218.2013. Epub 2013 Aug 21.

30.

Differential expression of HCN subunits alters voltage-dependent gating of h-channels in CA1 pyramidal neurons from dorsal and ventral hippocampus.

Dougherty KA, Nicholson DA, Diaz L, Buss EW, Neuman KM, Chetkovich DM, Johnston D.

J Neurophysiol. 2013 Apr;109(7):1940-53. doi: 10.1152/jn.00010.2013. Epub 2013 Jan 16.

31.

TRIP8b-independent trafficking and plasticity of adult cortical presynaptic HCN1 channels.

Huang Z, Lujan R, Martinez-Hernandez J, Lewis AS, Chetkovich DM, Shah MM.

J Neurosci. 2012 Oct 17;32(42):14835-48. doi: 10.1523/JNEUROSCI.1544-12.2012.

32.

Structure and stoichiometry of an accessory subunit TRIP8b interaction with hyperpolarization-activated cyclic nucleotide-gated channels.

Bankston JR, Camp SS, DiMaio F, Lewis AS, Chetkovich DM, Zagotta WN.

Proc Natl Acad Sci U S A. 2012 May 15;109(20):7899-904. doi: 10.1073/pnas.1201997109. Epub 2012 May 1.

33.

Differential dorso-ventral distributions of Kv4.2 and HCN proteins confer distinct integrative properties to hippocampal CA1 pyramidal cell distal dendrites.

Marcelin B, Lugo JN, Brewster AL, Liu Z, Lewis AS, McClelland S, Chetkovich DM, Baram TZ, Anderson AE, Becker A, Esclapez M, Bernard C.

J Biol Chem. 2012 May 18;287(21):17656-61. doi: 10.1074/jbc.C112.367110. Epub 2012 Apr 16.

34.

Dorsoventral differences in intrinsic properties in developing CA1 pyramidal cells.

Marcelin B, Liu Z, Chen Y, Lewis AS, Becker A, McClelland S, Chetkovich DM, Migliore M, Baram TZ, Esclapez M, Bernard C.

J Neurosci. 2012 Mar 14;32(11):3736-47. doi: 10.1523/JNEUROSCI.5870-11.2012.

35.

Regulation of axonal HCN1 trafficking in perforant path involves expression of specific TRIP8b isoforms.

Wilkars W, Liu Z, Lewis AS, Stoub TR, Ramos EM, Brandt N, Nicholson DA, Chetkovich DM, Bender RA.

PLoS One. 2012;7(2):e32181. doi: 10.1371/journal.pone.0032181. Epub 2012 Feb 21.

36.

Differential regulation of HCN channel isoform expression in thalamic neurons of epileptic and non-epileptic rat strains.

Kanyshkova T, Meuth P, Bista P, Liu Z, Ehling P, Caputi L, Doengi M, Chetkovich DM, Pape HC, Budde T.

Neurobiol Dis. 2012 Jan;45(1):450-61. doi: 10.1016/j.nbd.2011.08.032. Epub 2011 Sep 16.

37.

Deletion of the hyperpolarization-activated cyclic nucleotide-gated channel auxiliary subunit TRIP8b impairs hippocampal Ih localization and function and promotes antidepressant behavior in mice.

Lewis AS, Vaidya SP, Blaiss CA, Liu Z, Stoub TR, Brager DH, Chen X, Bender RA, Estep CM, Popov AB, Kang CE, Van Veldhoven PP, Bayliss DA, Nicholson DA, Powell CM, Johnston D, Chetkovich DM.

J Neurosci. 2011 May 18;31(20):7424-40. doi: 10.1523/JNEUROSCI.0936-11.2011.

38.

Trafficking and gating of hyperpolarization-activated cyclic nucleotide-gated channels are regulated by interaction with tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) and cyclic AMP at distinct sites.

Han Y, Noam Y, Lewis AS, Gallagher JJ, Wadman WJ, Baram TZ, Chetkovich DM.

J Biol Chem. 2011 Jun 10;286(23):20823-34. doi: 10.1074/jbc.M111.236125. Epub 2011 Apr 19.

39.

HCN channels in behavior and neurological disease: too hyper or not active enough?

Lewis AS, Chetkovich DM.

Mol Cell Neurosci. 2011 Feb;46(2):357-67. doi: 10.1016/j.mcn.2010.11.007. Epub 2010 Dec 3. Review.

40.

HCN channelopathy in external globus pallidus neurons in models of Parkinson's disease.

Chan CS, Glajch KE, Gertler TS, Guzman JN, Mercer JN, Lewis AS, Goldberg AB, Tkatch T, Shigemoto R, Fleming SM, Chetkovich DM, Osten P, Kita H, Surmeier DJ.

Nat Neurosci. 2011 Jan;14(1):85-92. doi: 10.1038/nn.2692. Epub 2010 Nov 14.

41.

BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization.

Hitt BD, Jaramillo TC, Chetkovich DM, Vassar R.

Mol Neurodegener. 2010 Aug 23;5:31. doi: 10.1186/1750-1326-5-31.

42.

The fast and slow ups and downs of HCN channel regulation.

Lewis AS, Estep CM, Chetkovich DM.

Channels (Austin). 2010 May-Jun;4(3):215-31. Review.

43.

Trafficking and surface expression of hyperpolarization-activated cyclic nucleotide-gated channels in hippocampal neurons.

Noam Y, Zha Q, Phan L, Wu RL, Chetkovich DM, Wadman WJ, Baram TZ.

J Biol Chem. 2010 May 7;285(19):14724-36. doi: 10.1074/jbc.M109.070391. Epub 2010 Mar 9.

44.

Regulation of stargazin synaptic trafficking by C-terminal PDZ ligand phosphorylation in bidirectional synaptic plasticity.

Stein EL, Chetkovich DM.

J Neurochem. 2010 Apr;113(1):42-53. doi: 10.1111/j.1471-4159.2009.06529.x. Epub 2009 Dec 4.

45.

Alternatively spliced isoforms of TRIP8b differentially control h channel trafficking and function.

Lewis AS, Schwartz E, Chan CS, Noam Y, Shin M, Wadman WJ, Surmeier DJ, Baram TZ, Macdonald RL, Chetkovich DM.

J Neurosci. 2009 May 13;29(19):6250-65. doi: 10.1523/JNEUROSCI.0856-09.2009.

46.

Absence epilepsy in apathetic, a spontaneous mutant mouse lacking the h channel subunit, HCN2.

Chung WK, Shin M, Jaramillo TC, Leibel RL, LeDuc CA, Fischer SG, Tzilianos E, Gheith AA, Lewis AS, Chetkovich DM.

Neurobiol Dis. 2009 Mar;33(3):499-508. doi: 10.1016/j.nbd.2008.12.004. Epub 2008 Dec 25.

47.

Mislocalization of h channel subunits underlies h channelopathy in temporal lobe epilepsy.

Shin M, Brager D, Jaramillo TC, Johnston D, Chetkovich DM.

Neurobiol Dis. 2008 Oct;32(1):26-36. doi: 10.1016/j.nbd.2008.06.013. Epub 2008 Jul 3.

48.

Activity-dependent regulation of h channel distribution in hippocampal CA1 pyramidal neurons.

Shin M, Chetkovich DM.

J Biol Chem. 2007 Nov 9;282(45):33168-80. Epub 2007 Sep 11.

49.

Evaluation of HCN2 abnormalities as a cause of juvenile audiogenic seizures in Black Swiss mice.

Shin M, Simkin D, Suyeoka GM, Chetkovich DM.

Brain Res. 2006 Apr 14;1083(1):14-20. Epub 2006 Mar 20.

PMID:
16542642
50.

AMPA receptor synaptic targeting regulated by stargazin interactions with the Golgi-resident PDZ protein nPIST.

Cuadra AE, Kuo SH, Kawasaki Y, Bredt DS, Chetkovich DM.

J Neurosci. 2004 Aug 25;24(34):7491-502.

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