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Items: 1 to 50 of 93

1.

Noninvasive Mechanical Joint Loading as an Alternative Model for Osteoarthritic Pain.

Ter Heegde F, Luiz AP, Santana-Varela S, Chessell IP, Welsh F, Wood JN, Chenu C.

Arthritis Rheumatol. 2019 Jul;71(7):1078-1088. doi: 10.1002/art.40835. Epub 2019 May 17.

PMID:
30638309
2.

Discovery of {4-[4,9-bis(ethyloxy)-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl]-2-fluorophenyl}acetic acid (GSK726701A), a novel EP4 receptor partial agonist for the treatment of pain.

Healy MP, Allan AC, Bailey K, Billinton A, Chessell IP, Clayton NM, Giblin GMP, Kay MA, Khaznadar T, Michel AD, Naylor A, Price H, Spalding DJ, Stevens DA, Swarbrick ME, Wilson AW.

Bioorg Med Chem Lett. 2018 Jun 1;28(10):1892-1896. doi: 10.1016/j.bmcl.2018.03.091. Epub 2018 Mar 31.

PMID:
29636218
3.

Comparison between semiquantitative and quantitative methods for the assessment of knee synovitis in osteoarthritis using non-enhanced and gadolinium-enhanced MRI.

Crema MD, Roemer FW, Li L, Alexander RC, Chessell IP, Dudley AD, Karlsten R, Rosen LB, Guermazi A.

Osteoarthritis Cartilage. 2017 Feb;25(2):267-271. doi: 10.1016/j.joca.2016.09.016. Epub 2016 Sep 30.

4.

The Expression of Inflammatory Mediators in Bladder Pain Syndrome.

Offiah I, Didangelos A, Dawes J, Cartwright R, Khullar V, Bradbury EJ, O'Sullivan S, Williams D, Chessell IP, Pallas K, Graham G, O'Reilly BA, McMahon SB.

Eur Urol. 2016 Aug;70(2):283-90. doi: 10.1016/j.eururo.2016.02.058. Epub 2016 Mar 7.

5.

Biologics: the next generation of analgesic drugs?

Chessell IP, Dudley A, Billinton A.

Drug Discov Today. 2012 Aug;17(15-16):875-9. doi: 10.1016/j.drudis.2012.03.005. Epub 2012 Mar 24. Review.

PMID:
22464946
6.

A novel series of benzimidazole NR2B-selective NMDA receptor antagonists.

Davies DJ, Crowe M, Lucas N, Quinn J, Miller DD, Pritchard S, Grose D, Bettini E, Calcinaghi N, Virginio C, Abberley L, Goldsmith P, Michel AD, Chessell IP, Kew JN, Miller ND, Gunthorpe MJ.

Bioorg Med Chem Lett. 2012 Apr 1;22(7):2620-3. doi: 10.1016/j.bmcl.2012.01.108. Epub 2012 Feb 6.

PMID:
22366657
7.

Transient P2X7 receptor activation triggers macrophage death independent of Toll-like receptors 2 and 4, caspase-1, and pannexin-1 proteins.

Hanley PJ, Kronlage M, Kirschning C, del Rey A, Di Virgilio F, Leipziger J, Chessell IP, Sargin S, Filippov MA, Lindemann O, Mohr S, Königs V, Schillers H, Bähler M, Schwab A.

J Biol Chem. 2012 Mar 23;287(13):10650-63. doi: 10.1074/jbc.M111.332676. Epub 2012 Jan 10.

8.

Biologics: the next-generation therapeutics for analgesia?

Hatcher JP, Chessell IP, Hughes JP.

Expert Rev Neurother. 2011 Nov;11(11):1653-8. doi: 10.1586/ern.11.66. Review.

PMID:
22014142
9.

Biologic drugs for analgesia: redefining the opportunity.

Hughes J, Hatcher JP, Chessell IP.

Curr Pharm Biotechnol. 2011 Oct;12(10):1660-70. Review.

PMID:
21466448
10.

Dynamic regulation of spinal pro-inflammatory cytokine release in the rat in vivo following peripheral nerve injury.

Whitehead KJ, Smith CG, Delaney SA, Curnow SJ, Salmon M, Hughes JP, Chessell IP.

Brain Behav Immun. 2010 May;24(4):569-76. doi: 10.1016/j.bbi.2009.12.007. Epub 2009 Dec 24.

PMID:
20035858
11.

Discovery of 1-[4-(3-chlorophenylamino)-1-methyl-1H-pyrrolo[3,2-c]pyridin-7-yl]-1-morpholin-4-ylmethanone (GSK554418A), a brain penetrant 5-azaindole CB2 agonist for the treatment of chronic pain.

Giblin GM, Billinton A, Briggs M, Brown AJ, Chessell IP, Clayton NM, Eatherton AJ, Goldsmith P, Haslam C, Johnson MR, Mitchell WL, Naylor A, Perboni A, Slingsby BP, Wilson AW.

J Med Chem. 2009 Oct 8;52(19):5785-8. doi: 10.1021/jm9009857.

PMID:
19743867
12.

Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors.

Swarbrick ME, Beswick PJ, Gleave RJ, Green RH, Bingham S, Bountra C, Carter MC, Chambers LJ, Chessell IP, Clayton NM, Collins SD, Corfield JA, Hartley CD, Kleanthous S, Lambeth PF, Lucas FS, Mathews N, Naylor A, Page LW, Payne JJ, Pegg NA, Price HS, Skidmore J, Stevens AJ, Stocker R, Stratton SC, Stuart AJ, Wiseman JO.

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4504-8. doi: 10.1016/j.bmcl.2009.02.085. Epub 2009 Feb 26.

PMID:
19520573
13.

Pyridine-3-carboxamides as novel CB(2) agonists for analgesia.

Mitchell WL, Giblin GM, Naylor A, Eatherton AJ, Slingsby BP, Rawlings AD, Jandu KS, Haslam CP, Brown AJ, Goldsmith P, Clayton NM, Wilson AW, Chessell IP, Green RH, Whittington AR, Wall ID.

Bioorg Med Chem Lett. 2009 Jan 1;19(1):259-63. doi: 10.1016/j.bmcl.2008.10.118. Epub 2008 Nov 5.

PMID:
19010671
14.

Up-regulation of P2X4 receptors in spinal microglia after peripheral nerve injury mediates BDNF release and neuropathic pain.

Ulmann L, Hatcher JP, Hughes JP, Chaumont S, Green PJ, Conquet F, Buell GN, Reeve AJ, Chessell IP, Rassendren F.

J Neurosci. 2008 Oct 29;28(44):11263-8. doi: 10.1523/JNEUROSCI.2308-08.2008.

15.

Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons.

Anand U, Otto WR, Sanchez-Herrera D, Facer P, Yiangou Y, Korchev Y, Birch R, Benham C, Bountra C, Chessell IP, Anand P.

Pain. 2008 Sep 15;138(3):667-80. doi: 10.1016/j.pain.2008.06.007. Epub 2008 Aug 9.

PMID:
18692962
16.

The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain.

Staton PC, Hatcher JP, Walker DJ, Morrison AD, Shapland EM, Hughes JP, Chong E, Mander PK, Green PJ, Billinton A, Fulleylove M, Lancaster HC, Smith JC, Bailey LT, Wise A, Brown AJ, Richardson JC, Chessell IP.

Pain. 2008 Sep 30;139(1):225-36. doi: 10.1016/j.pain.2008.04.006. Epub 2008 May 27.

PMID:
18502582
17.

TRPA1 receptor localisation in the human peripheral nervous system and functional studies in cultured human and rat sensory neurons.

Anand U, Otto WR, Facer P, Zebda N, Selmer I, Gunthorpe MJ, Chessell IP, Sinisi M, Birch R, Anand P.

Neurosci Lett. 2008 Jun 20;438(2):221-7. doi: 10.1016/j.neulet.2008.04.007. Epub 2008 Apr 8.

PMID:
18456404
18.

Activation of the alpha7-nicotinic acetylcholine receptor reverses complete freund adjuvant-induced mechanical hyperalgesia in the rat via a central site of action.

Medhurst SJ, Hatcher JP, Hille CJ, Bingham S, Clayton NM, Billinton A, Chessell IP.

J Pain. 2008 Jul;9(7):580-7. doi: 10.1016/j.jpain.2008.01.336.

PMID:
18420461
19.

The role of P2X₇ in pain and inflammation.

Hughes JP, Hatcher JP, Chessell IP.

Purinergic Signal. 2007 Mar;3(1-2):163-9. doi: 10.1007/s11302-006-9031-1. Epub 2007 Jan 3.

20.

Novel histamine H3 receptor antagonists GSK189254 and GSK334429 are efficacious in surgically-induced and virally-induced rat models of neuropathic pain.

Medhurst SJ, Collins SD, Billinton A, Bingham S, Dalziel RG, Brass A, Roberts JC, Medhurst AD, Chessell IP.

Pain. 2008 Aug 15;138(1):61-9. doi: 10.1016/j.pain.2007.11.006. Epub 2007 Dec 31.

PMID:
18164820
21.

Changes in the expression of NaV1.7, NaV1.8 and NaV1.9 in a distinct population of dorsal root ganglia innervating the rat knee joint in a model of chronic inflammatory joint pain.

Strickland IT, Martindale JC, Woodhams PL, Reeve AJ, Chessell IP, McQueen DS.

Eur J Pain. 2008 Jul;12(5):564-72. Epub 2007 Oct 18.

PMID:
17950013
22.

Voltage-gated ion channel Nav1.7 innervation in patients with idiopathic rectal hypersensitivity and paroxysmal extreme pain disorder (familial rectal pain).

Yiangou Y, Facer P, Chessell IP, Bountra C, Chan C, Fertleman C, Smith V, Anand P.

Neurosci Lett. 2007 Nov 5;427(2):77-82. Epub 2007 Sep 20.

PMID:
17928139
23.

Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score.

Yilmaz Z, Renton T, Yiangou Y, Zakrzewska J, Chessell IP, Bountra C, Anand P.

J Clin Neurosci. 2007 Sep;14(9):864-71. Epub 2007 Jun 19.

PMID:
17582772
24.

Demonstration of a novel technique to quantitatively assess inflammatory mediators and cells in rat knee joints.

Barton NJ, Stevens DA, Hughes JP, Rossi AG, Chessell IP, Reeve AJ, McQueen DS.

J Inflamm (Lond). 2007 Jun 13;4:13.

25.
26.

Discovery of 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro- 2H-pyran-4-yl)methyl]-4-(trifluoromethyl)- 5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory pain.

Giblin GM, O'Shaughnessy CT, Naylor A, Mitchell WL, Eatherton AJ, Slingsby BP, Rawlings DA, Goldsmith P, Brown AJ, Haslam CP, Clayton NM, Wilson AW, Chessell IP, Wittington AR, Green R.

J Med Chem. 2007 May 31;50(11):2597-600. Epub 2007 May 4.

PMID:
17477516
27.

Chronic secondary hypersensitivity of dorsal horn neurones following inflammation of the knee joint.

Martindale JC, Wilson AW, Reeve AJ, Chessell IP, Headley PM.

Pain. 2007 Dec 15;133(1-3):79-86. Epub 2007 Apr 27.

PMID:
17467170
28.

Pressure application measurement (PAM): a novel behavioural technique for measuring hypersensitivity in a rat model of joint pain.

Barton NJ, Strickland IT, Bond SM, Brash HM, Bate ST, Wilson AW, Chessell IP, Reeve AJ, McQueen DS.

J Neurosci Methods. 2007 Jun 15;163(1):67-75. Epub 2007 Feb 20.

PMID:
17383008
29.

Direct labelling of the human P2X7 receptor and identification of positive and negative cooperativity of binding.

Michel AD, Chambers LJ, Clay WC, Condreay JP, Walter DS, Chessell IP.

Br J Pharmacol. 2007 May;151(1):103-14. Epub 2007 Mar 5.

30.

Identification of novel glycine sulfonamide antagonists for the EP1 receptor.

McKeown SC, Hall A, Blunt R, Brown SH, Chessell IP, Chowdhury A, Giblin GM, Healy MP, Johnson MR, Lorthioir O, Michel AD, Naylor A, Lewell X, Roman S, Watson SP, Winchester WJ, Wilson RJ.

Bioorg Med Chem Lett. 2007 Mar 15;17(6):1750-4. Epub 2006 Dec 22.

PMID:
17236765
31.

Discovery of novel, non-acidic 1,5-biaryl pyrrole EP1 receptor antagonists.

Hall A, Atkinson S, Brown SH, Chessell IP, Chowdhury A, Giblin GM, Goldsmith P, Healy MP, Jandu KS, Johnson MR, Michel AD, Naylor A, Sweeting JA.

Bioorg Med Chem Lett. 2007 Mar 1;17(5):1200-5. Epub 2006 Dec 12.

PMID:
17196385
32.

Pain during ice water test distinguishes clinical bladder hypersensitivity from overactivity disorders.

Mukerji G, Waters J, Chessell IP, Bountra C, Agarwal SK, Anand P.

BMC Urol. 2006 Dec 27;6:31.

33.

1,5-Biaryl pyrrole derivatives as EP1 receptor antagonists. Structure-activity relationships of 6-substituted and 5,6-disubstituted benzoic acid derivatives.

Hall A, Brown SH, Chessell IP, Chowdhury A, Clayton NM, Coleman T, Giblin GM, Hammond B, Healy MP, Johnson MR, Metcalf A, Michel AD, Naylor A, Novelli R, Spalding DJ, Sweeting J, Winyard L.

Bioorg Med Chem Lett. 2007 Feb 15;17(4):916-20. Epub 2006 Nov 22.

PMID:
17175160
34.

The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity.

Amaya F, Wang H, Costigan M, Allchorne AJ, Hatcher JP, Egerton J, Stean T, Morisset V, Grose D, Gunthorpe MJ, Chessell IP, Tate S, Green PJ, Woolf CJ.

J Neurosci. 2006 Dec 13;26(50):12852-60.

35.

Localisation and modulation of prostanoid receptors EP1 and EP4 in the rat chronic constriction injury model of neuropathic pain.

Woodhams PL, MacDonald RE, Collins SD, Chessell IP, Day NC.

Eur J Pain. 2007 Aug;11(6):605-13. Epub 2006 Nov 15.

PMID:
17110143
36.

1,5-Biaryl pyrrole derivatives as EP1 receptor antagonists: Structure-activity relationships of 4- and 5-substituted benzoic acid derivatives.

Hall A, Brown SH, Chessell IP, Chowdhury A, Clayton NM, Coleman T, Giblin GM, Hammond B, Healy MP, Johnson MR, Metcalf A, Michel AD, Naylor A, Novelli R, Spalding DJ, Sweeting J.

Bioorg Med Chem Lett. 2007 Feb 1;17(3):732-5. Epub 2006 Oct 28.

PMID:
17098427
37.

The discovery of 6-[2-(5-chloro-2-{[(2,4-difluorophenyl)methyl]oxy}phenyl)-1-cyclopenten-1-yl]-2-pyridinecarboxylic acid, GW848687X, a potent and selective prostaglandin EP1 receptor antagonist for the treatment of inflammatory pain.

Giblin GM, Bit RA, Brown SH, Chaignot HM, Chowdhury A, Chessell IP, Clayton NM, Coleman T, Hall A, Hammond B, Hurst DN, Michel AD, Naylor A, Novelli R, Scoccitti T, Spalding D, Tang SP, Wilson AW, Wilson R.

Bioorg Med Chem Lett. 2007 Jan 15;17(2):385-9. Epub 2006 Oct 20.

PMID:
17084082
38.

The role of the cylooxygenase pathway in nociception and pain.

Bingham S, Beswick PJ, Blum DE, Gray NM, Chessell IP.

Semin Cell Dev Biol. 2006 Oct;17(5):544-54. Epub 2006 Sep 23. Review.

PMID:
17071117
39.

GW406381, a novel COX-2 inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury.

Zhao FY, Spanswick D, Martindale JC, Reeve AJ, Chessell IP.

Pain. 2007 Mar;128(1-2):78-87. Epub 2006 Oct 19.

PMID:
17055166
40.

Transgenic models of pain: a brief review.

Hatcher JP, Chessell IP.

Curr Opin Investig Drugs. 2006 Jul;7(7):647-52. Review.

PMID:
16869119
41.

Identification of novel pyrazole acid antagonists for the EP1 receptor.

McKeown SC, Hall A, Giblin GM, Lorthioir O, Blunt R, Lewell XQ, Wilson RJ, Brown SH, Chowdhury A, Coleman T, Watson SP, Chessell IP, Pipe A, Clayton N, Goldsmith P.

Bioorg Med Chem Lett. 2006 Sep 15;16(18):4767-71. Epub 2006 Jul 14.

PMID:
16843659
42.

Attenuation of experimental arthritis in TRPV1R knockout mice.

Barton NJ, McQueen DS, Thomson D, Gauldie SD, Wilson AW, Salter DM, Chessell IP.

Exp Mol Pathol. 2006 Oct;81(2):166-70. Epub 2006 Jun 16.

PMID:
16781708
43.

Investigation into the role of P2X(3)/P2X(2/3) receptors in neuropathic pain following chronic constriction injury in the rat: an electrophysiological study.

Sharp CJ, Reeve AJ, Collins SD, Martindale JC, Summerfield SG, Sargent BS, Bate ST, Chessell IP.

Br J Pharmacol. 2006 Jul;148(6):845-52. Epub 2006 Jun 12.

44.

Structure-activity relationships of 1,5-biaryl pyrroles as EP1 receptor antagonists.

Hall A, Atkinson S, Brown SH, Chessell IP, Chowdhury A, Clayton NM, Coleman T, Giblin GM, Gleave RJ, Hammond B, Healy MP, Johnson MR, Michel AD, Naylor A, Novelli R, Spalding DJ, Tang SP.

Bioorg Med Chem Lett. 2006 Jul 15;16(14):3657-62. Epub 2006 May 11.

PMID:
16697196
45.

Changes in dorsal root ganglion CGRP expression in a chronic inflammatory model of the rat knee joint: differential modulation by rofecoxib and paracetamol.

Staton PC, Wilson AW, Bountra C, Chessell IP, Day NC.

Eur J Pain. 2007 Apr;11(3):283-9. Epub 2006 May 11.

PMID:
16690336
46.

COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord.

Yiangou Y, Facer P, Durrenberger P, Chessell IP, Naylor A, Bountra C, Banati RR, Anand P.

BMC Neurol. 2006 Mar 2;6:12.

47.

Discovery of novel biaryl heterocyclic EP1 receptor antagonists.

Hall A, Bit RA, Brown SH, Chaignot HM, Chessell IP, Coleman T, Giblin GM, Hurst DN, Kilford IR, Lewell XQ, Michel AD, Mohamed S, Naylor A, Novelli R, Skinner L, Spalding DJ, Tang SP, Wilson RJ.

Bioorg Med Chem Lett. 2006 May 15;16(10):2666-71. Epub 2006 Feb 28.

PMID:
16503138
48.

Prostanoid receptor EP1 and Cox-2 in injured human nerves and a rat model of nerve injury: a time-course study.

Durrenberger PF, Facer P, Casula MA, Yiangou Y, Gray RA, Chessell IP, Day NC, Collins SD, Bingham S, Wilson AW, Elliot D, Birch R, Anand P.

BMC Neurol. 2006 Jan 4;6:1.

49.

An animal model of chronic inflammatory pain: pharmacological and temporal differentiation from acute models.

Wilson AW, Medhurst SJ, Dixon CI, Bontoft NC, Winyard LA, Brackenborough KT, De Alba J, Clarke CJ, Gunthorpe MJ, Hicks GA, Bountra C, McQueen DS, Chessell IP.

Eur J Pain. 2006 Aug;10(6):537-49. Epub 2005 Sep 30.

PMID:
16199187
50.

Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain.

Chessell IP, Hatcher JP, Bountra C, Michel AD, Hughes JP, Green P, Egerton J, Murfin M, Richardson J, Peck WL, Grahames CB, Casula MA, Yiangou Y, Birch R, Anand P, Buell GN.

Pain. 2005 Apr;114(3):386-96.

PMID:
15777864

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