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Items: 1 to 50 of 136

1.

Prospects for finding the mechanisms of sex differences in addiction with human and model organism genetic analysis.

Datta U, Schoenrock SE, Bubier JA, Bogue MA, Jentsch JD, Logan RW, Tarantino LM, Chesler EJ.

Genes Brain Behav. 2020 Mar;19(3):e12645. doi: 10.1111/gbb.12645. Epub 2020 Feb 11. Review.

2.

Human and mouse essentiality screens as a resource for disease gene discovery.

Cacheiro P, Muñoz-Fuentes V, Murray SA, Dickinson ME, Bucan M, Nutter LMJ, Peterson KA, Haselimashhadi H, Flenniken AM, Morgan H, Westerberg H, Konopka T, Hsu CW, Christiansen A, Lanza DG, Beaudet AL, Heaney JD, Fuchs H, Gailus-Durner V, Sorg T, Prochazka J, Novosadova V, Lelliott CJ, Wardle-Jones H, Wells S, Teboul L, Cater H, Stewart M, Hough T, Wurst W, Sedlacek R, Adams DJ, Seavitt JR, Tocchini-Valentini G, Mammano F, Braun RE, McKerlie C, Herault Y, de Angelis MH, Mallon AM, Lloyd KCK, Brown SDM, Parkinson H, Meehan TF, Smedley D; Genomics England Research Consortium; International Mouse Phenotyping Consortium.

Nat Commun. 2020 Jan 31;11(1):655. doi: 10.1038/s41467-020-14284-2.

3.

Characterization of genetically complex Collaborative Cross mouse strains that model divergent locomotor activating and reinforcing properties of cocaine.

Schoenrock SA, Kumar P, Gómez-A A, Dickson PE, Kim SM, Bailey L, Neira S, Riker KD, Farrington J, Gaines CH, Khan S, Wilcox TD, Roy TA, Leonardo MR, Olson AA, Gagnon LH, Philip VM, Valdar W, de Villena FP, Jentsch JD, Logan RW, McClung CA, Robinson DL, Chesler EJ, Tarantino LM.

Psychopharmacology (Berl). 2020 Jan 3. doi: 10.1007/s00213-019-05429-3. [Epub ahead of print]

PMID:
31897574
4.

A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice.

Bubier JA, Philip VM, Quince C, Campbell J, Zhou Y, Vishnivetskaya T, Duvvuru S, Blair RH, Ndukum J, Donohue KD, Foster CM, Mellert DJ, Weinstock G, Culiat CT, O'Hara BF, Palumbo AV, Podar M, Chesler EJ.

Genetics. 2020 Mar;214(3):719-733. doi: 10.1534/genetics.119.303013. Epub 2020 Jan 2.

5.

The Genetics of Neuropathic Pain from Model Organisms to Clinical Application.

Calvo M, Davies AJ, Hébert HL, Weir GA, Chesler EJ, Finnerup NB, Levitt RC, Smith BH, Neely GG, Costigan M, Bennett DL.

Neuron. 2019 Nov 20;104(4):637-653. doi: 10.1016/j.neuron.2019.09.018. Review.

6.

Mouse Phenome Database: a data repository and analysis suite for curated primary mouse phenotype data.

Bogue MA, Philip VM, Walton DO, Grubb SC, Dunn MH, Kolishovski G, Emerson J, Mukherjee G, Stearns T, He H, Sinha V, Kadakkuzha B, Kunde-Ramamoorthy G, Chesler EJ.

Nucleic Acids Res. 2020 Jan 8;48(D1):D716-D723. doi: 10.1093/nar/gkz1032.

PMID:
31696236
7.

Cisplatin-resistant triple-negative breast cancer subtypes: multiple mechanisms of resistance.

Hill DP, Harper A, Malcolm J, McAndrews MS, Mockus SM, Patterson SE, Reynolds T, Baker EJ, Bult CJ, Chesler EJ, Blake JA.

BMC Cancer. 2019 Nov 4;19(1):1039. doi: 10.1186/s12885-019-6278-9.

8.

On Finding and Enumerating Maximal and Maximum k-Partite Cliques in k-Partite Graphs.

Phillips CA, Wang K, Baker EJ, Bubier JA, Chesler EJ, Langston MA.

Algorithms. 2019 Jan;12(1). pii: 23. doi: 10.3390/a12010023. Epub 2019 Jan 15.

9.

Genetic mapping in Diversity Outbred mice identifies a Trpa1 variant influencing late-phase formalin response.

Recla JM, Bubier JA, Gatti DM, Ryan JL, Long KH, Robledo RF, Glidden NC, Hou G, Churchill GA, Maser RS, Zhang ZW, Young EE, Chesler EJ, Bult CJ.

Pain. 2019 Aug;160(8):1740-1753. doi: 10.1097/j.pain.0000000000001571.

PMID:
31335644
10.

High-Diversity Mouse Populations for Complex Traits.

Saul MC, Philip VM, Reinholdt LG; Center for Systems Neurogenetics of Addiction, Chesler EJ.

Trends Genet. 2019 Jul;35(7):501-514. doi: 10.1016/j.tig.2019.04.003. Epub 2019 May 24. Review.

11.

Reference Trait Analysis Reveals Correlations Between Gene Expression and Quantitative Traits in Disjoint Samples.

Skelly DA, Raghupathy N, Robledo RF, Graber JH, Chesler EJ.

Genetics. 2019 Jul;212(3):919-929. doi: 10.1534/genetics.118.301865. Epub 2019 May 21.

PMID:
31113812
12.

Testing Pleiotropy vs. Separate QTL in Multiparental Populations.

Boehm FJ, Chesler EJ, Yandell BS, Broman KW.

G3 (Bethesda). 2019 Jul 9;9(7):2317-2324. doi: 10.1534/g3.119.400098.

13.

Integration of heterogeneous functional genomics data in gerontology research to find genes and pathway underlying aging across species.

Bubier JA, Sutphin GL, Reynolds TJ, Korstanje R, Fuksman-Kumpa A, Baker EJ, Langston MA, Chesler EJ.

PLoS One. 2019 Apr 12;14(4):e0214523. doi: 10.1371/journal.pone.0214523. eCollection 2019.

14.

Robust mouse tracking in complex environments using neural networks.

Geuther BQ, Deats SP, Fox KJ, Murray SA, Braun RE, White JK, Chesler EJ, Lutz CM, Kumar V.

Commun Biol. 2019 Mar 29;2:124. doi: 10.1038/s42003-019-0362-1. eCollection 2019.

15.

Curating gene sets: challenges and opportunities for integrative analysis.

Bubier J, Hill D, Mukherjee G, Reynolds T, Baker EJ, Berger A, Emerson J, Blake JA, Chesler EJ.

Database (Oxford). 2019 Jan 1;2019. pii: baz036. doi: 10.1093/database/baz036.

16.

Large-scale discovery of mouse transgenic integration sites reveals frequent structural variation and insertional mutagenesis.

Goodwin LO, Splinter E, Davis TL, Urban R, He H, Braun RE, Chesler EJ, Kumar V, van Min M, Ndukum J, Philip VM, Reinholdt LG, Svenson K, White JK, Sasner M, Lutz C, Murray SA.

Genome Res. 2019 Mar;29(3):494-505. doi: 10.1101/gr.233866.117. Epub 2019 Jan 18.

17.

Author Correction: Comparing phenotypic variation between inbred and outbred mice.

Tuttle AH, Philip VM, Chesler EJ, Mogil JS.

Nat Methods. 2019 Feb;16(2):206. doi: 10.1038/s41592-018-0298-2.

PMID:
30584248
18.

Comparing phenotypic variation between inbred and outbred mice.

Tuttle AH, Philip VM, Chesler EJ, Mogil JS.

Nat Methods. 2018 Dec;15(12):994-996. doi: 10.1038/s41592-018-0224-7. No abstract available. Erratum in: Nat Methods. 2019 Feb;16(2):206.

19.

Systems genetics of sensation seeking.

Dickson PE, Roy TA, McNaughton KA, Wilcox TD, Kumar P, Chesler EJ.

Genes Brain Behav. 2019 Mar;18(3):e12519. doi: 10.1111/gbb.12519. Epub 2018 Oct 8.

20.

Genome-wide association for testis weight in the diversity outbred mouse population.

Yuan JT, Gatti DM, Philip VM, Kasparek S, Kreuzman AM, Mansky B, Sharif K, Taterra D, Taylor WM, Thomas M, Ward JO, Holmes A, Chesler EJ, Parker CC.

Mamm Genome. 2018 Jun;29(5-6):310-324. doi: 10.1007/s00335-018-9745-8. Epub 2018 Apr 24.

21.

Mechanistic Differences in Neuropathic Pain Modalities Revealed by Correlating Behavior with Global Expression Profiling.

Cobos EJ, Nickerson CA, Gao F, Chandran V, Bravo-Caparrós I, González-Cano R, Riva P, Andrews NA, Latremoliere A, Seehus CR, Perazzoli G, Nieto FR, Joller N, Painter MW, Ma CHE, Omura T, Chesler EJ, Geschwind DH, Coppola G, Rangachari M, Woolf CJ, Costigan M.

Cell Rep. 2018 Jan 30;22(5):1301-1312. doi: 10.1016/j.celrep.2018.01.006.

22.

Reproducibility and replicability of rodent phenotyping in preclinical studies.

Kafkafi N, Agassi J, Chesler EJ, Crabbe JC, Crusio WE, Eilam D, Gerlai R, Golani I, Gomez-Marin A, Heller R, Iraqi F, Jaljuli I, Karp NA, Morgan H, Nicholson G, Pfaff DW, Richter SH, Stark PB, Stiedl O, Stodden V, Tarantino LM, Tucci V, Valdar W, Williams RW, Würbel H, Benjamini Y.

Neurosci Biobehav Rev. 2018 Apr;87:218-232. doi: 10.1016/j.neubiorev.2018.01.003. Epub 2018 Jan 31. Review.

23.

Identification of a novel gene regulating amygdala-mediated fear extinction.

Gunduz-Cinar O, Brockway E, Lederle L, Wilcox T, Halladay LR, Ding Y, Oh H, Busch EF, Kaugars K, Flynn S, Limoges A, Bukalo O, MacPherson KP, Masneuf S, Pinard C, Sibille E, Chesler EJ, Holmes A.

Mol Psychiatry. 2019 Apr;24(4):601-612. doi: 10.1038/s41380-017-0003-3. Epub 2018 Jan 8.

24.

Mouse Phenome Database: an integrative database and analysis suite for curated empirical phenotype data from laboratory mice.

Bogue MA, Grubb SC, Walton DO, Philip VM, Kolishovski G, Stearns T, Dunn MH, Skelly DA, Kadakkuzha B, TeHennepe G, Kunde-Ramamoorthy G, Chesler EJ.

Nucleic Acids Res. 2018 Jan 4;46(D1):D843-D850. doi: 10.1093/nar/gkx1082.

25.

Prevalence of sexual dimorphism in mammalian phenotypic traits.

Karp NA, Mason J, Beaudet AL, Benjamini Y, Bower L, Braun RE, Brown SDM, Chesler EJ, Dickinson ME, Flenniken AM, Fuchs H, Angelis MH, Gao X, Guo S, Greenaway S, Heller R, Herault Y, Justice MJ, Kurbatova N, Lelliott CJ, Lloyd KCK, Mallon AM, Mank JE, Masuya H, McKerlie C, Meehan TF, Mott RF, Murray SA, Parkinson H, Ramirez-Solis R, Santos L, Seavitt JR, Smedley D, Sorg T, Speak AO, Steel KP, Svenson KL; International Mouse Phenotyping Consortium, Wakana S, West D, Wells S, Westerberg H, Yaacoby S, White JK.

Nat Commun. 2017 Jun 26;8:15475. doi: 10.1038/ncomms15475.

26.

Male Infertility Is Responsible for Nearly Half of the Extinction Observed in the Mouse Collaborative Cross.

Shorter JR, Odet F, Aylor DL, Pan W, Kao CY, Fu CP, Morgan AP, Greenstein S, Bell TA, Stevans AM, Feathers RW, Patel S, Cates SE, Shaw GD, Miller DR, Chesler EJ, McMillian L, O'Brien DA, Villena FP.

Genetics. 2017 Jun;206(2):557-572. doi: 10.1534/genetics.116.199596.

27.

QTL and systems genetics analysis of mouse grooming and behavioral responses to novelty in an open field.

Delprato A, Algéo MP, Bonheur B, Bubier JA, Lu L, Williams RW, Chesler EJ, Crusio WE.

Genes Brain Behav. 2017 Nov;16(8):790-799. doi: 10.1111/gbb.12392. Epub 2017 Jun 22.

28.

Systems Genetic Analysis in GeneNetwork.org.

Parker CC, Dickson PE, Philip VM, Thomas M, Chesler EJ.

Curr Protoc Neurosci. 2017 Apr 10;79:8.39.1-8.39.20. doi: 10.1002/cpns.23.

29.

Integrative Functional Genomics for Systems Genetics in GeneWeaver.org.

Bubier JA, Langston MA, Baker EJ, Chesler EJ.

Methods Mol Biol. 2017;1488:131-152.

PMID:
27933523
30.

Analysis of morphine responses in mice reveals a QTL on Chromosome 7.

Crusio WE, Dhawan E, Chesler EJ, Delprato A.

Version 2. F1000Res. 2016 Sep 2 [revised 2016 Jan 1];5:2156. eCollection 2016.

31.

Kv7 channels in the nucleus accumbens are altered by chronic drinking and are targets for reducing alcohol consumption.

McGuier NS, Griffin WC 3rd, Gass JT, Padula AE, Chesler EJ, Mulholland PJ.

Addict Biol. 2016 Nov;21(6):1097-1112. doi: 10.1111/adb.12279. Epub 2015 Jun 23.

32.

Diversity Outbred Mice at 21: Maintaining Allelic Variation in the Face of Selection.

Chesler EJ, Gatti DM, Morgan AP, Strobel M, Trepanier L, Oberbeck D, McWeeney S, Hitzemann R, Ferris M, McMullan R, Clayshultle A, Bell TA, Manuel de Villena FP, Churchill GA.

G3 (Bethesda). 2016 Dec 7;6(12):3893-3902. doi: 10.1534/g3.116.035527.

33.

Systems genetic and pharmacological analysis identifies candidate genes underlying mechanosensation in the von Frey test.

Young EE, Bryant CD, Lee SE, Peng X, Cook B, Nair HK, Dreher KJ, Zhang X, Palmer AA, Chung JM, Mogil JS, Chesler EJ, Lariviere WR.

Genes Brain Behav. 2016 Jul;15(6):604-15. doi: 10.1111/gbb.12302.

34.

Identification of quantitative trait loci and candidate genes for an anxiolytic-like response to ethanol in BXD recombinant inbred strains.

Putman AH, Wolen AR, Harenza JL, Yordanova RK, Webb BT, Chesler EJ, Miles MF.

Genes Brain Behav. 2016 Apr;15(4):367-81. doi: 10.1111/gbb.12289.

35.

R2d2 Drives Selfish Sweeps in the House Mouse.

Didion JP, Morgan AP, Yadgary L, Bell TA, McMullan RC, Ortiz de Solorzano L, Britton-Davidian J, Bult CJ, Campbell KJ, Castiglia R, Ching YH, Chunco AJ, Crowley JJ, Chesler EJ, Förster DW, French JE, Gabriel SI, Gatti DM, Garland T Jr, Giagia-Athanasopoulou EB, Giménez MD, Grize SA, Gündüz İ, Holmes A, Hauffe HC, Herman JS, Holt JM, Hua K, Jolley WJ, Lindholm AK, López-Fuster MJ, Mitsainas G, da Luz Mathias M, McMillan L, Ramalhinho Mda G, Rehermann B, Rosshart SP, Searle JB, Shiao MS, Solano E, Svenson KL, Thomas-Laemont P, Threadgill DW, Ventura J, Weinstock GM, Pomp D, Churchill GA, Pardo-Manuel de Villena F.

Mol Biol Evol. 2016 Jun;33(6):1381-95. doi: 10.1093/molbev/msw036. Epub 2016 Feb 15.

36.

Cross-Species Integrative Functional Genomics in GeneWeaver Reveals a Role for Pafah1b1 in Altered Response to Alcohol.

Bubier JA, Wilcox TD, Jay JJ, Langston MA, Baker EJ, Chesler EJ.

Front Behav Neurosci. 2016 Jan 21;10:1. doi: 10.3389/fnbeh.2016.00001. eCollection 2016.

37.

GeneWeaver: data driven alignment of cross-species genomics in biology and disease.

Baker E, Bubier JA, Reynolds T, Langston MA, Chesler EJ.

Nucleic Acids Res. 2016 Jan 4;44(D1):D555-9. doi: 10.1093/nar/gkv1329. Epub 2015 Dec 9.

38.

Systems genetics of intravenous cocaine self-administration in the BXD recombinant inbred mouse panel.

Dickson PE, Miller MM, Calton MA, Bubier JA, Cook MN, Goldowitz D, Chesler EJ, Mittleman G.

Psychopharmacology (Berl). 2016 Feb;233(4):701-14. doi: 10.1007/s00213-015-4147-z. Epub 2015 Nov 19.

39.

Identification of microRNAs associated with allergic airway disease using a genetically diverse mouse population.

Rutledge H, Baran-Gale J, de Villena FP, Chesler EJ, Churchill GA, Sethupathy P, Kelada SN.

BMC Genomics. 2015 Aug 25;16:633. doi: 10.1186/s12864-015-1732-9.

40.

Collaborative Cross and Diversity Outbred data resources in the Mouse Phenome Database.

Bogue MA, Churchill GA, Chesler EJ.

Mamm Genome. 2015 Oct;26(9-10):511-20. doi: 10.1007/s00335-015-9595-6. Epub 2015 Aug 19.

41.

Sex and strain influence attribution of incentive salience to reward cues in mice.

Dickson PE, McNaughton KA, Hou L, Anderson LC, Long KH, Chesler EJ.

Behav Brain Res. 2015 Oct 1;292:305-15. doi: 10.1016/j.bbr.2015.05.039. Epub 2015 Jun 20.

42.

GeneWeaver: finding consilience in heterogeneous cross-species functional genomics data.

Bubier JA, Phillips CA, Langston MA, Baker EJ, Chesler EJ.

Mamm Genome. 2015 Oct;26(9-10):556-66. doi: 10.1007/s00335-015-9575-x. Epub 2015 Jun 20.

43.

Aging Research Using Mouse Models.

Ackert-Bicknell CL, Anderson LC, Sheehan S, Hill WG, Chang B, Churchill GA, Chesler EJ, Korstanje R, Peters LL.

Curr Protoc Mouse Biol. 2015 Jun 1;5(2):95-133. doi: 10.1002/9780470942390.mo140195.

44.

Applying the ARRIVE Guidelines to an In Vivo Database.

Karp NA, Meehan TF, Morgan H, Mason JC, Blake A, Kurbatova N, Smedley D, Jacobsen J, Mott RF, Iyer V, Matthews P, Melvin DG, Wells S, Flenniken AM, Masuya H, Wakana S, White JK, Lloyd KC, Reynolds CL, Paylor R, West DB, Svenson KL, Chesler EJ, de Angelis MH, Tocchini-Valentini GP, Sorg T, Herault Y, Parkinson H, Mallon AM, Brown SD.

PLoS Biol. 2015 May 20;13(5):e1002151. doi: 10.1371/journal.pbio.1002151. eCollection 2015 May.

45.

A multi-megabase copy number gain causes maternal transmission ratio distortion on mouse chromosome 2.

Didion JP, Morgan AP, Clayshulte AM, Mcmullan RC, Yadgary L, Petkov PM, Bell TA, Gatti DM, Crowley JJ, Hua K, Aylor DL, Bai L, Calaway M, Chesler EJ, French JE, Geiger TR, Gooch TJ, Garland T Jr, Harrill AH, Hunter K, McMillan L, Holt M, Miller DR, O'Brien DA, Paigen K, Pan W, Rowe LB, Shaw GD, Simecek P, Sullivan PF, Svenson KL, Weinstock GM, Threadgill DW, Pomp D, Churchill GA, Pardo-Manuel de Villena F.

PLoS Genet. 2015 Feb 13;11(2):e1004850. doi: 10.1371/journal.pgen.1004850. eCollection 2015 Feb.

46.

KCNN Genes that Encode Small-Conductance Ca2+-Activated K+ Channels Influence Alcohol and Drug Addiction.

Padula AE, Griffin WC 3rd, Lopez MF, Nimitvilai S, Cannady R, McGuier NS, Chesler EJ, Miles MF, Williams RW, Randall PK, Woodward JJ, Becker HC, Mulholland PJ.

Neuropsychopharmacology. 2015 Jul;40(8):1928-39. doi: 10.1038/npp.2015.42. Epub 2015 Feb 9.

47.

Accessing Data Resources in the Mouse Phenome Database for Genetic Analysis of Murine Life Span and Health Span.

Bogue MA, Peters LL, Paigen B, Korstanje R, Yuan R, Ackert-Bicknell C, Grubb SC, Churchill GA, Chesler EJ.

J Gerontol A Biol Sci Med Sci. 2016 Feb;71(2):170-7. doi: 10.1093/gerona/glu223. Epub 2014 Dec 22.

48.

Identifying common components across biological network graphs using a bipartite data model.

Baker E, Culpepper C, Philips C, Bubier J, Langston M, Chesler E.

BMC Proc. 2014 Oct 13;8(Suppl 6 Proceedings of the Great Lakes Bioinformatics Confer):S4. doi: 10.1186/1753-6561-8-S6-S4. eCollection 2014.

49.

Association of novelty-related behaviors and intravenous cocaine self-administration in Diversity Outbred mice.

Dickson PE, Ndukum J, Wilcox T, Clark J, Roy B, Zhang L, Li Y, Lin DT, Chesler EJ.

Psychopharmacology (Berl). 2015 Mar;232(6):1011-24. doi: 10.1007/s00213-014-3737-5. Epub 2014 Sep 20.

50.

Quantitative trait locus mapping methods for diversity outbred mice.

Gatti DM, Svenson KL, Shabalin A, Wu LY, Valdar W, Simecek P, Goodwin N, Cheng R, Pomp D, Palmer A, Chesler EJ, Broman KW, Churchill GA.

G3 (Bethesda). 2014 Sep 18;4(9):1623-33. doi: 10.1534/g3.114.013748.

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