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Items: 1 to 50 of 322

1.

Peripherally delivered hepatopreferential insulin analog insulin-406 mimics the hypoglycaemia-sparing effect of portal vein human insulin infusion in dogs.

Gregory JM, Kraft G, Scott MF, Neal DW, Farmer B, Smith MS, Hastings JR, Madsen P, Kjeldsen TB, Hostrup S, Brand CL, Fledelius C, Nishimura E, Cherrington AD.

Diabetes Obes Metab. 2019 Oct;21(10):2294-2304. doi: 10.1111/dom.13808. Epub 2019 Jul 8.

PMID:
31183936
2.

A New Animal Model of Insulin-Glucose Dynamics in the Intraperitoneal Space Enhances Closed-Loop Control Performance.

Chakrabarty A, Gregory JM, Moore LM, Williams PE, Farmer B, Cherrington AD, Lord P, Shelton B, Cohen D, Zisser HC, Doyle FJ 3rd, Dassau E.

J Process Control. 2019 Apr;76:62-73. doi: 10.1016/j.jprocont.2019.01.002. Epub 2019 Feb 23.

PMID:
31178632
3.

Effect of portal glucose sensing on incretin hormone secretion in a canine model.

Edgerton DS, Kraft G, Smith MS, Moore LM, Farmer B, Scott M, Moore MC, Nauck MA, Cherrington AD.

Am J Physiol Endocrinol Metab. 2019 Aug 1;317(2):E244-E249. doi: 10.1152/ajpendo.00100.2019. Epub 2019 May 21.

PMID:
31112407
4.

Iatrogenic Hyperinsulinemia, Not Hyperglycemia, Drives Insulin Resistance in Type 1 Diabetes as Revealed by Comparison With GCK-MODY (MODY2).

Gregory JM, Smith TJ, Slaughter JC, Mason HR, Hughey CC, Smith MS, Kandasamy B, Greeley SAW, Philipson LH, Naylor RN, Letourneau LR, Abumrad NN, Cherrington AD, Moore DJ.

Diabetes. 2019 Aug;68(8):1565-1576. doi: 10.2337/db19-0324. Epub 2019 May 15.

PMID:
31092478
5.

Sympathetic Denervation of the Common Hepatic Artery Lessens Glucose Intolerance in the Fat- and Fructose-Fed Dog.

Kraft G, Vrba A, Scott M, Allen E, Edgerton DS, Williams PE, Vafai SB, Azamian BR, Cherrington AD.

Diabetes. 2019 Jun;68(6):1143-1155. doi: 10.2337/db18-1209. Epub 2019 Apr 1.

PMID:
30936143
6.

Targeting insulin to the liver corrects defects in glucose metabolism caused by peripheral insulin delivery.

Edgerton DS, Scott M, Farmer B, Williams PE, Madsen P, Kjeldsen T, Brand CL, Fledelius C, Nishimura E, Cherrington AD.

JCI Insight. 2019 Feb 26;5. pii: 126974. doi: 10.1172/jci.insight.126974.

7.

Enterically delivered insulin tregopil exhibits rapid absorption characteristics and a pharmacodynamic effect similar to human insulin in conscious dogs.

Gregory JM, Lautz M, Moore LM, Williams PE, Reddy P, Cherrington AD.

Diabetes Obes Metab. 2019 Jan;21(1):160-169. doi: 10.1111/dom.13498. Epub 2018 Sep 16.

PMID:
30095210
8.

Morning Hyperinsulinemia Primes the Liver for Glucose Uptake and Glycogen Storage Later in the Day.

Moore MC, Smith MS, Farmer B, Coate KC, Kraft G, Shiota M, Williams PE, Cherrington AD.

Diabetes. 2018 Jul;67(7):1237-1245. doi: 10.2337/db17-0979. Epub 2018 Apr 17.

9.

Superior Glycemic Control With a Glucose-Responsive Insulin Analog: Hepatic and Nonhepatic Impacts.

Moore MC, Kelley DE, Camacho RC, Zafian P, Ye T, Lin S, Kaarsholm NC, Nargund R, Kelly TM, Van Heek M, Previs SF, Moyes C, Smith MS, Farmer B, Williams P, Cherrington AD.

Diabetes. 2018 Jun;67(6):1173-1181. doi: 10.2337/db18-0099. Epub 2018 Mar 14.

10.

Animal models of obesity and diabetes mellitus.

Kleinert M, Clemmensen C, Hofmann SM, Moore MC, Renner S, Woods SC, Huypens P, Beckers J, de Angelis MH, Schürmann A, Bakhti M, Klingenspor M, Heiman M, Cherrington AD, Ristow M, Lickert H, Wolf E, Havel PJ, Müller TD, Tschöp MH.

Nat Rev Endocrinol. 2018 Mar;14(3):140-162. doi: 10.1038/nrendo.2017.161. Epub 2018 Jan 19. Review.

11.

Glucagon's effect on liver protein metabolism in vivo.

Kraft G, Coate KC, Winnick JJ, Dardevet D, Donahue EP, Cherrington AD, Williams PE, Moore MC.

Am J Physiol Endocrinol Metab. 2017 Sep 1;313(3):E263-E272. doi: 10.1152/ajpendo.00045.2017. Epub 2017 May 23.

12.

Glucose autoregulation is the dominant component of the hormone-independent counterregulatory response to hypoglycemia in the conscious dog.

Gregory JM, Rivera N, Kraft G, Winnick JJ, Farmer B, Allen EJ, Donahue EP, Smith MS, Edgerton DS, Williams PE, Cherrington AD.

Am J Physiol Endocrinol Metab. 2017 Sep 1;313(3):E273-E283. doi: 10.1152/ajpendo.00099.2017. Epub 2017 May 16.

13.

Insulin's direct hepatic effect explains the inhibition of glucose production caused by insulin secretion.

Edgerton DS, Kraft G, Smith M, Farmer B, Williams PE, Coate KC, Printz RL, O'Brien RM, Cherrington AD.

JCI Insight. 2017 Mar 23;2(6):e91863. doi: 10.1172/jci.insight.91863.

14.

Hydrothermal Duodenal Mucosal Resurfacing: Role in the Treatment of Metabolic Disease.

Cherrington AD, Rajagopalan H, Maggs D, Devière J.

Gastrointest Endosc Clin N Am. 2017 Apr;27(2):299-311. doi: 10.1016/j.giec.2016.12.002. Review.

15.

Priming Effect of a Morning Meal on Hepatic Glucose Disposition Later in the Day.

Moore MC, Smith MS, Farmer B, Kraft G, Shiota M, Williams PE, Cherrington AD.

Diabetes. 2017 May;66(5):1136-1145. doi: 10.2337/db16-1308. Epub 2017 Feb 7.

16.

Endoscopic Duodenal Mucosal Resurfacing for the Treatment of Type 2 Diabetes: 6-Month Interim Analysis From the First-in-Human Proof-of-Concept Study.

Rajagopalan H, Cherrington AD, Thompson CC, Kaplan LM, Rubino F, Mingrone G, Becerra P, Rodriguez P, Vignolo P, Caplan J, Rodriguez L, Galvao Neto MP.

Diabetes Care. 2016 Dec;39(12):2254-2261. Epub 2016 Aug 12.

PMID:
27519448
17.

Hepatic and Whole-Body Insulin Metabolism during Proestrus and Estrus in Mongrel Dogs.

Yu EN, Winnick JJ, Edgerton DS, Scott MF, Smith MS, Farmer B, Williams PE, Cherrington AD, Moore MC.

Comp Med. 2016;66(3):235-40.

18.

Hepatic glycogen can regulate hypoglycemic counterregulation via a liver-brain axis.

Winnick JJ, Kraft G, Gregory JM, Edgerton DS, Williams P, Hajizadeh IA, Kamal MZ, Smith M, Farmer B, Scott M, Neal D, Donahue EP, Allen E, Cherrington AD.

J Clin Invest. 2016 Jun 1;126(6):2236-48. doi: 10.1172/JCI79895. Epub 2016 May 3.

19.

Insulin Delivery Into the Peripheral Circulation: A Key Contributor to Hypoglycemia in Type 1 Diabetes.

Gregory JM, Kraft G, Scott MF, Neal DW, Farmer B, Smith MS, Hastings JR, Allen EJ, Donahue EP, Rivera N, Winnick JJ, Edgerton DS, Nishimura E, Fledelius C, Brand CL, Cherrington AD.

Diabetes. 2015 Oct;64(10):3439-51. doi: 10.2337/db15-0071. Epub 2015 Jun 17.

20.

Noninvasive measurements of glycogen in perfused mouse livers using chemical exchange saturation transfer NMR and comparison to (13)C NMR spectroscopy.

Miller CO, Cao J, Chekmenev EY, Damon BM, Cherrington AD, Gore JC.

Anal Chem. 2015 Jun 2;87(11):5824-30. doi: 10.1021/acs.analchem.5b01296. Epub 2015 May 22.

21.

Chronic overeating impairs hepatic glucose uptake and disposition.

Coate KC, Kraft G, Shiota M, Smith MS, Farmer B, Neal DW, Williams P, Cherrington AD, Moore MC.

Am J Physiol Endocrinol Metab. 2015 May 15;308(10):E860-7. doi: 10.1152/ajpendo.00069.2015. Epub 2015 Mar 17.

22.

Is brain insulin action relevant to the control of plasma glucose in humans?

Edgerton DS, Cherrington AD.

Diabetes. 2015 Mar;64(3):696-9. doi: 10.2337/db14-1666. No abstract available.

23.

Changes in glucose and fat metabolism in response to the administration of a hepato-preferential insulin analog.

Edgerton DS, Moore MC, Winnick JJ, Scott M, Farmer B, Naver H, Jeppesen CB, Madsen P, Kjeldsen TB, Nishimura E, Brand CL, Cherrington AD.

Diabetes. 2014 Nov;63(11):3946-54. doi: 10.2337/db14-0266. Epub 2014 Jun 19.

24.

Hepatic glucose uptake and disposition during short-term high-fat vs. high-fructose feeding.

Coate KC, Kraft G, Moore MC, Smith MS, Ramnanan C, Irimia JM, Roach PJ, Farmer B, Neal DW, Williams P, Cherrington AD.

Am J Physiol Endocrinol Metab. 2014 Jul 15;307(2):E151-60. doi: 10.1152/ajpendo.00083.2014. Epub 2014 May 27.

25.

Effect of the glucagon-like peptide-1 receptor agonist lixisenatide on postprandial hepatic glucose metabolism in the conscious dog.

Moore MC, Werner U, Smith MS, Farmer TD, Cherrington AD.

Am J Physiol Endocrinol Metab. 2013 Dec;305(12):E1473-82. doi: 10.1152/ajpendo.00354.2013. Epub 2013 Oct 22.

26.

Novel PEGylated basal insulin LY2605541 has a preferential hepatic effect on glucose metabolism.

Moore MC, Smith MS, Sinha VP, Beals JM, Michael MD, Jacober SJ, Cherrington AD.

Diabetes. 2014 Feb;63(2):494-504. doi: 10.2337/db13-0826. Epub 2013 Oct 2.

27.

Glucagon's yin and yang effects on hepatic glucose production.

Edgerton DS, Cherrington AD.

Nat Med. 2013 Jun;19(6):674-5. doi: 10.1038/nm.3202. No abstract available.

28.

Effects of intraportal exenatide on hepatic glucose metabolism in the conscious dog.

Edgerton DS, An Z, Johnson KM, Farmer T, Farmer B, Neal D, Cherrington AD.

Am J Physiol Endocrinol Metab. 2013 Jul 1;305(1):E132-9. doi: 10.1152/ajpendo.00160.2013. Epub 2013 May 14.

29.

Canine body composition quantification using 3 tesla fat-water MRI.

Gifford A, Kullberg J, Berglund J, Malmberg F, Coate KC, Williams PE, Cherrington AD, Avison MJ, Welch EB.

J Magn Reson Imaging. 2014 Feb;39(2):485-91. doi: 10.1002/jmri.24156. Epub 2013 Apr 17.

30.

Dissecting the actions of widely used diabetes drugs.

Unger RH, Berglund ED, Habener JF, Cherrington AD.

Nat Med. 2013 Mar;19(3):272-3. doi: 10.1038/nm.3123. No abstract available.

PMID:
23467236
31.

Effects of 11β-hydroxysteroid dehydrogenase-1 inhibition on hepatic glycogenolysis and gluconeogenesis.

Winnick JJ, Ramnanan CJ, Saraswathi V, Roop J, Scott M, Jacobson P, Jung P, Basu R, Cherrington AD, Edgerton DS.

Am J Physiol Endocrinol Metab. 2013 Apr 1;304(7):E747-56. doi: 10.1152/ajpendo.00639.2012. Epub 2013 Feb 12.

32.

Portal vein glucose entry triggers a coordinated cellular response that potentiates hepatic glucose uptake and storage in normal but not high-fat/high-fructose-fed dogs.

Coate KC, Kraft G, Irimia JM, Smith MS, Farmer B, Neal DW, Roach PJ, Shiota M, Cherrington AD.

Diabetes. 2013 Feb;62(2):392-400. doi: 10.2337/db12-0417. Epub 2012 Oct 1.

33.

Interaction between the central and peripheral effects of insulin in controlling hepatic glucose metabolism in the conscious dog.

Ramnanan CJ, Kraft G, Smith MS, Farmer B, Neal D, Williams PE, Lautz M, Farmer T, Donahue EP, Cherrington AD, Edgerton DS.

Diabetes. 2013 Jan;62(1):74-84. doi: 10.2337/db12-0148. Epub 2012 Sep 25.

34.

Portal glucose delivery stimulates muscle but not liver protein metabolism.

Kraft G, Coate KC, Dardevet D, Farmer B, Donahue EP, Williams PE, Cherrington AD, Moore MC.

Am J Physiol Endocrinol Metab. 2012 Nov 15;303(10):E1202-11. doi: 10.1152/ajpendo.00140.2012. Epub 2012 Sep 25.

35.

Liver glycogen loading dampens glycogen synthesis seen in response to either hyperinsulinemia or intraportal glucose infusion.

Winnick JJ, An Z, Kraft G, Ramnanan CJ, Irimia JM, Smith M, Lautz M, Roach PJ, Cherrington AD.

Diabetes. 2013 Jan;62(1):96-101. doi: 10.2337/db11-1773. Epub 2012 Aug 24.

36.

A cyclic guanosine monophosphate-dependent pathway can regulate net hepatic glucose uptake in vivo.

An Z, Winnick JJ, Moore MC, Farmer B, Smith M, Irimia JM, Roach PJ, Cherrington AD.

Diabetes. 2012 Oct;61(10):2433-41. Epub 2012 Jun 11.

37.

Regulation of hepatic glucose uptake and storage in vivo.

Moore MC, Coate KC, Winnick JJ, An Z, Cherrington AD.

Adv Nutr. 2012 May 1;3(3):286-94. doi: 10.3945/an.112.002089. Review.

38.

Evidence against a physiologic role for acute changes in CNS insulin action in the rapid regulation of hepatic glucose production.

Ramnanan CJ, Edgerton DS, Cherrington AD.

Cell Metab. 2012 May 2;15(5):656-64. doi: 10.1016/j.cmet.2012.03.006. Review.

39.

Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover.

Unger RH, Cherrington AD.

J Clin Invest. 2012 Jan;122(1):4-12. doi: 10.1172/JCI60016. Epub 2012 Jan 3. Review.

40.

Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs.

Ramnanan CJ, Saraswathi V, Smith MS, Donahue EP, Farmer B, Farmer TD, Neal D, Williams PE, Lautz M, Mari A, Cherrington AD, Edgerton DS.

J Clin Invest. 2011 Sep;121(9):3713-23. doi: 10.1172/JCI45472. Epub 2011 Aug 25.

41.

Physiologic action of glucagon on liver glucose metabolism.

Ramnanan CJ, Edgerton DS, Kraft G, Cherrington AD.

Diabetes Obes Metab. 2011 Oct;13 Suppl 1:118-25. doi: 10.1111/j.1463-1326.2011.01454.x. Review.

42.

A high-fat, high-fructose diet accelerates nutrient absorption and impairs net hepatic glucose uptake in response to a mixed meal in partially pancreatectomized dogs.

Coate KC, Kraft G, Lautz M, Smith M, Neal DW, Cherrington AD.

J Nutr. 2011 Sep;141(9):1643-51. doi: 10.3945/jn.111.145359. Epub 2011 Jul 20.

43.

Endogenously released GLP-1 is not sufficient to alter postprandial glucose regulation in the dog.

Johnson KM, Farmer T, Schurr K, Patrick Donahue E, Farmer B, Neal D, Cherrington AD.

Endocrine. 2011 Jun;39(3):229-34. doi: 10.1007/s12020-011-9441-x. Epub 2011 Mar 10.

44.

Impact of a glycogen phosphorylase inhibitor and metformin on basal and glucagon-stimulated hepatic glucose flux in conscious dogs.

Torres TP, Sasaki N, Donahue EP, Lacy B, Printz RL, Cherrington AD, Treadway JL, Shiota M.

J Pharmacol Exp Ther. 2011 Jun;337(3):610-20. doi: 10.1124/jpet.110.177899. Epub 2011 Mar 1.

45.

Hepatic glycogen supercompensation activates AMP-activated protein kinase, impairs insulin signaling, and reduces glycogen deposition in the liver.

Winnick JJ, An Z, Ramnanan CJ, Smith M, Irimia JM, Neal DW, Moore MC, Roach PJ, Cherrington AD.

Diabetes. 2011 Feb;60(2):398-407. doi: 10.2337/db10-0592.

46.

Glucagon as a critical factor in the pathology of diabetes.

Edgerton DS, Cherrington AD.

Diabetes. 2011 Feb;60(2):377-80. doi: 10.2337/db10-1594. No abstract available.

47.

Insulin-induced hypoglycemia increases hepatic sensitivity to glucagon in dogs.

Rivera N, Ramnanan CJ, An Z, Farmer T, Smith M, Farmer B, Irimia JM, Snead W, Lautz M, Roach PJ, Cherrington AD.

J Clin Invest. 2010 Dec;120(12):4425-35. doi: 10.1172/JCI40919. Epub 2010 Nov 15.

48.

Chronic consumption of a high-fat/high-fructose diet renders the liver incapable of net hepatic glucose uptake.

Coate KC, Scott M, Farmer B, Moore MC, Smith M, Roop J, Neal DW, Williams P, Cherrington AD.

Am J Physiol Endocrinol Metab. 2010 Dec;299(6):E887-98. doi: 10.1152/ajpendo.00372.2010. Epub 2010 Sep 7.

49.

A soluble guanylate cyclase-dependent mechanism is involved in the regulation of net hepatic glucose uptake by nitric oxide in vivo.

An Z, Winnick JJ, Farmer B, Neal D, Lautz M, Irimia JM, Roach PJ, Cherrington AD.

Diabetes. 2010 Dec;59(12):2999-3007. doi: 10.2337/db10-0138. Epub 2010 Sep 7.

50.

Molecular characterization of insulin-mediated suppression of hepatic glucose production in vivo.

Ramnanan CJ, Edgerton DS, Rivera N, Irimia-Dominguez J, Farmer B, Neal DW, Lautz M, Donahue EP, Meyer CM, Roach PJ, Cherrington AD.

Diabetes. 2010 Jun;59(6):1302-11. doi: 10.2337/db09-1625. Epub 2010 Feb 25.

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