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Items: 35

1.

OT-82, a novel anticancer drug candidate that targets the strong dependence of hematological malignancies on NAD biosynthesis.

Korotchkina L, Kazyulkin D, Komarov PG, Polinsky A, Andrianova EL, Joshi S, Gupta M, Vujcic S, Kononov E, Toshkov I, Tian Y, Krasnov P, Chernov MV, Veith J, Antoch MP, Middlemiss S, Somers K, Lock RB, Norris MD, Henderson MJ, Haber M, Chernova OB, Gudkov AV.

Leukemia. 2020 Jan 2. doi: 10.1038/s41375-019-0692-5. [Epub ahead of print]

PMID:
31896781
2.

Chronic treatment with novel nanoformulated micelles of rapamycin, Rapatar, protects diabetic heart against ischaemia/reperfusion injury.

Samidurai A, Salloum FN, Durrant D, Chernova OB, Kukreja RC, Das A.

Br J Pharmacol. 2017 Dec;174(24):4771-4784. doi: 10.1111/bph.14059. Epub 2017 Nov 24.

3.

p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli.

Hall BM, Balan V, Gleiberman AS, Strom E, Krasnov P, Virtuoso LP, Rydkina E, Vujcic S, Balan K, Gitlin II, Leonova KI, Consiglio CR, Gollnick SO, Chernova OB, Gudkov AV.

Aging (Albany NY). 2017 Aug 2;9(8):1867-1884. doi: 10.18632/aging.101268.

4.

Murine mesenchymal cells that express elevated levels of the CDK inhibitor p16(Ink4a) in vivo are not necessarily senescent.

Frescas D, Hall BM, Strom E, Virtuoso LP, Gupta M, Gleiberman AS, Rydkina E, Balan V, Vujcic S, Chernova OB, Gudkov AV.

Cell Cycle. 2017 Aug 18;16(16):1526-1533. doi: 10.1080/15384101.2017.1339850. Epub 2017 Jun 26.

5.

Physiological frailty index (PFI): quantitative in-life estimate of individual biological age in mice.

Antoch MP, Wrobel M, Kuropatwinski KK, Gitlin I, Leonova KI, Toshkov I, Gleiberman AS, Hutson AD, Chernova OB, Gudkov AV.

Aging (Albany NY). 2017 Mar 19;9(3):615-626. doi: 10.18632/aging.101206.

6.

Senescent cells expose and secrete an oxidized form of membrane-bound vimentin as revealed by a natural polyreactive antibody.

Frescas D, Roux CM, Aygun-Sunar S, Gleiberman AS, Krasnov P, Kurnasov OV, Strom E, Virtuoso LP, Wrobel M, Osterman AL, Antoch MP, Mett V, Chernova OB, Gudkov AV.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):E1668-E1677. doi: 10.1073/pnas.1614661114. Epub 2017 Feb 13.

7.

Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells.

Hall BM, Balan V, Gleiberman AS, Strom E, Krasnov P, Virtuoso LP, Rydkina E, Vujcic S, Balan K, Gitlin I, Leonova K, Polinsky A, Chernova OB, Gudkov AV.

Aging (Albany NY). 2016 Jul;8(7):1294-315. doi: 10.18632/aging.100991.

8.

CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements.

Somers K, Chudakova DA, Middlemiss SM, Wen VW, Clifton M, Kwek A, Liu B, Mayoh C, Bongers A, Karsa M, Pan S, Cruikshank S, Scandlyn M, Hoang W, Imamura T, Kees UR, Gudkov AV, Chernova OB, Haber M, Norris MD, Henderson MJ.

Oncotarget. 2016 Jul 19;7(29):46067-46087. doi: 10.18632/oncotarget.10022.

9.

Rapatar, a nanoformulation of rapamycin, decreases chemically-induced benign prostate hyperplasia in rats.

Lesovaya EA, Kirsanov KI, Antoshina EE, Trukhanova LS, Gorkova TG, Shipaeva EV, Salimov RM, Belitsky GA, Blagosklonny MV, Yakubovskaya MG, Chernova OB.

Oncotarget. 2015;6(12):9718-27.

10.

Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice.

Komarova EA, Antoch MP, Novototskaya LR, Chernova OB, Paszkiewicz G, Leontieva OV, Blagosklonny MV, Gudkov AV.

Aging (Albany NY). 2012 Oct;4(10):709-14.

11.

New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53-/- mice by delaying carcinogenesis.

Comas M, Toshkov I, Kuropatwinski KK, Chernova OB, Polinsky A, Blagosklonny MV, Gudkov AV, Antoch MP.

Aging (Albany NY). 2012 Oct;4(10):715-22.

12.

Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation.

Strom E, Sathe S, Komarov PG, Chernova OB, Pavlovska I, Shyshynova I, Bosykh DA, Burdelya LG, Macklis RM, Skaliter R, Komarova EA, Gudkov AV.

Nat Chem Biol. 2006 Sep;2(9):474-9. Epub 2006 Jul 23.

PMID:
16862141
13.
14.
15.

Molecular characterization of the breakpoint region associated with a constitutional t(2;15)(q34;q26) in a patient with multiple myeloma.

Kitamura E, Kuemerle BA, Chernova OB, Cowell JK.

Cancer Genet Cytogenet. 2001 Sep;129(2):112-9.

PMID:
11566340
16.

A novel member of the WD-repeat gene family, WDR11, maps to the 10q26 region and is disrupted by a chromosome translocation in human glioblastoma cells.

Chernova OB, Hunyadi A, Malaj E, Pan H, Crooks C, Roe B, Cowell JK.

Oncogene. 2001 Aug 30;20(38):5378-92.

17.

A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors.

Chernova OB, Somerville RP, Cowell JK.

Oncogene. 1998 Dec 3;17(22):2873-81.

18.

The p53 network.

Agarwal ML, Taylor WR, Chernov MV, Chernova OB, Stark GR.

J Biol Chem. 1998 Jan 2;273(1):1-4. Review. No abstract available.

19.

MYC abrogates p53-mediated cell cycle arrest in N-(phosphonacetyl)-L-aspartate-treated cells, permitting CAD gene amplification.

Chernova OB, Chernov MV, Ishizaka Y, Agarwal ML, Stark GR.

Mol Cell Biol. 1998 Jan;18(1):536-45.

20.

Multiple mechanisms of N-phosphonacetyl-L-aspartate resistance in human cell lines: carbamyl-P synthetase/aspartate transcarbamylase/dihydro-orotase gene amplification is frequent only when chromosome 2 is rearranged.

Smith KA, Chernova OB, Groves RP, Stark MB, Martínez JL, Davidson JN, Trent JM, Patterson TE, Agarwal A, Duncan P, Agarwal ML, Stark GR.

Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1816-21.

21.

Use of genetic suppressor elements to dissect distinct biological effects of separate p53 domains.

Ossovskaya VS, Mazo IA, Chernov MV, Chernova OB, Strezoska Z, Kondratov R, Stark GR, Chumakov PM, Gudkov AV.

Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10309-14.

22.

Inefficient growth arrest in response to dNTP starvation stimulates gene amplification through bridge-breakage-fusion cycles.

Poupon MF, Smith KA, Chernova OB, Gilbert C, Stark GR.

Mol Biol Cell. 1996 Mar;7(3):345-54.

23.

The role of p53 in regulating genomic stability when DNA and RNA synthesis are inhibited.

Chernova OB, Chernov MV, Agarwal ML, Taylor WR, Stark GR.

Trends Biochem Sci. 1995 Oct;20(10):431-4. Review.

PMID:
8533158
24.

Regulation and mechanisms of gene amplification.

Smith KA, Agarwal ML, Chernov MV, Chernova OB, Deguchi Y, Ishizaka Y, Patterson TE, Poupon MF, Stark GR.

Philos Trans R Soc Lond B Biol Sci. 1995 Jan 30;347(1319):49-56. Review.

PMID:
7746853
25.

Decreased sensitivity of multidrug-resistant tumor cells to cisplatin is correlated with sorcin gene co-amplification.

Demidova NS, Ilyinskaya GV, Shiryaeva OA, Chernova OB, Goncharova SA, Kopnin BP.

Neoplasma. 1995;42(4):195-201.

PMID:
7659186
26.

Newly formed chromosome-like structures in independent mouse P388 sublines with developed in vivo mdr1 gene amplification.

Demidova NS, Chernova OB, Siyanova EY, Goncharova AS, Kopnin BP.

Somat Cell Mol Genet. 1991 Nov;17(6):581-90.

PMID:
1685030
27.

[Multiple drug resistance and differentiation in the population of transformed dog kidney cells MDCK].

Stavrovskaia AA, Stromskaia TP, Chernova OB, Dzhuraeva FKh.

Mol Gen Mikrobiol Virusol. 1990 May;(5):3-7. Russian.

PMID:
2381439
28.

Cloning and characterization of DNA sequences amplified in multidrug-resistant Djungarian hamster and mouse cells.

Gudkov AV, Chernova OB, Kazarov AR, Kopnin BP.

Somat Cell Mol Genet. 1987 Nov;13(6):609-19.

PMID:
2823393
29.

[Gene amplification in murine leukemia cells with multiple drug resistance acquired in vivo].

Demidova NS, Goncharova SA, Chernova OB, Kopnin BP, Gudkov AV.

Genetika. 1987 Oct;23(10):1797-806. Russian.

PMID:
3692152
30.

[Pattern of evolution of amplicons during the development of multiple drug resistance in Djungarian hamster cells].

Gudkov AV, Chernova OB, Kazarov AR, Kopnin BP.

Mol Gen Mikrobiol Virusol. 1987 Jun;(6):33-8. Russian.

PMID:
3476848
31.

[Cloning and characteristics of DNA sequences amplified in Djungarian hamster cells with multidrug resistance].

Chernova OB, Shifrin VI, Sokova OI, Kopnin BP, Gudkov AV.

Mol Gen Mikrobiol Virusol. 1987 Apr;(4):14-9. Russian.

PMID:
3600679
32.

[Isolation of DNA probes for the detection of sequences amplified in colchicine-resistant cells].

Gudkov AV, Chernova OB, Sianova EIu, Sokova OI, Kopnin BP.

Mol Biol (Mosk). 1986 Jan-Feb;20(1):146-53. Russian.

PMID:
3456484
33.
34.

[Hormone-dependent process of the maturation of the major structural proteins of the mouse mammary tumor virus].

Beriashvili MM, Chernova OB, Kolobkov SL, Kriukova IN.

Vopr Virusol. 1982 Jan-Feb;(1):34-8. Russian.

PMID:
6280389
35.

[Characteristics of A-type intracytoplasmic particles produced by human cells].

Kolobkov SL, Miller GG, Chernova OB, Kriukova IN.

Biull Eksp Biol Med. 1981 Mar;91(3):324-7. Russian.

PMID:
6166336

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