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Items: 13

1.

Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain.

McKerrall SJ, Nguyen T, Lai KW, Bergeron P, Deng L, DiPasquale A, Chang JH, Chen J, Chernov-Rogan T, Hackos DH, Maher J, Ortwine DF, Pang J, Payandeh J, Proctor WR, Shields SD, Vogt J, Ji P, Liu W, Ballini E, Schumann L, Tarozzo G, Bankar G, Chowdhury S, Hasan A, Johnson JP Jr, Khakh K, Lin S, Cohen CJ, Dehnhardt CM, Safina BS, Sutherlin DP.

J Med Chem. 2019 Apr 25;62(8):4091-4109. doi: 10.1021/acs.jmedchem.9b00141. Epub 2019 Apr 16.

PMID:
30943032
2.

Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors.

Chernov-Rogan T, Li T, Lu G, Verschoof H, Khakh K, Jones SW, Beresini MH, Liu C, Ortwine DF, McKerrall SJ, Hackos DH, Sutherlin D, Cohen CJ, Chen J.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E792-E801. doi: 10.1073/pnas.1713701115. Epub 2018 Jan 8.

3.

An impedance-based cell contraction assay using human primary smooth muscle cells and fibroblasts.

Bravo DD, Chernov-Rogan T, Chen J, Wang J.

J Pharmacol Toxicol Methods. 2018 Jan - Feb;89:47-53. doi: 10.1016/j.vascn.2017.10.006. Epub 2017 Oct 19.

PMID:
29056519
4.

High-throughput electrophysiological assays for voltage gated ion channels using SyncroPatch 768PE.

Li T, Lu G, Chiang EY, Chernov-Rogan T, Grogan JL, Chen J.

PLoS One. 2017 Jul 6;12(7):e0180154. doi: 10.1371/journal.pone.0180154. eCollection 2017.

5.

Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer.

Gross MI, Demo SD, Dennison JB, Chen L, Chernov-Rogan T, Goyal B, Janes JR, Laidig GJ, Lewis ER, Li J, Mackinnon AL, Parlati F, Rodriguez ML, Shwonek PJ, Sjogren EB, Stanton TF, Wang T, Yang J, Zhao F, Bennett MK.

Mol Cancer Ther. 2014 Apr;13(4):890-901. doi: 10.1158/1535-7163.MCT-13-0870. Epub 2014 Feb 12.

6.

Discovery of a novel potent GABA(B) receptor agonist.

Xu F, Peng G, Phan T, Dilip U, Chen JL, Chernov-Rogan T, Zhang X, Grindstaff K, Annamalai T, Koller K, Gallop MA, Wustrow DJ.

Bioorg Med Chem Lett. 2011 Nov 1;21(21):6582-5. doi: 10.1016/j.bmcl.2011.08.006. Epub 2011 Aug 17.

PMID:
21920749
7.

XP13512 [(+/-)-1-([(alpha-isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug: I. Design, synthesis, enzymatic conversion to gabapentin, and transport by intestinal solute transporters.

Cundy KC, Branch R, Chernov-Rogan T, Dias T, Estrada T, Hold K, Koller K, Liu X, Mann A, Panuwat M, Raillard SP, Upadhyay S, Wu QQ, Xiang JN, Yan H, Zerangue N, Zhou CX, Barrett RW, Gallop MA.

J Pharmacol Exp Ther. 2004 Oct;311(1):315-23. Epub 2004 May 14.

PMID:
15146028
8.

A generic method for the production of cell lines expressing high levels of 7-transmembrane receptors.

Koller KJ, Whitehorn EA, Tate E, Ries T, Aguilar B, Chernov-Rogan T, Davis AM, Dobbs A, Yen M, Barrett RW.

Anal Biochem. 1997 Jul 15;250(1):51-60.

PMID:
9234898
9.

Ligand binding kinetics of IL-2 and IL-15 to heteromers formed by extracellular domains of the three IL-2 receptor subunits.

Balasubramanian S, Chernov-Rogan T, Davis AM, Whitehorn E, Tate E, Bell MP, Zurawski G, Barrett RW.

Int Immunol. 1995 Nov;7(11):1839-49.

PMID:
8580082
10.

Generation of a water-soluble oligomeric ectodomain of the Rous sarcoma virus envelope glycoprotein.

Gilbert JM, Hernandez LD, Chernov-Rogan T, White JM.

J Virol. 1993 Nov;67(11):6889-92.

11.

Recognition of human polymorphonuclear leukocyte receptors for leukotriene B4 by rabbit anti-idiotypic antibodies to a mouse monoclonal antileukotriene B4.

Gifford LA, Chernov-Rogan T, Harvey JP, Koo CH, Goldman DW, Goetzl EJ.

J Immunol. 1987 Feb 15;138(4):1184-9.

PMID:
3027172
12.

Alterations in human leukocyte function induced by ingestion of eicosapentaenoic acid.

Payan DG, Wong MY, Chernov-Rogan T, Valone FH, Pickett WC, Blake VA, Gold WM, Goetzl EJ.

J Clin Immunol. 1986 Sep;6(5):402-10.

PMID:
3021806
13.

Endogenous somatostatin-like peptides of rat basophilic leukemia cells.

Goetzl EJ, Chernov-Rogan T, Cooke MP, Renold F, Payan DG.

J Immunol. 1985 Oct;135(4):2707-12.

PMID:
2411811

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