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Yeast Models for Amyloids and Prions: Environmental Modulation and Drug Discovery.

Chernova TA, Chernoff YO, Wilkinson KD.

Molecules. 2019 Sep 18;24(18). pii: E3388. doi: 10.3390/molecules24183388. Review.


Role of the Cell Asymmetry Apparatus and Ribosome-Associated Chaperones in the Destabilization of a Saccharomyces cerevisiae Prion by Heat Shock.

Howie RL, Jay-Garcia LM, Kiktev DA, Faber QL, Murphy M, Rees KA, Sachwani N, Chernoff YO.

Genetics. 2019 Jul;212(3):757-771. doi: 10.1534/genetics.119.302237. Epub 2019 May 29.


Biomolecular Assemblies: Moving from Observation to Predictive Design.

Wilson CJ, Bommarius AS, Champion JA, Chernoff YO, Lynn DG, Paravastu AK, Liang C, Hsieh MC, Heemstra JM.

Chem Rev. 2018 Dec 26;118(24):11519-11574. doi: 10.1021/acs.chemrev.8b00038. Epub 2018 Oct 3. Review.


A standard model of Alzheimer's disease?

Walker LC, Lynn DG, Chernoff YO.

Prion. 2018;12(5-6):261-265. doi: 10.1080/19336896.2018.1525256. Epub 2018 Oct 9.


Modulation of the Formation of Aβ- and Sup35NM-Based Amyloids by Complex Interplay of Specific and Nonspecific Ion Effects.

Sharma A, Behrens SH, Chernoff YO, Bommarius AS.

J Phys Chem B. 2018 May 17;122(19):4972-4981. doi: 10.1021/acs.jpcb.7b12836. Epub 2018 May 3.


Mammalian amyloidogenic proteins promote prion nucleation in yeast.

Chandramowlishwaran P, Sun M, Casey KL, Romanyuk AV, Grizel AV, Sopova JV, Rubel AA, Nussbaum-Krammer C, Vorberg IM, Chernoff YO.

J Biol Chem. 2018 Mar 2;293(9):3436-3450. doi: 10.1074/jbc.M117.809004. Epub 2018 Jan 12.


Proteolysis suppresses spontaneous prion generation in yeast.

Okamoto A, Hosoda N, Tanaka A, Newnam GP, Chernoff YO, Hoshino SI.

J Biol Chem. 2017 Dec 8;292(49):20113-20124. doi: 10.1074/jbc.M117.811323. Epub 2017 Oct 16.


Differential effects of chaperones on yeast prions: CURrent view.

Matveenko AG, Barbitoff YA, Jay-Garcia LM, Chernoff YO, Zhouravleva GA.

Curr Genet. 2018 Apr;64(2):317-325. doi: 10.1007/s00294-017-0750-3. Epub 2017 Sep 20. Review.


Prion-based memory of heat stress in yeast.

Chernova TA, Chernoff YO, Wilkinson KD.

Prion. 2017 May 4;11(3):151-161. doi: 10.1080/19336896.2017.1328342. Epub 2017 May 19.


To CURe or not to CURe? Differential effects of the chaperone sorting factor Cur1 on yeast prions are mediated by the chaperone Sis1.

Barbitoff YA, Matveenko AG, Moskalenko SE, Zemlyanko OM, Newnam GP, Patel A, Chernova TA, Chernoff YO, Zhouravleva GA.

Mol Microbiol. 2017 Jul;105(2):242-257. doi: 10.1111/mmi.13697. Epub 2017 May 9.


In memory of Susan Lindquist (1949-2016).

Chernoff YO.

Prion. 2017 Jan 2;11(1):1-3. doi: 10.1080/19336896.2017.1285618. No abstract available.


Yeast Short-Lived Actin-Associated Protein Forms a Metastable Prion in Response to Thermal Stress.

Chernova TA, Kiktev DA, Romanyuk AV, Shanks JR, Laur O, Ali M, Ghosh A, Kim D, Yang Z, Mang M, Chernoff YO, Wilkinson KD.

Cell Rep. 2017 Jan 17;18(3):751-761. doi: 10.1016/j.celrep.2016.12.082.


Prions, Chaperones, and Proteostasis in Yeast.

Chernova TA, Wilkinson KD, Chernoff YO.

Cold Spring Harb Perspect Biol. 2017 Feb 1;9(2). pii: a023663. doi: 10.1101/cshperspect.a023663. Review.


Strain conformation controls the specificity of cross-species prion transmission in the yeast model.

Grizel AV, Rubel AA, Chernoff YO.

Prion. 2016 Jul 3;10(4):269-82. doi: 10.1080/19336896.2016.1204060.


Distinct types of translation termination generate substrates for ribosome-associated quality control.

Shcherbik N, Chernova TA, Chernoff YO, Pestov DG.

Nucleic Acids Res. 2016 Aug 19;44(14):6840-52. doi: 10.1093/nar/gkw566. Epub 2016 Jun 20.


Are there prions in plants?

Chernoff YO.

Proc Natl Acad Sci U S A. 2016 May 31;113(22):6097-9. doi: 10.1073/pnas.1605671113. Epub 2016 May 23. No abstract available.


Dual role of ribosome-associated chaperones in prion formation and propagation.

Chernoff YO, Kiktev DA.

Curr Genet. 2016 Nov;62(4):677-685. Epub 2016 Mar 11. Review.


The call of the unknown: The story of [PSI(+)].

Chernoff YO.

Prion. 2015;9(5):315-7. doi: 10.1080/19336896.2015.1112656. No abstract available.


Contributions of the Prion Protein Sequence, Strain, and Environment to the Species Barrier.

Sharma A, Bruce KL, Chen B, Gyoneva S, Behrens SH, Bommarius AS, Chernoff YO.

J Biol Chem. 2016 Jan 15;291(3):1277-88. doi: 10.1074/jbc.M115.684100. Epub 2015 Nov 12.


RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils.

Zaarur N, Xu X, Lestienne P, Meriin AB, McComb M, Costello CE, Newnam GP, Ganti R, Romanova NV, Shanmugasundaram M, Silva ST, Bandeiras TM, Matias PM, Lobachev KS, Lednev IK, Chernoff YO, Sherman MY.

EMBO J. 2015 Sep 14;34(18):2363-82. doi: 10.15252/embj.201591245. Epub 2015 Aug 24.


Feedback control of prion formation and propagation by the ribosome-associated chaperone complex.

Kiktev DA, Melomed MM, Lu CD, Newnam GP, Chernoff YO.

Mol Microbiol. 2015 May;96(3):621-32. doi: 10.1111/mmi.12960. Epub 2015 Mar 11.


Stress-dependent proteolytic processing of the actin assembly protein Lsb1 modulates a yeast prion.

Ali M, Chernova TA, Newnam GP, Yin L, Shanks J, Karpova TS, Lee A, Laur O, Subramanian S, Kim D, McNally JG, Seyfried NT, Chernoff YO, Wilkinson KD.

J Biol Chem. 2014 Oct 3;289(40):27625-39. doi: 10.1074/jbc.M114.582429. Epub 2014 Aug 20.


Yeast studies reveal moonlighting functions of the ancient actin cytoskeleton.

Sattlegger E, Chernova TA, Gogoi NM, Pillai IV, Chernoff YO, Munn AL.

IUBMB Life. 2014 Aug;66(8):538-45. doi: 10.1002/iub.1294. Epub 2014 Aug 19. Review.


Physiological and environmental control of yeast prions.

Chernova TA, Wilkinson KD, Chernoff YO.

FEMS Microbiol Rev. 2014 Mar;38(2):326-44. doi: 10.1111/1574-6976.12053. Epub 2013 Dec 4. Review.


Identification of PrP sequences essential for the interaction between the PrP polymers and Aβ peptide in a yeast-based assay.

Rubel AA, Ryzhova TA, Antonets KS, Chernoff YO, Galkin A.

Prion. 2013 Nov-Dec;7(6):469-76. Epub 2013 Oct 23.


Ion-specific effects on prion nucleation and strain formation.

Rubin J, Khosravi H, Bruce KL, Lydon ME, Behrens SH, Chernoff YO, Bommarius AS.

J Biol Chem. 2013 Oct 18;288(42):30300-8. doi: 10.1074/jbc.M113.467829. Epub 2013 Aug 29.


Regulation of chaperone effects on a yeast prion by cochaperone Sgt2.

Kiktev DA, Patterson JC, Müller S, Bariar B, Pan T, Chernoff YO.

Mol Cell Biol. 2012 Dec;32(24):4960-70. doi: 10.1128/MCB.00875-12. Epub 2012 Oct 8.


Prions in yeast.

Liebman SW, Chernoff YO.

Genetics. 2012 Aug;191(4):1041-72. doi: 10.1534/genetics.111.137760. Review.


A special focus issue on the materials of Prion 2011 meeting in Montreal, Canada.

Cashman NR, Chernoff YO.

Prion. 2012 Apr-Jun;6(2):95-6. doi: 10.4161/pri.20455. No abstract available.


Polyglutamine toxicity is controlled by prion composition and gene dosage in yeast.

Gong H, Romanova NV, Allen KD, Chandramowlishwaran P, Gokhale K, Newnam GP, Mieczkowski P, Sherman MY, Chernoff YO.

PLoS Genet. 2012;8(4):e1002634. doi: 10.1371/journal.pgen.1002634. Epub 2012 Apr 19.


Potential roles for prions and protein-only inheritance in cancer.

Antony H, Wiegmans AP, Wei MQ, Chernoff YO, Khanna KK, Munn AL.

Cancer Metastasis Rev. 2012 Jun;31(1-2):1-19. doi: 10.1007/s10555-011-9325-9. Review.


Mutations and natural selection in the protein world.

Chernoff YO.

J Mol Biol. 2011 Oct 28;413(3):525-6. doi: 10.1016/j.jmb.2011.08.013. Epub 2011 Aug 10. No abstract available.


Prion induction by the short-lived, stress-induced protein Lsb2 is regulated by ubiquitination and association with the actin cytoskeleton.

Chernova TA, Romanyuk AV, Karpova TS, Shanks JR, Ali M, Moffatt N, Howie RL, O'Dell A, McNally JG, Liebman SW, Chernoff YO, Wilkinson KD.

Mol Cell. 2011 Jul 22;43(2):242-52. doi: 10.1016/j.molcel.2011.07.001.


Identification of genes influencing synthetic lethality of genetic and epigenetic alterations in translation termination factors in yeast.

Kiktev DA, Chernoff YO, Archipenko AV, Zhouravleva GA.

Dokl Biochem Biophys. 2011 May-Jun;438:117-9. doi: 10.1134/S1607672911030021. Epub 2011 Jul 3. No abstract available.


Sequence specificity and fidelity of prion transmission in yeast.

Bruce KL, Chernoff YO.

Semin Cell Dev Biol. 2011 Jul;22(5):444-51. doi: 10.1016/j.semcdb.2011.03.005. Epub 2011 Mar 23. Review.


Destabilization and recovery of a yeast prion after mild heat shock.

Newnam GP, Birchmore JL, Chernoff YO.

J Mol Biol. 2011 May 6;408(3):432-48. doi: 10.1016/j.jmb.2011.02.034. Epub 2011 Mar 15.


Genetic and epigenetic control of the efficiency and fidelity of cross-species prion transmission.

Chen B, Bruce KL, Newnam GP, Gyoneva S, Romanyuk AV, Chernoff YO.

Mol Microbiol. 2010 Jun;76(6):1483-99. doi: 10.1111/j.1365-2958.2010.07177.x. Epub 2010 Apr 23.


Pathogenic polyglutamine tracts are potent inducers of spontaneous Sup35 and Rnq1 amyloidogenesis.

Goehler H, Dröge A, Lurz R, Schnoegl S, Chernoff YO, Wanker EE.

PLoS One. 2010 Mar 10;5(3):e9642. doi: 10.1371/journal.pone.0009642.


The Hofmeister effect on amyloid formation using yeast prion protein.

Yeh V, Broering JM, Romanyuk A, Chen B, Chernoff YO, Bommarius AS.

Protein Sci. 2010 Jan;19(1):47-56. doi: 10.1002/pro.281.


Hsp104 and prion propagation.

Romanova NV, Chernoff YO.

Protein Pept Lett. 2009;16(6):598-605. Review.


Abnormal proteins can form aggresome in yeast: aggresome-targeting signals and components of the machinery.

Wang Y, Meriin AB, Zaarur N, Romanova NV, Chernoff YO, Costello CE, Sherman MY.

FASEB J. 2009 Feb;23(2):451-63. doi: 10.1096/fj.08-117614. Epub 2008 Oct 14.


Identity determinants of infectious proteins.

Chernoff YO.

Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13191-2. doi: 10.1073/pnas.0806234105. Epub 2008 Sep 4. No abstract available.


Prion: disease or relief?

Chernoff YO.

Nat Cell Biol. 2008 Sep;10(9):1019-21. doi: 10.1038/ncb0908-1019.


Gene prediction in novel fungal genomes using an ab initio algorithm with unsupervised training.

Ter-Hovhannisyan V, Lomsadze A, Chernoff YO, Borodovsky M.

Genome Res. 2008 Dec;18(12):1979-90. doi: 10.1101/gr.081612.108. Epub 2008 Aug 29.


Biological roles of prion domains.

Inge-Vechtomov SG, Zhouravleva GA, Chernoff YO.

Prion. 2007 Oct-Dec;1(4):228-35. Review.


Chaperone effects on prion and nonprion aggregates.

Rikhvanov EG, Romanova NV, Chernoff YO.

Prion. 2007 Oct-Dec;1(4):217-22. Epub 2007 Oct 6. Review.


Stress and prions: lessons from the yeast model.

Chernoff YO.

FEBS Lett. 2007 Jul 31;581(19):3695-701. Epub 2007 May 8. Review.


Prions and related phenomena.

Chernoff YO.

Prion. 2007 Apr-Jun;1(2):81-2. Epub 2007 Apr 28. No abstract available.


Endocytosis machinery is involved in aggregation of proteins with expanded polyglutamine domains.

Meriin AB, Zhang X, Alexandrov IM, Salnikova AB, Ter-Avanesian MD, Chernoff YO, Sherman MY.

FASEB J. 2007 Jun;21(8):1915-25. Epub 2007 Mar 6.


Prion species barrier between the closely related yeast proteins is detected despite coaggregation.

Chen B, Newnam GP, Chernoff YO.

Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2791-6. Epub 2007 Feb 12.

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