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Items: 25

1.

Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs.

Bradley SJ, Molloy C, Valuskova P, Dwomoh L, Scarpa M, Rossi M, Finlayson L, Svensson KA, Chernet E, Barth VN, Gherbi K, Sykes DA, Wilson CA, Mistry R, Sexton PM, Christopoulos A, Mogg AJ, Rosethorne EM, Sakata S, John Challiss RA, Broad LM, Tobin AB.

Nat Chem Biol. 2020 Mar;16(3):240-249. doi: 10.1038/s41589-019-0453-9. Epub 2020 Feb 20.

PMID:
32080630
2.

Preclinical profile of a dopamine D1 potentiator suggests therapeutic utility in neurological and psychiatric disorders.

Bruns RF, Mitchell SN, Wafford KA, Harper AJ, Shanks EA, Carter G, O'Neill MJ, Murray TK, Eastwood BJ, Schaus JM, Beck JP, Hao J, Witkin JM, Li X, Chernet E, Katner JS, Wang H, Ryder JW, Masquelin ME, Thompson LK, Love PL, Maren DL, Falcone JF, Menezes MM, Zhang L, Yang CR, Svensson KA.

Neuropharmacology. 2018 Jan;128:351-365. doi: 10.1016/j.neuropharm.2017.10.032. Epub 2017 Oct 26.

3.

A validated LC-MS/MS method for neurotransmitter metabolite analysis in human cerebrospinal fluid using benzoyl chloride derivatization.

Cox JM, Butler JP, Lutzke BS, Jones BA, Buckholz JE, Biondolillo R, Talbot JA, Chernet E, Svensson KA, Ackermann BL.

Bioanalysis. 2015 Oct;7(19):2461-75. doi: 10.4155/bio.15.170. Epub 2015 Oct 16.

PMID:
26470737
4.

Glucose metabolic trapping in mouse arteries: nonradioactive assay of atherosclerotic plaque inflammation applicable to drug discovery.

Conway RG, Chernet E, De Rosa DC, Benschop RJ, Need AB, Collins EC, Bean JS, Kalbfleisch JM, Rekhter MD.

PLoS One. 2012;7(11):e50349. doi: 10.1371/journal.pone.0050349. Epub 2012 Nov 28.

5.

Synthesis, ex vivo evaluation, and radiolabeling of potent 1,5-diphenylpyrrolidin-2-one cannabinoid subtype-1 receptor ligands as candidates for in vivo imaging.

Donohue SR, Krushinski JH, Pike VW, Chernet E, Phebus L, Chesterfield AK, Felder CC, Halldin C, Schaus JM.

J Med Chem. 2008 Sep 25;51(18):5833-42. doi: 10.1021/jm800416m.

6.

Positron emission tomography imaging using an inverse agonist radioligand to assess cannabinoid CB1 receptors in rodents.

Terry G, Liow JS, Chernet E, Zoghbi SS, Phebus L, Felder CC, Tauscher J, Schaus JM, Pike VW, Halldin C, Innis RB.

Neuroimage. 2008 Jul 1;41(3):690-8. doi: 10.1016/j.neuroimage.2008.03.004. Epub 2008 Mar 18.

7.

The PET radioligand [11C]MePPEP binds reversibly and with high specific signal to cannabinoid CB1 receptors in nonhuman primate brain.

Yasuno F, Brown AK, Zoghbi SS, Krushinski JH, Chernet E, Tauscher J, Schaus JM, Phebus LA, Chesterfield AK, Felder CC, Gladding RL, Hong J, Halldin C, Pike VW, Innis RB.

Neuropsychopharmacology. 2008 Jan;33(2):259-69. Epub 2007 Mar 28.

8.

Comparison of rat dopamine D2 receptor occupancy for a series of antipsychotic drugs measured using radiolabeled or nonlabeled raclopride tracer.

Barth VN, Chernet E, Martin LJ, Need AB, Rash KS, Morin M, Phebus LA.

Life Sci. 2006 May 22;78(26):3007-12. Epub 2006 Jan 24.

PMID:
16434058
9.

The relationship of in vivo central CB1 receptor occupancy to changes in cortical monoamine release and feeding elicited by CB1 receptor antagonists in rats.

Need AB, Davis RJ, Alexander-Chacko JT, Eastwood B, Chernet E, Phebus LA, Sindelar DK, Nomikos GG.

Psychopharmacology (Berl). 2006 Jan;184(1):26-35. Epub 2005 Nov 18.

PMID:
16328376
10.

Use of LC/MS to assess brain tracer distribution in preclinical, in vivo receptor occupancy studies: dopamine D2, serotonin 2A and NK-1 receptors as examples.

Chernet E, Martin LJ, Li D, Need AB, Barth VN, Rash KS, Phebus LA.

Life Sci. 2005 Dec 12;78(4):340-6. Epub 2005 Sep 1.

PMID:
16139310
11.

Fluoxetine, but not other selective serotonin uptake inhibitors, increases norepinephrine and dopamine extracellular levels in prefrontal cortex.

Bymaster FP, Zhang W, Carter PA, Shaw J, Chernet E, Phebus L, Wong DT, Perry KW.

Psychopharmacology (Berl). 2002 Apr;160(4):353-61. Epub 2002 Jan 29.

PMID:
11919662
12.

Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease.

Du Y, Ma Z, Lin S, Dodel RC, Gao F, Bales KR, Triarhou LC, Chernet E, Perry KW, Nelson DL, Luecke S, Phebus LA, Bymaster FP, Paul SM.

Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14669-74. Epub 2001 Nov 27.

13.
14.

Quantitative autoradiography of mu-opioid receptors in the CNS of high-alcohol-drinking (HAD) and low-alcohol-drinking (LAD) rats.

Learn JE, Chernet E, McBride WJ, Lumeng L, Li TK.

Alcohol Clin Exp Res. 2001 Apr;25(4):524-30.

PMID:
11329492
15.

Quantitative autoradiography of mu-opioid receptors in the CNS of alcohol-naive alcohol-preferring P and -nonpreferring NP rats.

McBride WJ, Chernet E, McKinzie DL, Lumeng L, Li TK.

Alcohol. 1998 Nov;16(4):317-23.

PMID:
9818984
16.

Ethanol and negative feedback regulation of mesolimbic dopamine release in rats.

Kohl RR, Katner JS, Chernet E, McBride WJ.

Psychopharmacology (Berl). 1998 Sep;139(1-2):79-85.

PMID:
9768545
17.

Regional CNS densities of serotonin and dopamine receptors in high alcohol-drinking (HAD) and low alcohol-drinking (LAD) rats.

McBride WJ, Chernet E, Russell RN, Chamberlain JK, Lumeng L, Li TK.

Alcohol. 1997 Nov-Dec;14(6):603-9.

PMID:
9401677
18.

Regional densities of benzodiazepine sites in the CNS of alcohol-naive P and NP rats.

Thielen RJ, McBride WJ, Chernet E, Lumeng L, Li TK.

Pharmacol Biochem Behav. 1997 Aug;57(4):875-82.

PMID:
9259019
19.

Regional CNS densities of monoamine receptors in alcohol-naive alcohol-preferring P and -nonpreferring NP rats.

McBride WJ, Chernet E, Russell RN, Wong DT, Guan XM, Lumeng L, Li TK.

Alcohol. 1997 Mar-Apr;14(2):141-8.

PMID:
9085714
20.

Regional serotonin1A receptors in the CNS of alcohol-preferring and -nonpreferring rats.

McBride WJ, Guan XM, Chernet E, Lumeng L, Li TK.

Pharmacol Biochem Behav. 1994 Sep;49(1):7-12.

PMID:
7816892
21.

Serotonin-2 receptors in the CNS of alcohol-preferring and -nonpreferring rats.

McBride WJ, Chernet E, Rabold JA, Lumeng L, Li TK.

Pharmacol Biochem Behav. 1993 Nov;46(3):631-6.

PMID:
8278440
22.

Densities of dopamine D2 receptors are reduced in CNS regions of alcohol-preferring P rats.

McBride WJ, Chernet E, Dyr W, Lumeng L, Li TK.

Alcohol. 1993 Sep-Oct;10(5):387-90.

PMID:
8216885
23.

Quantification of changes in serotonin uptake with spinal cord injury.

Shapiro S, McBride W, Sartorius C, Chernet E, Sanders S, Hall P.

Neurosurgery. 1990 Mar;26(3):424-8.

PMID:
2320211
24.

Effects of dorsal bilateral rhizotomy treatment on transmitter systems in the spinal cord of normal and spastic dogs.

McBride WJ, Shapiro S, Chernet E, Sartorius C, Hall PV.

J Neurochem. 1988 Feb;50(2):603-8.

PMID:
2891792
25.

Alterations of amino acid transmitter systems in spinal cords of chronic paraplegic dogs.

McBride WJ, Hall PV, Chernet E, Patrick JT, Shapiro S.

J Neurochem. 1984 Jun;42(6):1625-31.

PMID:
6144726

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