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Survival analysis of local excision vs total mesorectal excision for middle and low rectal cancer in pT1/pT2 stage and intermediate pathological risk.

Lai IL, You JF, Chern YJ, Tsai WS, Chiang JM, Hsieh PS, Hung HY, Yeh CY, Chiang SF, Lai CC, Tang RP, Chen JS, Hsu YJ.

World J Surg Oncol. 2019 Dec 9;17(1):212. doi: 10.1186/s12957-019-1763-9.


Twist1 Plays an Anti-apoptotic Role in Mutant Huntingtin Expression Striatal Progenitor Cells.

Jen WP, Chen HM, Lin YS, Chern Y, Lee YC.

Mol Neurobiol. 2019 Dec 7. doi: 10.1007/s12035-019-01836-x. [Epub ahead of print]


Deletion of equilibrative nucleoside transporter-2 protects against lipopolysaccharide-induced neuroinflammation and blood-brain barrier dysfunction in mice.

Wu KC, Lee CY, Chou FY, Chern Y, Lin CJ.

Brain Behav Immun. 2019 Nov 18. pii: S0889-1591(19)30474-X. doi: 10.1016/j.bbi.2019.11.008. [Epub ahead of print]


Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor.

Carvalho K, Faivre E, Pietrowski MJ, Marques X, Gomez-Murcia V, Deleau A, Huin V, Hansen JN, Kozlov S, Danis C, Temido-Ferreira M, Coelho JE, Mériaux C, Eddarkaoui S, Gras SL, Dumoulin M, Cellai L; NeuroCEB Brain Bank, Landrieu I, Chern Y, Hamdane M, Buée L, Boutillier AL, Levi S, Halle A, Lopes LV, Blum D.

Brain. 2019 Nov 1;142(11):3636-3654. doi: 10.1093/brain/awz288.


Functional roles of ST8SIA3-mediated sialylation of striatal dopamine D2 and adenosine A2A receptors.

Lin CY, Lai HL, Chen HM, Siew JJ, Hsiao CT, Chang HC, Liao KS, Tsai SC, Wu CY, Kitajima K, Sato C, Khoo KH, Chern Y.

Transl Psychiatry. 2019 Aug 27;9(1):209. doi: 10.1038/s41398-019-0529-z.


Novel Adenosine Analog, N6-(4-Hydroxybenzyl)-Adenosine, Dampens Alcohol Drinking and Seeking Behaviors.

Hong SI, Peyton L, Chern Y, Choi DS.

J Pharmacol Exp Ther. 2019 Nov;371(2):260-267. doi: 10.1124/jpet.119.261529. Epub 2019 Aug 13.


Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington's disease.

Siew JJ, Chen HM, Chen HY, Chen HL, Chen CM, Soong BW, Wu YR, Chang CP, Chan YC, Lin CH, Liu FT, Chern Y.

Nat Commun. 2019 Aug 2;10(1):3473. doi: 10.1038/s41467-019-11441-0.


The interaction between SPARC and GRP78 interferes with ER stress signaling and potentiates apoptosis via PERK/eIF2α and IRE1α/XBP-1 in colorectal cancer.

Chern YJ, Wong JCT, Cheng GSW, Yu A, Yin Y, Schaeffer DF, Kennecke HF, Morin G, Tai IT.

Cell Death Dis. 2019 Jun 26;10(7):504. doi: 10.1038/s41419-019-1687-x.


Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X.

Paudel P, Zhang Q, Leung C, Greenberg HC, Guo Y, Chern YH, Dong A, Li Y, Vedadi M, Zhuang Z, Tong Y.

Proc Natl Acad Sci U S A. 2019 Apr 9;116(15):7288-7297. doi: 10.1073/pnas.1815027116. Epub 2019 Mar 26.


Enhanced Na+ -K+ -2Cl- cotransporter 1 underlies motor dysfunction in huntington's disease.

Hsu YT, Chang YG, Liu YC, Wang KY, Chen HM, Lee DJ, Yang SS, Tsai CH, Lien CC, Chern Y.

Mov Disord. 2019 Jun;34(6):845-857. doi: 10.1002/mds.27651. Epub 2019 Mar 6.


Degeneration of ipRGCs in Mouse Models of Huntington's Disease Disrupts Non-Image-Forming Behaviors Before Motor Impairment.

Lin MS, Liao PY, Chen HM, Chang CP, Chen SK, Chern Y.

J Neurosci. 2019 Feb 20;39(8):1505-1524. doi: 10.1523/JNEUROSCI.0571-18.2018. Epub 2018 Dec 26.


Insights into GABAAergic system alteration in Huntington's disease.

Hsu YT, Chang YG, Chern Y.

Open Biol. 2018 Dec 5;8(12). pii: 180165. doi: 10.1098/rsob.180165. Review.


The TRAX, DISC1, and GSK3 complex in mental disorders and therapeutic interventions.

Weng YT, Chien T, Kuan II, Chern Y.

J Biomed Sci. 2018 Oct 4;25(1):71. doi: 10.1186/s12929-018-0473-x. Review.


Spatial Clustering of Dengue Fever Incidence and Its Association with Surrounding Greenness.

Huang CC, Tam TYT, Chern YR, Lung SC, Chen NT, Wu CD.

Int J Environ Res Public Health. 2018 Aug 29;15(9). pii: E1869. doi: 10.3390/ijerph15091869.


Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer's Disease.

Faivre E, Coelho JE, Zornbach K, Malik E, Baqi Y, Schneider M, Cellai L, Carvalho K, Sebda S, Figeac M, Eddarkaoui S, Caillierez R, Chern Y, Heneka M, Sergeant N, Müller CE, Halle A, Buée L, Lopes LV, Blum D.

Front Mol Neurosci. 2018 Jul 12;11:235. doi: 10.3389/fnmol.2018.00235. eCollection 2018.


The Role of Adenosine Tone and Adenosine Receptors in Huntington's Disease.

Blum D, Chern Y, Domenici MR, Buée L, Lin CY, Rea W, Ferré S, Popoli P.

J Caffeine Adenosine Res. 2018 Jun 1;8(2):43-58. doi: 10.1089/caff.2018.0006. Review.


Trax: A versatile signaling protein plays key roles in synaptic plasticity and DNA repair.

Chern Y, Chien T, Fu X, Shah AP, Abel T, Baraban JM.

Neurobiol Learn Mem. 2019 Mar;159:46-51. doi: 10.1016/j.nlm.2018.07.003. Epub 2018 Jul 11. Review.


The dark side of laparoscopic surgery for colorectal cancer patients aged 75 years or older.

Chern YJ, Tsai WS, Hung HY, Chen JS, Tang R, Chiang JM, Yeh CY, You YT, Hsieh PS, Chiang SF, Lai CC, Lin GP, Hsu YR, You JF.

Int J Colorectal Dis. 2018 Oct;33(10):1367-1371. doi: 10.1007/s00384-018-3130-7. Epub 2018 Jul 15.


Adenylyl cyclase 6 is required for maintaining acid-base homeostasis.

Poulsen SB, Marin De Evsikova C, Murali SK, Praetorius J, Chern Y, Fenton RA, Rieg T.

Clin Sci (Lond). 2018 Aug 30;132(16):1779-1796. doi: 10.1042/CS20180060. Print 2018 Aug 31.


Microglial Lectins in Health and Neurological Diseases.

Siew JJ, Chern Y.

Front Mol Neurosci. 2018 May 14;11:158. doi: 10.3389/fnmol.2018.00158. eCollection 2018. Review.


Adenosine Augmentation Evoked by an ENT1 Inhibitor Improves Memory Impairment and Neuronal Plasticity in the APP/PS1 Mouse Model of Alzheimer's Disease.

Lee CC, Chang CP, Lin CJ, Lai HL, Kao YH, Cheng SJ, Chen HM, Liao YP, Faivre E, Buée L, Blum D, Fang JM, Chern Y.

Mol Neurobiol. 2018 Dec;55(12):8936-8952. doi: 10.1007/s12035-018-1030-z. Epub 2018 Apr 4.


The D2 Dopamine Receptor Interferes With the Protective Effect of the A2A Adenosine Receptor on TDP-43 Mislocalization in Experimental Models of Motor Neuron Degeneration.

Lai CY, Liu YJ, Lai HL, Chen HM, Kuo HC, Liao YP, Chern Y.

Front Neurosci. 2018 Mar 20;12:187. doi: 10.3389/fnins.2018.00187. eCollection 2018.


GSK3β negatively regulates TRAX, a scaffold protein implicated in mental disorders, for NHEJ-mediated DNA repair in neurons.

Chien T, Weng YT, Chang SY, Lai HL, Chiu FL, Kuo HC, Chuang DM, Chern Y.

Mol Psychiatry. 2018 Dec;23(12):2375-2390. doi: 10.1038/s41380-017-0007-z. Epub 2018 Jan 3.


The adenosine A2A receptor agonist T1-11 ameliorates neurovisceral symptoms and extends the lifespan of a mouse model of Niemann-Pick type C disease.

Ferrante A, Pezzola A, Matteucci A, Di Biase A, Attorri L, Armida M, Martire A, Chern Y, Popoli P.

Neurobiol Dis. 2018 Feb;110:1-11. doi: 10.1016/j.nbd.2017.10.013. Epub 2017 Oct 25.


Advancing a High Throughput Glycotope-centric Glycomics Workflow Based on nanoLC-MS2-product Dependent-MS3 Analysis of Permethylated Glycans.

Hsiao CT, Wang PW, Chang HC, Chen YY, Wang SH, Chern Y, Khoo KH.

Mol Cell Proteomics. 2017 Dec;16(12):2268-2280. doi: 10.1074/mcp.TIR117.000156. Epub 2017 Oct 24.


The type VI adenylyl cyclase protects cardiomyocytes from β-adrenergic stress by a PKA/STAT3-dependent pathway.

Wu YS, Chen CC, Chien CL, Lai HL, Jiang ST, Chen YC, Lai LP, Hsiao WF, Chen WP, Chern Y.

J Biomed Sci. 2017 Sep 4;24(1):68. doi: 10.1186/s12929-017-0367-3.


Altered behavioral responses to gamma-aminobutyric acid pharmacological agents in a mouse model of Huntington's disease.

Hsu YT, Chang YG, Chang CP, Siew JJ, Chen HM, Tsai CH, Chern Y.

Mov Disord. 2017 Nov;32(11):1600-1609. doi: 10.1002/mds.27107. Epub 2017 Aug 7.


Energy Homeostasis and Abnormal RNA Metabolism in Amyotrophic Lateral Sclerosis.

Liu YJ, Tsai PY, Chern Y.

Front Cell Neurosci. 2017 May 4;11:126. doi: 10.3389/fncel.2017.00126. eCollection 2017. Review.


Early Assessment of Colorectal Cancer by Quantifying Circulating Tumor Cells in Peripheral Blood: ECT2 in Diagnosis of Colorectal Cancer.

Chen CJ, Sung WW, Chen HC, Chern YJ, Hsu HT, Lin YM, Lin SH, Peck K, Yeh KT.

Int J Mol Sci. 2017 Mar 31;18(4). pii: E743. doi: 10.3390/ijms18040743.


Targeting the equilibrative nucleoside transporter ENT1 in Huntington disease.

Guitart X, Chern Y, Ferré S.

Oncotarget. 2017 Feb 21;8(8):12550-12551. doi: 10.18632/oncotarget.15111. No abstract available.


Targeting ENT1 and adenosine tone for the treatment of Huntington's disease.

Kao YH, Lin MS, Chen CM, Wu YR, Chen HM, Lai HL, Chern Y, Lin CJ.

Hum Mol Genet. 2017 Feb 1;26(3):467-478. doi: 10.1093/hmg/ddw402.


Equilibrative nucleoside transporter ENT1 as a biomarker of Huntington disease.

Guitart X, Bonaventura J, Rea W, Orrú M, Cellai L, Dettori I, Pedata F, Brugarolas M, Cortés A, Casadó V, Chang CP, Narayanan M, Chern Y, Ferré S.

Neurobiol Dis. 2016 Dec;96:47-53. doi: 10.1016/j.nbd.2016.08.013. Epub 2016 Aug 24.


Type VI adenylyl cyclase negatively regulates GluN2B-mediated LTD and spatial reversal learning.

Chang CP, Lee CT, Hou WH, Lin MS, Lai HL, Chien CL, Chang C, Cheng PL, Lien CC, Chern Y.

Sci Rep. 2016 Mar 2;6:22529. doi: 10.1038/srep22529.


Regulation of P-glycoprotein expression in brain capillaries in Huntington's disease and its impact on brain availability of antipsychotic agents risperidone and paliperidone.

Kao YH, Chern Y, Yang HT, Chen HM, Lin CJ.

J Cereb Blood Flow Metab. 2016 Aug;36(8):1412-23. doi: 10.1177/0271678X15606459. Epub 2015 Oct 13.


Conformational switch of polyglutamine-expanded huntingtin into benign aggregates leads to neuroprotective effect.

Sun CS, Lee CC, Li YN, Yao-Chen Yang S, Lin CH, Chang YC, Liu PF, He RY, Wang CH, Chen W, Chern Y, Jen-Tse Huang J.

Sci Rep. 2015 Oct 9;5:14992. doi: 10.1038/srep14992.


Elucidating the role of the A2A adenosine receptor in neurodegeneration using neurons derived from Huntington's disease iPSCs.

Chiu FL, Lin JT, Chuang CY, Chien T, Chen CM, Chen KH, Hsiao HY, Lin YS, Chern Y, Kuo HC.

Hum Mol Genet. 2015 Nov 1;24(21):6066-79. doi: 10.1093/hmg/ddv318. Epub 2015 Aug 11.


AMPK-mediated regulation of neuronal metabolism and function in brain diseases.

Liu YJ, Chern Y.

J Neurogenet. 2015;29(2-3):50-8. doi: 10.3109/01677063.2015.1067203. Epub 2015 Sep 30. Review.


A central role of TRAX in the ATM-mediated DNA repair.

Wang JY, Chen SY, Sun CN, Chien T, Chern Y.

Oncogene. 2016 Mar 31;35(13):1657-70. doi: 10.1038/onc.2015.228. Epub 2015 Jun 22.


High Protein Diet and Huntington's Disease.

Chen CM, Lin YS, Wu YR, Chen P, Tsai FJ, Yang CL, Tsao YT, Chang W, Hsieh IS, Chern Y, Soong BW.

PLoS One. 2015 May 19;10(5):e0127654. doi: 10.1371/journal.pone.0127654. eCollection 2015.


Aberrant astrocytes impair vascular reactivity in Huntington disease.

Hsiao HY, Chen YC, Huang CH, Chen CC, Hsu YH, Chen HM, Chiu FL, Kuo HC, Chang C, Chern Y.

Ann Neurol. 2015 Aug;78(2):178-92. doi: 10.1002/ana.24428. Epub 2015 Jun 30.


[Prospective and comparative study of the double eyelid blepharoplasty with central minimal incision and with three minimal incisions].

Li M, Xie Y, Zhou Y, Zhan M, Wang L, Chern Y, Guo Y.

Zhonghua Zheng Xing Wai Ke Za Zhi. 2014 Nov;30(6):409-13. Chinese.


Effects on murine behavior and lifespan of selectively decreasing expression of mutant huntingtin allele by supt4h knockdown.

Cheng HM, Chern Y, Chen IH, Liu CR, Li SH, Chun SJ, Rigo F, Bennett CF, Deng N, Feng Y, Lin CS, Yan YT, Cohen SN, Cheng TH.

PLoS Genet. 2015 Mar 11;11(3):e1005043. doi: 10.1371/journal.pgen.1005043. eCollection 2015 Mar.


Aberrant activation of AMP-activated protein kinase contributes to the abnormal distribution of HuR in amyotrophic lateral sclerosis.

Liu YJ, Lee LM, Lai HL, Chern Y.

FEBS Lett. 2015 Feb 13;589(4):432-9. doi: 10.1016/j.febslet.2014.12.029. Epub 2015 Jan 12.


Disruption of the nuclear membrane by perinuclear inclusions of mutant huntingtin causes cell-cycle re-entry and striatal cell death in mouse and cell models of Huntington's disease.

Liu KY, Shyu YC, Barbaro BA, Lin YT, Chern Y, Thompson LM, James Shen CK, Marsh JL.

Hum Mol Genet. 2015 Mar 15;24(6):1602-16. doi: 10.1093/hmg/ddu574. Epub 2014 Nov 14.


Activation of AMP-activated protein kinase α1 mediates mislocalization of TDP-43 in amyotrophic lateral sclerosis.

Liu YJ, Ju TC, Chen HM, Jang YS, Lee LM, Lai HL, Tai HC, Fang JM, Lin YL, Tu PH, Chern Y.

Hum Mol Genet. 2015 Feb 1;24(3):787-801. doi: 10.1093/hmg/ddu497. Epub 2014 Sep 25.


Adenosine receptors and Huntington's disease.

Lee CF, Chern Y.

Int Rev Neurobiol. 2014;119:195-232. doi: 10.1016/B978-0-12-801022-8.00010-6. Review.


Adenosine receptor neurobiology: overview.

Chen JF, Lee CF, Chern Y.

Int Rev Neurobiol. 2014;119:1-49. doi: 10.1016/B978-0-12-801022-8.00001-5. Review.


The influence of pathological mutations and proline substitutions in TDP-43 glycine-rich peptides on its amyloid properties and cellular toxicity.

Sun CS, Wang CY, Chen BP, He RY, Liu GC, Wang CH, Chen W, Chern Y, Huang JJ.

PLoS One. 2014 Aug 4;9(8):e103644. doi: 10.1371/journal.pone.0103644. eCollection 2014.


AMPK-α1 functions downstream of oxidative stress to mediate neuronal atrophy in Huntington's disease.

Ju TC, Chen HM, Chen YC, Chang CP, Chang C, Chern Y.

Biochim Biophys Acta. 2014 Sep;1842(9):1668-80. doi: 10.1016/j.bbadis.2014.06.012. Epub 2014 Jun 16.

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