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Items: 1 to 50 of 188

1.

Bis(alkyl) scandium and yttrium complexes coordinated by an amidopyridinate ligand: synthesis, characterization and catalytic performance in isoprene polymerization, hydroelementation and carbon dioxide hydrosilylation.

Gurina GA, Kissel AA, Lyubov DM, Luconi L, Rossin A, Tuci G, Cherkasov AV, Lyssenko KA, Shavyrin AS, Ob'edkov AM, Giambastiani G, Trifonov AA.

Dalton Trans. 2019 Dec 10. doi: 10.1039/c9dt04338a. [Epub ahead of print]

PMID:
31819930
2.

The Nature of P(σ2λ3↔σ2λ1) Dualism: 3a,6a-Diaza-1,4-diphosphapentalene as a Form of Stabilized Singlet Phosphinidene.

Kornev AN, Panova YS, Sushev VV, Dorado Daza DF, Novikov AS, Cherkasov AV, Fukin GK, Abakumov GA.

Inorg Chem. 2019 Dec 2;58(23):16144-16153. doi: 10.1021/acs.inorgchem.9b02690. Epub 2019 Nov 15.

PMID:
31729872
3.

Androgen receptor plasticity and its implications for prostate cancer therapy.

Snow O, Lallous N, Singh K, Lack N, Rennie P, Cherkasov A.

Cancer Treat Rev. 2019 Dec;81:101871. doi: 10.1016/j.ctrv.2019.05.001. Epub 2019 Jun 11. Review.

PMID:
31698174
4.

Computer-Aided Discovery of Small Molecule Inhibitors of Thymocyte Selection-Associated High Mobility Group Box Protein (TOX) as Potential Therapeutics for Cutaneous T-Cell Lymphomas.

Agrawal V, Su M, Huang Y, Hsing M, Cherkasov A, Zhou Y.

Molecules. 2019 Sep 24;24(19). pii: E3459. doi: 10.3390/molecules24193459.

5.

DeepCOP - Deep Learning-Based Approach to Predict Gene Regulating Effects of Small Molecules.

Woo G, Fernandez M, Hsing M, Lack NA, Cavga AD, Cherkasov A.

Bioinformatics. 2019 Aug 26. pii: btz645. doi: 10.1093/bioinformatics/btz645. [Epub ahead of print]

PMID:
31504186
6.

Synthesis, structure and magnetic properties of a series of Ln(iii) complexes with radical-anionic iminopyridine ligands: effect of lanthanide ions on the slow relaxation of the magnetization.

Long J, Skvortsov GG, Cherkasov AV, Lyssenko KA, Poddel'sky AI, Guari Y, Larionova J, Trifonov AA.

Dalton Trans. 2019 Aug 28;48(32):12018-12022. doi: 10.1039/c9dt00738e. Epub 2019 Aug 2.

PMID:
31373595
7.

Tetrahedral nickel(ii) and cobalt(ii) bis-o-iminobenzosemiquinonates.

Ershova IV, Smolyaninov IV, Bogomyakov AS, Fedin MV, Starikov AG, Cherkasov AV, Fukin GK, Piskunov AV.

Dalton Trans. 2019 Jul 16;48(28):10723-10732. doi: 10.1039/c9dt01424a.

PMID:
31246209
8.

Alternative (κ1-N:η6-arene vs.κ2-N,N) coordination of a sterically demanding amidinate ligand: are size and electronic structure of the Ln ion decisive factors?

Tolpygin AO, Shavyrin AS, Cherkasov AV, Fukin GK, Del Rosal I, Maron L, Trifonov AA.

Dalton Trans. 2019 Jun 21;48(23):8317-8326. doi: 10.1039/c9dt01162e. Epub 2019 May 21.

PMID:
31111858
9.

Correction: Amido Ca(ii) complexes supported by Schiff base ligands for catalytic cross-dehydrogenative coupling of amines with silanes.

Forosenko NV, Basalov IV, Cherkasov AV, Fukin GK, Shubina ES, Trifonov AA.

Dalton Trans. 2019 Apr 23;48(17):5842. doi: 10.1039/c9dt90088h.

PMID:
30973563
10.

Thermally Stable Ln(II) and Ca(II) Bis(benzhydryl) Complexes: Excellent Precatalysts for Intermolecular Hydrophosphination of C-C Multiple Bonds.

Selikhov AN, Plankin GS, Cherkasov AV, Shavyrin AS, Louyriac E, Maron L, Trifonov AA.

Inorg Chem. 2019 Apr 15;58(8):5325-5334. doi: 10.1021/acs.inorgchem.9b00490. Epub 2019 Apr 1.

PMID:
30933487
11.

ETS transcription factors as emerging drug targets in cancer.

Hsing M, Wang Y, Rennie PS, Cox ME, Cherkasov A.

Med Res Rev. 2019 Mar 29. doi: 10.1002/med.21575. [Epub ahead of print] Review.

PMID:
30927317
12.

Computer-Aided Discovery of Small Molecules Targeting the RNA Splicing Activity of hnRNP A1 in Castration-Resistant Prostate Cancer.

Carabet LA, Leblanc E, Lallous N, Morin H, Ghaidi F, Lee J, Rennie PS, Cherkasov A.

Molecules. 2019 Feb 20;24(4). pii: E763. doi: 10.3390/molecules24040763.

13.

Identification and characterization of small molecule inhibitors of the ubiquitin ligases Siah1/2 in melanoma and prostate cancer cells.

Feng Y, Sessions EH, Zhang F, Ban F, Placencio-Hickok V, Ma CT, Zeng FY, Pass I, Terry DB, Cadwell G, Bankston LA, Liddington RC, Chung TDY, Pinkerton AB, Sergienko E, Gleave M, Bhowmick NA, Jackson MR, Cherkasov A, Ronai ZA.

Cancer Lett. 2019 May 1;449:145-162. doi: 10.1016/j.canlet.2019.02.012. Epub 2019 Feb 14.

PMID:
30771432
14.

Quantitative Structure-Price Relationship (QS$R) Modeling and the Development of Economically Feasible Drug Discovery Projects.

Fernandez M, Ban F, Woo G, Isaev O, Perez C, Fokin V, Tropsha A, Cherkasov A.

J Chem Inf Model. 2019 Apr 22;59(4):1306-1313. doi: 10.1021/acs.jcim.8b00747. Epub 2019 Feb 28.

PMID:
30767528
15.

Therapeutic Inhibition of Myc in Cancer. Structural Bases and Computer-Aided Drug Discovery Approaches.

Carabet LA, Rennie PS, Cherkasov A.

Int J Mol Sci. 2018 Dec 29;20(1). pii: E120. doi: 10.3390/ijms20010120. Review.

16.

Targeting Semaphorin 3C in Prostate Cancer With Small Molecules.

Lee CCW, Munuganti RSN, Peacock JW, Dalal K, Jiao IZF, Shepherd A, Liu L, Tam KJ, Sedgwick CG, Bhasin S, Lee KCK, Gooding L, Vanderkruk B, Tombe T, Gong Y, Gleave ME, Cherkasov A, Ong CJ.

J Endocr Soc. 2018 Oct 11;2(12):1381-1394. doi: 10.1210/js.2018-00170. eCollection 2018 Dec 1.

17.

Computer-Aided Discovery of Small Molecule Inhibitors of Transcriptional Activity of TLX (NR2E1) Nuclear Receptor.

Dueva E, Singh K, Kalyta A, LeBlanc E, Rennie PS, Cherkasov A.

Molecules. 2018 Nov 14;23(11). pii: E2967. doi: 10.3390/molecules23112967.

18.

CaII , YbII and SmII Bis(Amido) Complexes Coordinated by NHC Ligands: Efficient Catalysts for Highly Regio- and Chemoselective Consecutive Hydrophosphinations with PH3.

Lapshin IV, Basalov IV, Lyssenko KA, Cherkasov AV, Trifonov AA.

Chemistry. 2019 Jan 7;25(2):459-463. doi: 10.1002/chem.201804549. Epub 2018 Dec 11.

PMID:
30411413
19.

Ca(ii), Yb(ii) and Tm(iii) complexes with tri- and tetra-anions of 1,2-bis[(2,6-diisopropylphenyl)imino]acenaphthene.

Fedushkin IL, Lukina DA, Skatova AA, Lukoyanov AN, Cherkasov AV.

Chem Commun (Camb). 2018 Nov 15;54(92):12950-12953. doi: 10.1039/c8cc08108e.

PMID:
30383054
20.

Dysprosium Single-Molecule Magnets with Bulky Schiff Base Ligands: Modification of the Slow Relaxation of the Magnetization by Substituent Change.

Long J, Basalov IV, Forosenko NV, Lyssenko KA, Mamontova E, Cherkasov AV, Damjanović M, Chibotaru LF, Guari Y, Larionova J, Trifonov AA.

Chemistry. 2019 Jan 7;25(2):474-478. doi: 10.1002/chem.201804429. Epub 2018 Dec 6.

PMID:
30376601
21.

Computer-aided drug discovery of Myc-Max inhibitors as potential therapeutics for prostate cancer.

Carabet LA, Lallous N, Leblanc E, Ban F, Morin H, Lawn S, Ghaidi F, Lee J, Mills IG, Gleave ME, Rennie PS, Cherkasov A.

Eur J Med Chem. 2018 Dec 5;160:108-119. doi: 10.1016/j.ejmech.2018.09.023. Epub 2018 Sep 11.

PMID:
30326371
22.

Small molecule-induced degradation of the full length and V7 truncated variant forms of human androgen receptor.

Dalal K, Morin H, Ban F, Shepherd A, Fernandez M, Tam KJ, Li H, LeBlanc E, Lack N, Prinz H, Rennie PS, Cherkasov A.

Eur J Med Chem. 2018 Sep 5;157:1164-1173. doi: 10.1016/j.ejmech.2018.08.059. Epub 2018 Aug 24.

PMID:
30193215
23.

Selectively targeting the dimerization interface of human androgen receptor with small-molecules to treat castration-resistant prostate cancer.

Dalal K, Ban F, Li H, Morin H, Roshan-Moniri M, Tam KJ, Shepherd A, Sharma A, Peacock J, Carlson ML, LeBlanc E, Perez C, Duong F, Ong CJ, Rennie PS, Cherkasov A.

Cancer Lett. 2018 Nov 28;437:35-43. doi: 10.1016/j.canlet.2018.08.016. Epub 2018 Aug 27.

PMID:
30165195
24.

Toxic Colors: The Use of Deep Learning for Predicting Toxicity of Compounds Merely from Their Graphic Images.

Fernandez M, Ban F, Woo G, Hsing M, Yamazaki T, LeBlanc E, Rennie PS, Welch WJ, Cherkasov A.

J Chem Inf Model. 2018 Aug 27;58(8):1533-1543. doi: 10.1021/acs.jcim.8b00338. Epub 2018 Aug 15.

PMID:
30063345
25.

Amido Ca(ii) complexes supported by Schiff base ligands for catalytic cross-dehydrogenative coupling of amines with silanes.

Forosenko NV, Basalov IV, Cherkasov AV, Fukin GK, Shubina ES, Trifonov AA.

Dalton Trans. 2018 Sep 18;47(36):12570-12581. doi: 10.1039/c8dt01130c. Erratum in: Dalton Trans. 2019 Apr 23;48(17):5842.

PMID:
29877538
26.

20(S)-protopanaxadiol regio-selectively targets androgen receptor: anticancer effects in castration-resistant prostate tumors.

Ben-Eltriki M, Deb S, Hassona M, Meckling G, Fazli L, Chin MY, Lallous N, Yamazaki T, Jia W, Rennie PS, Cherkasov A, Tomlinson Guns ES.

Oncotarget. 2018 Apr 20;9(30):20965-20978. doi: 10.18632/oncotarget.24695. eCollection 2018 Apr 20.

27.

Cheminformatics Driven Development of Novel Therapies for Drug Resistant Prostate Cancer.

Ban F, Dalal K, LeBlanc E, Morin H, Rennie PS, Cherkasov A.

Mol Inform. 2018 Sep;37(9-10):e1800043. doi: 10.1002/minf.201800043. Epub 2018 May 7. Review.

PMID:
29733509
28.

Synthesis, structure and magnetic properties of tris(pyrazolyl)methane lanthanide complexes: effect of the anion on the slow relaxation of magnetization.

Long J, Lyubov DM, Mahrova TV, Cherkasov AV, Fukin GK, Guari Y, Larionova J, Trifonov AA.

Dalton Trans. 2018 Apr 17;47(15):5153-5156. doi: 10.1039/C8DT00458G.

PMID:
29557466
29.

Cooption of heat shock regulatory system for anhydrobiosis in the sleeping chironomid Polypedilum vanderplanki.

Mazin PV, Shagimardanova E, Kozlova O, Cherkasov A, Sutormin R, Stepanova VV, Stupnikov A, Logacheva M, Penin A, Sogame Y, Cornette R, Tokumoto S, Miyata Y, Kikawada T, Gelfand MS, Gusev O.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2477-E2486. doi: 10.1073/pnas.1719493115. Epub 2018 Feb 20.

30.

Benzothiophenone Derivatives Targeting Mutant Forms of Estrogen Receptor-α in Hormone-Resistant Breast Cancers.

Singh K, Munuganti RSN, Lallous N, Dalal K, Yoon JS, Sharma A, Yamazaki T, Cherkasov A, Rennie PS.

Int J Mol Sci. 2018 Feb 15;19(2). pii: E579. doi: 10.3390/ijms19020579.

31.

Amido Ca and Yb(II) Complexes Coordinated by Amidine-Amidopyridinate Ligands for Catalytic Intermolecular Olefin Hydrophosphination.

Lapshin IV, Yurova OS, Basalov IV, Rad'kov VY, Musina EI, Cherkasov AV, Fukin GK, Karasik AA, Trifonov AA.

Inorg Chem. 2018 Mar 5;57(5):2942-2952. doi: 10.1021/acs.inorgchem.8b00088. Epub 2018 Feb 14.

PMID:
29443529
32.

Use of antigen-primed dendritic cells for inducing antitumor immune responses in vitro in patients with non-small cell lung cancer.

Obleukhova I, Kiryishina N, Falaleeva S, Lopatnikova J, Kurilin V, Kozlov V, Vitsin A, Cherkasov A, Kulikova E, Sennikov S.

Oncol Lett. 2018 Jan;15(1):1297-1306. doi: 10.3892/ol.2017.7403. Epub 2017 Nov 14.

33.

Computer-aided Discovery of Peptides that Specifically Attack Bacterial Biofilms.

Haney EF, Brito-Sánchez Y, Trimble MJ, Mansour SC, Cherkasov A, Hancock REW.

Sci Rep. 2018 Jan 30;8(1):1871. doi: 10.1038/s41598-018-19669-4.

34.

Steric control in the metal-ligand electron transfer of iminopyridine-ytterbocene complexes.

Trifonov AA, Mahrova TV, Luconi L, Giambastiani G, Lyubov DM, Cherkasov AV, Sorace L, Louyriac E, Maron L, Lyssenko KA.

Dalton Trans. 2018 Jan 30;47(5):1566-1576. doi: 10.1039/c7dt04299j.

PMID:
29322131
35.

Role of Androgen Receptor Variants in Prostate Cancer: Report from the 2017 Mission Androgen Receptor Variants Meeting.

Luo J, Attard G, Balk SP, Bevan C, Burnstein K, Cato L, Cherkasov A, De Bono JS, Dong Y, Gao AC, Gleave M, Heemers H, Kanayama M, Kittler R, Lang JM, Lee RJ, Logothetis CJ, Matusik R, Plymate S, Sawyers CL, Selth LA, Soule H, Tilley W, Weigel NL, Zoubeidi A, Dehm SM, Raj GV.

Eur Urol. 2018 May;73(5):715-723. doi: 10.1016/j.eururo.2017.11.038. Epub 2017 Dec 16. Review.

36.

Rare-earth metal-mediated PhC[triple bond, length as m-dash]N insertion into N,N-bis(trimethylsilyl)naphthalene-1,8-diamido dianion - a synthetic approach to complexes coordinated by ansa-bridged amido-amidinato ligand.

Lyubov DM, Cherkasov AV, Fukin GK, Lyssenko KA, Rychagova EA, Ketkov SY, Trifonov AA.

Dalton Trans. 2018 Jan 2;47(2):438-451. doi: 10.1039/c7dt03809g.

PMID:
29226296
37.

Strictosidine Synthase Triggered Enantioselective Synthesis of N-Substituted (S)-3,14,18,19-Tetrahydroangustines as Novel Topoisomerase I Inhibitors.

Cai Y, Zhu H, Alperstein Z, Yu W, Cherkasov A, Zou H.

ACS Chem Biol. 2017 Dec 15;12(12):3086-3092. doi: 10.1021/acschembio.7b00740. Epub 2017 Nov 22.

PMID:
29140075
38.

SimBoost: a read-across approach for predicting drug-target binding affinities using gradient boosting machines.

He T, Heidemeyer M, Ban F, Cherkasov A, Ester M.

J Cheminform. 2017 Apr 18;9(1):24. doi: 10.1186/s13321-017-0209-z.

39.

Perspectives on the discovery of NOTCH2-specific inhibitors.

Dobranowski P, Ban F, Contreras-Sanz A, Cherkasov A, Black PC.

Chem Biol Drug Des. 2018 Mar;91(3):691-706. doi: 10.1111/cbdd.13132. Epub 2017 Nov 15. Review.

PMID:
29078041
40.

Gallium Hydrides with a Radical-Anionic Ligand.

Sokolov VG, Koptseva TS, Moskalev MV, Bazyakina NL, Piskunov AV, Cherkasov AV, Fedushkin IL.

Inorg Chem. 2017 Nov 6;56(21):13401-13410. doi: 10.1021/acs.inorgchem.7b02138.

PMID:
29023115
41.

Moving Towards Precision Urologic Oncology: Targeting Enzalutamide-resistant Prostate Cancer and Mutated Forms of the Androgen Receptor Using the Novel Inhibitor Darolutamide (ODM-201).

Borgmann H, Lallous N, Ozistanbullu D, Beraldi E, Paul N, Dalal K, Fazli L, Haferkamp A, Lejeune P, Cherkasov A, Gleave ME.

Eur Urol. 2018 Jan;73(1):4-8. doi: 10.1016/j.eururo.2017.08.012. Epub 2017 Aug 26.

PMID:
28851578
42.

Bypassing Drug Resistance Mechanisms of Prostate Cancer with Small Molecules that Target Androgen Receptor-Chromatin Interactions.

Dalal K, Che M, Que NS, Sharma A, Yang R, Lallous N, Borgmann H, Ozistanbullu D, Tse R, Ban F, Li H, Tam KJ, Roshan-Moniri M, LeBlanc E, Gleave ME, Gewirth DT, Dehm SM, Cherkasov A, Rennie PS.

Mol Cancer Ther. 2017 Oct;16(10):2281-2291. doi: 10.1158/1535-7163.MCT-17-0259. Epub 2017 Aug 3.

43.

Discovery and characterization of small molecules targeting the DNA-binding ETS domain of ERG in prostate cancer.

Butler MS, Roshan-Moniri M, Hsing M, Lau D, Kim A, Yen P, Mroczek M, Nouri M, Lien S, Axerio-Cilies P, Dalal K, Yau C, Ghaidi F, Guo Y, Yamazaki T, Lawn S, Gleave ME, Gregory-Evans CY, McIntosh LP, Cox ME, Rennie PS, Cherkasov A.

Oncotarget. 2017 Jun 27;8(26):42438-42454. doi: 10.18632/oncotarget.17124.

44.

Best Practices of Computer-Aided Drug Discovery: Lessons Learned from the Development of a Preclinical Candidate for Prostate Cancer with a New Mechanism of Action.

Ban F, Dalal K, Li H, LeBlanc E, Rennie PS, Cherkasov A.

J Chem Inf Model. 2017 May 22;57(5):1018-1028. doi: 10.1021/acs.jcim.7b00137. Epub 2017 May 4.

PMID:
28441481
45.

An organolanthanide(iii) single-molecule magnet with an axial crystal-field: influence of the Raman process over the slow relaxation.

Long J, Shestakov BG, Liu D, Chibotaru LF, Guari Y, Cherkasov AV, Fukin GK, Trifonov AA, Larionova J.

Chem Commun (Camb). 2017 Apr 25;53(34):4706-4709. doi: 10.1039/c7cc02213a.

PMID:
28401213
46.

Selectively targeting the DNA-binding domain of the androgen receptor as a prospective therapy for prostate cancer.

Dalal K, Roshan-Moniri M, Sharma A, Li H, Ban F, Hassona MD, Hsing M, Singh K, LeBlanc E, Dehm S, Tomlinson Guns ES, Cherkasov A, Rennie PS.

J Biol Chem. 2017 Mar 10;292(10):4359. doi: 10.1074/jbc.A117.553818. No abstract available.

47.

Correction to Discovery of Small-Molecule Inhibitors Selectively Targeting the DNA-Binding Domain of the Human Androgen Receptor.

Li H, Ban F, Dalal K, Leblanc E, Frewin K, Ma D, Adomat H, Rennie PS, Cherkasov A.

J Med Chem. 2017 Feb 9;60(3):1225. doi: 10.1021/acs.jmedchem.7b00005. Epub 2017 Jan 24. No abstract available.

PMID:
28118004
48.

Androgen receptor transcriptionally regulates semaphorin 3C in a GATA2-dependent manner.

Tam KJ, Dalal K, Hsing M, Cheng CW, Khosravi S, Yenki P, Tse C, Peacock JW, Sharma A, Chiang YT, Wang Y, Cherkasov A, Rennie PS, Gleave ME, Ong CJ.

Oncotarget. 2017 Feb 7;8(6):9617-9633. doi: 10.18632/oncotarget.14168.

49.

Cheminformatics Modeling of Adverse Drug Responses by Clinically Relevant Mutants of Human Androgen Receptor.

Paul N, Carabet LA, Lallous N, Yamazaki T, Gleave ME, Rennie PS, Cherkasov A.

J Chem Inf Model. 2016 Dec 27;56(12):2507-2516. doi: 10.1021/acs.jcim.6b00400. Epub 2016 Nov 18.

PMID:
28024400
50.

Half-Sandwich Alkyl, Amido, and Iodo Samarium(II) Complexes: Non-Conventional Sterically Governed Oxidation of (tBu4 Carb)2 Sm.

Selikhov AN, Mahrova TV, Cherkasov AV, Fukin GK, Maron L, Trifonov AA.

Chemistry. 2017 Jan 26;23(6):1436-1443. doi: 10.1002/chem.201604896. Epub 2016 Dec 19.

PMID:
27865012

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