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Items: 1 to 50 of 105

1.

PAK3 mutations responsible for severe intellectual disability and callosal agenesis inhibit cell migration.

Duarte K, Heide S, Poëa-Guyon S, Rousseau V, Depienne C, Rastetter A, Nava C, Attié-Bitach T, Razavi F, Martinovic J, Moutard ML, Cherfils J, Mignot C, Héron D, Barnier JV.

Neurobiol Dis. 2020 Mar;136:104709. doi: 10.1016/j.nbd.2019.104709. Epub 2019 Dec 14.

2.

On the explicit use of experimental images in high resolution cryo-EM refinement.

Cherfils J, Navaza J.

Version 2. F1000Res. 2019 May 15 [revised 2019 Jan 1];8:665. doi: 10.12688/f1000research.19230.2. eCollection 2019.

3.

MglA functions as a three-state GTPase to control movement reversals of Myxococcus xanthus.

Galicia C, Lhospice S, Varela PF, Trapani S, Zhang W, Navaza J, Herrou J, Mignot T, Cherfils J.

Nat Commun. 2019 Nov 22;10(1):5300. doi: 10.1038/s41467-019-13274-3.

4.

Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes.

Das S, Malaby AW, Nawrotek A, Zhang W, Zeghouf M, Maslen S, Skehel M, Chakravarthy S, Irving TC, Bilsel O, Cherfils J, Lambright DG.

Structure. 2019 Dec 3;27(12):1782-1797.e7. doi: 10.1016/j.str.2019.09.007. Epub 2019 Oct 7.

5.

ARF GTPases and their GEFs and GAPs: concepts and challenges.

Sztul E, Chen PW, Casanova JE, Cherfils J, Dacks JB, Lambright DG, Lee FS, Randazzo PA, Santy LC, Schürmann A, Wilhelmi I, Yohe ME, Kahn RA.

Mol Biol Cell. 2019 May 15;30(11):1249-1271. doi: 10.1091/mbc.E18-12-0820. Review.

6.

A Ca2+-regulated deAMPylation switch in human and bacterial FIC proteins.

Veyron S, Oliva G, Rolando M, Buchrieser C, Peyroche G, Cherfils J.

Nat Commun. 2019 Mar 8;10(1):1142. doi: 10.1038/s41467-019-09023-1.

7.

Publisher Correction: PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling.

Nawrotek A, Benabdi S, Niyomchon S, Kryszke MH, Ginestier C, Cañeque T, Tepshi L, Mariani A, St Onge RP, Giaever G, Nislow C, Charafe-Jauffret E, Rodriguez R, Zeghouf M, Cherfils J.

Nat Chem Biol. 2019 May;15(5):549. doi: 10.1038/s41589-019-0255-0.

PMID:
30833779
8.

PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling.

Nawrotek A, Benabdi S, Niyomchon S, Kryszke MH, Ginestier C, Cañeque T, Tepshi L, Mariani A, St Onge RP, Giaever G, Nislow C, Charafe-Jauffret E, Rodriguez R, Zeghouf M, Cherfils J.

Nat Chem Biol. 2019 Apr;15(4):358-366. doi: 10.1038/s41589-019-0228-3. Epub 2019 Feb 11. Erratum in: Nat Chem Biol. 2019 Mar 4;:.

PMID:
30742123
9.

Small GTPase peripheral binding to membranes: molecular determinants and supramolecular organization.

Peurois F, Peyroche G, Cherfils J.

Biochem Soc Trans. 2019 Feb 28;47(1):13-22. doi: 10.1042/BST20170525. Epub 2018 Dec 17. Review.

PMID:
30559268
10.

Nonselective Chemical Inhibition of Sec7 Domain-Containing ARF GTPase Exchange Factors.

Mishev K, Lu Q, Denoo B, Peurois F, Dejonghe W, Hullaert J, De Rycke R, Boeren S, Bretou M, De Munck S, Sharma I, Goodman K, Kalinowska K, Storme V, Nguyen LSL, Drozdzecki A, Martins S, Nerinckx W, Audenaert D, Vert G, Madder A, Otegui MS, Isono E, Savvides SN, Annaert W, De Vries S, Cherfils J, Winne J, Russinova E.

Plant Cell. 2018 Oct;30(10):2573-2593. doi: 10.1105/tpc.18.00145. Epub 2018 Jul 17.

11.

The Inhibitor Endosidin 4 Targets SEC7 Domain-Type ARF GTPase Exchange Factors and Interferes with Subcellular Trafficking in Eukaryotes.

Kania U, Nodzyński T, Lu Q, Hicks GR, Nerinckx W, Mishev K, Peurois F, Cherfils J, De Rycke R, Grones P, Robert S, Russinova E, Friml J.

Plant Cell. 2018 Oct;30(10):2553-2572. doi: 10.1105/tpc.18.00127. Epub 2018 Jul 17.

12.

FIC proteins: from bacteria to humans and back again.

Veyron S, Peyroche G, Cherfils J.

Pathog Dis. 2018 Mar 1;76(2). doi: 10.1093/femspd/fty012. Review.

PMID:
29617857
13.

Encoding Allostery in mTOR Signaling: The Structure of the Rag GTPase/Ragulator Complex.

Cherfils J.

Mol Cell. 2017 Dec 7;68(5):823-824. doi: 10.1016/j.molcel.2017.11.027.

14.

Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule.

Ferrandez Y, Zhang W, Peurois F, Akendengué L, Blangy A, Zeghouf M, Cherfils J.

Sci Rep. 2017 Oct 31;7(1):14409. doi: 10.1038/s41598-017-13619-2.

15.

Multiple interactions between an Arf/GEF complex and charged lipids determine activation kinetics on the membrane.

Karandur D, Nawrotek A, Kuriyan J, Cherfils J.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11416-11421. doi: 10.1073/pnas.1707970114. Epub 2017 Sep 18.

16.

Family-wide Analysis of the Inhibition of Arf Guanine Nucleotide Exchange Factors with Small Molecules: Evidence of Unique Inhibitory Profiles.

Benabdi S, Peurois F, Nawrotek A, Chikireddy J, Cañeque T, Yamori T, Shiina I, Ohashi Y, Dan S, Rodriguez R, Cherfils J, Zeghouf M.

Biochemistry. 2017 Sep 26;56(38):5125-5133. doi: 10.1021/acs.biochem.7b00706. Epub 2017 Sep 13.

PMID:
28858527
17.

Chlamydia Hijacks ARF GTPases To Coordinate Microtubule Posttranslational Modifications and Golgi Complex Positioning.

Wesolowski J, Weber MM, Nawrotek A, Dooley CA, Calderon M, St Croix CM, Hackstadt T, Cherfils J, Paumet F.

mBio. 2017 May 2;8(3). pii: e02280-16. doi: 10.1128/mBio.02280-16.

18.

Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation.

Andrio E, Lotte R, Hamaoui D, Cherfils J, Doye A, Daugaard M, Sorensen PH, Bost F, Ruimy R, Mettouchi A, Lemichez E.

Sci Rep. 2017 Mar 20;7:44779. doi: 10.1038/srep44779.

19.

Characterization of the activation of small GTPases by their GEFs on membranes using artificial membrane tethering.

Peurois F, Veyron S, Ferrandez Y, Ladid I, Benabdi S, Zeghouf M, Peyroche G, Cherfils J.

Biochem J. 2017 Mar 23;474(7):1259-1272. doi: 10.1042/BCJ20170015.

PMID:
28196833
20.

Allosteric regulation of Arf GTPases and their GEFs at the membrane interface.

Nawrotek A, Zeghouf M, Cherfils J.

Small GTPases. 2016 Oct;7(4):283-296. Epub 2016 Jul 22. Review.

21.

Hybrid Structural Analysis of the Arp2/3 Regulator Arpin Identifies Its Acidic Tail as a Primary Binding Epitope.

Fetics S, Thureau A, Campanacci V, Aumont-Nicaise M, Dang I, Gautreau A, Pérez J, Cherfils J.

Structure. 2016 Feb 2;24(2):252-60. doi: 10.1016/j.str.2015.12.001. Epub 2016 Jan 7.

22.

Structure and function of Fic proteins.

Roy CR, Cherfils J.

Nat Rev Microbiol. 2015 Oct;13(10):631-40. doi: 10.1038/nrmicro3520. Epub 2015 Aug 24. Review.

PMID:
26299785
23.

Pharmacological inhibition of Dock5 prevents osteolysis by affecting osteoclast podosome organization while preserving bone formation.

Vives V, Cres G, Richard C, Busson M, Ferrandez Y, Planson AG, Zeghouf M, Cherfils J, Malaval L, Blangy A.

Nat Commun. 2015 Feb 3;6:6218. doi: 10.1038/ncomms7218.

PMID:
25645278
24.

On the use of Legionella/Rickettsia chimeras to investigate the structure and regulation of Rickettsia effector RalF.

Folly-Klan M, Sancerne B, Alix E, Roy CR, Cherfils J, Campanacci V.

J Struct Biol. 2015 Feb;189(2):98-104. doi: 10.1016/j.jsb.2014.12.001. Epub 2014 Dec 9.

PMID:
25498244
25.

Arf GTPases and their effectors: assembling multivalent membrane-binding platforms.

Cherfils J.

Curr Opin Struct Biol. 2014 Dec;29:67-76. doi: 10.1016/j.sbi.2014.09.007. Epub 2014 Nov 20. Review.

PMID:
25460270
26.

EFA6 controls Arf1 and Arf6 activation through a negative feedback loop.

Padovani D, Folly-Klan M, Labarde A, Boulakirba S, Campanacci V, Franco M, Zeghouf M, Cherfils J.

Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12378-83. doi: 10.1073/pnas.1409832111. Epub 2014 Aug 11.

27.

Mapping the cellular response to small molecules using chemogenomic fitness signatures.

Lee AY, St Onge RP, Proctor MJ, Wallace IM, Nile AH, Spagnuolo PA, Jitkova Y, Gronda M, Wu Y, Kim MK, Cheung-Ong K, Torres NP, Spear ED, Han MK, Schlecht U, Suresh S, Duby G, Heisler LE, Surendra A, Fung E, Urbanus ML, Gebbia M, Lissina E, Miranda M, Chiang JH, Aparicio AM, Zeghouf M, Davis RW, Cherfils J, Boutry M, Kaiser CA, Cummins CL, Trimble WS, Brown GW, Schimmer AD, Bankaitis VA, Nislow C, Bader GD, Giaever G.

Science. 2014 Apr 11;344(6180):208-11. doi: 10.1126/science.1250217. Erratum in: Science. 2014 May 23;344(6186):1255771.

28.

A novel membrane sensor controls the localization and ArfGEF activity of bacterial RalF.

Folly-Klan M, Alix E, Stalder D, Ray P, Duarte LV, Delprato A, Zeghouf M, Antonny B, Campanacci V, Roy CR, Cherfils J.

PLoS Pathog. 2013;9(11):e1003747. doi: 10.1371/journal.ppat.1003747. Epub 2013 Nov 14.

29.

Inhibitory signalling to the Arp2/3 complex steers cell migration.

Dang I, Gorelik R, Sousa-Blin C, Derivery E, Guérin C, Linkner J, Nemethova M, Dumortier JG, Giger FA, Chipysheva TA, Ermilova VD, Vacher S, Campanacci V, Herrada I, Planson AG, Fetics S, Henriot V, David V, Oguievetskaia K, Lakisic G, Pierre F, Steffen A, Boyreau A, Peyriéras N, Rottner K, Zinn-Justin S, Cherfils J, Bièche I, Alexandrova AY, David NB, Small JV, Faix J, Blanchoin L, Gautreau A.

Nature. 2013 Nov 14;503(7475):281-4. doi: 10.1038/nature12611. Epub 2013 Oct 16.

PMID:
24132237
30.

Integrated conformational and lipid-sensing regulation of endosomal ArfGEF BRAG2.

Aizel K, Biou V, Navaza J, Duarte LV, Campanacci V, Cherfils J, Zeghouf M.

PLoS Biol. 2013 Sep;11(9):e1001652. doi: 10.1371/journal.pbio.1001652. Epub 2013 Sep 10.

31.

Structure of the Legionella effector AnkX reveals the mechanism of phosphocholine transfer by the FIC domain.

Campanacci V, Mukherjee S, Roy CR, Cherfils J.

EMBO J. 2013 May 15;32(10):1469-77. doi: 10.1038/emboj.2013.82. Epub 2013 Apr 9.

32.

Roger Fourme (1942-2012).

Cherfils J, Prangé T, Helliwell JR, Sakabe N, Sauvage M, van der Veen JF.

J Synchrotron Radiat. 2013 Mar;20(Pt 2):390-2. doi: 10.1107/S0909049513003130. Epub 2013 Feb 6. No abstract available.

PMID:
23412499
33.

High yield production of myristoylated Arf6 small GTPase by recombinant N-myristoyl transferase.

Padovani D, Zeghouf M, Traverso JA, Giglione C, Cherfils J.

Small GTPases. 2013 Jan-Mar;4(1):3-8. doi: 10.4161/sgtp.22895. Epub 2013 Jan 1.

34.

Regulation of small GTPases by GEFs, GAPs, and GDIs.

Cherfils J, Zeghouf M.

Physiol Rev. 2013 Jan;93(1):269-309. doi: 10.1152/physrev.00003.2012. Review.

35.

Fam65b is a new transcriptional target of FOXO1 that regulates RhoA signaling for T lymphocyte migration.

Rougerie P, Largeteau Q, Megrelis L, Carrette F, Lejeune T, Toffali L, Rossi B, Zeghouf M, Cherfils J, Constantin G, Laudanna C, Bismuth G, Mangeney M, Delon J.

J Immunol. 2013 Jan 15;190(2):748-55. doi: 10.4049/jimmunol.1201174. Epub 2012 Dec 14.

36.

The capping domain in RalF regulates effector functions.

Alix E, Chesnel L, Bowzard BJ, Tucker AM, Delprato A, Cherfils J, Wood DO, Kahn RA, Roy CR.

PLoS Pathog. 2012;8(11):e1003012. doi: 10.1371/journal.ppat.1003012. Epub 2012 Nov 15.

37.

Chronicles of the GTPase switch.

Cherfils J, Zeghouf M.

Nat Chem Biol. 2011 Jul 18;7(8):493-5. doi: 10.1038/nchembio.608. No abstract available.

PMID:
21769091
38.

RhoGDI3 and RhoG: Vesicular trafficking and interactions with the Sec3 Exocyst subunit.

Morin A, Cordelières FP, Cherfils J, Olofsson B.

Small GTPases. 2010 Nov;1(3):142-156.

39.

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

Vigil D, Cherfils J, Rossman KL, Der CJ.

Nat Rev Cancer. 2010 Dec;10(12):842-57. doi: 10.1038/nrc2960. Epub 2010 Nov 24. Review.

40.

Insight into the role of dynamics in the conformational switch of the small GTP-binding protein Arf1.

Buosi V, Placial JP, Leroy JL, Cherfils J, Guittet É, van Heijenoort C.

J Biol Chem. 2010 Dec 3;285(49):37987-94. doi: 10.1074/jbc.M110.134445. Epub 2010 Sep 21.

41.

LG186: An inhibitor of GBF1 function that causes Golgi disassembly in human and canine cells.

Boal F, Guetzoyan L, Sessions RB, Zeghouf M, Spooner RA, Lord JM, Cherfils J, Clarkson GJ, Roberts LM, Stephens DJ.

Traffic. 2010 Dec;11(12):1537-51. doi: 10.1111/j.1600-0854.2010.01122.x. Epub 2010 Oct 15.

42.

SAXS and X-ray crystallography suggest an unfolding model for the GDP/GTP conformational switch of the small GTPase Arf6.

Biou V, Aizel K, Roblin P, Thureau A, Jacquet E, Hansson S, Guibert B, Guittet E, van Heijenoort C, Zeghouf M, Perez J, Cherfils J.

J Mol Biol. 2010 Oct 1;402(4):696-707. doi: 10.1016/j.jmb.2010.08.002. Epub 2010 Aug 13.

PMID:
20709080
43.

Modulation of cell adhesion and migration by the histone methyltransferase subunit mDpy-30 and its interacting proteins.

Xia B, Joubert A, Groves B, Vo K, Ashraf D, Djavaherian D, Awe J, Xiong Y, Cherfils J, Ma D.

PLoS One. 2010 Jul 23;5(7):e11771. doi: 10.1371/journal.pone.0011771.

44.

Aptamer-derived peptides as potent inhibitors of the oncogenic RhoGEF Tgat.

Bouquier N, Fromont S, Zeeh JC, Auziol C, Larrousse P, Robert B, Zeghouf M, Cherfils J, Debant A, Schmidt S.

Chem Biol. 2009 Apr 24;16(4):391-400. doi: 10.1016/j.chembiol.2009.02.006.

45.

An Arf1 GTPase mutant with different responses to GEF inhibitors.

Flisiak S, Zeeh JC, Guibert B, Cherfils J, Zeghouf M.

Biochem Biophys Res Commun. 2008 Dec 5;377(1):156-60. doi: 10.1016/j.bbrc.2008.09.107. Epub 2008 Oct 1.

PMID:
18834864
46.

In vitro assays to characterize inhibitors of the activation of small G proteins by their guanine nucleotide exchange factors.

Zeeh JC, Antonny B, Cherfils J, Zeghouf M.

Methods Enzymol. 2008;438:41-56. doi: 10.1016/S0076-6879(07)38004-X.

PMID:
18413240
47.

Interactions between conserved domains within homodimers in the BIG1, BIG2, and GBF1 Arf guanine nucleotide exchange factors.

Ramaen O, Joubert A, Simister P, Belgareh-Touzé N, Olivares-Sanchez MC, Zeeh JC, Chantalat S, Golinelli-Cohen MP, Jackson CL, Biou V, Cherfils J.

J Biol Chem. 2007 Sep 28;282(39):28834-42. Epub 2007 Jul 19.

48.

Structure-based discovery of an inhibitor of Arf activation by Sec7 domains through targeting of protein-protein complexes.

Viaud J, Zeghouf M, Barelli H, Zeeh JC, Padilla A, Guibert B, Chardin P, Royer CA, Cherfils J, Chavanieu A.

Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10370-5. Epub 2007 Jun 11.

49.

Crystal structures of GMP kinase in complex with ganciclovir monophosphate and Ap5G.

Hible G, Daalova P, Gilles AM, Cherfils J.

Biochimie. 2006 Sep;88(9):1157-64. Epub 2006 Apr 27.

PMID:
16690197
50.

Nomenclature for the human Arf family of GTP-binding proteins: ARF, ARL, and SAR proteins.

Kahn RA, Cherfils J, Elias M, Lovering RC, Munro S, Schurmann A.

J Cell Biol. 2006 Feb 27;172(5):645-50. Review.

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