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Items: 47

1.

Correction: Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP.

Chepurny OG, Matsuokas MT, Liapakis G, Leech CA, Milliken BT, Doyle RP, Holz GG.

J Biol Chem. 2019 May 31;294(22):8714. doi: 10.1074/jbc.AAC119.009193. No abstract available.

2.

"A-kinase" regulator runs amok to provide a paradigm shift in cAMP signaling.

Holz GG, Chepurny OG, Leech CA.

J Biol Chem. 2019 Feb 15;294(7):2247-2248. doi: 10.1074/jbc.H119.007622.

3.

Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP.

Chepurny OG, Matsoukas MT, Liapakis G, Leech CA, Milliken BT, Doyle RP, Holz GG.

J Biol Chem. 2019 Mar 8;294(10):3514-3531. doi: 10.1074/jbc.RA118.005682. Epub 2019 Jan 8. Erratum in: J Biol Chem. 2019 May 31;294(22):8714.

PMID:
30622136
4.

Restoration of Glucose-Stimulated Cdc42-Pak1 Activation and Insulin Secretion by a Selective Epac Activator in Type 2 Diabetic Human Islets.

Veluthakal R, Chepurny OG, Leech CA, Schwede F, Holz GG, Thurmond DC.

Diabetes. 2018 Oct;67(10):1999-2011. doi: 10.2337/db17-1174. Epub 2018 Jul 9.

5.

Publisher Correction: Chimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors.

Chepurny OG, Bonaccorso RL, Leech CA, Wöllert T, Langford GM, Schwede F, Roth CL, Doyle RP, Holz GG.

Sci Rep. 2018 Apr 13;8(1):6192. doi: 10.1038/s41598-018-24359-2.

6.

Chimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors.

Chepurny OG, Bonaccorso RL, Leech CA, Wöllert T, Langford GM, Schwede F, Roth CL, Doyle RP, Holz GG.

Sci Rep. 2018 Feb 28;8(1):3749. doi: 10.1038/s41598-018-22106-1. Erratum in: Sci Rep. 2018 Apr 13;8(1):6192.

7.

PI3 kinases p110α and PI3K-C2β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets.

Kolic J, Manning Fox JE, Chepurny OG, Spigelman AF, Ferdaoussi M, Schwede F, Holz GG, MacDonald PE.

Mol Metab. 2016 May 11;5(7):459-471. doi: 10.1016/j.molmet.2016.05.003. eCollection 2016 Jul.

8.

Synthetic small molecule GLP-1 secretagogues prepared by means of a three-component indole annulation strategy.

Chepurny OG, Leech CA, Tomanik M, DiPoto MC, Li H, Han X, Meng Q, Cooney RN, Wu J, Holz GG.

Sci Rep. 2016 Jun 29;6:28934. doi: 10.1038/srep28934.

9.

GPR119 Agonist AS1269574 Activates TRPA1 Cation Channels to Stimulate GLP-1 Secretion.

Chepurny OG, Holz GG, Roe MW, Leech CA.

Mol Endocrinol. 2016 Jun;30(6):614-29. doi: 10.1210/me.2015-1306. Epub 2016 Apr 15.

10.

Enhanced Peptide Stability Against Protease Digestion Induced by Intrinsic Factor Binding of a Vitamin B12 Conjugate of Exendin-4.

Bonaccorso RL, Chepurny OG, Becker-Pauly C, Holz GG, Doyle RP.

Mol Pharm. 2015 Sep 8;12(9):3502-6. doi: 10.1021/acs.molpharmaceut.5b00390. Epub 2015 Aug 11.

11.

Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion.

Schwede F, Chepurny OG, Kaufholz M, Bertinetti D, Leech CA, Cabrera O, Zhu Y, Mei F, Cheng X, Manning Fox JE, MacDonald PE, Genieser HG, Herberg FW, Holz GG.

Mol Endocrinol. 2015 Jul;29(7):988-1005. doi: 10.1210/me.2014-1330. Epub 2015 Jun 10.

12.

Vitamin B12 conjugation of peptide-YY(3-36) decreases food intake compared to native peptide-YY(3-36) upon subcutaneous administration in male rats.

Henry KE, Elfers CT, Burke RM, Chepurny OG, Holz GG, Blevins JE, Roth CL, Doyle RP.

Endocrinology. 2015 May;156(5):1739-49. doi: 10.1210/en.2014-1825. Epub 2015 Feb 6.

13.

New insights concerning the molecular basis for defective glucoregulation in soluble adenylyl cyclase knockout mice.

Holz GG, Leech CA, Chepurny OG.

Biochim Biophys Acta. 2014 Dec;1842(12 Pt B):2593-600. doi: 10.1016/j.bbadis.2014.06.023. Epub 2014 Jun 27. Review.

14.

Regulation of glucose homeostasis by GLP-1.

Nadkarni P, Chepurny OG, Holz GG.

Prog Mol Biol Transl Sci. 2014;121:23-65. doi: 10.1016/B978-0-12-800101-1.00002-8. Review.

15.

Leptin-stimulated KATP channel trafficking: a new paradigm for β-cell stimulus-secretion coupling?

Holz GG, Chepurny OG, Leech CA.

Islets. 2013 Sep-Dec;5(5):229-32. doi: 10.4161/isl.26958. Epub 2013 Nov 8. Review.

16.

Epac2A makes a new impact in β-cell biology.

Holz GG, Chepurny OG, Leech CA.

Diabetes. 2013 Aug;62(8):2665-6. doi: 10.2337/db13-0796. No abstract available.

17.

Stimulation of proglucagon gene expression by human GPR119 in enteroendocrine L-cell line GLUTag.

Chepurny OG, Bertinetti D, Diskar M, Leech CA, Afshari P, Tsalkova T, Cheng X, Schwede F, Genieser HG, Herberg FW, Holz GG.

Mol Endocrinol. 2013 Aug;27(8):1267-82. doi: 10.1210/me.2013-1029. Epub 2013 Jun 24.

18.

Identification and characterization of small molecules as potent and specific EPAC2 antagonists.

Chen H, Tsalkova T, Chepurny OG, Mei FC, Holz GG, Cheng X, Zhou J.

J Med Chem. 2013 Feb 14;56(3):952-62. doi: 10.1021/jm3014162. Epub 2013 Jan 15.

19.

Synthesis, characterization and pharmacodynamics of vitamin-B(12)-conjugated glucagon-like peptide-1.

Clardy-James S, Chepurny OG, Leech CA, Holz GG, Doyle RP.

ChemMedChem. 2013 Apr;8(4):582-6. doi: 10.1002/cmdc.201200461. Epub 2012 Nov 30.

20.

Isoform-specific antagonists of exchange proteins directly activated by cAMP.

Tsalkova T, Mei FC, Li S, Chepurny OG, Leech CA, Liu T, Holz GG, Woods VL Jr, Cheng X.

Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18613-8. doi: 10.1073/pnas.1210209109. Epub 2012 Oct 22.

21.

Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic β cells.

Leech CA, Dzhura I, Chepurny OG, Kang G, Schwede F, Genieser HG, Holz GG.

Prog Biophys Mol Biol. 2011 Nov;107(2):236-47. doi: 10.1016/j.pbiomolbio.2011.07.005. Epub 2011 Jul 19. Review.

22.

Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans.

Dzhura I, Chepurny OG, Leech CA, Roe MW, Dzhura E, Xu X, Lu Y, Schwede F, Genieser HG, Smrcka AV, Holz GG.

Islets. 2011 May-Jun;3(3):121-8. Epub 2011 May 1.

23.

Glucose-dependent potentiation of mouse islet insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM.

Kelley GG, Chepurny OG, Schwede F, Genieser HG, Leech CA, Roe MW, Li X, Dzhura I, Dzhura E, Afshari P, Holz GG.

Islets. 2009 Nov-Dec;1(3):260-5. doi: 10.4161/isl.1.3.9645.

24.

Epac2-dependent rap1 activation and the control of islet insulin secretion by glucagon-like peptide-1.

Leech CA, Chepurny OG, Holz GG.

Vitam Horm. 2010;84:279-302. doi: 10.1016/B978-0-12-381517-0.00010-2. Review.

25.

Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice.

Dzhura I, Chepurny OG, Kelley GG, Leech CA, Roe MW, Dzhura E, Afshari P, Malik S, Rindler MJ, Xu X, Lu Y, Smrcka AV, Holz GG.

J Physiol. 2010 Dec 15;588(Pt 24):4871-89. doi: 10.1113/jphysiol.2010.198424. Epub 2010 Nov 1. Erratum in: J Physiol. 2012 Mar 15;590(Pt 6):1511.

26.
27.

PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM in human islets of Langerhans.

Chepurny OG, Kelley GG, Dzhura I, Leech CA, Roe MW, Dzhura E, Li X, Schwede F, Genieser HG, Holz GG.

Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E622-33. doi: 10.1152/ajpendo.00630.2009. Epub 2009 Dec 15.

28.

Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2'-O-Me-cAMP-AM.

Chepurny OG, Leech CA, Kelley GG, Dzhura I, Dzhura E, Li X, Rindler MJ, Schwede F, Genieser HG, Holz GG.

J Biol Chem. 2009 Apr 17;284(16):10728-36. doi: 10.1074/jbc.M900166200. Epub 2009 Feb 25.

29.

Role of the cAMP sensor Epac as a determinant of KATP channel ATP sensitivity in human pancreatic beta-cells and rat INS-1 cells.

Kang G, Leech CA, Chepurny OG, Coetzee WA, Holz GG.

J Physiol. 2008 Mar 1;586(5):1307-19. doi: 10.1113/jphysiol.2007.143818. Epub 2008 Jan 17.

30.
32.

Simultaneous optical measurements of cytosolic Ca2+ and cAMP in single cells.

Harbeck MC, Chepurny O, Nikolaev VO, Lohse MJ, Holz GG, Roe MW.

Sci STKE. 2006 Sep 19;2006(353):pl6.

33.

Cell physiology of cAMP sensor Epac.

Holz GG, Kang G, Harbeck M, Roe MW, Chepurny OG.

J Physiol. 2006 Nov 15;577(Pt 1):5-15. Epub 2006 Sep 14. Review.

34.

cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells.

Kang G, Chepurny OG, Malester B, Rindler MJ, Rehmann H, Bos JL, Schwede F, Coetzee WA, Holz GG.

J Physiol. 2006 Jun 15;573(Pt 3):595-609. Epub 2006 Apr 13.

35.

Interplay of Ca2+ and cAMP signaling in the insulin-secreting MIN6 beta-cell line.

Landa LR Jr, Harbeck M, Kaihara K, Chepurny O, Kitiphongspattana K, Graf O, Nikolaev VO, Lohse MJ, Holz GG, Roe MW.

J Biol Chem. 2005 Sep 2;280(35):31294-302. Epub 2005 Jun 29.

36.

A cAMP and Ca2+ coincidence detector in support of Ca2+-induced Ca2+ release in mouse pancreatic beta cells.

Kang G, Chepurny OG, Rindler MJ, Collis L, Chepurny Z, Li WH, Harbeck M, Roe MW, Holz GG.

J Physiol. 2005 Jul 1;566(Pt 1):173-88. Epub 2005 Apr 28.

37.

Diabetes outfoxed by GLP-1?

Holz GG, Chepurny OG.

Sci STKE. 2005 Jan 25;2005(268):pe2. Review.

38.
39.

Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells.

Kang G, Joseph JW, Chepurny OG, Monaco M, Wheeler MB, Bos JL, Schwede F, Genieser HG, Holz GG.

J Biol Chem. 2003 Mar 7;278(10):8279-85. Epub 2002 Dec 20.

42.
43.

Expression of cAMP-regulated guanine nucleotide exchange factors in pancreatic beta-cells.

Leech CA, Holz GG, Chepurny O, Habener JF.

Biochem Biophys Res Commun. 2000 Nov 11;278(1):44-7.

44.

A novel ubiquitously expressed alpha-latrotoxin receptor is a member of the CIRL family of G-protein-coupled receptors.

Ichtchenko K, Bittner MA, Krasnoperov V, Little AR, Chepurny O, Holz RW, Petrenko AG.

J Biol Chem. 1999 Feb 26;274(9):5491-8.

46.

alpha-Latrotoxin stimulates exocytosis by the interaction with a neuronal G-protein-coupled receptor.

Krasnoperov VG, Bittner MA, Beavis R, Kuang Y, Salnikow KV, Chepurny OG, Little AR, Plotnikov AN, Wu D, Holz RW, Petrenko AG.

Neuron. 1997 Jun;18(6):925-37.

47.

The calcium-independent receptor of alpha-latrotoxin is not a neurexin.

Krasnoperov VG, Beavis R, Chepurny OG, Little AR, Plotnikov AN, Petrenko AG.

Biochem Biophys Res Commun. 1996 Oct 23;227(3):868-75.

PMID:
8886023

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