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Items: 1 to 50 of 128

1.

Catalytic Ring Expansions of Cyclic Alcohols Enabled by Proton-Coupled Electron Transfer.

Zhao K, Yamashita K, Carpenter JE, Sherwood TC, Ewing WR, Cheng PTW, Knowles RR.

J Am Chem Soc. 2019 Jun 5;141(22):8752-8757. doi: 10.1021/jacs.9b03973. Epub 2019 May 23.

PMID:
31117664
2.

Artist's Statement: When Dreams End.

Cheng PTM.

Acad Med. 2019 Apr;94(4):481. doi: 10.1097/ACM.0000000000002579. No abstract available.

PMID:
30913079
3.

Growth of Polystyrene Pillars in Electric Field.

Cheng PT, Zhou W, Yang F, Lee S.

Langmuir. 2019 Apr 9;35(14):4966-4975. doi: 10.1021/acs.langmuir.9b00207. Epub 2019 Mar 27.

PMID:
30875470
4.

Audit of 117 otoplasties for prominent ear by one surgeon using a cartilage-cutting procedure.

Brian T, Cheng PT, Loo SS.

ANZ J Surg. 2019 Mar;89(3):E66-E70. doi: 10.1111/ans.14401. Epub 2018 Feb 7.

PMID:
29415346
5.

Selective C-H Halogenation with a Highly Fluorinated Manganese Porphyrin.

Li G, Dilger AK, Cheng PT, Ewing WR, Groves JT.

Angew Chem Int Ed Engl. 2018 Jan 26;57(5):1251-1255. doi: 10.1002/anie.201710676. Epub 2017 Dec 28.

PMID:
29235203
6.

Ligand-accelerated non-directed C-H functionalization of arenes.

Wang P, Verma P, Xia G, Shi J, Qiao JX, Tao S, Cheng PTW, Poss MA, Farmer ME, Yeung KS, Yu JQ.

Nature. 2017 Nov 22;551(7681):489-493. doi: 10.1038/nature24632.

7.

Grief reactions of couples to perinatal loss: A one-year prospective follow-up.

Tseng YF, Cheng HR, Chen YP, Yang SF, Cheng PT.

J Clin Nurs. 2017 Dec;26(23-24):5133-5142. doi: 10.1111/jocn.14059. Epub 2017 Oct 6.

PMID:
28880461
8.

Experiences with Cutting Matrix Fentanyl Patches as a Method of Dose Titration in Cancer Patients.

Cheng PTM, Hawley P.

J Palliat Med. 2017 Dec;20(12):1311-1312. doi: 10.1089/jpm.2017.0368. Epub 2017 Aug 16. No abstract available.

PMID:
28813614
9.

Soft tissue infections from fish spike wounds: normal commensal bacteria are more common than marine pathogens.

Collins H, Lee KM, Cheng PT, Hulme S.

ANZ J Surg. 2018 Jan;88(1-2):E40-E44. doi: 10.1111/ans.13850. Epub 2017 Mar 20.

PMID:
28320052
10.

How patient educators help students to learn: An exploratory study.

Cheng PT, Towle A.

Med Teach. 2017 Mar;39(3):308-314. doi: 10.1080/0142159X.2017.1270426. Epub 2016 Dec 26.

PMID:
28024431
11.

Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARα Selective Agonist.

Shi Y, Li J, Kennedy LJ, Tao S, Hernández AS, Lai Z, Chen S, Wong H, Zhu J, Trehan A, Lim NK, Zhang H, Chen BC, Locke KT, O'Malley KM, Zhang L, Srivastava RA, Miao B, Meyers DS, Monshizadegan H, Search D, Grimm D, Zhang R, Harrity T, Kunselman LK, Cap M, Muckelbauer J, Chang C, Krystek SR, Li YX, Hosagrahara V, Zhang L, Kadiyala P, Xu C, Blanar MA, Zahler R, Mukherjee R, Cheng PT, Tino JA.

ACS Med Chem Lett. 2016 Apr 4;7(6):590-4. doi: 10.1021/acsmedchemlett.6b00033. eCollection 2016 Jun 9.

12.

[The Childbearing Experiences of Taiwanese Women After a Stillbirth].

Tseng YF, Chen YP, Cheng PT, Yuan CP, Kuo PC.

Hu Li Za Zhi. 2016 Jun;63(3):52-61. doi: 10.6224/JN.63.3.52. Chinese.

PMID:
27250959
13.

Ligand-Promoted Borylation of C(sp(3))-H Bonds with Palladium(II) Catalysts.

He J, Jiang H, Takise R, Zhu RY, Chen G, Dai HX, Dhar TG, Shi J, Zhang H, Cheng PT, Yu JQ.

Angew Chem Int Ed Engl. 2016 Jan 11;55(2):785-9. doi: 10.1002/anie.201509996. Epub 2015 Nov 27.

14.

Utilization of the Zucker Diabetic Fatty (ZDF) Rat Model for Investigating Hypoglycemia-related Toxicities.

Tirmenstein M, Horvath J, Graziano M, Mangipudy R, Dorr T, Colman K, Zinker B, Kirby M, Cheng PT, Patrone L, Kozlosky J, Reilly TP, Wang V, Janovitz E.

Toxicol Pathol. 2015 Aug;43(6):825-37. doi: 10.1177/0192623315581020. Epub 2015 Jun 17.

PMID:
26085543
15.

Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARα/γ agonists.

Zhang H, Ding CZ, Lai Z, Chen SS, Devasthale P, Herpin T, Morton G, Qu F, Ryono D, Smirk R, Wang W, Wu S, Ye XX, Li YX, Apedo A, Farrelly D, Wang T, Gu L, Morgan N, Flynn N, Chu C, Kunselman L, Lippy J, Locke K, O'Malley K, Harrity T, Cap M, Zhang L, Hosagrahara V, Kadiyala P, Xu C, Doweyko AM, Zahler R, Hariharan N, Cheng PT.

Bioorg Med Chem Lett. 2015 Mar 15;25(6):1196-205. doi: 10.1016/j.bmcl.2015.01.066. Epub 2015 Feb 4.

PMID:
25686852
16.

Modified total thigh musculocutaneous flap: 'operation of last resort' for massive pressure ulcers.

Cheng PT, Adams BM, Chunilal A.

J Plast Reconstr Aesthet Surg. 2014 Feb;67(2):260-3. doi: 10.1016/j.bjps.2013.06.017. Epub 2013 Jun 25.

PMID:
23806262
17.

The strength/weakness of the AJCC/UICC staging system (7th edition) for nasopharyngeal cancer and suggestions for future improvement.

Lee AWM, Ng WT, Chan LK, Chan OSH, Hung WM, Chan CC, Cheng PTC, Sze H, Lam TS, Yau TK.

Oral Oncol. 2012 Oct;48(10):1007-1013. doi: 10.1016/j.oraloncology.2012.03.022. Epub 2012 Apr 22.

PMID:
22525607
18.

Acute sleeve gastrectomy for a strangulated paraoesophageal hernia.

Cheng P, Ronald M, Poole G.

J Surg Case Rep. 2011 Nov 1;2011(11):3. doi: 10.1093/jscr/2011.11.3.

19.

Metabolism and disposition of 14C-labeled peliglitazar in humans.

Wang L, Munsick C, Chen S, Bonacorsi S, Cheng PT, Humphreys WG, Zhang D.

Drug Metab Dispos. 2011 Feb;39(2):228-38. doi: 10.1124/dmd.110.035089. Epub 2010 Oct 26.

PMID:
20978103
20.

Plasma stability-dependent circulation of acyl glucuronide metabolites in humans: how circulating metabolite profiles of muraglitazar and peliglitazar can lead to misleading risk assessment.

Zhang D, Raghavan N, Wang L, Xue Y, Obermeier M, Chen S, Tao S, Zhang H, Cheng PT, Li W, Ramanathan R, Yang Z, Humphreys WG.

Drug Metab Dispos. 2011 Jan;39(1):123-31. doi: 10.1124/dmd.110.035048. Epub 2010 Sep 28.

PMID:
20876787
21.

Synthesis and structure-activity relationships of 2-aryl-4-oxazolylmethoxy benzylglycines and 2-aryl-4-thiazolylmethoxy benzylglycines as novel, potent PPARalpha selective activators- PPARalpha and PPARgamma selectivity modulation.

Ye XY, Chen S, Zhang H, Locke KT, O'Malley K, Zhang L, Srivastava R, Miao B, Meyers D, Monshizadegan H, Search D, Grimm D, Zhang R, Lippy J, Twamley C, Muckelbauer JK, Chang C, An Y, Hosagrahara V, Zhang L, Yang TJ, Mukherjee R, Cheng PT, Tino JA.

Bioorg Med Chem Lett. 2010 May 1;20(9):2933-7. doi: 10.1016/j.bmcl.2010.03.019. Epub 2010 Mar 7.

PMID:
20356736
22.

Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453).

Li J, Kennedy LJ, Shi Y, Tao S, Ye XY, Chen SY, Wang Y, Hernández AS, Wang W, Devasthale PV, Chen S, Lai Z, Zhang H, Wu S, Smirk RA, Bolton SA, Ryono DE, Zhang H, Lim NK, Chen BC, Locke KT, O'Malley KM, Zhang L, Srivastava RA, Miao B, Meyers DS, Monshizadegan H, Search D, Grimm D, Zhang R, Harrity T, Kunselman LK, Cap M, Kadiyala P, Hosagrahara V, Zhang L, Xu C, Li YX, Muckelbauer JK, Chang C, An Y, Krystek SR, Blanar MA, Zahler R, Mukherjee R, Cheng PT, Tino JA.

J Med Chem. 2010 Apr 8;53(7):2854-64. doi: 10.1021/jm9016812.

PMID:
20218621
23.

Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists.

Zhang H, Ryono DE, Devasthale P, Wang W, O'Malley K, Farrelly D, Gu L, Harrity T, Cap M, Chu C, Locke K, Zhang L, Lippy J, Kunselman L, Morgan N, Flynn N, Moore L, Hosagrahara V, Zhang L, Kadiyala P, Xu C, Doweyko AM, Bell A, Chang C, Muckelbauer J, Zahler R, Hariharan N, Cheng PT.

Bioorg Med Chem Lett. 2009 Mar 1;19(5):1451-6. doi: 10.1016/j.bmcl.2009.01.030. Epub 2009 Jan 15.

PMID:
19201606
24.

Novel peroxisome proliferator-activated receptor alpha agonists lower low-density lipoprotein and triglycerides, raise high-density lipoprotein, and synergistically increase cholesterol excretion with a liver X receptor agonist.

Mukherjee R, Locke KT, Miao B, Meyers D, Monshizadegan H, Zhang R, Search D, Grimm D, Flynn M, O'Malley KM, Zhang L, Li J, Shi Y, Kennedy LJ, Blanar M, Cheng PT, Tino J, Srivastava RA.

J Pharmacol Exp Ther. 2008 Dec;327(3):716-26. doi: 10.1124/jpet.108.143271. Epub 2008 Sep 17.

PMID:
18799592
25.

Major late toxicities after conformal radiotherapy for nasopharyngeal carcinoma-patient- and treatment-related risk factors.

Lee AW, Ng WT, Hung WM, Choi CW, Tung R, Ling YH, Cheng PT, Yau TK, Chang AT, Leung SK, Lee MC, Bentzen SM.

Int J Radiat Oncol Biol Phys. 2009 Mar 15;73(4):1121-8. doi: 10.1016/j.ijrobp.2008.05.023. Epub 2008 Aug 23.

PMID:
18723296
26.

Design, synthesis, and structure-activity relationships of piperidine and dehydropiperidine carboxylic acids as novel, potent dual PPARalpha/gamma agonists.

Ye XY, Li YX, Farrelly D, Flynn N, Gu L, Locke KT, Lippy J, O'Malley K, Twamley C, Zhang L, Ryono DE, Zahler R, Hariharan N, Cheng PT.

Bioorg Med Chem Lett. 2008 Jun 15;18(12):3545-50. doi: 10.1016/j.bmcl.2008.05.014. Epub 2008 May 6.

PMID:
18511276
27.

Potential improvement of tumor control probability by induction chemotherapy for advanced nasopharyngeal carcinoma.

Lee AW, Lau KY, Hung WM, Ng WT, Lee MC, Choi CW, Chan CC, Tung R, Cheng PT, Yau TK.

Radiother Oncol. 2008 May;87(2):204-10. doi: 10.1016/j.radonc.2008.02.003. Epub 2008 Mar 10.

PMID:
18329742
28.

Discovery of azetidinone acids as conformationally-constrained dual PPARalpha/gamma agonists.

Wang W, Devasthale P, Farrelly D, Gu L, Harrity T, Cap M, Chu C, Kunselman L, Morgan N, Ponticiello R, Zebo R, Zhang L, Locke K, Lippy J, O'Malley K, Hosagrahara V, Zhang L, Kadiyala P, Chang C, Muckelbauer J, Doweyko AM, Zahler R, Ryono D, Hariharan N, Cheng PT.

Bioorg Med Chem Lett. 2008 Mar 15;18(6):1939-44. doi: 10.1016/j.bmcl.2008.01.126. Epub 2008 Feb 7.

PMID:
18291645
30.

Discovery of a tetrazole-based growth hormone secretagogue: 4-(hydroxybutyl)carbamic acid 2-{5-[1-(2-amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl ester (BMS-317180).

Li J, Chen SY, Li JJ, Wang H, Hernandez AS, Tao S, Musial CM, Qu F, Swartz S, Chao ST, Flynn N, Murphy BJ, Slusarchyk DA, Seethala R, Yan M, Sleph P, Grover G, Smith MA, Beehler B, Giupponi L, Dickinson KE, Zhang H, Humphreys WG, Patel BP, Schwinden M, Stouch T, Cheng PT, Biller SA, Ewing WR, Gordon D, Robl JA, Tino JA.

J Med Chem. 2007 Nov 29;50(24):5890-3. Epub 2007 Oct 31.

PMID:
17973363
31.

Discovery, synthesis, and structure-activity studies of tetrazole based growth hormone secretagogues.

Hernández AS, Cheng PT, Musial CM, Swartz SG, George RJ, Grover G, Slusarchyk D, Seethala RK, Smith M, Dickinson K, Giupponi L, Longhi DA, Flynn N, Murphy BJ, Gordon DA, Biller SA, Robl JA, Tino JA.

Bioorg Med Chem Lett. 2007 Nov 1;17(21):5928-33. Epub 2007 Aug 23.

PMID:
17869100
32.

Arylpropanolamines: selective beta3 agonists arising from strategies to mitigate phase I metabolic transformations.

Washburn WN, Harper TW, Wu G, Godfrey JD, McCann P, Girotra R, Shao C, Zhang H, Gavai A, Mikkilineni A, Dejneka T, Ahmed S, Caringal Y, Hangeland J, Zhang M, Cheng PT, Russell AD, Skwish S, Slusarchyk DA, Allen GT, Frohlich BH, Abboa-Offei BE, Cap M, Waldron TL, George RJ, Tesfamariam B, Dickinson KE, Seymour AA, Sher PM.

Bioorg Med Chem Lett. 2007 Aug 1;17(15):4290-6. Epub 2007 May 16.

PMID:
17533126
33.

Ground reaction force patterns in stroke patients with various degrees of motor recovery determined by plantar dynamic analysis.

Chen CY, Hong PW, Chen CL, Chou SW, Wu CY, Cheng PT, Tang FT, Chen HC.

Chang Gung Med J. 2007 Jan-Feb;30(1):62-72.

34.

A rapid, homogeneous, fluorescence polarization binding assay for peroxisome proliferator-activated receptors alpha and gamma using a fluorescein-tagged dual PPARalpha/gamma activator.

Seethala R, Golla R, Ma Z, Zhang H, O'Malley K, Lippy J, Cheng L, Mookhtiar K, Farrelly D, Zhang L, Hariharan N, Cheng PT.

Anal Biochem. 2007 Apr 15;363(2):263-74. Epub 2007 Jan 28.

PMID:
17335769
35.

Discovery of tertiary aminoacids as dual PPARalpha/gamma agonists-I.

Devasthale PV, Chen S, Jeon Y, Qu F, Ryono DE, Wang W, Zhang H, Cheng L, Farrelly D, Golla R, Grover G, Ma Z, Moore L, Seethala R, Sun W, Doweyko AM, Chandrasena G, Sleph P, Hariharan N, Cheng PT.

Bioorg Med Chem Lett. 2007 Apr 15;17(8):2312-6. Epub 2007 Jan 25.

PMID:
17292606
36.

The dual peroxisome proliferator-activated receptor alpha/gamma activator muraglitazar prevents the natural progression of diabetes in db/db mice.

Tozzo E, Ponticiello R, Swartz J, Farrelly D, Zebo R, Welzel G, Egan D, Kunselman L, Peters A, Gu L, French M, Chen S, Devasthale P, Janovitz E, Staal A, Harrity T, Belder R, Cheng PT, Whaley J, Taylor S, Hariharan N.

J Pharmacol Exp Ther. 2007 Apr;321(1):107-15. Epub 2007 Jan 26.

PMID:
17259449
37.

Pharmacokinetics of muraglitazar (BMS-298585), a dual peroxisome proliferator-activated receptors (PPAR) alpha and gamma activator, in mice, rats, dogs, and monkeys.

Hosagrahara VP, Chandrasena G, Chang SY, Koplowitz B, Hariharan N, Cheng PT, Humphreys WG.

Xenobiotica. 2006 Dec;36(12):1227-38.

PMID:
17162469
38.

Comparative metabolism of radiolabeled muraglitazar in animals and humans by quantitative and qualitative metabolite profiling.

Zhang D, Wang L, Raghavan N, Zhang H, Li W, Cheng PT, Yao M, Zhang L, Zhu M, Bonacorsi S, Yeola S, Mitroka J, Hariharan N, Hosagrahara V, Chandrasena G, Shyu WC, Humphreys WG.

Drug Metab Dispos. 2007 Jan;35(1):150-67. Epub 2006 Oct 24.

PMID:
17062777
39.

Determination of the absolute configuration and solution conformation of a novel disubstituted pyrrolidine acid A by vibrational circular dichroism.

Freedman TB, Cao X, Phillips LM, Cheng PT, Dalterio R, Shu YZ, Zhang H, Zhao N, Shukla RB, Tymiak A, Gozo SK, Nafie LA, Gougoutas JZ.

Chirality. 2006 Sep;18(9):746-53.

PMID:
16856170
40.

Enhancement of operational efficiencies for people with high cervical spinal cord injuries using a flexible integrated pointing device apparatus.

Chen CL, Chen HC, Cheng PT, Chen CY, Chen HC, Chou SW.

Arch Phys Med Rehabil. 2006 Jun;87(6):866-73.

PMID:
16731224
41.

Critical score of Glasgow Coma Scale for pediatric traumatic brain injury.

Chung CY, Chen CL, Cheng PT, See LC, Tang SF, Wong AM.

Pediatr Neurol. 2006 May;34(5):379-87.

PMID:
16647999
42.
43.

Biotransformation of carbon-14-labeled muraglitazar in male mice: interspecies difference in metabolic pathways leading to unique metabolites.

Li W, Zhang D, Wang L, Zhang H, Cheng PT, Zhang D, Everett DW, Humphreys WG.

Drug Metab Dispos. 2006 May;34(5):807-20. Epub 2006 Feb 7.

PMID:
16467134
44.

Glucuronidation as a major metabolic clearance pathway of 14c-labeled muraglitazar in humans: metabolic profiles in subjects with or without bile collection.

Wang L, Zhang D, Swaminathan A, Xue Y, Cheng PT, Wu S, Mosqueda-Garcia R, Aurang C, Everett DW, Humphreys WG.

Drug Metab Dispos. 2006 Mar;34(3):427-39. Epub 2005 Dec 28.

PMID:
16381667
45.

Muraglitazar, a novel dual (alpha/gamma) peroxisome proliferator-activated receptor activator, improves diabetes and other metabolic abnormalities and preserves beta-cell function in db/db mice.

Harrity T, Farrelly D, Tieman A, Chu C, Kunselman L, Gu L, Ponticiello R, Cap M, Qu F, Shao C, Wang W, Zhang H, Fenderson W, Chen S, Devasthale P, Jeon Y, Seethala R, Yang WP, Ren J, Zhou M, Ryono D, Biller S, Mookhtiar KA, Wetterau J, Gregg R, Cheng PT, Hariharan N.

Diabetes. 2006 Jan;55(1):240-8.

46.

Structural elucidation of human oxidative metabolites of muraglitazar: use of microbial bioreactors in the biosynthesis of metabolite standards.

Zhang D, Zhang H, Aranibar N, Hanson R, Huang Y, Cheng PT, Wu S, Bonacorsi S, Zhu M, Swaminathan A, Humphreys WG.

Drug Metab Dispos. 2006 Feb;34(2):267-80. Epub 2005 Nov 9.

PMID:
16280454
47.

PPARs as targets for metabolic and cardiovascular diseases.

Cheng PT, Mukherjee R.

Mini Rev Med Chem. 2005 Aug;5(8):741-53.

PMID:
16101410
48.

Design and synthesis of N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a novel peroxisome proliferator-activated receptor alpha/gamma dual agonist with efficacious glucose and lipid-lowering activities.

Devasthale PV, Chen S, Jeon Y, Qu F, Shao C, Wang W, Zhang H, Cap M, Farrelly D, Golla R, Grover G, Harrity T, Ma Z, Moore L, Ren J, Seethala R, Cheng L, Sleph P, Sun W, Tieman A, Wetterau JR, Doweyko A, Chandrasena G, Chang SY, Humphreys WG, Sasseville VG, Biller SA, Ryono DE, Selan F, Hariharan N, Cheng PT.

J Med Chem. 2005 Mar 24;48(6):2248-50.

PMID:
15771468
49.

The relationship of social function with motor and speech functions in children with autism.

Hsu HC, Chen CL, Cheng PT, Chen CH, Chong CY, Lin YY.

Chang Gung Med J. 2004 Oct;27(10):750-7.

50.

Effects of visual feedback rhythmic weight-shift training on hemiplegic stroke patients.

Cheng PT, Wang CM, Chung CY, Chen CL.

Clin Rehabil. 2004 Nov;18(7):747-53.

PMID:
15573830

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