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Development and Characterization of Monoclonal Antibodies to Botulinum Neurotoxin Type E.

Bever CS, Scotcher M, Cheng LW, Hnasko RM, Stanker LH.

Toxins (Basel). 2019 Jul 13;11(7). pii: E407. doi: 10.3390/toxins11070407.


Publisher Correction: The degree of prevalence of similarity between outer tropical cyclone rainbands and squall lines.

Yu CK, Lin CY, Cheng LW, Luo JS, Wu CC, Chen Y.

Sci Rep. 2019 Jun 6;9(1):8489. doi: 10.1038/s41598-019-44434-6.


High Efficiency Drug Repurposing Design for New Antifungal Agents.

Kim JH, Chan KL, Cheng LW, Tell LA, Byrne BA, Clothier K, Land KM.

Methods Protoc. 2019 Apr 17;2(2). pii: E31. doi: 10.3390/mps2020031.


Influence of Food Matrices on the Stability and Bioavailability of Abrin.

Tam CC, Henderson TD 2nd, Stanker LH, Cheng LW.

Toxins (Basel). 2018 Dec 1;10(12). pii: E502. doi: 10.3390/toxins10120502.


A Rapid, Sensitive, and Portable Biosensor Assay for the Detection of Botulinum Neurotoxin Serotype A in Complex Food Matrices.

Tam CC, Flannery AR, Cheng LW.

Toxins (Basel). 2018 Nov 15;10(11). pii: E476. doi: 10.3390/toxins10110476.


Highly Potent 1H-1,2,3-Triazole-Tethered Isatin-Metronidazole Conjugates Against Anaerobic Foodborne, Waterborne, and Sexually-Transmitted Protozoal Parasites.

Kumar S, Bains T, Won Kim AS, Tam C, Kim J, Cheng LW, Land KM, Debnath A, Kumar V.

Front Cell Infect Microbiol. 2018 Oct 30;8:380. doi: 10.3389/fcimb.2018.00380. eCollection 2018.


Cinnamoyl-Oxaborole Amides: Synthesis and Their in Vitro Biological Activity.

Gumbo M, Beteck RM, Mandizvo T, Seldon R, Warner DF, Hoppe HC, Isaacs M, Laming D, Tam CC, Cheng LW, Liu N, Land KM, Khanye SD.

Molecules. 2018 Aug 15;23(8). pii: E2038. doi: 10.3390/molecules23082038.


Potato Peels and Their Bioactive Glycoalkaloids and Phenolic Compounds Inhibit the Growth of Pathogenic Trichomonads.

Friedman M, Huang V, Quiambao Q, Noritake S, Liu J, Kwon O, Chintalapati S, Young J, Levin CE, Tam C, Cheng LW, Land KM.

J Agric Food Chem. 2018 Aug 1;66(30):7942-7947. doi: 10.1021/acs.jafc.8b01726. Epub 2018 Jul 24.


Synthesis and Preliminary Antimicrobial Analysis of Isatin-Ferrocene and Isatin-Ferrocenyl Chalcone Conjugates.

Singh A, Fong G, Liu J, Wu YH, Chang K, Park W, Kim J, Tam C, Cheng LW, Land KM, Kumar V.

ACS Omega. 2018 May 31;3(5):5808-5813. doi: 10.1021/acsomega.8b00553. Epub 2018 May 30.


A New Conjugation Method Used for the Development of an Immunoassay for the Detection of Amanitin, a Deadly Mushroom Toxin.

Bever CS, Barnych B, Hnasko R, Cheng LW, Stanker LH.

Toxins (Basel). 2018 Jun 28;10(7). pii: E265. doi: 10.3390/toxins10070265.


Role of interleukin-21 and interleukin-21 receptor polymorphisms in the treatment of HBeAg-positive chronic hepatitis B patients with peginterferon.

Wang X, Xu ZQ, Fu JJ, Cheng LW, Li Y, Li L, Pan XC.

Medicine (Baltimore). 2018 Jun;97(23):e10891. doi: 10.1097/MD.0000000000010891.


The degree of prevalence of similarity between outer tropical cyclone rainbands and squall lines.

Yu CK, Lin CY, Cheng LW, Luo JS, Wu CC, Chen Y.

Sci Rep. 2018 May 29;8(1):8247. doi: 10.1038/s41598-018-26553-8. Erratum in: Sci Rep. 2019 Jun 6;9(1):8489.


Organometallic Conjugates of the Drug Sulfadoxine for Combatting Antimicrobial Resistance.

Chellan P, Avery VM, Duffy S, Triccas JA, Nagalingam G, Tam C, Cheng LW, Liu J, Land KM, Clarkson GJ, Romero-Canelón I, Sadler PJ.

Chemistry. 2018 Apr 13. doi: 10.1002/chem.201801090. [Epub ahead of print]


A Single Tri-Epitopic Antibody Virtually Recapitulates the Potency of a Combination of Three Monoclonal Antibodies in Neutralization of Botulinum Neurotoxin Serotype A.

Lou J, Wen W, Conrad F, Meng Q, Dong J, Sun Z, Garcia-Rodriguez C, Farr-Jones S, Cheng LW, Henderson TD, Brown JL, Smith TJ, Smith LA, Cormier A, Marks JD.

Toxins (Basel). 2018 Feb 15;10(2). pii: E84. doi: 10.3390/toxins10020084.


Design, Synthesis and Preliminary Antimicrobial Evaluation of N-Alkyl Chain Tethered C-5 Functionalized Bis-Isatins.

Singh A, Nisha, Bains T, Hahn HJ, Liu N, Tam C, Cheng LW, Kim J, Debnath A, Land KM, Kumar V.

Medchemcomm. 2017;8(10):1982-1992. doi: 10.1039/C7MD00434F. Epub 2017 Sep 19.


An Improved Method for the Sensitive Detection of Shiga Toxin 2 in Human Serum.

He X, Ardissino G, Patfield S, Cheng LW, Silva CJ, Brigotti M.

Toxins (Basel). 2018 Jan 31;10(2). pii: E59. doi: 10.3390/toxins10020059.


Detection of Abrin Holotoxin Using Novel Monoclonal Antibodies.

He X, Patfield S, Cheng LW, Stanker LH, Rasooly R, McKeon TA, Zhang Y, Brandon DL.

Toxins (Basel). 2017 Nov 28;9(12). pii: E386. doi: 10.3390/toxins9120386.


Cinnamic Acid Analogs as Intervention Catalysts for Overcoming Antifungal Tolerance.

Kim JH, Chan KL, Cheng LW.

Molecules. 2017 Oct 21;22(10). pii: E1783. doi: 10.3390/molecules22101783.


A Monoclonal-Monoclonal Antibody Based Capture ELISA for Abrin.

Tam CC, Cheng LW, He X, Merrill P, Hodge D, Stanker LH.

Toxins (Basel). 2017 Oct 18;9(10). pii: E328. doi: 10.3390/toxins9100328.


Abrin Toxicity and Bioavailability after Temperature and pH Treatment.

Tam CC, Henderson TD, Stanker LH, He X, Cheng LW.

Toxins (Basel). 2017 Oct 13;9(10). pii: E320. doi: 10.3390/toxins9100320.


Phytochemical-rich foods inhibit the growth of pathogenic trichomonads.

Noritake SM, Liu J, Kanetake S, Levin CE, Tam C, Cheng LW, Land KM, Friedman M.

BMC Complement Altern Med. 2017 Sep 13;17(1):461. doi: 10.1186/s12906-017-1967-x.


Antimicrobial activity of organometallic isonicotinyl and pyrazinyl ferrocenyl-derived complexes.

Stringer T, Seldon R, Liu N, Warner DF, Tam C, Cheng LW, Land KM, Smith PJ, Chibale K, Smith GS.

Dalton Trans. 2017 Aug 14;46(30):9875-9885. doi: 10.1039/c7dt01952a. Epub 2017 Jul 17.


Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature.

Peck MW, Smith TJ, Anniballi F, Austin JW, Bano L, Bradshaw M, Cuervo P, Cheng LW, Derman Y, Dorner BG, Fisher A, Hill KK, Kalb SR, Korkeala H, Lindström M, Lista F, Lúquez C, Mazuet C, Pirazzini M, Popoff MR, Rossetto O, Rummel A, Sesardic D, Singh BR, Stringer SC.

Toxins (Basel). 2017 Jan 18;9(1). pii: E38. doi: 10.3390/toxins9010038. Review.


Probiotic Microorganisms Inhibit Epithelial Cell Internalization of Botulinum Neurotoxin Serotype A.

Lam TI, Tam CC, Stanker LH, Cheng LW.

Toxins (Basel). 2016 Dec 16;8(12). pii: E377. doi: 10.3390/toxins8120377.


Antiprotozoal Effects of the Tomato Tetrasaccharide Glycoalkaloid Tomatine and the Aglycone Tomatidine on Mucosal Trichomonads.

Liu J, Kanetake S, Wu YH, Tam C, Cheng LW, Land KM, Friedman M.

J Agric Food Chem. 2016 Nov 23;64(46):8806-8810. Epub 2016 Nov 11.


Bioisosteric ferrocenyl-containing quinolines with antiplasmodial and antitrichomonal properties.

Adams M, Stringer T, de Kock C, Smith PJ, Land KM, Liu N, Tam C, Cheng LW, Njoroge M, Chibale K, Smith GS.

Dalton Trans. 2016 Nov 29;45(47):19086-19095.


Bithionol blocks pathogenicity of bacterial toxins, ricin, and Zika virus.

Leonardi W, Zilbermintz L, Cheng LW, Zozaya J, Tran SH, Elliott JH, Polukhina K, Manasherob R, Li A, Chi X, Gharaibeh D, Kenny T, Zamani R, Soloveva V, Haddow AD, Nasar F, Bavari S, Bassik MC, Cohen SN, Levitin A, Martchenko M.

Sci Rep. 2016 Sep 30;6:34475. doi: 10.1038/srep34475.


Mono- and multimeric ferrocene congeners of quinoline-based polyamines as potential antiparasitics.

Stringer T, De Kock C, Guzgay H, Okombo J, Liu J, Kanetake S, Kim J, Tam C, Cheng LW, Smith PJ, Hendricks DT, Land KM, Egan TJ, Smith GS.

Dalton Trans. 2016 Sep 14;45(34):13415-26. doi: 10.1039/c6dt02685k. Epub 2016 Aug 3.


Mechanism for doping induced p type C60 using thermally evaporated molybdenum trioxide (MoO3) as a dopant.

Yang JP, Wang WQ, Cheng LW, Li YQ, Tang JX, Kera S, Ueno N, Zeng XH.

J Phys Condens Matter. 2016 May 11;28(18):185502. doi: 10.1088/0953-8984/28/18/185502. Epub 2016 Apr 8.


Use of Monoclonal Antibodies in the Sensitive Detection and Neutralization of Botulinum Neurotoxin Serotype B.

Cheng LW, Henderson TD 2nd, Lam TI, Stanker LH.

Toxins (Basel). 2015 Nov 27;7(12):5068-78. doi: 10.3390/toxins7124863.


Inhibiting oral intoxication of botulinum neurotoxin A complex by carbohydrate receptor mimics.

Lee K, Lam KH, Kruel AM, Mahrhold S, Perry K, Cheng LW, Rummel A, Jin R.

Toxicon. 2015 Dec 1;107(Pt A):43-9. doi: 10.1016/j.toxicon.2015.08.003. Epub 2015 Aug 10.


Detection of K-ras Mutations in Predicting Efficacy of Epidermal Growth Factor Receptor Tyrosine Kinase (EGFR-TK) Inhibitor in Patients with Metastatic Colorectal Cancer.

Li Z, Liu XW, Chi ZC, Sun BS, Cheng Y, Cheng LW.

PLoS One. 2015 May 7;10(5):e0101019. doi: 10.1371/journal.pone.0101019. eCollection 2015.


Translocation of botulinum neurotoxin serotype A and associated proteins across the intestinal epithelia.

Lam TI, Stanker LH, Lee K, Jin R, Cheng LW.

Cell Microbiol. 2015 Aug;17(8):1133-43. doi: 10.1111/cmi.12424. Epub 2015 Feb 15.


Synthesis of novel polyhydroxylated pyrrolidine-triazole/-isoxazole hybrid molecules.

Lin CK, Cheng LW, Li HY, Yun WY, Cheng WC.

Org Biomol Chem. 2015 Feb 21;13(7):2100-7. doi: 10.1039/c4ob01934b.


Centrifugal microfluidic platform for ultrasensitive detection of botulinum toxin.

Koh CY, Schaff UY, Piccini ME, Stanker LH, Cheng LW, Ravichandran E, Singh BR, Sommer GJ, Singh AK.

Anal Chem. 2015 Jan 20;87(2):922-8. doi: 10.1021/ac504054u. Epub 2015 Jan 5.


Controlled release of β-carotene in β-lactoglobulin-dextran-conjugated nanoparticles' in vitro digestion and transport with Caco-2 monolayers.

Yi J, Lam TI, Yokoyama W, Cheng LW, Zhong F.

J Agric Food Chem. 2014 Sep 3;62(35):8900-7. doi: 10.1021/jf502639k. Epub 2014 Aug 21.


[The application of integrated surveillance system for symptoms in surveillance of influenza among children].

Tian LH, Tan L, Fan YZ, Wang Y, Zhang J, Cheng LW, Wei S, Liu L, Yan WR, Xu B, Dong HJ, Nie SF.

Zhonghua Yu Fang Yi Xue Za Zhi. 2013 Dec;47(12):1095-9. Chinese.


Cellular uptake of β-carotene from protein stabilized solid lipid nanoparticles prepared by homogenization-evaporation method.

Yi J, Lam TI, Yokoyama W, Cheng LW, Zhong F.

J Agric Food Chem. 2014 Feb 5;62(5):1096-104. doi: 10.1021/jf404073c. Epub 2014 Jan 24.


Mouse in vivo neutralization of Escherichia coli Shiga toxin 2 with monoclonal antibodies.

Cheng LW, Henderson TD, Patfield S, Stanker LH, He X.

Toxins (Basel). 2013 Oct 22;5(10):1845-58. doi: 10.3390/toxins5101845.


Structure of a bimodular botulinum neurotoxin complex provides insights into its oral toxicity.

Lee K, Gu S, Jin L, Le TT, Cheng LW, Strotmeier J, Kruel AM, Yao G, Perry K, Rummel A, Jin R.

PLoS Pathog. 2013;9(10):e1003690. doi: 10.1371/journal.ppat.1003690. Epub 2013 Oct 10.


HBcAg-specific IL-21-producing CD4+ T cells are associated with relative viral control in patients with chronic hepatitis B.

Li L, Liu M, Cheng LW, Gao XY, Fu JJ, Kong G, Feng X, Pan XC.

Scand J Immunol. 2013 Nov;78(5):439-46. doi: 10.1111/sji.12099.


Substrates and controls for the quantitative detection of active botulinum neurotoxin in protease-containing samples.

Bagramyan K, Kaplan BE, Cheng LW, Strotmeier J, Rummel A, Kalkum M.

Anal Chem. 2013 Jun 4;85(11):5569-76. doi: 10.1021/ac4008418. Epub 2013 May 22.


Development and characterization of six monoclonal antibodies to hemagglutinin-70 of Clostridium botulinum and their application in a sandwich ELISA.

Scotcher MC, Cheng LW, Ching K, McGarvey J, Hnasko R, Stanker L.

Monoclon Antib Immunodiagn Immunother. 2013 Feb;32(1):6-15. doi: 10.1089/mab.2012.0071.


Detection of botulinum neurotoxin serotypes A and B using a chemiluminescent versus electrochemiluminescent immunoassay in food and serum.

Cheng LW, Stanker LH.

J Agric Food Chem. 2013 Jan 23;61(3):755-60. doi: 10.1021/jf3041963. Epub 2013 Jan 10.


Comparison of neutralizing and hemagglutination-inhibiting antibody responses for evaluating the seasonal influenza vaccine.

Cheng LW, Huang SW, Huang LM, Chang LY, Shao PL, Kiang D, Wang JR.

J Virol Methods. 2012 Jun;182(1-2):43-9. doi: 10.1016/j.jviromet.2012.03.004. Epub 2012 Mar 13.


Junction temperature measurement of light emitting diode by electroluminescence.

He SM, Luo XD, Zhang B, Fu L, Cheng LW, Wang JB, Lu W.

Rev Sci Instrum. 2011 Dec;82(12):123101. doi: 10.1063/1.3664619.


Comparison of oral toxicological properties of botulinum neurotoxin serotypes A and B.

Cheng LW, Henderson TD 2nd.

Toxicon. 2011 Jul;58(1):62-7. doi: 10.1016/j.toxicon.2011.05.003. Epub 2011 May 11.


Ricin toxicokinetics and its sensitive detection in mouse sera or feces using immuno-PCR.

He X, McMahon S, Henderson TD 2nd, Griffey SM, Cheng LW.

PLoS One. 2010 Sep 22;5(9):e12858. doi: 10.1371/journal.pone.0012858.


Detection of botulinum neurotoxin serotype B at sub mouse LD(50) levels by a sandwich immunoassay and its application to toxin detection in milk.

Scotcher MC, Cheng LW, Stanker LH.

PLoS One. 2010 Jun 10;5(6):e11047. doi: 10.1371/journal.pone.0011047.


Antibody protection against botulinum neurotoxin intoxication in mice.

Cheng LW, Stanker LH, Henderson TD 2nd, Lou J, Marks JD.

Infect Immun. 2009 Oct;77(10):4305-13. doi: 10.1128/IAI.00405-09. Epub 2009 Aug 3.

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