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Enhanced CRISPR-based DNA demethylation by Casilio-ME-mediated RNA-guided coupling of methylcytosine oxidation and DNA repair pathways.

Taghbalout A, Du M, Jillette N, Rosikiewicz W, Rath A, Heinen CD, Li S, Cheng AW.

Nat Commun. 2019 Sep 20;10(1):4296. doi: 10.1038/s41467-019-12339-7.


The Extraction Socket Management Continuum: A Hierarchical Approach to Dental Implant Site Development.

Cheng AW, Berridge JP, McGary RT, Erley KJ, Johnson TM.

Clin Adv Periodontics. 2019 Jun;9(2):91-104. doi: 10.1002/cap.10049. Epub 2018 Nov 1.


Focus on Epithelialized Palatal Grafts. Part 3: Methods to Enhance Patient Comfort at Palatal Donor Sites.

Berridge JP, Johnson TM, Cheng AW, Swenson DT, Miller PD Jr.

Clin Adv Periodontics. 2019 Apr 8. doi: 10.1002/cap.10066. [Epub ahead of print]


Disentangling the Effects of Exposure to Maternal Substance Misuse and Physical Abuse and Neglect on Child Behavioral Problems.

Wong RS, Tung KTS, Cheng AWF, Shiu YK, Wong WHS, Tso WWY, Ho MSP, Chan KL, Ho FKW, Lo CKM, Chow CB, Ip P.

J Interpers Violence. 2019 May 26:886260519849661. doi: 10.1177/0886260519849661. [Epub ahead of print]


Catechin attenuates TNF-α induced inflammatory response via AMPK-SIRT1 pathway in 3T3-L1 adipocytes.

Cheng AW, Tan X, Sun JY, Gu CM, Liu C, Guo X.

PLoS One. 2019 May 17;14(5):e0217090. doi: 10.1371/journal.pone.0217090. eCollection 2019.


Psychological Distress in Bullied Deaf and Hard of Hearing Adolescents.

Cheng AW, Chou YC, Lin FG.

J Deaf Stud Deaf Educ. 2019 Oct 1;24(4):366-377. doi: 10.1093/deafed/enz014.


[Microbial Carbon Source Metabolic Profile in Rice Rhizosphere and Non-rhizosphere Soils with Different Long-term Fertilization Management].

Ning Z, Cheng AW, Tang HM, Ge TD, Deng YW, Su YR, Chen XB.

Huan Jing Ke Xue. 2019 Mar 8;40(3):1475-1482. doi: 10.13227/j.hjkx.201808022. Chinese.


Supercritical CO2 fluid extraction of croton crassifolius Geisel root: Chemical composition and anti-proliferative, autophagic, apoptosis-inducing, and related molecular effects on A549 tumour cells.

Liu C, Zhang RR, Wang YM, Zhang J, Wang Q, Cheng AW, Guo X, Wang XK, Sun JY.

Phytomedicine. 2019 Aug;61:152846. doi: 10.1016/j.phymed.2019.152846. Epub 2019 Jan 29.


College counseling services: Meeting today's demands.

Fu M, Cheng AW.

Psychol Serv. 2017 Nov;14(4):403-406. doi: 10.1037/ser0000219.


CRISPR-Cas9-mediated multiplex gene editing in CAR-T cells.

Liu X, Zhang Y, Cheng C, Cheng AW, Zhang X, Li N, Xia C, Wei X, Liu X, Wang H.

Cell Res. 2017 Jan;27(1):154-157. doi: 10.1038/cr.2016.142. Epub 2016 Dec 2. No abstract available.


Asian American and White College Students' Heavy Episodic Drinking Behaviors and Alcohol-Related Problems.

Iwamoto DK, Grivel MM, Cheng AW, Zamboanga BL.

Subst Use Misuse. 2016 Aug 23;51(10):1384-92. doi: 10.3109/10826084.2016.1170142. Epub 2016 May 31.


Model Minority Stereotype: Influence on Perceived Mental Health Needs of Asian Americans.

Cheng AW, Chang J, O'Brien J, Budgazad MS, Tsai J.

J Immigr Minor Health. 2017 Jun;19(3):572-581. doi: 10.1007/s10903-016-0440-0.


Model minority stereotype and the diagnosis of alcohol use disorders: Implications for practitioners working with Asian Americans.

Cheng AW, Iwamoto DK, McMullen D.

J Ethn Subst Abuse. 2018 Jul-Sep;17(3):255-272. doi: 10.1080/15332640.2016.1175990. Epub 2016 May 26.


Transcriptional activity of acetylcholinesterase gene is regulated by DNA methylation during C2C12 myogenesis.

Lau KM, Gong AGW, Xu ML, Lam CTW, Zhang LML, Bi CWC, Cui D, Cheng AWM, Dong TTX, Tsim KWK, Lin H.

Brain Res. 2016 Jul 1;1642:114-123. doi: 10.1016/j.brainres.2016.03.013. Epub 2016 Mar 26.


Casilio: a versatile CRISPR-Cas9-Pumilio hybrid for gene regulation and genomic labeling.

Cheng AW, Jillette N, Lee P, Plaskon D, Fujiwara Y, Wang W, Taghbalout A, Wang H.

Cell Res. 2016 Feb;26(2):254-7. doi: 10.1038/cr.2016.3. Epub 2016 Jan 15. No abstract available.


A new triterpenoid saponin from Gleditsia sinensis and its antiproliferative activity.

Liu C, Sun H, Wang WT, Zhang JB, Cheng AW, Guo X, Sun JY.

Nat Prod Res. 2016 Sep;30(18):2065-70. doi: 10.1080/14786419.2015.1110704. Epub 2015 Nov 11.


Successful thoracoscopic resection of large symptomatic mediastinal lymphatic malformations: Report of 3 cases.

Cheng AW, Shaul DB, Sydorak RM.

J Thorac Cardiovasc Surg. 2015 Oct;150(4):e59-60. doi: 10.1016/j.jtcvs.2015.07.020. Epub 2015 Jul 10. No abstract available.


Three N-Glycosylation Sites of Human Acetylcholinesterase Shares Similar Glycan Composition.

Xu ML, Luk WK, Lau KM, Bi CW, Cheng AW, Gong AG, Lin H, Tsim KW.

J Mol Neurosci. 2015 Dec;57(4):486-91. doi: 10.1007/s12031-015-0629-z. Epub 2015 Aug 1.


Synchronous colorectal liver metastases in pregnancy and post-partum.

Robson DE, Lewin J, Cheng AW, O'Rourke NA, Cavallucci DJ.

ANZ J Surg. 2017 Oct;87(10):800-804. doi: 10.1111/ans.13196. Epub 2015 Jun 15.


Reduced Expression of P2Y2 Receptor and Acetylcholinesterase at Neuromuscular Junction of P2Y1 Receptor Knock-out Mice.

Xu ML, Bi CW, Cheng LK, Mak S, Yao P, Luk WK, Lau KK, Cheng AW, Tsim KW.

J Mol Neurosci. 2015 Nov;57(3):446-51. doi: 10.1007/s12031-015-0591-9. Epub 2015 Jun 3.


CRISPR-Cas9-mediated genome editing and guide RNA design.

Wiles MV, Qin W, Cheng AW, Wang H.

Mamm Genome. 2015 Oct;26(9-10):501-10. doi: 10.1007/s00335-015-9565-z. Epub 2015 May 20. Review.


Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease.

Qin W, Dion SL, Kutny PM, Zhang Y, Cheng AW, Jillette NL, Malhotra A, Geurts AM, Chen YG, Wang H.

Genetics. 2015 Jun;200(2):423-30. doi: 10.1534/genetics.115.176594. Epub 2015 Mar 27.


CRISPR-Cas9 genome editing of a single regulatory element nearly abolishes target gene expression in mice--brief report.

Han Y, Slivano OJ, Christie CK, Cheng AW, Miano JM.

Arterioscler Thromb Vasc Biol. 2015 Feb;35(2):312-5. doi: 10.1161/ATVBAHA.114.305017. Epub 2014 Dec 23.


Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state.

Katz Y, Li F, Lambert NJ, Sokol ES, Tam WL, Cheng AW, Airoldi EM, Lengner CJ, Gupta PB, Yu Z, Jaenisch R, Burge CB.

Elife. 2014 Nov 7;3:e03915. doi: 10.7554/eLife.03915.


Can you hear me? Sudden sensorineural hearing loss in the emergency department.

Cheng AW, Mitchell Z, Foote J.

Can Fam Physician. 2014 Oct;60(10):907-9, e475-7. English, French. No abstract available.


Outcome of abdominal wall hernia repair with biologic mesh: Permacol™ versus Strattice™.

Cheng AW, Abbas MA, Tejirian T.

Am Surg. 2014 Oct;80(10):999-1002.


Genetic and chemical correction of cholesterol accumulation and impaired autophagy in hepatic and neural cells derived from Niemann-Pick Type C patient-specific iPS cells.

Maetzel D, Sarkar S, Wang H, Abi-Mosleh L, Xu P, Cheng AW, Gao Q, Mitalipova M, Jaenisch R.

Stem Cell Reports. 2014 May 15;2(6):866-80. doi: 10.1016/j.stemcr.2014.03.014. eCollection 2014 Jun 3.


Muscleblind-like 1 (Mbnl1) regulates pre-mRNA alternative splicing during terminal erythropoiesis.

Cheng AW, Shi J, Wong P, Luo KL, Trepman P, Wang ET, Choi H, Burge CB, Lodish HF.

Blood. 2014 Jul 24;124(4):598-610. doi: 10.1182/blood-2013-12-542209. Epub 2014 May 28.


Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells.

Wu X, Scott DA, Kriz AJ, Chiu AC, Hsu PD, Dadon DB, Cheng AW, Trevino AE, Konermann S, Chen S, Jaenisch R, Zhang F, Sharp PA.

Nat Biotechnol. 2014 Jul;32(7):670-6. doi: 10.1038/nbt.2889. Epub 2014 Apr 20.


Loss of Tet enzymes compromises proper differentiation of embryonic stem cells.

Dawlaty MM, Breiling A, Le T, Barrasa MI, Raddatz G, Gao Q, Powell BE, Cheng AW, Faull KF, Lyko F, Jaenisch R.

Dev Cell. 2014 Apr 14;29(1):102-11. doi: 10.1016/j.devcel.2014.03.003.


Cartilage tissue engineering application of injectable gelatin hydrogel with in situ visible-light-activated gelation capability in both air and aqueous solution.

Lin H, Cheng AW, Alexander PG, Beck AM, Tuan RS.

Tissue Eng Part A. 2014 Sep;20(17-18):2402-11. doi: 10.1089/ten.TEA.2013.0642. Epub 2014 Apr 9.


Three-dimensional osteochondral microtissue to model pathogenesis of osteoarthritis.

Lozito TP, Alexander PG, Lin H, Gottardi R, Cheng AW, Tuan RS.

Stem Cell Res Ther. 2013;4 Suppl 1:S6. doi: 10.1186/scrt367. Epub 2013 Dec 20. Review.


Laparoscopic redo nissen fundoplication after previous open antireflux surgery in infants and children.

Cheng AW, Shaul DB, Lau ST, Sydorak RM.

J Laparoendosc Adv Surg Tech A. 2014 May;24(5):359-61. doi: 10.1089/lap.2013.0464. Epub 2014 Jan 11.


Outcome of abdominal wall hernia repair with Permacol™ biologic mesh.

Cheng AW, Abbas MA, Tejirian T.

Am Surg. 2013 Oct;79(10):992-6.


Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons.

Li Y, Wang H, Muffat J, Cheng AW, Orlando DA, Lovén J, Kwok SM, Feldman DA, Bateup HS, Gao Q, Hockemeyer D, Mitalipova M, Lewis CA, Vander Heiden MG, Sur M, Young RA, Jaenisch R.

Cell Stem Cell. 2013 Oct 3;13(4):446-58. doi: 10.1016/j.stem.2013.09.001.


Tet1 is critical for neuronal activity-regulated gene expression and memory extinction.

Rudenko A, Dawlaty MM, Seo J, Cheng AW, Meng J, Le T, Faull KF, Jaenisch R, Tsai LH.

Neuron. 2013 Sep 18;79(6):1109-1122. doi: 10.1016/j.neuron.2013.08.003.


One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering.

Yang H, Wang H, Shivalila CS, Cheng AW, Shi L, Jaenisch R.

Cell. 2013 Sep 12;154(6):1370-9. doi: 10.1016/j.cell.2013.08.022. Epub 2013 Aug 29.


Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system.

Cheng AW, Wang H, Yang H, Shi L, Katz Y, Theunissen TW, Rangarajan S, Shivalila CS, Dadon DB, Jaenisch R.

Cell Res. 2013 Oct;23(10):1163-71. doi: 10.1038/cr.2013.122. Epub 2013 Aug 27.


The effects of race and other socioeconomic factors on health service use among American military veterans.

Tsai J, Desai MU, Cheng AW, Chang J.

Psychiatr Q. 2014 Mar;85(1):35-47. doi: 10.1007/s11126-013-9268-0.


Single-cell analysis reveals that expression of nanog is biallelic and equally variable as that of other pluripotency factors in mouse ESCs.

Faddah DA, Wang H, Cheng AW, Katz Y, Buganim Y, Jaenisch R.

Cell Stem Cell. 2013 Jul 3;13(1):23-9. doi: 10.1016/j.stem.2013.04.019.


TALEN-mediated editing of the mouse Y chromosome.

Wang H, Hu YC, Markoulaki S, Welstead GG, Cheng AW, Shivalila CS, Pyntikova T, Dadon DB, Voytas DF, Bogdanove AJ, Page DC, Jaenisch R.

Nat Biotechnol. 2013 Jun;31(6):530-2. doi: 10.1038/nbt.2595. Epub 2013 May 12.


One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering.

Wang H, Yang H, Shivalila CS, Dawlaty MM, Cheng AW, Zhang F, Jaenisch R.

Cell. 2013 May 9;153(4):910-8. doi: 10.1016/j.cell.2013.04.025. Epub 2013 May 2.


SOX2 co-occupies distal enhancer elements with distinct POU factors in ESCs and NPCs to specify cell state.

Lodato MA, Ng CW, Wamstad JA, Cheng AW, Thai KK, Fraenkel E, Jaenisch R, Boyer LA.

PLoS Genet. 2013;9(2):e1003288. doi: 10.1371/journal.pgen.1003288. Epub 2013 Feb 21.


Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development.

Dawlaty MM, Breiling A, Le T, Raddatz G, Barrasa MI, Cheng AW, Gao Q, Powell BE, Li Z, Xu M, Faull KF, Lyko F, Jaenisch R.

Dev Cell. 2013 Feb 11;24(3):310-23. doi: 10.1016/j.devcel.2012.12.015. Epub 2013 Jan 24.


High-affinity VEGF antagonists by oligomerization of a minimal sequence VEGF-binding domain.

Stefano JE, Bird J, Kyazike J, Cheng AW, Boudanova E, Dwyer M, Hou L, Qiu H, Matthews G, O'Callaghan M, Pan CQ.

Bioconjug Chem. 2012 Dec 19;23(12):2354-64. doi: 10.1021/bc300301m. Epub 2012 Dec 10.


Application of visible light-based projection stereolithography for live cell-scaffold fabrication with designed architecture.

Lin H, Zhang D, Alexander PG, Yang G, Tan J, Cheng AW, Tuan RS.

Biomaterials. 2013 Jan;34(2):331-9. doi: 10.1016/j.biomaterials.2012.09.048. Epub 2012 Oct 22.


Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase.

Buganim Y, Faddah DA, Cheng AW, Itskovich E, Markoulaki S, Ganz K, Klemm SL, van Oudenaarden A, Jaenisch R.

Cell. 2012 Sep 14;150(6):1209-22. doi: 10.1016/j.cell.2012.08.023.


Direct reprogramming of fibroblasts into embryonic Sertoli-like cells by defined factors.

Buganim Y, Itskovich E, Hu YC, Cheng AW, Ganz K, Sarkar S, Fu D, Welstead GG, Page DC, Jaenisch R.

Cell Stem Cell. 2012 Sep 7;11(3):373-86. doi: 10.1016/j.stem.2012.07.019.


X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner.

Welstead GG, Creyghton MP, Bilodeau S, Cheng AW, Markoulaki S, Young RA, Jaenisch R.

Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):13004-9. doi: 10.1073/pnas.1210787109. Epub 2012 Jul 23.

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