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Experimental error, kurtosis, activity cliffs, and methodology: What limits the predictivity of QSAR models?

Sheridan RP, Karnachi P, Tudor M, Xu Y, Liaw A, Shah F, Cheng A, Joshi EM, Glick M, Alvarez J.

J Chem Inf Model. 2020 Mar 24. doi: 10.1021/acs.jcim.9b01067. [Epub ahead of print]


Author Correction: Cytokine storms are primarily responsible for the rapid death of ducklings infected with duck hepatitis A virus type 1.

Xie J, Wang M, Cheng A, Zhao XX, Liu M, Zhu D, Chen S, Jia R, Yang Q, Wu Y, Zhang S, Liu Y, Yu Y, Zhang L, Sun K, Chen X.

Sci Rep. 2020 Mar 24;10(1):5672. doi: 10.1038/s41598-020-62439-4.


GOLT1A-KISS1 fusion is associated with metastasis in adenoid cystic carcinomas.

Zhang L, Cheng A, Yu Y, Zou N, Wang W, Lv L, Guo X, Chen M, Zhang Y.

Biochem Biophys Res Commun. 2020 Mar 17. pii: S0006-291X(20)30467-8. doi: 10.1016/j.bbrc.2020.03.005. [Epub ahead of print]


The 21st Century Agriculture: When Rice Research Draws Attention to Climate Variability and How Weedy Rice and Underutilized Grains Come in Handy.

Hanafiah NM, Mispan MS, Lim PE, Baisakh N, Cheng A.

Plants (Basel). 2020 Mar 16;9(3). pii: E365. doi: 10.3390/plants9030365. Review.


Carbohydrates do not accelerate force recovery after glycogen-depleting followed by high-intensity exercise in humans.

Cheng AJ, Chaillou T, Kamandulis S, Subocius A, Westerblad H, Brazaitis M, Venckunas T.

Scand J Med Sci Sports. 2020 Mar 18. doi: 10.1111/sms.13655. [Epub ahead of print]


Structure-Activity Relationship and Anticancer Profile of Second-Generation Anti-MRSA Synthetic Retinoids.

Cheng AV, Kim W, Escobar IE, Mylonakis E, Wuest WM.

ACS Med Chem Lett. 2019 Jul 17;11(3):393-397. doi: 10.1021/acsmedchemlett.9b00159. eCollection 2020 Mar 12.


6q25.1 (TAB2) microdeletion is a risk factor for hypoplastic left heart: a case report that expands the phenotype.

Cheng A, Neufeld-Kaiser W, Byers PH, Liu YJ.

BMC Cardiovasc Disord. 2020 Mar 17;20(1):137. doi: 10.1186/s12872-020-01404-5.


Associations Between Economic Factors and Condom Use Behavior Among Female Sex Workers in Dakar and Mbour, Senegal.

Yang F, Ketende S, Jennings Mayo-Wilson L, Lyons CE, Liestman B, Diouf D, Drame FM, Coly K, Turpin G, Mboup S, Toure-Kane C, Castor D, Cheng A, Diop-Ndiaye H, Leye-Diouf N, Kennedy C, Baral S.

AIDS Behav. 2020 Mar 16. doi: 10.1007/s10461-020-02832-2. [Epub ahead of print]


The Transcription Factor-microRNA Regulatory Network during hESC-chondrogenesis.

Griffiths R, Woods S, Cheng A, Wang P, Griffiths-Jones S, Ronshaugen M, Kimber SJ.

Sci Rep. 2020 Mar 16;10(1):4744. doi: 10.1038/s41598-020-61734-4.


Intramuscular mechanisms of overtraining.

Cheng AJ, Jude B, Lanner JT.

Redox Biol. 2020 Feb 26:101480. doi: 10.1016/j.redox.2020.101480. [Epub ahead of print] Review.


[Expression and correlation analysis of hypoxia inducible factor 1α and autophagy related molecules in rat nucleus pulposus cells under hypoxia].

Cheng A, He P, Zhang J, Zheng W, Yang M.

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2020 Mar 15;34(3):318-322. doi: 10.7507/1002-1892.201908088. Chinese.


Addition of ethylamines to the phenols of bithionol and synthetic retinoids does not elicit activity in gram-negative bacteria.

Cheng AV, Schrank CL, Escobar IE, Mylonakis E, Wuest WM.

Bioorg Med Chem Lett. 2020 Mar 9:127099. doi: 10.1016/j.bmcl.2020.127099. [Epub ahead of print]


Cardiorenal risk reduction guidance in diabetes: can we reach consensus?

Sattar N, McMurray JJ, Cheng AY.

Lancet Diabetes Endocrinol. 2020 Mar 11. pii: S2213-8587(20)30062-0. doi: 10.1016/S2213-8587(20)30062-0. [Epub ahead of print] No abstract available.


Recommendations and guidelines for the treatment of Clostridioides difficile infection in Taiwan.

Wu KS, Syue LS, Cheng A, Yen TY, Chen HM, Chiu YH, Hsu YL, Chiu CH, Su TY, Tsai WL, Chen WY, Huang CH, Hung HM, Huang LJ, Kuo HJ, Lin PC, Yang CH, Hong PL, Lee SS, Chen YS, Liu YC, Huang LM; Infectious Diseases Society of Taiwan; Medical Foundation in Memory of Dr. Deh-Lin Cheng; Foundation of Professor Wei-Chuan Hsieh for Infectious Diseases Research and Education; CY Lee's Research Foundation for Pediatric Infectious Diseases and Vaccines; 5th Guidelines Recommendations for Evidence-based Antimicrobial agents use in Taiwan (GREAT) working group.

J Microbiol Immunol Infect. 2020 Feb 14. pii: S1684-1182(20)30012-8. doi: 10.1016/j.jmii.2020.02.002. [Epub ahead of print] Review.


Household water storage management, hygiene practices and associated drinking water quality in rural India.

McGuinness S, O'Toole J, Barker SF, Forbes AB, Boving TB, Giriyan A, Patil K, D'Souza F, Vhaval R, Cheng A, Leder K.

Environ Sci Technol. 2020 Mar 13. doi: 10.1021/acs.est.9b04818. [Epub ahead of print]


Atrial Fibrillation Burden and Subsequent Heart Failure Events In Patients with Cardiac Resynchronization Therapy Devices.

Tanawuttiwat T, Lande J, Smeets P, Gerritse B, Nazarian S, Guallar E, Cheng A.

J Cardiovasc Electrophysiol. 2020 Mar 12. doi: 10.1111/jce.14444. [Epub ahead of print]


Two first-in-human studies of xentuzumab, a humanised insulin-like growth factor (IGF)-neutralising antibody, in patients with advanced solid tumours.

de Bono J, Lin CC, Chen LT, Corral J, Michalarea V, Rihawi K, Ong M, Lee JH, Hsu CH, Yang JC, Shiah HS, Yen CJ, Anthoney A, Jove M, Buschke S, Fuertig R, Schmid U, Goeldner RG, Strelkowa N, Huang DC, Bogenrieder T, Twelves C, Cheng AL.

Br J Cancer. 2020 Mar 12. doi: 10.1038/s41416-020-0774-1. [Epub ahead of print]


Enterovirus D68 seroepidemiology in Taiwan, a cross sectional study from 2017.

Lee JT, Shih WL, Yen TY, Cheng AL, Lu CY, Chang LY, Huang LM.

PLoS One. 2020 Mar 10;15(3):e0230180. doi: 10.1371/journal.pone.0230180. eCollection 2020.


Autism-associated PTEN missense mutation leads to enhanced nuclear localization and neurite outgrowth in an induced pluripotent stem cell line.

Wong CW, Wang Y, Liu T, Li L, Cheung SKK, Or PM, Cheng AS, Choy KW, Burbach JPH, Bo F, Chang RCC, Chan AM.

FEBS J. 2020 Mar 9. doi: 10.1111/febs.15287. [Epub ahead of print]


An outbreak of COVID-19 caused by a new coronavirus: what we know so far.

Cheng AC, Williamson DA.

Med J Aust. 2020 Mar 8. doi: 10.5694/mja2.50530. [Epub ahead of print] No abstract available.


Immunomodulatory and antioxidant effects of Astragalus polysaccharide liposome in large yellow croaker (Larimichthys crocea).

Zhang W, Zhang M, Cheng A, Hao E, Huang X, Chen X.

Fish Shellfish Immunol. 2020 Mar 4;100:126-136. doi: 10.1016/j.fsi.2020.03.004. [Epub ahead of print]


A simplified qPCR method revealing tRNAome remodeling upon infection by genotype 3 hepatitis E virus.

Ou X, Ma B, Zhang R, Miao Z, Cheng A, Peppelenbosch MP, Pan Q.

FEBS Lett. 2020 Mar 4. doi: 10.1002/1873-3468.13764. [Epub ahead of print]


Sarcopenia as a predictor of mortality in women with breast cancer: a meta-analysis and systematic review.

Zhang XM, Dou QL, Zeng Y, Yang Y, Cheng ASK, Zhang WW.

BMC Cancer. 2020 Mar 4;20(1):172. doi: 10.1186/s12885-020-6645-6.


Graph embedding and unsupervised learning predict genomic sub-compartments from HiC chromatin interaction data.

Ashoor H, Chen X, Rosikiewicz W, Wang J, Cheng A, Wang P, Ruan Y, Li S.

Nat Commun. 2020 Mar 3;11(1):1173. doi: 10.1038/s41467-020-14974-x.


Gastric cancer: genome damaged by bugs.

Zhao Y, Zhang J, Cheng ASL, Yu J, To KF, Kang W.

Oncogene. 2020 Mar 2. doi: 10.1038/s41388-020-1241-4. [Epub ahead of print] Review.


Incorrect diagnoses in patients with neutralizing anti-interferon-gamma-autoantibodies.

Wu UI, Wang JT, Sheng WH, Sun HY, Cheng A, Hsu LY, Chang SC, Chen YC.

Clin Microbiol Infect. 2020 Feb 28. pii: S1198-743X(20)30134-8. doi: 10.1016/j.cmi.2020.02.030. [Epub ahead of print]


Cross-linguistic f0 differences in bilingual speakers of English and Korean.

Cheng A.

J Acoust Soc Am. 2020 Feb;147(2):EL67. doi: 10.1121/10.0000498.


Design characteristics and statistical methods used in interrupted time series studies evaluating public health interventions: a review.

Turner SL, Karahalios A, Forbes AB, Taljaard M, Grimshaw JM, Cheng AC, Bero L, McKenzie JE.

J Clin Epidemiol. 2020 Feb 25;122:1-11. doi: 10.1016/j.jclinepi.2020.02.006. [Epub ahead of print] Review.


The impact of new universal child influenza programs in Australia: Vaccine coverage, effectiveness and disease epidemiology in hospitalised children in 2018.

Blyth CC, Cheng AC, Crawford NW, Clark JE, Buttery JP, Marshall HS, Francis JR, McRae J, Kotsimbos T, Kelly PM, Macartney KK; Paediatric Active Enhanced Disease Surveillance (PAEDS), Influenza Complications Alert Network (FluCAN) Collaboration.

Vaccine. 2020 Mar 17;38(13):2779-2787. doi: 10.1016/j.vaccine.2020.02.031. Epub 2020 Feb 24.


Effect of a Cardiopulmonary Resuscitation Coach on Workload During Pediatric Cardiopulmonary Arrest: A Multicenter, Simulation-Based Study.

Tofil NM, Cheng A, Lin Y, Davidson J, Hunt EA, Chatfield J, MacKinnon L, Kessler D; International Network for Simulation-based Pediatric Innovation, Research and Education (INSPIRE) CPR Investigators.

Pediatr Crit Care Med. 2020 Feb 26. doi: 10.1097/PCC.0000000000002275. [Epub ahead of print]


Modified in-continuity resection is advantageous for prognosis and as a new surgical strategy for management of oral tongue cancer.

Li B, Wang C, Cheng A, Kim K, Liu H, Li M, Mao M, Han Z, Feng Z.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2019 Oct 14. pii: S2212-4403(19)31504-4. doi: 10.1016/j.oooo.2019.09.016. [Epub ahead of print]


Knowledge, attitude and practice regarding nursing interruptions among Chinese nurses: A nationwide cross-sectional survey.

Xie J, Sun Q, Tang S, Ding S, Zhong Z, Zeng S, Duan Y, Zhang X, Cheng AS.

Int J Nurs Sci. 2019 Dec 16;7(1):66-73. doi: 10.1016/j.ijnss.2019.12.004. eCollection 2020 Jan 10.


A case of drug reaction with eosinophilia and systemic symptoms (DRESS) without a typical precipitant.

Griffin DW, Martin GE, McLean C, Cheng AC, Giles ML.

Med J Aust. 2020 Feb 24. doi: 10.5694/mja2.50519. [Epub ahead of print] No abstract available.


Phase 3 (COSMIC-312) study of cabozantinib in combination with atezolizumab vs sorafenib in patients with advanced hepatocellular carcinoma (aHCC) who have not received previous systemic anticancer therapy.

Rimassa L, Cheng A, Braiteh F, Benzaghou F, Hazra S, Borgman A, Sinha R, Kayali Z, Zhu A, Kelley R.

Ann Oncol. 2019 Jul;30 Suppl 4:iv65-iv66. doi: 10.1093/annonc/mdz155.237. Epub 2019 Dec 4. No abstract available.


A phase 3 study of durvalumab with or without bevacizumab as adjuvant therapy in patients with hepatocellular carcinoma at high risk of recurrence after curative hepatic resection or ablation: EMERALD-2.

Knox J, Cheng A, Cleary S, Galle P, Kokudo N, Lencioni R, Park J, Zhou J, Mann H, Morgan S, Liu X, Chin S, Vlahovic G, Fan J.

Ann Oncol. 2019 Jul;30 Suppl 4:iv59-iv60. doi: 10.1093/annonc/mdz155.216. Epub 2019 Dec 4. No abstract available.


A phase 3 study of durvalumab with or without bevacizumab as adjuvant therapy in patients with hepatocellular carcinoma (HCC) who are at high risk of recurrence after curative hepatic resection.

Knox J, Cheng A, Cleary S, Galle P, Kokudo N, Lencioni R, Park J, Zhou J, Mann H, Morgan S, Liu X, Chin S, Vlahovic G, Fan J.

Ann Oncol. 2019 Jul;30 Suppl 4:iv51. doi: 10.1093/annonc/mdz155.186. Epub 2019 Dec 4. No abstract available.


Pembrolizumab (Pembro) therapy vs best supportive care (BSC) in advanced hepatocellular carcinoma (HCC): KEYNOTE-240.

Finn RS, Ryoo BY, Merle P, Kudo M, Bouattour M, Lim HY, Breder V, Edeline J, Chao Y, Ogasawara S, Yau T, Garrido M, Chan SL, Knox J, Daniele B, Ebbinghaus SW, Chen E, Siegel AB, Zhu AX, Cheng AL; KEYNOTE-240 Investigators*.

Ann Oncol. 2019 Jul;30 Suppl 4:iv135-iv136. doi: 10.1093/annonc/mdz154.026. Epub 2019 Dec 4. No abstract available.


Outcomes based on Albumin-Bilirubin (ALBI) grade in the phase 3 CELESTIAL trial of cabozantinib versus placebo in patients with advanced hepatocellular carcinoma (HCC).

Miksad R, Cicin I, Chen Y, Klumpen H, Kim S, Lin Z, Youkstetter J, Sen S, Cheng A, Meyer T, Kelley R, Abou-Alfa G.

Ann Oncol. 2019 Jul;30 Suppl 4:iv134. doi: 10.1093/annonc/mdz154.021. Epub 2019 Dec 4. No abstract available.


Regulatory agencies have a role to play in maintaining consumer confidence in vaccine safety for pregnant women.

Giles ML, Cheng AC.

Hum Vaccin Immunother. 2020 Feb 20:1-4. doi: 10.1080/21645515.2020.1718976. [Epub ahead of print] No abstract available.


Binding of Duck Tembusu virus nonstructural protein 2A to duSTING disrupts the induction of its signal transduction cascade to inhibit IFN-β induction.

Zhang W, Jiang B, Zeng M, Duan Y, Wu Z, Wu Y, Wang T, Wang M, Jia R, Zhu D, Liu M, Zhao X, Yang Q, Wu Y, Zhang S, Liu Y, Zhang L, Yu Y, Pan L, Chen S, Cheng A.

J Virol. 2020 Feb 19. pii: JVI.01850-19. doi: 10.1128/JVI.01850-19. [Epub ahead of print]


Effects of Subsequent Systemic Anticancer Medication Following First-Line Lenvatinib: A Post Hoc Responder Analysis from the Phase 3 REFLECT Study in Unresectable Hepatocellular Carcinoma.

Alsina A, Kudo M, Vogel A, Cheng AL, Tak WY, Ryoo BY, Evans TRJ, López López C, Daniele B, Misir S, Ren M, Izumi N, Qin S, Finn RS.

Liver Cancer. 2020 Jan;9(1):93-104. doi: 10.1159/000504624. Epub 2019 Dec 16.


Pan-Asian adapted ESMO Clinical Practice Guidelines for the management of patients with intermediate and advanced/relapsed hepatocellular carcinoma: a TOS-ESMO initiative endorsed by CSCO, ISMPO, JSMO, KSMO, MOS and SSO.

Chen LT, Martinelli E, Cheng AL, Pentheroudakis G, Qin S, Bhattacharyya GS, Ikeda M, Lim HY, Ho GF, Choo SP, Ren Z, Malhotra H, Ueno M, Ryoo BY, Kiang TC, Tai D, Vogel A, Cervantes A, Lu SN, Yen CJ, Huang YH, Chen SC, Hsu C, Shen YC, Tabernero J, Yen Y, Hsu CH, Yoshino T, Douillard JY.

Ann Oncol. 2020 Mar;31(3):334-351. doi: 10.1016/j.annonc.2019.12.001. Epub 2019 Dec 20.


Tensions between Fiscal Accountability Policy and Collaborative Management Implementation in State Wildlife Agencies.

Towry RK Jr, Cheng AS.

Environ Manage. 2020 Feb 17. doi: 10.1007/s00267-020-01261-0. [Epub ahead of print]


Isolation and Selection of Duck Primary Cells as Pathogenic and Innate Immunologic Cell Models for Duck Plague Virus.

Tian B, Cai D, He T, Deng L, Wu L, Wang M, Jia R, Zhu D, Liu M, Yang Q, Wu Y, Zhao X, Chen S, Zhang S, Huang J, Ou X, Mao S, Yu Y, Zhang L, Liu Y, Cheng A.

Front Immunol. 2020 Jan 28;10:3131. doi: 10.3389/fimmu.2019.03131. eCollection 2019.


The geology and geophysics of Kuiper Belt object (486958) Arrokoth.

Spencer JR, Stern SA, Moore JM, Weaver HA, Singer KN, Olkin CB, Verbiscer AJ, McKinnon WB, Parker JW, Beyer RA, Keane JT, Lauer TR, Porter SB, White OL, Buratti BJ, El-Maarry MR, Lisse CM, Parker AH, Throop HB, Robbins SJ, Umurhan OM, Binzel RP, Britt DT, Buie MW, Cheng AF, Cruikshank DP, Elliott HA, Gladstone GR, Grundy WM, Hill ME, Horanyi M, Jennings DE, Kavelaars JJ, Linscott IR, McComas DJ, McNutt RL Jr, Protopapa S, Reuter DC, Schenk PM, Showalter MR, Young LA, Zangari AM, Abedin AY, Beddingfield CB, Benecchi SD, Bernardoni E, Bierson CJ, Borncamp D, Bray VJ, Chaikin AL, Dhingra RD, Fuentes C, Fuse T, Gay PL, Gwyn SDJ, Hamilton DP, Hofgartner JD, Holman MJ, Howard AD, Howett CJA, Karoji H, Kaufmann DE, Kinczyk M, May BH, Mountain M, Pätzold M, Petit JM, Piquette MR, Reid IN, Reitsema HJ, Runyon KD, Sheppard SS, Stansberry JA, Stryk T, Tanga P, Tholen DJ, Trilling DE, Wasserman LH.

Science. 2020 Feb 28;367(6481). pii: eaay3999. doi: 10.1126/science.aay3999. Epub 2020 Feb 13.


Color, composition, and thermal environment of Kuiper Belt object (486958) Arrokoth.

Grundy WM, Bird MK, Britt DT, Cook JC, Cruikshank DP, Howett CJA, Krijt S, Linscott IR, Olkin CB, Parker AH, Protopapa S, Ruaud M, Umurhan OM, Young LA, Dalle Ore CM, Kavelaars JJ, Keane JT, Pendleton YJ, Porter SB, Scipioni F, Spencer JR, Stern SA, Verbiscer AJ, Weaver HA, Binzel RP, Buie MW, Buratti BJ, Cheng A, Earle AM, Elliott HA, Gabasova L, Gladstone GR, Hill ME, Horanyi M, Jennings DE, Lunsford AW, McComas DJ, McKinnon WB, McNutt RL Jr, Moore JM, Parker JW, Quirico E, Reuter DC, Schenk PM, Schmitt B, Showalter MR, Singer KN, Weigle GE 2nd, Zangari AM.

Science. 2020 Feb 28;367(6481). pii: eaay3705. doi: 10.1126/science.aay3705. Epub 2020 Feb 13.


Separating the signal from the noise in metagenomic cell-free DNA sequencing.

Burnham P, Gomez-Lopez N, Heyang M, Cheng AP, Lenz JS, Dadhania DM, Lee JR, Suthanthiran M, Romero R, De Vlaminck I.

Microbiome. 2020 Feb 11;8(1):18. doi: 10.1186/s40168-020-0793-4.


Effect of Vancomycin or Daptomycin With vs Without an Antistaphylococcal β-Lactam on Mortality, Bacteremia, Relapse, or Treatment Failure in Patients With MRSA Bacteremia: A Randomized Clinical Trial.

Tong SYC, Lye DC, Yahav D, Sud A, Robinson JO, Nelson J, Archuleta S, Roberts MA, Cass A, Paterson DL, Foo H, Paul M, Guy SD, Tramontana AR, Walls GB, McBride S, Bak N, Ghosh N, Rogers BA, Ralph AP, Davies J, Ferguson PE, Dotel R, McKew GL, Gray TJ, Holmes NE, Smith S, Warner MS, Kalimuddin S, Young BE, Runnegar N, Andresen DN, Anagnostou NA, Johnson SA, Chatfield MD, Cheng AC, Fowler VG Jr, Howden BP, Meagher N, Price DJ, van Hal SJ, O'Sullivan MVN, Davis JS; Australasian Society for Infectious Diseases Clinical Research Network.

JAMA. 2020 Feb 11;323(6):527-537. doi: 10.1001/jama.2020.0103.


Evaluation of the brain functional activities in rats various location-endometriosis pain model.

Zheng P, Mei J, Leng J, Jia S, Gu Z, Chen S, Zhang W, Cheng A, Guo D, Lang J.

Ann Transl Med. 2019 Dec;7(23):767. doi: 10.21037/atm.2019.11.73.


Modeling defibrillation benefit for survival among cardiac resynchronization therapy defibrillator recipients.

Bilchick KC, Wang Y, Curtis JP, Cheng A, Dharmarajan K, Shadman R, Dardas TF, Anand I, Lund LH, Dahlström U, Sartipy U, Maggioni A, O'Connor C, Levy WC.

Am Heart J. 2020 Apr;222:93-104. doi: 10.1016/j.ahj.2019.12.017. Epub 2019 Dec 27.


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