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Items: 35

1.

Crystal structure of human cytochrome P450 2D6.

Rowland P, Blaney FE, Smyth MG, Jones JJ, Leydon VR, Oxbrow AK, Lewis CJ, Tennant MG, Modi S, Eggleston DS, Chenery RJ, Bridges AM.

J Biol Chem. 2006 Mar 17;281(11):7614-22. Epub 2005 Dec 13.

2.

Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of rosiglitazone.

Baldwin SJ, Clarke SE, Chenery RJ.

Br J Clin Pharmacol. 1999 Sep;48(3):424-32.

3.

Disposition of ropinirole in animals and man.

Ramji JV, Keogh JP, Blake TJ, Broom C, Chenery RJ, Citerone DR, Lewis VA, Taylor AC, Yeulet SE.

Xenobiotica. 1999 Mar;29(3):311-25.

PMID:
10219970
4.

Fetal calf serum decreases CYP3A induction in rat but not in dog or human hepatocyte cultures.

Jackson FC, Chenery RJ, Hawksworth GM.

Biochem Soc Trans. 1997 Nov;25(4):S607. No abstract available.

PMID:
9450035
5.

In vitro identification of the P450 enzymes responsible for the metabolism of ropinirole.

Bloomer JC, Clarke SE, Chenery RJ.

Drug Metab Dispos. 1997 Jul;25(7):840-4.

PMID:
9224778
6.

Induction of cytochrome P4503A by the antiglucocorticoid mifepristone and a novel hypocholesterolaemic drug.

Williams JA, Chenery RJ, Berkhout TA, Hawksworth GM.

Drug Metab Dispos. 1997 Jun;25(6):757-61.

PMID:
9193879
7.

Determination of P4501A2 activity in human liver microsomes using [3-14C-methyl]caffeine.

Bloomer JC, Clarke SE, Chenery RJ.

Xenobiotica. 1995 Sep;25(9):917-27.

PMID:
8553685
8.

Ketoconazole and sulphaphenazole as the respective selective inhibitors of P4503A and 2C9.

Baldwin SJ, Bloomer JC, Smith GJ, Ayrton AD, Clarke SE, Chenery RJ.

Xenobiotica. 1995 Mar;25(3):261-70.

PMID:
7618352
9.

Role of aldehyde oxidase in the in vitro conversion of famciclovir to penciclovir in human liver.

Clarke SE, Harrell AW, Chenery RJ.

Drug Metab Dispos. 1995 Feb;23(2):251-4.

PMID:
7736920
10.

Characterisation of the cytochrome P450 enzymes involved in the in vitro metabolism of granisetron.

Bloomer JC, Baldwin SJ, Smith GJ, Ayrton AD, Clarke SE, Chenery RJ.

Br J Clin Pharmacol. 1994 Dec;38(6):557-66.

11.

Lauric acid as a model substrate for the simultaneous determination of cytochrome P450 2E1 and 4A in hepatic microsomes.

Clarke SE, Baldwin SJ, Bloomer JC, Ayrton AD, Sozio RS, Chenery RJ.

Chem Res Toxicol. 1994 Nov-Dec;7(6):836-42.

PMID:
7696540
12.

Characterization of the inhibition of P4501A2 by furafylline.

Clarke SE, Ayrton AD, Chenery RJ.

Xenobiotica. 1994 Jun;24(6):517-26.

PMID:
7975717
13.

Induction of CYP3A enzymes in human and rat hepatocyte cultures.

Williams JA, Chenery RJ, Hawksworth GM.

Biochem Soc Trans. 1994 May;22(2):131S. No abstract available.

PMID:
7958202
14.

Use of rat and human in vitro systems to assess the effectiveness and enzymology of deoxyguanine analogs as prodrugs of an antiviral agent.

Harrell AW, Wheeler SM, East P, Clarke SE, Chenery RJ.

Drug Metab Dispos. 1994 Mar-Apr;22(2):189-93.

PMID:
8013273
15.

Use of rat and human in vitro systems to assess the effectiveness and enzymology of deoxy-guanine analogues as prodrugs of an antiviral agent.

Harrell AW, Wheeler SM, East P, Clarke SE, Chenery RJ.

Drug Metab Dispos. 1994 Jan-Feb;22(1):124-8.

PMID:
8149871
16.

Evidence that famciclovir (BRL 42810) and its associated metabolites do not inhibit the 6 beta-hydroxylation of testosterone in human liver microsomes.

Harrell AW, Wheeler SM, Pennick M, Clarke SE, Chenery RJ.

Drug Metab Dispos. 1993 Jan-Feb;21(1):18-23.

PMID:
8095215
17.
18.

Cytochrome P450 maintenance and diazepam metabolism in cultured rat hepatocytes.

Blankson EA, Chenery RJ, Paine AJ.

Biochem Pharmacol. 1991 Aug 22;42(6):1241-5.

PMID:
1888333
19.

The disposition of 2-cyano-1-methyl 3-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)phenyl)guanidine in animals.

Walker DG, Hutchison M, Shepard TA, Osborne PM, Allenby SM, Webb AJ, Viney NJ, Pue MA, Chenery RJ, Wood PJ, et al.

Drug Metab Dispos. 1990 Sep-Oct;18(5):613-20.

PMID:
1981709
20.

Metabolism of temelastine (SK&F 93944) in hepatocytes from rat, dog, cynomolgus monkey and man.

Oldham HG, Standring P, Norman SJ, Blake TJ, Beattie I, Cox PJ, Chenery RJ.

Drug Metab Dispos. 1990 Mar-Apr;18(2):146-52.

PMID:
1971564
21.
22.

In vitro drug metabolism and pharmacokinetics of diazepam in cynomolgus monkey hepatocytes during culture for six days.

Seddon T, Lockwood GF, Chenery RJ.

Biochem Pharmacol. 1989 Aug 15;38(16):2621-30.

PMID:
2504170
23.

Comparative drug metabolism of diazepam in hepatocytes isolated from man, rat, monkey and dog.

Seddon T, Michelle I, Chenery RJ.

Biochem Pharmacol. 1989 May 15;38(10):1657-65.

PMID:
2730679
24.

The interaction of temelastine with cytochrome P450 mixed-function oxidase enzymes in vivo and in vitro.

Chenery RJ, Cox PJ, Rath LC, Standring P, Oldham HG.

Biochem Pharmacol. 1989 Jan 1;38(1):209-13. No abstract available.

PMID:
2562918
25.

The metabolism of 5-(4-acetamidophenyl)pyrazin-2(1H)-one in rat, dog and cynomolgus monkey.

Ross DA, Osborne PM, Pue MA, Blake TJ, Chenery RJ, Metcalf R.

Xenobiotica. 1988 Dec;18(12):1373-87.

PMID:
3245231
26.

The antipyrine breath test in the rat: a pharmacokinetic model.

Lockwood GF, Chenery RJ, Oldham HG, Standring P, Norman SJ.

Eur J Drug Metab Pharmacokinet. 1988 Jul-Sep;13(3):207-14.

PMID:
3149242
27.

The interaction of omeprazole with rat liver cytochrome P450-mediated monooxygenase reactions in vitro and in vivo.

Chenery RJ, Ayrton A, Oldham HG, Norman SJ, Standring P.

Biochem Pharmacol. 1988 Apr 1;37(7):1407-14.

PMID:
3258518
28.

Antipyrine metabolism in cultured rat hepatocytes.

Chenery RJ, Oldham HG, Standring P, Norman SJ, Jennings P, Mason PA.

Biochem Pharmacol. 1987 Sep 15;36(18):3077-81. No abstract available.

PMID:
3632725
29.

Diazepam metabolism in cultured hepatocytes from rat, rabbit, dog, guinea pig, and man.

Chenery RJ, Ayrton A, Oldham HG, Standring P, Norman SJ, Seddon T, Kirby R.

Drug Metab Dispos. 1987 May-Jun;15(3):312-7.

PMID:
2886305
30.

Primary cultures of adult rat hepatocytes--a model for the toxicity of histamine H2-receptor antagonists.

Oldham HG, Norman SJ, Chenery RJ.

Toxicology. 1985 Aug;36(2-3):215-29.

PMID:
2864753
31.

Interaction of cimetidine and ranitidine with the FAD monooxygenase in pig liver microsomes.

Oldham HG, Chenery RJ.

Biochem Pharmacol. 1985 Jul 1;34(13):2398-401. No abstract available.

PMID:
4015682
32.

The effect of cimetidine and ranitidine on paracetamol glucuronidation and sulphation in cultured rat hepatocytes.

Emery S, Oldham HG, Norman SJ, Chenery RJ.

Biochem Pharmacol. 1985 May 1;34(9):1415-21.

PMID:
3994756
33.

The effect of ionophore A23187 and 2,4-dinitrophenol on the structure and function of cultured liver cells.

George M, Chenery RJ, Krishna G.

Toxicol Appl Pharmacol. 1982 Dec;66(3):349-60. No abstract available.

PMID:
6820198
34.

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