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Ciprofloxacin Enhances the Chemosensitivity of Cancer Cells to ABCB1 Substrates.

Gupta P, Gao HL, Ashar YV, Karadkhelkar NM, Yoganathan S, Chen ZS.

Int J Mol Sci. 2019 Jan 11;20(2). pii: E268. doi: 10.3390/ijms20020268.


AQAMAN, a bisamidine-based inhibitor of toxic protein inclusions in neurons, ameliorates cytotoxicity in polyglutamine disease models.

Hong H, Koon AC, Chen ZS, Wei Y, An Y, Li W, Lau MHY, Lau KF, Ngo JCK, Wong CH, Au-Yeung HY, Zimmerman SC, Chan HYE.

J Biol Chem. 2018 Dec 28. pii: jbc.RA118.006307. doi: 10.1074/jbc.RA118.006307. [Epub ahead of print]


A personalized and long-acting local therapeutic platform combining photothermal therapy and chemotherapy for the treatment of multidrug-resistant colon tumor.

Wang B, Wu S, Lin Z, Jiang Y, Chen Y, Chen ZS, Yang X, Gao W.

Int J Nanomedicine. 2018 Dec 10;13:8411-8427. doi: 10.2147/IJN.S184728. eCollection 2018.


Exosomal microRNAs as potential biomarkers for cancer cell migration and prognosis in hepatocellular carcinoma patient-derived cell models.

Yu LX, Zhang BL, Yang Y, Wang MC, Lei GL, Gao Y, Liu H, Xiao CH, Xu JJ, Qin H, Xu XY, Chen ZS, Zhang DD, Li FG, Zhang SG, Liu R.

Oncol Rep. 2019 Jan;41(1):257-269. doi: 10.3892/or.2018.6829. Epub 2018 Oct 29.


Proteomic analysis of the Heliothis virescens ascovirus 3i (HvAV-3i) virion.

Chen ZS, Cheng XW, Wang X, Hou DH, Huang GH.

J Gen Virol. 2018 Dec 12. doi: 10.1099/jgv.0.001197. [Epub ahead of print]


Discovery of Novel Quinoline-Chalcone Derivatives as Potent Anti-tumor Agents with Microtubule Polymerization Inhibitory Activity.

Li W, Xu F, Shuai W, Sun H, Yao H, Ma C, Xu S, Yao H, Zhu Z, Yang DH, Chen ZS, Xu J.

J Med Chem. 2018 Dec 11. doi: 10.1021/acs.jmedchem.8b01755. [Epub ahead of print]


Characterization of the Ubiquitin C-Terminal Hydrolase and Ubiquitin-Specific Protease Families in Rice (Oryza sativa).

Wang DH, Song W, Wei SW, Zheng YF, Chen ZS, Han JD, Zhang HT, Luo JC, Qin YM, Xu ZH, Bai SN.

Front Plant Sci. 2018 Nov 15;9:1636. doi: 10.3389/fpls.2018.01636. eCollection 2018.


Modulating ROS to overcome multidrug resistance in cancer.

Cui Q, Wang JQ, Assaraf YG, Ren L, Gupta P, Wei L, Ashby CR Jr, Yang DH, Chen ZS.

Drug Resist Updat. 2018 Nov;41:1-25. doi: 10.1016/j.drup.2018.11.001. Epub 2018 Nov 14.


Ulixertinib (BVD-523) antagonizes ABCB1- and ABCG2-mediated chemotherapeutic drug resistance.

Ji N, Yang Y, Lei ZN, Cai CY, Wang JQ, Gupta P, Xian X, Yang DH, Kong D, Chen ZS.

Biochem Pharmacol. 2018 Dec;158:274-285. doi: 10.1016/j.bcp.2018.10.028. Epub 2018 Oct 26.


VS-4718 Antagonizes Multidrug Resistance in ABCB1- and ABCG2-Overexpressing Cancer Cells by Inhibiting the Efflux Function of ABC Transporters.

Ji N, Yang Y, Cai CY, Lei ZN, Wang JQ, Gupta P, Teng QX, Chen ZS, Kong D, Yang DH.

Front Pharmacol. 2018 Oct 30;9:1236. doi: 10.3389/fphar.2018.01236. eCollection 2018.


Discovery of a non-toxic [1,2,4]triazolo[1,5-a]pyrimidin-7-one (WS-10) that modulates ABCB1-mediated multidrug resistance (MDR).

Chang L, Xiao M, Yang L, Wang S, Wang SQ, Bender A, Hu A, Chen ZS, Yu B, Liu HM.

Bioorg Med Chem. 2018 Dec 1;26(22):5974-5985. doi: 10.1016/j.bmc.2018.10.027. Epub 2018 Nov 3.


Familial ataxia, tremor, and dementia in a polish family with a novel mutation in the CCDC88C gene.

Leńska-Mieciek M, Charzewska A, Królicki L, Hoffman-Zacharska D, Chen ZS, Lau KF, Chan HYE, Gambin T, Fiszer U.

Mov Disord. 2019 Jan;34(1):142-144. doi: 10.1002/mds.27536. Epub 2018 Nov 6. No abstract available.


Regorafenib antagonizes BCRP-mediated multidrug resistance in colon cancer.

Zhang YK, Wang YJ, Lei ZN, Zhang GN, Zhang XY, Wang DS, Al-Rihani SB, Shukla S, Ambudkar SV, Kaddoumi A, Shi Z, Chen ZS.

Cancer Lett. 2019 Feb 1;442:104-112. doi: 10.1016/j.canlet.2018.10.032. Epub 2018 Oct 28.


Immuno-oncology agent IPI-549 is a modulator of P-glycoprotein (P-gp, MDR1, ABCB1)-mediated multidrug resistance (MDR) in cancer: In vitro and in vivo.

De Vera AA, Gupta P, Lei Z, Liao D, Narayanan S, Teng Q, Reznik SE, Chen ZS.

Cancer Lett. 2019 Feb 1;442:91-103. doi: 10.1016/j.canlet.2018.10.020. Epub 2018 Nov 1.


Olmutinib (BI1482694/HM61713), a Novel Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, Reverses ABCG2-Mediated Multidrug Resistance in Cancer Cells.

Zhang W, Fan YF, Cai CY, Wang JQ, Teng QX, Lei ZN, Zeng L, Gupta P, Chen ZS.

Front Pharmacol. 2018 Oct 9;9:1097. doi: 10.3389/fphar.2018.01097. eCollection 2018.


Updated Genetic Testing of Primary Hyperoxaluria Type 1 in a Chinese Population: Results from a Single Center Study and a Systematic Review.

Du DF, Li QQ, Chen C, Shi SM, Zhao YY, Jiang JP, Wang DW, Guo H, Zhang WJ, Chen ZS.

Curr Med Sci. 2018 Oct;38(5):749-757. doi: 10.1007/s11596-018-1941-y. Epub 2018 Oct 20.


Selonsertib (GS-4997), an ASK1 inhibitor, antagonizes multidrug resistance in ABCB1- and ABCG2-overexpressing cancer cells.

Ji N, Yang Y, Cai CY, Lei ZN, Wang JQ, Gupta P, Shukla S, Ambudkar SV, Kong D, Chen ZS.

Cancer Lett. 2019 Jan;440-441:82-93. doi: 10.1016/j.canlet.2018.10.007. Epub 2018 Oct 10.


Drosophila Exo70 Is Essential for Neurite Extension and Survival under Thermal Stress.

Koon AC, Chen ZS, Peng S, Fung JMS, Zhang X, Lembke KM, Chow HK, Frank CA, Jiang L, Lau KF, Chan HYE.

J Neurosci. 2018 Sep 12;38(37):8071-8086. doi: 10.1523/JNEUROSCI.0620-18.2018. Epub 2018 Aug 1.


Design, synthesis and biological evaluation of selective survivin inhibitors.

Xiao M, Xue Y, Wu Z, Lei ZN, Wang J, Chen ZS, Li W.

J Biomed Res. 2018 Aug 31. doi: 10.7555/JBR.31.20160173. [Epub ahead of print]


Discovery of a non-toxic [1,2,4]triazolo[1,5-a]pyrimidin-7-one (WS-10) that modulates ABCB1-mediated multidrug resistance (MDR).

Chang L, Xiao M, Yang L, Wang S, Wang SQ, Bender A, Hu A, Chen ZS, Yu B, Liu HM.

Bioorg Med Chem. 2018 Oct 1;26(18):5006-5017. doi: 10.1016/j.bmc.2018.08.021. Epub 2018 Aug 18. Erratum in: Bioorg Med Chem. 2018 Dec 1;26(22):5974-5985.


BdorOR88a Modulates the Responsiveness to Methyl Eugenol in Mature Males of Bactrocera dorsalis (Hendel).

Liu H, Chen ZS, Zhang DJ, Lu YY.

Front Physiol. 2018 Jul 26;9:987. doi: 10.3389/fphys.2018.00987. eCollection 2018.


Patterned Synthesis of ZnO Nanorod Arrays for Nanoplasmonic Waveguide Applications.

Lamson TL, Khan S, Wang Z, Zhang YK, Yu Y, Chen ZS, Xu H.

Opt Commun. 2018 Mar 15;411:53-58. doi: 10.1016/j.optcom.2017.10.070. Epub 2017 Nov 21.


Effect of KI-67 positive cellular index on prognosis after hepatectomy in Barcelona Clinic Liver Cancer stage A and B hepatocellular carcinoma with microvascular invasion.

Li HH, Qi LN, Ma L, Chen ZS, Xiang BD, Li LQ.

Onco Targets Ther. 2018 Aug 10;11:4747-4754. doi: 10.2147/OTT.S165244. eCollection 2018.


Planar cell polarity gene Fuz triggers apoptosis in neurodegenerative disease models.

Chen ZS, Li L, Peng S, Chen FM, Zhang Q, An Y, Lin X, Li W, Koon AC, Chan TF, Lau KF, Ngo JCK, Wong WT, Kwan KM, Chan HYE.

EMBO Rep. 2018 Sep;19(9). pii: e45409. doi: 10.15252/embr.201745409. Epub 2018 Jul 19.


Gold(III)-Catalyzed Regioselective Oxidation/Cycloisomerization of Diynes: An Approach to Fused Furan Derivatives.

Li J, Xing HW, Yang F, Chen ZS, Ji K.

Org Lett. 2018 Aug 3;20(15):4622-4626. doi: 10.1021/acs.orglett.8b01915. Epub 2018 Jul 13.


Oncosis-inducing cyclometalated iridium(iii) complexes.

Guan R, Chen Y, Zeng L, Rees TW, Jin C, Huang J, Chen ZS, Ji L, Chao H.

Chem Sci. 2018 May 3;9(23):5183-5190. doi: 10.1039/c8sc01142g. eCollection 2018 Jun 21.


Discovery of 5-Cyano-6-phenylpyrimidin Derivatives Containing an Acylurea Moiety as Orally Bioavailable Reversal Agents against P-Glycoprotein-Mediated Mutidrug Resistance.

Wang B, Ma LY, Wang JQ, Lei ZN, Gupta P, Zhao YD, Li ZH, Liu Y, Zhang XH, Li YN, Zhao B, Chen ZS, Liu HM.

J Med Chem. 2018 Jul 18. doi: 10.1021/acs.jmedchem.8b00335. [Epub ahead of print]


[Clinical features and prognosis of children with mature B-cell non-Hodgkin's lymphoma: an analysis of 28 cases].

Chen ZS, Zheng YZ, Chen YQ, Gao QL, Li J, Shen JZ.

Zhongguo Dang Dai Er Ke Za Zhi. 2018 Jun;20(6):470-474. Chinese.


Genomic analysis of a novel isolate Heliothis virescens ascovirus 3i (HvAV-3i) and identification of ascoviral repeat ORFs (aros).

Chen ZS, Hou DH, Cheng XW, Wang X, Huang GH.

Arch Virol. 2018 Oct;163(10):2849-2853. doi: 10.1007/s00705-018-3899-2. Epub 2018 Jun 14.


Curcumin ameliorates cisplatin-induced cystopathy via activating NRF2 pathway.

Shao YP, Zhou Q, Li YP, Zhang SC, Xu HW, Wu S, Shen BX, Ding LC, Xue J, Chen ZS, Wei ZQ.

Neurourol Urodyn. 2018 Nov;37(8):2470-2479. doi: 10.1002/nau.23731. Epub 2018 Jun 19.


Circulating Tumor Cells Undergoing EMT Provide a Metric for Diagnosis and Prognosis of Patients with Hepatocellular Carcinoma.

Qi LN, Xiang BD, Wu FX, Ye JZ, Zhong JH, Wang YY, Chen YY, Chen ZS, Ma L, Chen J, Gong WF, Han ZG, Lu Y, Shang JJ, Li LQ.

Cancer Res. 2018 Aug 15;78(16):4731-4744. doi: 10.1158/0008-5472.CAN-17-2459. Epub 2018 Jun 18.


Special Issue: Natural Products: Anticancer and Beyond.

Cui Q, Yang DH, Chen ZS.

Molecules. 2018 May 23;23(6). pii: E1246. doi: 10.3390/molecules23061246. No abstract available.


Evaluation of the Curative Effect of Umbilical Cord Mesenchymal Stem Cell Therapy for Knee Arthritis in Dogs Using Imaging Technology.

Zhang BY, Wang BY, Li SC, Luo DZ, Zhan X, Chen SF, Chen ZS, Liu CY, Ji HQ, Bai YS, Li DS, He Y.

Stem Cells Int. 2018 May 15;2018:1983025. doi: 10.1155/2018/1983025. eCollection 2018.


[Saw palmetto fruit extract improves LUTS in type ⅢA prostatitis patients].

Shao YP, Xue HL, Shen BX, Ding LC, Chen ZS, Wei ZQ.

Zhonghua Nan Ke Xue. 2017 May;23(5):417-421. Chinese.


Epidermal growth factor receptor (EGFR) inhibitor PD153035 reverses ABCG2-mediated multidrug resistance in non-small cell lung cancer: In vitro and in vivo.

Zhang GN, Zhang YK, Wang YJ, Gupta P, Ashby CR Jr, Alqahtani S, Deng T, Bates SE, Kaddoumi A, Wurpel JND, Lei YX, Chen ZS.

Cancer Lett. 2018 Jun 28;424:19-29. doi: 10.1016/j.canlet.2018.02.040. Epub 2018 Mar 5.


TC > 0.05 as a Pharmacokinetic Parameter of Paclitaxel for Therapeutic Efficacy and Toxicity in Cancer Patients.

Xin DS, Zhou L, Li CZ, Zhang SQ, Huang HQ, Qiu GD, Lin LF, She YQ, Zheng JT, Chen C, Fang L, Chen ZS, Zhang SY.

Recent Pat Anticancer Drug Discov. 2018;13(3):341-347. doi: 10.2174/1574892813666180305170439.


Author Correction: Down-regulated GATA-1 up-regulates interferon regulatory factor 3 in lung adenocarcinoma.

Wang LL, Chen ZS, Zhou WD, Shu J, Wang XH, Jin R, Zhuang LL, Hoda MA, Zhang H, Zhou GP.

Sci Rep. 2018 Mar 6;8(1):4299. doi: 10.1038/s41598-018-22517-0.


Synthesis and biological evaluation of indole-based UC-112 analogs as potent and selective survivin inhibitors.

Wang Q, Arnst KE, Xue Y, Lei ZN, Ma D, Chen ZS, Miller DD, Li W.

Eur J Med Chem. 2018 Apr 10;149:211-224. doi: 10.1016/j.ejmech.2018.02.045. Epub 2018 Feb 19.


Voruciclib, a Potent CDK4/6 Inhibitor, Antagonizes ABCB1 and ABCG2-Mediated Multi-Drug Resistance in Cancer Cells.

Gupta P, Zhang YK, Zhang XY, Wang YJ, Lu KW, Hall T, Peng R, Yang DH, Xie N, Chen ZS.

Cell Physiol Biochem. 2018;45(4):1515-1528. doi: 10.1159/000487578. Epub 2018 Feb 19.


Elimination of Bimodal Size in InAs/GaAs Quantum Dots for Preparation of 1.3-μm Quantum Dot Lasers.

Su XB, Ding Y, Ma B, Zhang KL, Chen ZS, Li JL, Cui XR, Xu YQ, Ni HQ, Niu ZC.

Nanoscale Res Lett. 2018 Feb 21;13(1):59. doi: 10.1186/s11671-018-2472-y.


Dacomitinib antagonizes multidrug resistance (MDR) in cancer cells by inhibiting the efflux activity of ABCB1 and ABCG2 transporters.

Fan YF, Zhang W, Zeng L, Lei ZN, Cai CY, Gupta P, Yang DH, Cui Q, Qin ZD, Chen ZS, Trombetta LD.

Cancer Lett. 2018 May 1;421:186-198. doi: 10.1016/j.canlet.2018.01.021. Epub 2018 Jan 11.


A peptidylic inhibitor for neutralizing expanded CAG RNA-induced nucleolar stress in polyglutamine diseases.

Zhang Q, Chen ZS, An Y, Liu H, Hou Y, Li W, Lau KF, Koon AC, Ngo JCK, Chan HYE.

RNA. 2018 Apr;24(4):486-498. doi: 10.1261/rna.062703.117. Epub 2018 Jan 2.


Comprehensive Synthesis of Amino Acid-Derived Thiazole Peptidomimetic Analogues to Understand the Enigmatic Drug/Substrate-Binding Site of P-Glycoprotein.

Patel BA, Abel B, Barbuti AM, Velagapudi UK, Chen ZS, Ambudkar SV, Talele TT.

J Med Chem. 2018 Feb 8;61(3):834-864. doi: 10.1021/acs.jmedchem.7b01340. Epub 2018 Jan 23.


Quizartinib (AC220) reverses ABCG2-mediated multidrug resistance: In vitro and in vivo studies.

Li J, Kumar P, Anreddy N, Zhang YK, Wang YJ, Chen Y, Talele TT, Gupta K, Trombetta LD, Chen ZS.

Oncotarget. 2017 Sep 16;8(55):93785-93799. doi: 10.18632/oncotarget.21078. eCollection 2017 Nov 7.


Cytotoxic and acute toxicity studies of isoniazid derivatives.

Naeem S, Akhtar S, Lei ZN, Lu K, Zafar S, Ahmed A, Ali M, Ahmed M, Chen ZS.

Pak J Pharm Sci. 2017 Nov;30(6(Supplementary)):2411-2415.


Transcription Factor OsTGA10 Is a Target of the MADS Protein OsMADS8 and Is Required for Tapetum Development.

Chen ZS, Liu XF, Wang DH, Chen R, Zhang XL, Xu ZH, Bai SN.

Plant Physiol. 2018 Jan;176(1):819-835. doi: 10.1104/pp.17.01419. Epub 2017 Nov 20.


CDX2 Stimulates the Proliferation of Porcine Intestinal Epithelial Cells by Activating the mTORC1 and Wnt/β-Catenin Signaling Pathways.

Fan HB, Zhai ZY, Li XG, Gao CQ, Yan HC, Chen ZS, Wang XQ.

Int J Mol Sci. 2017 Nov 18;18(11). pii: E2447. doi: 10.3390/ijms18112447.


Exploration of 1,2,3-triazole-pyrimidine hybrids as potent reversal agents against ABCB1-mediated multidrug resistance.

Wang B, Zhao B, Chen ZS, Pang LP, Zhao YD, Guo Q, Zhang XH, Liu Y, Liu GY, Hao-Zhang, Zhang XY, Ma LY, Liu HM.

Eur J Med Chem. 2018 Jan 1;143:1535-1542. doi: 10.1016/j.ejmech.2017.10.041. Epub 2017 Oct 21.


Design, synthesis and biological evaluation of WZ4002 analogues as EGFR inhibitors.

Romu AA, Lei Z, Zhou B, Chen ZS, Korlipara V.

Bioorg Med Chem Lett. 2017 Nov 1;27(21):4832-4837. doi: 10.1016/j.bmcl.2017.09.048. Epub 2017 Sep 25.


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